is a lack of nationwide access to human genetic care, especially in rural areas.The innovation fund project "OnkoRiskNET", led by a team from the MHH Institute of Human Genetics, has tackled this problem [...] Director of the Institute of Human Genetics until May 2023, adds: "We see that cancer patients in this stressful situation often cannot find the long way to an institute of human genetics. It was therefore [...] cancer and can lead to the development of tumors," says Professor Dr. Anke Bergmann, specialist in human genetics and head of the OnkoRiskNET project. "With this project, we want to ensure access to genetic

MZP Cardiomyocytes from human induced pluripotent stem cells as a cellular model for hypertrophic cardiomyopathy Researc h focus The focus of our research is the analysis of human induced pluripotent stem [...] β-Myosin heavy chain isoform-expressing myofibrils within human ESC-derived cardiomyocytes recapitulate the contractile features of adult human ventricular myofibrils?, J. Muscle Res. Cell. Motil., 2017 [...] Martin U, Zweigerdt R, Kraft T , Brenner B. Differences in Contractile Function of Myofibrils within Human Embryonic Stem Cell-Derived Cardiomyocytes vs. Adult Ventricular Myofibrils Are Related to Distinct

Toxicology and Experimental Medicine ITEM. Standardised production of mature immune cells The demand for human immune cells is high and growing daily. So far, however, it has been difficult to provide cells in [...] meet the steadily growing demand, biomedical research is therefore trying to obtain and multiply human immune cells through novel bioprocesses. The Attract group leader and his team have already laid a [...] researching and evaluating drug candidates because we can test their efficacy and safety directly on the human targets," says the scientist. The construction and testing of these tests will be advanced within

three-dimensional X-ray images of the human body possible. With a maximum resolution of up to 300 nanometres, they are equivalent to one tenth of the diameter of a human hair. "The networking between radiology [...] synchrotron particle accelerators. The international team of this worldwide unique project entitled "Human Organ Project" is composed of physicians from the European Synchrotron Facility ESRF in Grenoble and [...] and currently the brightest X-ray source in the world. The project promises images of the entire human body with a resolution of two micrometres, over a hundred times better than a CT scanner. "We were

for his research on human macrophages in the amount of 1.5 million euros over five years. Human immune cells - produced in the laboratory Professor Lachmann's method is based on human cells of the immune [...] adequately reflect human physiology in some cases and because the European authorities will no longer accept them from 2026. The MAT based on donated blood cells better reflects human physiology, but is

composition of sarcomeric proteins. Subcellular myofibrils can be obtained from human (e.g., biopsies), human-derived and non-human cardiac and skeletal small muscle samples (e.g., mouse, rat, rabbit, zebrafish [...] maturation of human pluripotent stem cell-derived cardiomyocytes; (2) Understanding the effects of missense mutations in sarcomeric proteins on the subcellular and cellular contractile function in human cardiac [...] School; Research topics: Force-related kinetic studies with subcellular myofibrils using human myocardial samples and human embryonic/induced pluripotent stem cell-derived cardiomyocytes. 2011-2013 : Junior

strong inhibitory and weak stimulatory signals in human immune cells when they interact with porcine tissues. Transgenic (tg) pigs expressing the human (h) inhibitory ligand hPD-L1 (CD274) and pigs lacking [...] vitro studies showed that SLA class I-deficient and hPD-L1 tg cells are only partially protected from human immune responses. We expect that hPD-L1 positive/SLA class I negative cells generated by combining

mechanisms. The second part of this project deals with human γδ T cells. We and other could recently show by next generation sequencing of human γδ TCRs that the adult, but not neonatal, γδ TCR repertoires [...] factors might fine-tune the development, organ-specificity and functional adaptation of murine and human γδ T cells. Murine IL-17 producing Vγ6 and Vγ4 T cells develop within an embryonic thymus and are

does not always come easy, we are offering free access to Meditricks - especially for students of human medicine – from 1 October 2024. And this is how it works: Simply register online via Meditricks and [...] Numerous videos, mnemonics and other learning aids are available. Requirement: If you are studying human medicine at the MHH and have an AMBOSS access, you are already perfectly equipped. Where to find

g communities in humans: an overview using Omics data. mSystems. 00130-17. Rath S, Heidrich B, Pieper DH, Vital M. 2017. Uncovering the trimethylamine-producing bacteria of the human gut microbiota. Microbiome [...] are colonized by a myriad of microorganisms including bacteria, fungi and viruses – the so-called “human microbiota”. Research efforts in the last decade revealed an important role of microbiota for our [...] Third-Generation (Oxford Nanopore)” Sequencing (“-omics”) techniques aiming to elucidate the role of human microbiota in health and disease. Bioinformatics and statistical analyses, included AI-based techniques