development of human, stem cell-derived cardiomyocytes (hPSC-CMs) Characterization and further maturation of human, stem cell-derived cardiomyocytes (hPSC-CMs) in direct comparison with human, adult card

2122467120 A specific, non-immune system-related isoform of the human inducible nitric oxide synthase is expressed during differentiation of human stem cells into various cell types. Gather F, Ihrig-Biedert [...] Gather F, Vogel T (2022) Int J Mol Sci. 23(2):954. https//doi.org/10.3390/ijms23020954 Regulation of human inducible nitric oxide synthase expression by an upstream open reading frame. Gather F, Schmitz K

AG Zweigerdt Zweigerdt Lab Applying human pluripotent stem cells (hPSCs) , we are working on aspects of developmental biology and regenerative medicine focused on the heart as well other tissues and lineages [...] Modulation of Histone Acetyl Transferases (IQ-1) and Wnt pathway (CHIR), synergistically stabilize human cardiac progenitors. SCPs depend on NR2F2 to sustain their progenitor phenotype. Upon removal of the [...] foregut endoderm tissues and a vascular network (Figure 3). Besides deciphering complex mechanisms of human organogenesis in a dish , the HFO model can also be used for replacing animal studies in the process

the human induced pluripotent stem cell derived cardiomyocytes (hiPSC-CMs) and further validate these findings in living myocardial slices isolated from left ventricular specimens of failing human hearts [...] the hiPSC-CMs and live human myocardial slices with the SARS-CoV-2 virus and analyze the transcriptome to identify potential non-coding RNAs involved in this process. Impact of human glycosylation on the [...] protein levels in rat primary cardiomyocytes. More importantly these findings were also translated into human induced pluripotent stem cell derived cardiomyocytes. We reported the first miRNA candidate that can

anti-infectives. Microbial metagenome of the respiratory tract The Human Microbiome Project has characterized the microbiome of healthy humans in numerous organs, but has left out the lower respiratory tract [...] Pseudomonas aeruginosa lives in soil, fresh and salt water and colonizes plant and animal surfaces. In humans, P. aeruginosa has become one of the most common bacterial pathogens of local infections of the eye

accumulation of mutations in somatic cells. For the first time in Germany, iPS cells were generated from human cord blood and differentiated into functional cardiomyocytes. In comparison to iPS cells derived from [...] within the scope of the annual general meeting of the GdF for their publication of iPS cells from human cord blood in the renowned journal Cell Stem Cell (Haase et al. 2009). Once a year, excellent researchers

Teilprojekt B1 Visualization of herpesviral infections and the immune response and modulation The humane cytomegalovirus (HCMV) causes, in particular in immunosuppressed patients, significant clinical diseases [...] with the murine CMV (MCMV) in the mouse, however, shows many similarities to the HCMV infection in human beings. Although comprehensive infection experiments with MCMV were carried out, the exact processes

Linden, Ricklingerstr. 5, 30449 Hannover, project: Regulation of chemokine receptor expression on human eosinophils Final exam on November 7th, 2003 (Dr.rer.nat.) Veit Erpenbeck GERMANY (Dr. med.) supervisor: [...] Sellge GERMANY supervisor: Prof. Dr. Bischoff, Gastroenterology and Hepatology, OE 6810, project: Human intestinal mast cells: versatile cells of the intestinal immune system Final exam on November 7th

logy/ Endocrinology, OE 6819, project: Generation of a functional mouse model with a human immune system and human liver cells for the study of HCV pathogenesis and therapy; study of the functional ability [...] supervisor: Prof. Dr. Ott, Gastroenterology/Hepatology/ Endocrinology, OE 6819, project: Standardised human mesenchymal stem cells for regenerative medicine Final exam June 2010 Natalie Naue GERMANY supervisor:

mechanisms of vasculogenesis. In parallel, we are studying new vessel formation in human renal organoids. We have discovered that human macrophages strongly influence vascularization and endothelial differentiation [...] of renal tissue. The goal is to vascularize organoids and to produce functional kidney tissue from human stem cells. We use zebrafish embryos with genetic markers for renal cells, macrophages and endothelium