Mamta Amrute-Nayak

Dr. rer. nat.

Copyright, MHH, MZP

Kontakt

Mamta Amrute

Tel: +49 511 532 -2754 (Büro), -3654 (Labor)

Fax: +49 511 532 -4296

Adresse: 30625 Hannover, Carl-Neuberg-Str.1

Büro:  Gebäude J03, Block 01, Ebene 03, Raum 1330

Profil bei ResearchGate


Werdegang

  • Since 2017: Principal Investigator im Institut für Molekular- und Zellphysiologie an der Medizinischen Hochschule Hannover (MHH)
  • 2012-2016: Postdoctoral researcher Institute of Molecular and Cell Physiology, Medical School Hannover, Germany.
  • 2008 - 2011:  Postdoctoral researcher in Medical research council- Laboratory of Molecular Biology (MRC-LMB), Cambridge, United Kingdom.
  • 2003 – 2006, Ph.D. in Institute of Molecular and Cell Physiology, Medical School Hannover, Germany.
  • 2001-2002, Junior research fellow in National Center for cell sciences (NCCS), Pune, India
  • Master of Science (M.Sc.) from Pune University, Maharashtra, India.

 

Aktuelle Forschungsschwerpunkte

  • Single molecule studies of molecular motor proteins, hypertrophic cardiomyopathy (HCM) mutations in β cardiac myosin.
  • Nanobiohybrid motors
  • Muscle atrophy

 

Expertisen

  • Single-molecule investigations using TIRF microscopy, Optical trapping, Zero-mode waveguides.
  • Teaching physiology courses (Studentisches Praktikum) for human medicine, dentistry students, and practicals for Master level biomedical students.

 

Wissenschaftliche Artikel in Fachzeitschriften

  • Single-molecule analysis reveals that regulatory light chains fine-tune skeletal myosin-II function, Nayak A, Wang T, Franz P, Steffen W, Chizhov I, Tsiavaliaris G, Amrute-Nayak M, J Biol Chem. 2020 Apr 9. pii: jbc.RA120.012774. doi: 10.1074/jbc.RA120.012774, PMID: 32273340, Artikel,PubMed
     
  • Regulation of SETD7 Methyltransferase by SENP3 Is Crucial for Sarcomere Organization and Cachexia. Nayak A, Lopez-Davila AJ, Kefalakes E, Holler T, Kraft T, Amrute-Nayak M. Cell Rep. 2019 May 28; 27(9):2725-2736.e4. doi: 10.1016/j.celrep.2019.04.107., PMID: 31141694; PubMed
  • Transformation of the Nonprocessive Fast Skeletal Myosin II into a Processive Motor. Amrute-NayakM, Nayak A, Steffen W, Tsiavaliaris G, Scholz T, Brenner B. Small. 2019 Feb;15(7):e1804313. doi: 10.1002/smll.201804313. Epub 2019 Jan 18., PMID: 30657637; PubMed
  • MARK4 regulates NLRP3 positioning and inflammasome activation through a microtubule-dependent mechanism. Li X, Thome S, Ma X, Amrute-Nayak M, Finigan A, Kitt L, Masters L, James JR, Shi Y, Meng G, Mallat Z. Nat Commun. 2017 Jun 28;8:15986. doi: 10.1038/ncomms15986., PMID: 28656979; PubMed
  • ATP turnover by individual myosin molecules hints at two conformers of the myosin active site. Amrute-Nayak M, Lambeck KA, Radocaj A, Huhnt HE, Scholz T, Hahn N, Tsiavaliaris G, Walter WJ, Brenner B. Proc Natl Acad Sci U S A. 2014 Feb 18;111(7):2536-41. doi: 10.1073/pnas.1316390111. Epub 2014 Feb 3., PMID: 24550279; PubMed
  • Single-molecule assays reveal that RNA localization signals regulate dynein-dynactin copy number on individual transcript cargoes. Amrute-Nayak M, Bullock SL. Nat Cell Biol. 2012 Feb 26; 14(4):416-23. doi: 10.1038/ncb2446., PMID: 22366687; PubMed
  • Targeted optimization of a protein nanomachine for operation in biohybrid devices. Amrute-Nayak M, Diensthuber RP, Steffen W, Kathmann D, Hartmann FK, Fedorov R, Urbanke C, Manstein DJ, Brenner B, Tsiavaliaris G. Angew Chem Int Ed Engl. 2010;49(2):312-6. doi: 10.1002/anie.200905200., PMID: 19921669; PubMed
  • Inorganic phosphate binds to the empty nucleotide binding pocket of conventional myosin II. Amrute-Nayak M, Antognozzi M, Scholz T, Kojima H, Brenner B. J Biol Chem. 2008 Feb 15;283(7):3773-81. Epub 2007 Dec 12., PMID:18079122; PubMed

 

Drittmittelfonds

  • Deutsche Forschungsgemeinschaft (DFG)
  • Fritz Thyssen Stiftung

 

Förderung von der Medical School Hannover (MHH)

  • Hochschulinternen Leistungsförderung (HilF), Early career research grant.

 

Kooperationspartner

  • Prof. Georgios Tsiavaliaris (Biophysical chemistry, Hannover Medical School)
  • Dr. Xuan Li (Cambridge, UK)
  • Dr. Toshio Yanagida (Riken, Japan)
  • Dr. Mitsuhiro Iwaki, (Riken, Japan)