i.e. the totality of genes of the respective isolates, and in their genetic backgrounds, in terms of the presence of virulence-associated genes and antimicrobial resistance genes," says Prof. Galardini

and gene regulation Flow of genetic information The cytoskeleton Microscopic techniques Membrane transport of small molecules Receptors and signal transduction Cell cycle and oncogenesis Human Gene finding [...] lymphoid organs Gene therapy : Stem cells, regulations of transgenes in somatic cells, embryonic and somatic cloning in mammals, Safety and efficiency in the use of viral vectors for gene therapy Microbiology [...] Scientific English 2.5 Radiation protection 2.7 Gene technological security 2.8 Introduction to ethics Ethical cases in medicine Ethical aspects of gene technology Scientific ethics 3. Other Courses 3

chloride and bicarbonate across the epithelial apical membrane. The CF-causing mutations in the CFTR gene result in either complete loss of function (mutation class I), decreased synthesis of CFTR (class [...] compensate for the underlying defect of CF. Although more than 2000 CF-causing mutations in the CFTR gene are known, the most common mutation p.Phe508del occurs on 70% of all CF chromosomes. p.Phe508del is [...] example to test which environmental factors and which genetic factors outside the causally affected gene modulate the severity of the clinical picture in a congenital disease. For the studies, we have DNA

consequences of distinct gene deficiencies on the function and/or differentiation of iNKT cells. In the course of our earlier work, we already identified several candidate genes and would expect that the [...] the experiments proposed here will unravel additional genes that influence iNKT cell biology.

receptor (TCR) gene transfer Final exam November 2010 Tobias Mätzig GERMANY supervisor: Prof. Dr. Baum, Experimental Hematology, OE 6960, project: Evaluation of retro- and lentiviral vectors for gene therapy [...] now University of Ulm project: Analysis of functional consequences of the deletion of candidate genes of the DNA damage pathway; analysis of a telomerase activating compound in improving liver regeneration [...] supervisor: Prof. Dr. Gaestel, Biochemistry, OE 4310, project: Characterisation of p38 MAPK regulated gene expression in MK2/3 deficient cells Final exam June 2010 Nidhi Narain INDIA supervisor: Prof. Dr.

deactivates the tumour suppressor genes, colloquially known as "tumour suppressor genes". Methylation acts like a cap that sits on top of the genetic material and blocks the gene. The HP virus thus has an easy

receptor-2 (FGFR2). In about 15 percent of patients with ICC, FGFR2 is fused, so to speak, with other genes due to a genetic malformation. These fusion rearrangements lead to a permanent activation of signalling [...] explains the medical scientist. In the mouse model, the researchers found indications that further gene mutations can profoundly alter the response to targeted FGFR inhibitors and thus lead to a failure [...] therapy is a promising option," explains Professor Dr. Vogel. A combination therapy against these gene alterations could make the cancer cells susceptible to the FGFR2 blocker again and stop the bile duct

Freise GERMANY supervisor: Prof. Dr. Zeidler, Dept. Rheumatology, OE 6850, project: Viability and gene expression of Chlamydia trachomatis during persistent infection. A study to establish new therapeutic [...] Feodor-Lynen-Str. 7, 30625 Hannover, project: Regulatory mechanism of mammalian circadian clock genes Final exam June 2006 Yijiang Li CHINA supervisor: Prof. Dr. Haverich/Dr. Simon, THG-Surgery, OE 6286 [...] TURKEY (Dr. med.) supervisor: Prof. Dr. Kreipe, Pathology, OE 5110, project: Quantitative analysis of gene expression in different mechanisms of early allograft damage after renal transplantation Final exam

approaches. The scientists focused on the APC gene of tumour cells, which is mutated in 90 percent of all cases of colon cancer. "We wanted to find genes that are only important for the survival of cells [...] If they inhibited the gene called eIF2B5, the mutated colon cancer cells died so-called programmed cell death. Healthy cells, on the other hand, tolerated the inhibition of the gene without any adverse effects [...] this finding, the research team wants to develop new treatment methods and also investigate other genes. But Wiegering is also taking a critical look at everyday hospital life. In 2020, he and his team

Hannover Medical School (MHH) has now found the key and demonstrated how it controls the process: The gene Tbx2 acts like a switch to determine whether inner or outer hair cells are formed. The work was supported [...] that can help renew the auditory sensory cells. "But for this, it is imperative to understand which genes control the formation of hair cells during embryonic development," emphasises the molecular biologist [...] development into inner and outer hair cells In their investigations, the research team focused on the gene Tbx2. It contains the information for a so-called transcription factor. Like an on-off switch, this