Medizinische Hochschule Hannover : Dr. rer. nat. Mamta Amrute

Mamta Amrute-Nayak

Tel: +49 511 532 -2754 (Büro), -3654 (Labor)

Fax: +49 511 532 -4296

Adresse: 30625 Hannover, Carl-Neuberg-Str.1

Büro: Gebäude J03, Block 01, Ebene 03, Raum 1330

Zur Forschungsseite der Arbeitsgruppe

Since 2017: Principal Investigator im Institut für Molekular- und Zellphysiologie an der Medizinischen Hochschule Hannover (MHH)
2012-2016: Postdoctoral researcher Institute of Molecular and Cell Physiology, Medical School Hannover, Germany.
2008 - 2011: Postdoctoral researcher in Medical research council- Laboratory of Molecular Biology (MRC-LMB), Cambridge, United Kingdom.
2003 – 2006, Ph.D. in Institute of Molecular and Cell Physiology, Medical School Hannover, Germany.
2001-2002, Junior research fellow in National Center for cell sciences (NCCS), Pune, India
Master of Science (M.Sc.) from Pune University, Maharashtra, India.

Single molecule studies of molecular motor proteins, hypertrophic cardiomyopathy (HCM) mutations in β cardiac myosin.

Single-molecule investigations using TIRF microscopy, Optical trapping, Zero-mode waveguides.

Teaching physiology courses (Studentisches Praktikum) for human medicine, dentistry students, and practicals for Master level biomedical students.

Chemotherapy triggers cachexia by deregulating synergetic function of histone-modifying enzymes, Mamta Amrute-Nayak, Gloria Pegoli, Tim Holler, Alfredo Jesus Lopez-Davila, Chiara Lanzuolo, Arnab Nayak, J Cachexia Sarcopenia Muscle, . 2020 Dec 10., doi: 10.1002/jcsm.12645. Online ahead of print, PubMed
Acto-Myosin Cross-Bridge Stiffness Depends on the Nucleotide State of Myosin II. Wang T, Brenner B, Nayak A, and Amrute-Nayak M. Nano Letters, 2020 Sep 15. doi: 10.1021/acs.nanolett.0c02960. [Online ahead of print] PubMed
Single-molecule analysis reveals that regulatory light chains fine-tune skeletal myosin-II function, Nayak A, Wang T, Franz P, Steffen W, Chizhov I, Tsiavaliaris G, Amrute-Nayak M, J Biol Chem. 2020 Apr 9. pii: jbc.RA120.012774. doi: 10.1074/jbc.RA120.012774, PMID: 32273340, Artikel, PubMed
Regulation of SETD7 Methyltransferase by SENP3 Is Crucial for Sarcomere Organization and Cachexia. Nayak A, Lopez-Davila AJ, Kefalakes E, Holler T, Kraft T, Amrute-Nayak M. Cell Rep. 2019 May 28; 27(9):2725-2736.e4. doi: 10.1016/j.celrep.2019.04.107., PMID: 31141694; PubMed
Transformation of the Nonprocessive Fast Skeletal Myosin II into a Processive Motor. Amrute-Nayak M, Nayak A, Steffen W, Tsiavaliaris G, Scholz T, Brenner B. Small. 2019 Feb;15(7):e1804313. doi: 10.1002/smll.201804313. Epub 2019 Jan 18., PMID: 30657637; PubMed

MARK4 regulates NLRP3 positioning and inflammasome activation through a microtubule-dependent mechanism. Li X, Thome S, Ma X, Amrute-Nayak M, Finigan A, Kitt L, Masters L, James JR, Shi Y, Meng G, Mallat Z. Nat Commun. 2017 Jun 28;8:15986. doi: 10.1038/ncomms15986., PMID: 28656979; PubMed

ATP turnover by individual myosin molecules hints at two conformers of the myosin active site. Amrute-Nayak M, Lambeck KA, Radocaj A, Huhnt HE, Scholz T, Hahn N, Tsiavaliaris G, Walter WJ, Brenner B. Proc Natl Acad Sci U S A. 2014 Feb 18;111(7):2536-41. doi: 10.1073/pnas.1316390111. Epub 2014 Feb 3., PMID: 24550279; PubMed

Single-molecule assays reveal that RNA localization signals regulate dynein-dynactin copy number on individual transcript cargoes. Amrute-Nayak M, Bullock SL. Nat Cell Biol. 2012 Feb 26; 14(4):416-23. doi: 10.1038/ncb2446., PMID: 22366687; PubMed

Targeted optimization of a protein nanomachine for operation in biohybrid devices. Amrute-Nayak M, Diensthuber RP, Steffen W, Kathmann D, Hartmann FK, Fedorov R, Urbanke C, Manstein DJ, Brenner B, Tsiavaliaris G. Angew Chem Int Ed Engl. 2010;49(2):312-6. doi: 10.1002/anie.200905200., PMID: 19921669; PubMed

Inorganic phosphate binds to the empty nucleotide binding pocket of conventional myosin II. Amrute-Nayak M, Antognozzi M, Scholz T, Kojima H, Brenner B. J Biol Chem. 2008 Feb 15;283(7):3773-81. Epub 2007 Dec 12., PMID:18079122; PubMed