Hildegard Büning and Professor Dr Axel Schambach agree on this. The gene therapy experts from the Institute of Experimental Haematology at Hannover Medical School (MHH), together with five other experts, [...] in 2020. "On 16 November, less than a fortnight ago, the world's first gene therapy based on this genetic technology was approved in the UK," reports Professor Büning. People suffering from the blood disorders [...] the genes" is already capable of today. "And it will be able to do even more: One idea is to use genetic scissors or 'erasers' in the genome to detect and correct possible malfunctions in common diseases

cells of the haematopoietic system multiply uncontrollably. This form of blood cancer is caused by genetic changes in the bone marrow that occur in the course of life. Therefore, it is mainly older people [...] Medicine, one of the world's most respected medical journals. Surprisingly strong effect also in humans The drugs in question are Ivosidenib and Azacitidine, which have so far been used individually against [...] Professor Heuser. In the clinical trial, the researchers were now also able to demonstrate this effect in humans who had newly diagnosed AML with gene alterations in the IDH1 enzyme. "We were surprised that the

about the molecular biological causes. A research team led by Professor Dr. Christian Bär from the Institute of Molecular and Translational Therapy Strategies of the Hannover Medical School (MHH) now wants [...] and over again. The reason for this is the so-called telomeres, the ends of the chromosomes. The genetic information is stored on the chromosomes. With each cell division, the telomeres shorten a bit. After [...] first investigate the role of immune and organ aging in the heart and lungs. For this purpose, two genetically different, so-called chimeric mouse models are produced, in which the biological ages of organs

Bengel, MHH Dean of Research. Key factor for liver metabolism The mRNA copies the genetic information contained in our genetic material, the DNA. The copy then serves as a template for building proteins, the [...] levels have been shown to decrease as the disease progresses. "In studies on the mouse model and in human liver cells, we have already been able to show that the therapeutic mRNA can be used to restore HFN4α

contains the genetic information for the blueprint of the so-called spike protein, which is located on the surface of the coronavirus and with the help of which the virus enters the cells. This genetic information [...] Immunology at Hannover Medical School (MHH) has now closed this gap. In cooperation with the MHH Institute of Immunology and the German Primate Centre Göttingen, the researchers have published the world's [...] samples to investigate immune reactions against SARS-CoV2 in employees of the MHH and affiliated institutions. "Our data can also make a significant contribution to better understanding the long-term immune

they not only do not attack the tumour cells, but even stimulate tumour growth. Researchers at the Institute of Clinical Biochemistry at the Hannover Medical School (MHH), in collaboration with specialists [...] group 2953 "Sialic acid as a regulator in development and immunity" and working group leader at the Institute of Clinical Biochemistry at MHH. "Through experiments on glioblastoma cells and macrophages in cell [...] glioblastomas examined," adds Dr Hauke Thiesler from Professor Hildebrandt's research group. "A simple genetic test in combination with other factors could enable a more precise individual prognosis." Furthermore

Whether such cells also exist in the human lung remained controversial in science. Now, a research team led by Professor Dr. Christian Mühlfeld, acting head of the Institute of Functional and Applied Anatomy [...] sections from healthy, fibrotic or damaged (emphysematous) human lung tissue provided by Professor Dr. Danny Jonigk's team from the MHH-Institute of Pathology. Dr. Julia Schipke used various markers to highlight [...] in the human lung and filled an important gap in lung research," Professor Mühlfeld is pleased to say. The method of correlative microscopy, which has been further developed in his institute, of first

three-dimensional X-ray images of the human body possible. With a maximum resolution of up to 300 nanometres, they are equivalent to one tenth of the diameter of a human hair. "The networking between radiology [...] covid-19," says PD Dr Maximilian Ackermann, Institute of Pathology at Helios University Hospital Wuppertal, University of Witten/Herdecke, and at the Institute of Functional and Clinical Anatomy at the [...] enormous clinical significance in the future," emphasises pathologist Prof. Dr. Danny Jonigk, MHH Institute of Pathology. "With the high-resolution three-dimensional imaging, we will be able to better understand

Ravens and Dr. Alina Fichtner from the Institute of Immunology at the Hannover Medical School (MHH) and Professor Dr. Immo Prinz and Dr. Likai Tan from the Institute of Systems Immunology at the University [...] down to the smallest detail. RESIST consists of six partner institutions, the spokesperson is Professor Dr. Thomas Schulz, head of the MHH Institute of Virology. RESIST is funded by the German Research Foundation [...] gamma-delta T cells in cord blood samples as well as from adult blood samples. "Interestingly, certain human Vγ9Vδ2 T cells are generated exclusively in the very early phase of life to be ready for immediate

11.05.2023 How do human cells defend themselves against adenoviruses? The team of RESIST Professor Dr. Sabrina Schreiner from the Institute of Virology at the Hannover Medical School (MHH) has come a good [...] from the Institute of Virology at the Technical University of Munich from Professor Schreiner's research group there. The team of authors also includes Dr Samuel Hofmann from the MHH Institute of Virology [...] Virology. Neither specific therapies nor vaccination available New treatment options against human adenoviruses are needed, as there are neither specific therapies against these viruses nor a vaccination for