establish an ex vivo organ-/immune-system interface simulating immune responses after engraftment of human donor livers. Precision-cut slices of donor livers performed prior engraftment serve as a three-d

elucidation of the molecular mechanisms of proteins whose function is vital for the health of the human organism. Combining leading techniques for structure determination with state-of-the-art cell biological

to explore potential toxic effects of anti-virals, alternative human airway models are required. In this project we aim to advance human induced pluripotent stem cells (hiPSC) derived respiratory epithelial [...] improve the global public health preparedness for outbreaks emerging in the future. COVID Protect / Human iPSC-derived respiratory epithelial cells to study NRF2 signalling in SARS-CoV-2 infections Project [...] for antibodies against SARS-CoV-2. These antibodies are formed a short time after infection by the human immune system and remain in the body even after the disease, and can thus react faster and better

Project leader: Prof. Dr. Danny D Jonigk, FRCPath Department / Institute: Institute of Pathology Human Non neoplastic interstitial lung diseases are complex, ill understood and consist of >120 defined [...] rypsin (A1AT) is an acute-phase glycoprotein and one of the most abundant protease inhibitors in humans. A1AT is also characterized as a protein with broad immunomodulatory and immunosuppressive capacities

The aorta is the largest blood vessel in the human body. It originates in the heart and carries oxygen-rich blood to all parts of the body. The most common disease of the aorta that requires treatment [...] by it reflexively. The silk is extremely thin and tear-resistant and completely degradable in the human body. Using a special apparatus that assistant physician Dr Helms constructed himself, the thread

"We have successfully tested the efficacy of our RNAi candidates on human lung tissue sections as well as in 3D cell cultures from human lung epithelium," explains Professor Dr. Armin Braun, Head of Preclinical

treated for six months a total of five times with mesenchymal stem cell products obtained from a human umbilical cord. "The treatment led to a significant improvement in growth, exercise tolerance and [...] stem cell therapy is based on cells from the umbilical cord of newborns and is also called HUCMSC (human umbilical cord mesenchymal stem cell). The researchers' analyses showed that the products of these

Korf-Klingebiel, biologist and first author of the study. Whether all of this is also significant for humans was investigated by the team in patients with heart failure due to aortic stenosis. In this disease [...] laboratory, the MYGDF level dropped to normal. Pressure overload thus also leads to MYDGF release in humans. The work shows that the positive aspects of inflammation must be considered when thinking about

isoforms You will learn and use the following methods : -Recombinant production and purification of human proteins - In vitro reconstitution and analysis of cytoskeletal actin dynamics using multicolour

Prof. Dr. med. Bettina Bohnhorst is a specialist in pediatrics and adolescent medicine . She studied human medicine in Hanover and completed her training as a specialist in pediatrics and adolescent medicine