university. Please pay particular attention to the information on the M1 and taking the module examinations if you do not have the M1! Further information on the application for a higher semester Conditions [...] ------------------------------------- ¹ Human Medicine: An application beyond the 2nd academic year (4th semester) is only possible if you have completed the 1st section of the Medical Examination. If [...] necessary, proof of intermediate examination (Preliminary Dental Examination (Zahnärztliche Vorprüfung) or 1st section of the Medical Examination)¹ if necessary, proof of sufficient knowledge of German ( certificate
Extracorporeal membrane oxygenation in non-intubated immunocompromised patients. Crit Care. 2021 Apr 30;25(1):164. doi: 10.1186/s13054-021-03584-8. PMID: 33931122 Djenoune L, Tomar R, Dorison A, Ghobrial I, Schenk [...] of endothelial microRNA 155 on capillary leakage in systemic inflammation. Crit Care. 2021 Feb 22;25(1):76. doi: 10.1186/s13054-021-03500-0. PMID: 33618730 Schenk H, Müller-Deile J, Schroder P, Bolaños-Palmieri [...] Characterizing renal involvement in Hermansky-Pudlak Syndrome in a zebrafish model. Sci Rep. 2019 Nov 27;9(1):17718. doi: 10.1038/s41598-019-54058-5. PMID: 31776394 Stahl K, Schenk H, Seeliger B, Wiesner O, Schmidt
infection. Trends Microbiol. 30(1): 22-33. doi: 10.1016/j.tim.2021.04.002. Koschel J, G. Nishanth, S. Just, K. Harit, A. Kröger, M. Deckert, M. Naumann, D. Schlüter (2021) OTUB1 prevents lethal hepatocyte [...] Schlüter (2019) The deubiquitinase OTUB1 inhibits central nervous system autoimmunity by preventing IFN-γ-induced hyperactivation of astrocytes through stabilization of SOCS1. EMBO J. e100947. doi: 10.15252/embj [...] necroptosis through stabilization of c-IAP1 during murine liver inflammation. Cell Death Differ. 28:2257-2275. doi: 10.1038/s41418-021-00752-9. Osbelt L, M. Wende, É. Almasi, E. Derksen, U. Muthukumarasamy
wherefore they are named iNKT1, iNKT2, and iNKT17 cells, respectively, in analogy to the well-established T helper cell paradigm. Nevertheless, mainly due to its novelty, the iNKT1/2/17-concept lacks a broad [...] Phenotypical and functional characterization of murine iNKT1, 2, and 17 cells Invariant natural killer T (iNKT) cells represent a subpopulation of T cells performing specialized functions. iNKT cells come [...] recognize non-peptide components such as glycolipids that are presented to iNKT cells in the context of CD1d, a polypeptide related to MHC class I. Recently, there was a fundamental reorientation in our understanding
9117 Carl-Neuberg-Str. 1, D-30625 Hannover Tel.: +49 - 511 / 532 - 6011 Fax: +49 - 511 / 532 - 2611 Email: hbrs @ mh-hannover.de Office: building J4 (Forschungswerkstätten), level 1 Dr. Kruse is certified [...] Behrens Rheumatology and Clinical Immunology Center of Internal Medicine at the MHH Carl-Neuberg-Str. 1, D-30625 Hannover Tel.: +49-511-532-5713 Fax: +49-511-532-2611 Email: behrens.georg @ mh-hannover.de
, M., Klimenkova, O., Lan, D., Gupta, K., Hussein, K., et al (2012) Interactions among HCLS1, HAX1 and LEF-1 proteins are essential for G-CSF-triggered granulopoiesis. Nat Med 18: 1550-1559. 144. Vallabhaneni [...] Menon, M. B., Tachibana, K., Doi, T., and Seidler, U. E. (2017). IL-1beta-Induced Downregulation of the Multifunctional PDZ Adaptor PDZK1 Is Attenuated by ERK Inhibition, RXRalpha, or PPARalpha Stimulation [...] Preusse, K., Madlung, J., et al (2014) S/T phosphorylation of DLL1 is required for full ligand activity in vitro but dispensable for DLL1 function in vivo during embryonic patterning and marginal zone B
Completed Projects of the Georgiev Group 05/2018 – 04/2020 Research Stipends GE 3062/1-1 Deciphering endogenous and environmental factors impacting on development and function of iNKT cell subsets.
detail for the NOD protein Apaf-1, the key switch in the mitochondrial pathway of apoptosis. Combining structural information from the X-ray structure of auto-inhibited Apaf-1 and the cryo-EM structure of [...] speck-like protein containing a caspase activation and recruitment domain ), and the effector pro-caspase 1. The transition from inactive monomer to active oligomer is characteristic for NOD proteins, to which [...] of the apoptosome, we depicted the conformational changes of Apaf-1, which eventually lead to the transduction of the cellular death signal. To understand the dynamics of the activation of NLRPs, we structurally
assembly and egress? Our focus is to analyze all virus-host interactions of Herpes Simplex Virus Type 1 (HSV-1) in cell types that it also interacts with in the human host: epithelial cells, neurons and immune [...] interactions that are required for efficient HSV1 cell entry, nuclear targeting of the viral genome, viral gene expression, virus assembly, egress and spread. We use HSV1 mutants as well as state-of-the-art biochemical [...] biochemical, life-cell imaging approaches and electron microscopy to characterize how HSV1 activates cellular signal transduction cascades to utilize the actin cytoskeleton, the microtubule transport machinery
Apr;85(1):1-13. Erratum in: J Biomed Mater Res A. 2008 Apr; 85(1):284 Petri S, Krampfl K, Kuhlemann K, Dengler R, Grothe C Preserved expression of fibroblast growth factor (FGF)-2 and FGF receptor 1 in brain [...] 25;29(24):3935-3944. doi: 10.1093/hmg/ddaa275. Low Density Lipoprotein Receptor-Related Protein-1 (LRP1) Is Involved in the Uptake of Clostridioides difficile Toxin A and Serves as an Internalizing Receptor [...] survival and gene expression in SOD1G93A amyotrophic lateral sclerosis mice. Eur J Neurosci. 2019 Mar 18. doi: 10.1111/ejn.14405. [Epub ahead of print] Ekaterini Kefalakes1, Sebastian Boeselt, Anastasia Sarikidi