Research at the Department of Human Genetics Our scientific findings make an important contribution to the understanding of ultra-rare genetic diseases, the identification of risk factors for cancer and [...] tool for advances in our field. Find out more about the research groups at the Department of Human Genetics!
Pierina Cetraro Research Topic : Regulation of tRNA biogenesis by Human Cytomegalovirus infections Supervisor: Prof. Dr. Dan Depledge, Institute of Virology, MHH Academic Background : Immunology, Universidad [...] MHC-I immunopeptidome Supervisor : Prof. Dr. Lars Dölken, Institute of Virology, MHH Academic Background : Surgery, Beijing Neurosurgical Institute of Capital Medical University Arsha Jos Research Topic : [...] cells in the lung Supervisor: Prof. Dr. Matthias Lochner, Institute for Medical Microbiology and Hospital Epidemiology Academic Background : Genetics, University of Delhi, India Jolane Kappes Research Topic
Dr. Doris Steinemann, Institut für Humangenetik, MHH: 'Repetitive sequences in human genomes and their contribution to disease development' Prof. Dr. Hildegard Büning, Institut für Experimentelle Hämatologie [...] Department of Pneumology, MHH Fraunhofer Institute for Toxicology and Experimental Medicine (ITEM) 22.02.2023 REBIRTH colloquium (1 pm s.t., online lecture) ‘Genetic engineering of organs to support graft [...] Heisterkamp,Institut für Quantenoptik, LUH: ‘Biophotonics - Application of light in cells and tissues’ 10.03.2021 - REBIRTH Kolloquium (1 pm s.t., online Vorträge) Prof. Dr. Axel Schambach, Institut für Ex
02.02.2022 Generation of human induced pluripotent stem cell lines Encoding for genetically encoded calcium indicators RCaMP1h and GCaMP6f Calcium plays a key role in cardiomyocytes (CMs) for the translation [...] transients in human induced pluripotent stem cell derived-cardiomyocytes (hiPSC-CMs) to investigate the cardiac electrophysiology in vitro and after cell transplantation in vivo. The genetically encoded calcium [...] Bakar, Sylvia Merkert, Alexandra Haase, Ulrich Martin (LEBAO, MHH) Gudrun Göhring (Department of Human Genetics, MHH) The original paper on ScienceDirect.com Further LEBAO Publications For more information
head of the Institute for Experimental Haematology at the Hannover Medical School (MHH), is developing RNA-based drugs to combat viral diseases in cooperation with the Fraunhofer Institute for Toxicology [...] "We have successfully tested the efficacy of our RNAi candidates on human lung tissue sections as well as in 3D cell cultures from human lung epithelium," explains Professor Dr. Armin Braun, Head of Preclinical [...] place on the viral RNA, thus making it unreadable and initiating its degradation. The result: the genetic blueprint packed in it is not implemented and virus replication is blocked. "In the meantime, we
at the Institute of Experimental Hematology. Doris Steinemann Doris Steinemann is a W2 Professor of "Functional Genomics." She leads the Functional Genomics TEAM at the Institute of Human Genetics. The focus [...] her research is the identification of the significance of genetic changes in hereditary cancer diseases. The research goal is to detect genetic alterations using the latest techniques that could predispose
therapy. Professor Dr. Dr. Axel Schambach, head of the Institute of Experimental Haematology at the Hannover Medical School (MHH), wants to genetically modify the immune cells in such a way that they detect [...] in the laboratory from “reprogrammed” adult body cells and can then produce any cell type in the human body – including NK cells of the innate immune system. The advantage: the NK cells can be produced [...] transplanted quickly and in unlimited numbers. But that is not enough. “The NK cells need to be genetically modified and put into a hyperactive and more targeted state, so that they can ensure greater targeting
organ nevertheless remains as small and effective as possible, as is the case with the human lung. In the human lung, about 100 to 140 square meters of breathing surface are packed into 300 million alveoli [...] artificial lungs can be transplanted into the human body. The DFG Priority Program SPP 2014 is funding a total of ten projects throughout Germany. The lead institutions are the Rheinisch-Westfälische Technische [...] g endothelial cells. "These endothelial cells, which are not endogenous to the body, are also genetically modified so that they are virtually invisible to the patient's immune system and are therefore
disease models Final exam November 2005 Krishna Kumar Singh INDIA supervisor: Prof. Dr. Schmidtke, Human Genetics, OE 6300, project: Disease related variants of ARMD and functional implications Final exam June [...] Students of the year 2002 Diya Abraham INDIA supervisor: Prof. Eichele, Max-Planck Institute f. Experimental Endocrinology, project: Analyzing the in vivo function of Protein kinase C by using mutant mice [...] project: Generation and characterization of hematopoietic stem cell lines as novel tools to investigate genetic and developmental aspects of congenital bone marrow failure syndromes Final exam November 2006 Thomas
the Paul Ehrlich Institute are monitoring the four-year project. If everything goes as planned, the researchers hope, prerequisites for a clinical trial of cell-based heart repair in humans can subsequently [...] over Europe and Israel, with more than six million euros, of which the MHH as the coordinating institution is receiving 1.4 million euros. Bringing heart muscle cells to the target In many heart diseases [...] is impaired. Unlike in some amphibians and fish species, such damage is not repaired in an adult human heart. Scientists around the world are therefore working on strategies to replace destroyed heart