2014) Vera Kreuzer: The influence of the hypoxia-inducible molecule adenosine and its receptors A2A and A2B on placental processes (Dr. med., Hanover, 2014) May-Britt Heidrich: Preeclampsia and cardiovascular [...] complicated pregnancy outcomes. ► Pathomechanisms of endometriosis related to infertility using a 3D organ-on-a-chip model ► Age-related decidualization defects of endometrial stromal cells in women with advanced [...] and counseling behavior (Dr. med., Hanover, 2018) Akin Sarisin: The influence of adenosine and the A2B adenosine receptor on trophoblastic and endothelial functions during placental development (Dr. med

recombinant antibodies that show a broad neutralizing effect not only against SARS-CoV-2 but also against related bat coronaviruses that could, in theory, serve as a starting point of a new zoonis - after all, [...] long term, new therapies against SARS-CoV-2 and related corona viruses are expected to be developed in this way. SARS-CoV-2 vaccine / Development of a SARS-CoV-2 vaccine Project leader: Prof. Dr. Reinhold [...] for a surface protein of SARS-CoV-2 has been inserted. A special feature of Modified-Vaccinia-Ankara-Virus: it infects cells but cannot replicate. The immune system reacts nonetheless and forms a protective

emerged as a global pandemic. Angiotensin-converting enzyme 2 (ACE2) is the main entry receptor of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) regulating host cell infection. ACE2 is known [...] enzyme 2 (ACE2) plays a crucial role in regulating the entry of the SARS-CoV-2 particles into the host cells. In this project, we aim to investigate the non-coding RNAs which regulate SARS-CoV-2 infection [...] cardiomyocytes. We identified a few miRNAs that can target ACE2 based on in-silico analysis. Furthermore, we successfully demonstrated that miR-200c can inhibit both Ace2 mRNA and Ace2 protein levels in rat primary

factor receptor-2 (FGFR2). In about 15 percent of patients with ICC, FGFR2 is fused, so to speak, with other genes due to a genetic malformation. These fusion rearrangements lead to a permanent activation [...] FGFR2," explains Dr. Saborowski. Such FGFR2 inhibitors have already been approved in the USA for ICC patients with FGFR2 fusion, for example, and the European regulatory authority has also given a positive [...] clinically inconspicuous for a long time, so that it is often only detected late. Because the tumour also only responds to chemotherapy to a limited extent, those affected often have a poor prognosis. For some

and outer hair cells develop before birth from a common type of precursor cells. Which factors control the different development was unknown for a long time. A research team led by Professor Dr. Andreas Kispert [...] molecular biologist. Tbx2 regulates development into inner and outer hair cells In their investigations, the research team focused on the gene Tbx2. It contains the information for a so-called transcription [...] also shown at a later stage of development. "If Tbx2 is deactivated in the inner hair cells, they transform into outer hair cells," the scientist explains. "Conversely, activation of Tbx2 in the outer hair

severity and long-term effects. Toxicological study SARS-CoV-2 vaccine / Toxicological study on the inhalation application of a SARS-CoV-2 vaccine candidate Project leader: Prof. Dr. Reinhold Förster [...] way, a particularly strong immune response is to be triggered in the lungs and the upper respiratory tract in order to prevent a serious course of the disease and, ideally, to prevent SARS-CoV-2 infection [...] duration of intensive care, as do inflammation and endothelial factors. The IgM, IgG, IgA responses against S1, S2, RBD and N proteins also show individual kinetics. From these immune patterns, we want

can benefit from SSO2 therapy. It is used in the event of an acute heart attack, directly after the previously occluded coronary vessel has been reopened through a catheter. During SSO2 therapy, cardiologists [...] - for the first time in Europe - the new SuperSaturated Oxygen (SSO2) therapy to reduce the extent of heart attacks. The procedure is a therapy already approved in the United States. It was newly approved [...] to combat muscle breakdown A heart attack occurs when the blood flow and thereby the oxygen supply to the heart is disturbed. Despite reopening of the coronary artery through a heart catheter, many patients

spectrometric index test from each patient, a first urine sample at day 0-2, a second on day 4-5, and a third on day 10-14. A total number of 1000 patients with SARS-COV-2 infection are included in the CRIT-COV [...] Transplant Engineering (ITT) A pandemic outbreak of a rapidly spreading emerging pathogen with a high mortality rate and the lack of targeted treatment makes passive immunization a conceivable therapeutic option [...] immunity development with regard to a SARS-CoV-2 infection in the group of national team and Paralympic athletes, - whether athletes with positive antibody detection for SARS-CoV-2 show impairments of health,

Transfer (FWT2) fwt2-wtt @ mh-hannover.de Patenting – how will I benefit? In many cases, a patent is an important prerequisite for commercializing an invention. A patent gives the patent holder a competitive [...] industry The MHH has a wealth of knowledge and holds a large number of patents. Below you find information regarding inventions and property rights. For industry Expert wanted The MHH has a strong research [...] MHH’s experts. Staff Unit for Research - Knowledge - Translation - Transfer (FWT2) Please feel free to contact us: fwt2-wtt@mh-hannover.de Networking We regularly organise networking events, covering exciting

that variants in BRCA1/2 or an MMR gene lead to childhood cancer is statistically significantly increased, but still in such a low range that the detection of such a variant in a healthy child would currently [...] that pathogenic variants in BRCA1/2 and the MMR genes may also contribute to the risk of cancer in individuals below age 18 years. "Children and adolescents with BRCA1/2 or MMR gene variants were mainly [...] Haematology and Oncology. The international research team conducted a meta-analysis based on 11 studies that included results on germline testing of a total of 3,775 children and adolescents suffering from cancer