providing scientists without previous microarray experience with an early insight into the most prominent gene expression changes and overall data reliability. By supplying clients with a “first impression” of [...] individual spots PDF Supplemental materials for publications Microarray-based mRNA expression analysis - Gene regulation by mRNA export protein, THOC5 PDF C/EBPβ is a transciptional key regulator of IL-36α in
ing of somatic cells for the production of induced pluripotent stem cells (iPS cells), so-called "gene editing" for the targeted genetic modification of cells, scalable bioreactor systems for stem cell [...] research include the elucidation of disease mechanisms, the development of new drugs and novel cell- and gene-based therapies for regeneration and the repair of damaged organs, especially in the cardiovascular
Wageningen University & Research, The Netherlands Xiangming Han Research Topic : Cell type-specific HCMV gene expression and its consequences for the MHC-I immunopeptidome Supervisor : Prof. Dr. Lars Dölken, [...] Research Topic : Development of a screening platform for fine mapping of functional herpes simplex virus gene elements by MuA transposon mutagenesis Supervisor: Prof. Dr. Lars Dölken, Institute of Virology, MHH [...] Immunology, Philipps University Marburg Yan Zheng Research Topic : Functional analysis of cytomegalovirus gene products and cellular effectors during lytic infection Supervisor: Prof. Dr. Lars Dölken, Institute
which is essential in the alveoli for normal lung function. To date, mutations in three different genes are known to cause SD (ATP-binding cassette protein member A3, surfactant proteins B and C). Both [...] by the “Mukoviszidose e.V.”, technologies are currently being developed to correct the underlying gene defect in patient-derived iPSCs prior to differentiation into the desired respiratory cell type (see
transplantation enables the opportunity of pre-Tx modification of hepatocytes by technologies such as gene therapy. Unfortunately, the promising results obtained in animal models could not be successfully
Mohr I. Targeting the m6A RNA modification pathway blocks SARS-CoV-2 and HCoV-OC43 replication. Genes & Dev . 2021 https://doi.org/10.1101/gad.348320.121 Ouwendijk WJD*, Depledge DP* , Rajbhandari L, [...] GMGM, Sadaoka T. Expression of varicella-zoster virus VLT-ORF63 fusion transcript induces broad viral gene expression during reactivation from neuronal latency. Nature Comms. 2020. https://doi.org/10.1038 [...] L, Mohr I. RNA m6A modification enzymes shape innate responses to DNA by regulating interferon β. Genes & Dev. 2018. https://doi.org/10.1101/gad.319475.118 Depledge DP* , Ouwendijk WJD*, Sadaoka T*, Braspenning
OE 6710, project: Pseudomonas aeruginosa - mammalian host cell interaction: Phagocyte-sensitizing genes of P. aeruginosa Final exam November 2006 Anuhar Chaturvedi INDIA supervisor: PD Dr. Eder, Hematology [...] 2006 Eric Hesse (Dr. med.) GERMANY supervisor: Prof. Dr. Krettek; Trauma Surgery, OE6230, project: Gene-expression analysis of mesenchymal stem cells and their matrix synthesis Final exam November 2007
supervisor: PD Dr. Michael Ott, Gastro-Hepa-Endo, OE 6810, Dr. Jens Bohne, Virology, OE 5230, project: Gene therapy of hereditary metabolic liver diseases by targeted genome editing Final exam June 2020. Maurice [...] Heckl, Ped. Hematology, OE 6780, project: High-throughput functional characterization of mutated genes in acute megakaryoblastic leukemia using CRISPR-Cas9 genome editing Final exam January 2019. Marcel
talks on the latest advancements in stem cell research, disease modeling, regenerative medicine, and gene therapies, highlighting cutting-edge developments and translational approaches. Beyond the presentations
2015 Apr 24. PMID: 25911549 Free PMC article. Clinical Trial. No abstract available. A novel G6PC3 gene mutation in severe congenital neutropenia: pancytopenia and variable bone marrow phenotype can also [...] Mutat. 2013 Jun;34(6):905-14. doi: 10.1002/humu.22308. Epub 2013 Apr 2. PMID: 23463630 A novel G6PC3 gene mutation in a patient with severe congenital neutropenia. Aytekin C, Germeshausen M, Tuygun N, Dogu [...] Sep;37(6):673-81. doi: 10.1055/s-0031-1291377. Epub 2011 Nov 18. PMID: 22102270 Review. Lentiviral gene transfer regenerates hematopoietic stem cells in a mouse model for Mpl-deficient aplastic anemia.