The team examined a collection of about 900 E. coli isolates that caused blood infections and 370 harmless isolates. The samples were collected over a 17-year period (from 2000 to 2017) by the team of Prof [...] death in Germany. The bacteria have caused increasingly more diseases Professor Dr. Marco Galardinis team has studied this in more detail and found that E. coli has a significant genetic variation that c [...] future, and these results might also be important for vaccines development," says Prof. Galardini. The team published their findings in the journal PLoSGenetics . First authors are Judit Burgaya and Julie Marin

interdisciplinary team includes researchers from the TU Munich, the University Hospital Freiburg, Princeton University (USA) and the University of Oxford (UK). With their work, the team has possibly made [...] viruses, for example HIV and herpes viruses. But until now it was not clear how it does this. Now a team led by Dr Manutea Serrero and Professor Dr Beate Sodeik from the Institute of Virology at Hannover [...] now being investigated, for example on the cytomegalovirus and the Epstein-Barr virus. So far, the team has been working with cell-free methods and with protein mixtures that are formed after the cell membranes

adenoviruses? The team of RESIST Professor Dr. Sabrina Schreiner from the Institute of Virology at the Hannover Medical School (MHH) has come a good deal closer to answering this question. The team has elucidated [...] Virology at the Technical University of Munich from Professor Schreiner's research group there. The team of authors also includes Dr Samuel Hofmann from the MHH Institute of Virology. Neither specific therapies [...] die from such an infection. Cells defend themselves with the protein Apobec3A Professor Schreiner's team has now found that human cells defend themselves against adenovirus infection with the help of Apobec3A

The "father" of surgery at MHH died on 8 September 2022 at the age of 94. "Professor Borst and his team laid the foundations for MHH surgery to achieve international standing," says MHH President Professor [...] specialist clinics in a departmental system. Professor Borst came to Hanover from Munich with his team in 1968. He built up the Centre for Surgery and in particular the Department of Thoracic, Cardiac [...] years. The up-and-coming MHH provided an ideal setting for cardiac surgery to flourish. Initially, his team still worked at the Oststadtkrankenhaus. Even before the central hospital on the Roderbruch campus

With the project "iGUARD (integrated Guided Ultrafast Antiviral RNAi Drug development)", a research team led by Professor Dr. Dr. Axel Schambach, head of the Institute for Experimental Haematology at the [...] Leap Innovations with 700,000 euros initially for one year. Blocking virus replication The research team is focusing on the parainfluenza virus, which attacks the lower respiratory tract and triggers flu-like [...] systems. The goal is to prevent the virus from multiplying and spreading in the body. The research team hopes to achieve this with the help of so-called RNA interference (RNAi). RNAi uses a natural mechanism

With the project "iGUARD (integrated Guided Ultrafast Antiviral RNAi Drug development)", a research team led by Professor Dr. Axel Schambach, head of the Institute for Experimental Haematology at the Hannover [...] 1.5 million euros for another year. Systematically blocking virus replication The iGUARD research team is focusing on the parainfluenza virus, which primarily attacks the lower respiratory tract in children [...] so to speak. With the help of artificial intelligence, the so-called in-silico design, the research team has primarily searched for "conserved" regions from gene databases. These are indispensable for the

This gave rise to the suspicion that the inflammation might also have its good side. Now, a research team led by Professor Dr. Kai Wollert, Head of Molecular and Translational Cardiology at the Department [...] further worsen the heart's function. However, there are exceptions. In the mouse model, the research team has identified an interaction between certain inflammatory cells and heart muscle cells that protects [...] first author of the study. Whether all of this is also significant for humans was investigated by the team in patients with heart failure due to aortic stenosis. In this disease, the heart valve between the

with enough blood. So far, this cardiac fibrosis is hardly treatable. Professor Thum and his research team are focusing on so-called long non-coding RNAs (lncRNA). These are building blocks of our genetic [...] of proteins, but control certain processes in the cells. In the ERC project LONGHEART, the research team discovered a specific lncRNA called Meg3, which controls fibrosis formation in heart failure, and [...] significantly reduced the tendency to fibrosis. In the ERC follow-up project MEGFIB, the research team investigated whether the Meg3 inhibitor could also stop fibrosis and improve heart failure in human

interdisciplinary team of experts from the MHH and two orthopedic technology companies filled this tool with content over a period of eight months. "It was very nice to observe how quickly the team came together [...] expertise to the area in an understandable way," explains Dr. Jörg Schiller, a member of the RehAmpTT team. The learning module is a simple, easy-to-use tool that can be valuable not only in Ukraine, but also [...] . RehAmpTT was developed in cooperation with the Department of Trauma Surgery , the MHH eLearning team at the Peter L. Reichertz Institute for Medical Informatics at TU-Braunschweig and MHH (PLRI), the

known, it is still unclear how exactly the loss of motor neurones occurs. An international research team led by Professor Dr. Peter Claus, molecular biologist at the Institute of Neuroanatomy and Cell Biology [...] the B-Raf switch is down regulated. Because this happens before symptoms even appear, the research team believes they have found an important regulator of the disease. "We used a molecular trick to investigate [...] expand the therapy options and thus achieve better results," says Professor Claus. Next, the research team therefore wants to investigate an improved therapy and search for further molecular switches. SERVICE: