signalling pathways. This reduces transcriptional noise and fine-tunes gene expression, ultimately regulating the overall gene expression profile of the cell. miRNAs therefore have important functions

protein production (E. coli, D. discoideum, Sf9-cells); Fluorescence Labeling techniques; gene silencing; stable gene expression; polyclonal antibody production. Functional Assays: Determination and chara

rases and Related Genes 1035-1045. Bakker, H. and Ashikov, A. (2014). UDP-Xylose and UDP-N-Acetylglucosamine Transporter (SLC35B4). Handbook of Glycosyltransferases and Related Genes 1393-1402. Bakker [...] and Related Genes 1439-1448. Bakker, H. , Ashikov, A., Routier, F.H., and Gerardy-Schahn, R. (2014). GDP-Fucose Transporter 1 (SLC35C1). Handbook of Glycosyltransferases and Related Genes 1403-1411. Buettner [...] A.C., van Zandbergen,G., Wenzel,A., Gerardy-Schahn,R., Wiese,M., and Routier,F.H. (2007). Targeted gene deletion of Leishmania major UDP-galactopyranose mutase leads to attenuated virulence. J. Biol. Chem

Single Cell Controller The Chromium Single Cell Gene Expression Solution provides a comprehensive, scalable solution for cell characterization and gene expression profiling of hundreds to tens of thousands [...] commercial software currently includes: Feature Extraction (Agilent Technologies) ImaGene (BioDiscovery Inc.) GeneSpring (Agilent Technologies) Omics Explorer (Qlucore) StrandNGS (Avadis) IPA (Qiagen)

in more than 60 genes can lead to proteinuria. Using genetic analysis (whole genome sequencing (WGS)), we search for mutations in previously unknown genes. By characterizing the genes in cell culture and [...] Podocytes form the slit membrane with their foot processes. In particular, mutations in podocytic genes can lead to disorders of the filtration barrier. Clinically, this manifests as increased protein loss [...] D, Callewaert B, van Tilbeurgh H, Zenker M, Antignac C, Hildebrandt F. Mutations in KEOPS-complex genes cause nephrotic syndrome with primary microcephaly. Nat Genet. 2017 Oct;49(10):1529-1538. Lovric S

Reports. 2021. Publisher's page Predicting genotoxicity of viral vectors for stem cell gene therapy using gene expression-based machine learning Schwarzer, Adrian, Talbot, Steven R., Selich, Anton, Morgan [...] page Identification and functional characterization of a spliced rhesus rhadinovirus gene with homology to the K15 gene of Kaposi's sarcoma-associated herpesvirus. Wang L, Pietrek M, Brinkmann MM, Havemeier [...] Frontiers in Cellular and Infection Microbiology. 2022. Publisher's page Analysis of myocardial cellular gene expression during pressure overload reveals matrix based functional intercellular communication Froese

Prof. Dr. Gossler, Molecular Biology, OE 5250, project: Molecular Genetic Analysis of the Mouse RV-Gene (Baby pause in 2001) Final exam on November 12th, 2004 Gernot Sellge GERMANY supervisor: Prof. Dr [...] Tiede GERMANY (Dr. med.) supervisor: PD Dr. Eder (Ganser), Hematology, OE 6860, project: Hemophilia gene therapy Final exam on November 7th, 2003

intelligence. The so-called in-silico design is to detect suitable target structures in the virus from gene databases and select suitable targets for RNAi. "In doing so, we are mainly looking for so-called [...] self-constructed development pipeline, the entire process should now be shortened to eight weeks. By gene taxi into the target cell The RNA therapeutic agent is not to be administered by injection or as a [...] the lower respiratory tract with as few side effects as possible. A harmless viral vector acts as a gene taxi to ensure that the therapeutic RNA is delivered directly to the target cell in the lungs that

Gessner, Clinical Immunology, OE 6830, project: Molecular characterization of complement-mediated FcgR gene regulation as an amplification loop of the innate immune response to immune complexes Final exam November [...] (Med.) supervisor: Prof. Dr. Gossler, Molecular Biology, project: Functional characterization of genes specifically expressed in intestine epithelium Final exam November 2007 Amar Sharma INDIA supervisor: [...] Virology, project: Transposon and targeted mutagenesis of a recombinant KSHV genome to identify viral genes required for replication in endothelial cells Final exam June 2006

Advanced Tissue Culture Models , biomimetic 3D models of neurodegenerative diseases, CRISPR/Cas-based gene editing, 3D bioprinting Education 2014-2020 Doctoral thesis (Dr. rer. nat.) Institute of Cell Biology [...] ts comply with Annex 1 of the Animal Welfare Act, 2013, and Annex V of Directive 2010/63/EU) 2012 Gene Technology, Biosafety, and Biosecurity: Government-certified training course according to §15 GenTSV [...] for neurodegenerative diseases Integration of 3D bioprinting and cell type-specific CRISPR/Cas-based gene editing for the development of specific disease-related cell culture models Online Presence ORCID: