Hildegard Büning and Professor Dr Axel Schambach agree on this. The gene therapy experts from the Institute of Experimental Haematology at Hannover Medical School (MHH), together with five other experts, [...] in 2020. "On 16 November, less than a fortnight ago, the world's first gene therapy based on this genetic technology was approved in the UK," reports Professor Büning. People suffering from the blood disorders [...] the genes" is already capable of today. "And it will be able to do even more: One idea is to use genetic scissors or 'erasers' in the genome to detect and correct possible malfunctions in common diseases

cells of the haematopoietic system multiply uncontrollably. This form of blood cancer is caused by genetic changes in the bone marrow that occur in the course of life. Therefore, it is mainly older people [...] Medicine, one of the world's most respected medical journals. Surprisingly strong effect also in humans The drugs in question are Ivosidenib and Azacitidine, which have so far been used individually against [...] Professor Heuser. In the clinical trial, the researchers were now also able to demonstrate this effect in humans who had newly diagnosed AML with gene alterations in the IDH1 enzyme. "We were surprised that the

about the molecular biological causes. A research team led by Professor Dr. Christian Bär from the Institute of Molecular and Translational Therapy Strategies of the Hannover Medical School (MHH) now wants [...] and over again. The reason for this is the so-called telomeres, the ends of the chromosomes. The genetic information is stored on the chromosomes. With each cell division, the telomeres shorten a bit. After [...] first investigate the role of immune and organ aging in the heart and lungs. For this purpose, two genetically different, so-called chimeric mouse models are produced, in which the biological ages of organs

consist of more than 20 different cell types. Disorders of embryonic development of the kidney due to genetic or environmental factors lead to congenital defects of the kidney and the urinary tract, arterial [...] for repair, this regenerative potential is significantly impaired in aging and in individuals with genetic or developmental predisposition or comorbidities such as diabetes or hypertension. The situation [...] targeted therapies. Our group investigates the molecular and cellular basis of developmental and genetic injury susceptibility, injury response and repair of epithelial cells within the kidney and allograft

Bengel, MHH Dean of Research. Key factor for liver metabolism The mRNA copies the genetic information contained in our genetic material, the DNA. The copy then serves as a template for building proteins, the [...] levels have been shown to decrease as the disease progresses. "In studies on the mouse model and in human liver cells, we have already been able to show that the therapeutic mRNA can be used to restore HFN4α

research focuses on advanced lung organoids, which are three-dimensional microtissue models derived from human induced pluripotent stem cells (hiPSC) that replicate the properties of the lower airways in vitro [...] pollutants and beyond. The disease-relevant signatures in the lung will also be correlated with genetic predisposition, biological sex, and epigenetic regulation. These patient-specific, hiPSC-derived

cardiac support system. With the help of induced pluripotent stem cells (iPS cells) from genetically reprogrammed human tissue cells, heart muscle cells can be produced. These should form the basic building

Conventional Imaging Nuclear imaging CT/MRI-guided biopsy procedures Pathological diagnostics Human genetic diagnostics Surgical therapy Resecting procedures (musculoskeletal, visceral and thoracic sarcomas

subgroups are mostly diseases whose genetic basis is not yet known. For this reason, future patient groups with a significant number of cases will be examineded for common genetic alterations. Accurate phenotyping [...] results a continuation of the project is planned involving further internal and external research institutions. On the basis of the results of the retrospective study previously published, various subgroups

contains the genetic information for the blueprint of the so-called spike protein, which is located on the surface of the coronavirus and with the help of which the virus enters the cells. This genetic information [...] Immunology at Hannover Medical School (MHH) has now closed this gap. In cooperation with the MHH Institute of Immunology and the German Primate Centre Göttingen, the researchers have published the world's [...] samples to investigate immune reactions against SARS-CoV2 in employees of the MHH and affiliated institutions. "Our data can also make a significant contribution to better understanding the long-term immune