and an unhealthy diet. Now a research team led by Professor Dr. Dietmar Manstein, Director of the Institute of Biophysical Chemistry at Hannover Medical School (MHH), has discovered another reason why people [...] which is formed in the rumen of ruminants, appears to dock well with the motor muscle protein in the human heart. Through food, conjugated trans fatty acid enters the bloodstream either directly or in the

Seit 1988 befindet sich das deutsche Referenzlabor für Adenoviren (später: Konsiliarlabor ) am Institut für Virologie der MHH. Das Labor und die zugehörige Forschergruppe wurden von Herrn Dr. Adrian gegründet [...] Fortschritt in der Adenovirusdiagnostik war die Entwicklung eines quantitativen PCR Verfahrens für humane Adenoviren, das heute als einfaches und schnelles Verfahren zum Adenovirusnachweis verwendet wird

treatment at the modernly equipped clinic. Because of the close cooperation with the other clinics and institutes of the Hanover Medical School and the Comprehensive Cancer Centre Lower Saxony, patients receive [...] treated with the help of sonography and interventional radiology as well as the most modern methods of genetic diagnostics. Treatment concepts (e.g. for monogenetically determined liver diseases using innovative

Balduini A, Raslova H, Di Buduo CA, Donada A, Ballmaier M, Germeshausen M, Balduini CL. Eur J Med Genet. 2018 Nov;61(11):715-722. doi: 10.1016/j.ejmg.2018.01.014. Epub 2018 Mar 13. PMID: 29545013 Review [...] Avedillo Díez I, Gulacsy V, Diestelhorst J, Ballmaier M, Welte K, Maródi L, Chernyshova L, Klein C. Clin Genet. 2008 Jul;74(1):68-74. doi: 10.1111/j.1399-0004.2008.01019.x. Epub 2008 May 13. PMID: 18479478 Tr [...] Melin M, Carlsson G, Fadeel B, Dahl N, Palmblad J, Henter JI, Zeidler C, Grimbacher B, Welte K. Nat Genet. 2007 Jan;39(1):86-92. doi: 10.1038/ng1940. Epub 2006 Dec 24. PMID: 17187068 LEF-1 is crucial for

neurones is disrupted. Treatment options are limited and there is no cure. A research team from the Institute of Clinical Biochemistry at Hannover Medical School (MHH) has discovered that the body's own sugar [...] function of our nervous system," says Professor Dr Rita Gerardy-Schahn, the former head of the MHH Institute. In the brain, PolySia also acts in the hippocampus - a kind of switchboard between short-term and [...] process have already been patented The next step for the researchers is to confirm the effect in human cell cultures. "We could then enter the clinical phase," hopes Dr Thiesler. If everything works as

the “Viral Immune and Neuromodulation” lab, we aim to understand how human viruses modulate these two systems. We mainly focus on human herpesviruses, including herpes simplex virus type 1, type 2, varicella [...] varicella zoster virus, Kaposi’s sarcoma-associated herpesvirus and human cytomegalovirus. We are interested in the viral modulation of extracellular proteins that play key roles in intra and intercellular [...] Investigator: Prof. Dr. Abel Viejo-Borbolla Medizinische Hochschule Hannover (Hannover Medical School) Institute of Virology, OE5230 Carl-Neuberg-Str. 1 30625 Hannover Phone: +49 (0)511 532 4382 | Departmental

occurs. An international research team led by Professor Dr. Peter Claus, molecular biologist at the Institute of Neuroanatomy and Cell Biology at the Hannover Medical School (MHH), has now found an important [...] explains Dr. Hensel. Therefore, the observation from the tiny worm can probably also be transferred to humans. There are already approved drugs against SMA. However, they do not work equally well at every point

catalyze - biophysical insights into enzymes. G. Tsiavaliaris. Actin dynamics at the meiotic spindle of human oocytes. April 2019, 16th Alpbach Workshop on Muscle and Motor Proteins , Alpbach, Austria. G. Ts [...] Molecular nanomachines at work: how myosins coordinate cellular movement and transport. Nov. 2011, Institut für Tierökologie und Zellbiologie, Prof. Bernd Schierwater, Tierärztliche Hochschule Hannover, Germany [...] zur Aufklärung der Funktionen von cCMP und cUMP. Oct. 2010, cCMP/cUMP Symposium, Pharmakologisches Institut der MHH, Prof. Roland Seifert, Hannover, Germany. G. Tsiavaliaris. Control of velocity and mode

e Career since 07.2018 Postdoc im Institut für Molekular- und Zellphysiologie an der Medizinischen Hochschule Hannover (MHH) 10.2013 to 02.2018 Promotion im Institut für Molekular- und Zellphysiologie [...] of sub-components of motor proteins Single molecule analysis of mutant myosin motors implicated in human hypertrophic cardiomyopathy using optical trap and TIRF microscopy Expertise Optical trapping, TIRF

Fedorov, R., Henn, A., Taft, M. H. #, and Manstein, D. J.# (2020) Mechanochemical properties of human myosin 1C are modulated by isoform-specific differences in the N-terminal extension. J Biol Chem. [...] and Gunning, P. W. (2018) Co-polymers of Actin and Tropomyosin Account for a Major Fraction of the Human Actin Cytoskeleton. Curr. Biol. 28, 2331-2337.e5. doi: 10.1016/j.cub.2018.05.053. Latham, S. L., Ehmke [...] A. O., Taft, M. H. , Manstein, D. J., and Henn, A. (2017) N-terminal splicing extensions of the human MYO1C gene fine-tune the kinetics of the three full-length myosin IC isoforms. J. Biol. Chem. pii: