molecular signalling during respiratory differentiation of human pluripotent stem cells Complex protocols have been developed to differentiate human induced pluripotent stem cells (hiPSC) via endoderm, foregut [...] lines in RG Martin In the Martin group, iPS cells have so far been produced from cells from mice and humans , but also from various primate species (macaque, gorilla, bonobo). Various cell types produced from [...] different questions, such as the investigation of brain development. Meanwhile, a large number of human patient- or disease-specific iPS cell lines have been established in the research group. This collection

term Human medicine 3., 5., 7., 9., 11. semester and for the Practical Year Dentistry 3., 5., 7. and 9. semester (= 3. and 5. pre-clinical semester, 2. and 4. clinical semester) Summer term Human medicine [...] Application for a place to study in a higher semester Human medicine or dentistry Copyright: Manolo Franco/Pixabay Applicants who have already started their desired course of study at another university [...] Before applying , please also be sure to read the "Further information on the model programme in Human medicine (HannibaL)" below regarding the i nformation on the creditability of achievements in the

11.05.2023 How do human cells defend themselves against adenoviruses? The team of RESIST Professor Dr. Sabrina Schreiner from the Institute of Virology at the Hannover Medical School (MHH) has come a good [...] Institute of Virology. Neither specific therapies nor vaccination available New treatment options against human adenoviruses are needed, as there are neither specific therapies against these viruses nor a vaccination [...] Cells defend themselves with the protein Apobec3A Professor Schreiner's team has now found that human cells defend themselves against adenovirus infection with the help of Apobec3A. "We found a significant

Projects Phylogeny and Function of Vγ9Vδ2 T cells: Human vs. Camelids (Prof. Dr. Thomas Herrmann) Plasticity of human gamma/delta T cells: (Epigenetic) Modulation by Vitamin C (Prof. Dr. Dietrich Kabelitz)

component of human blood. They are required for the treatment of infections within the framework of bone marrow transplantation or diseases of the haematopoietic system and can be obtained from human blood after

aim to elucidate the consequences of AA-induced myosin activation in the context of reconstituted human cardiac actin-troponin-tropomyosin complexes for wild-type and mutated sarcomeric proteins. In addition [...] physiological small molecules on the cellular level is studied in neonatal rat cardiomyocytes and human iPSC-derived differentiated cardiomyocytes. Collaboration with Prof. Dietmar Manstein (BPC, MHH), [...] Denise Hilfiker-Kleiner (Molecular Cardiology, MHH) and Dr. Robert Zweigerdt (HTTG/LEBAO/REBIRTH, MHH) Human class 18 myosins – versatile actin binding proteins Class-18 myosins challenge our established view

achieve our goals. We always try to work as close as possible to the human system, either directly with human tissue or with human models (organoids, cell culture). When necessary, these approaches are [...] interplay of a multitude of different cell types, and 3. good model systems to model the processes in the human kidney are sometimes difficult to obtain. The ultimate goal of our research group is always to try [...] Rajewsky N, Schmidt-Ott KM. Single-cell transcriptomics reveals common epithelial response patterns in human acute kidney injury. Genome Medicine . 2022;14:103. Hinze C , Karaiskos N, Boltengagen A, Walentin

the nextGENERATION program Agnes Bonifacius (Dr. rer. nat.) Year 2023 Dr. Agnes Bonifacius studied human biology (Bachelor of Science, Master of Science) at the University of Greifswald. She then completed [...] the nextGENERATION Medical Scientist Program, a novel T-cell therapy to combat infections with the human cytomegalovirus after solid organ transplantation is to be developed. Natalie Weber (Dr. med, PhD) [...] Natalie Weber auf die Entwicklung Stammzell-basierter regenerativer Therapien im ex vivo Modell humaner myokardialer Schnitte.

NK cells are not restricted to humans but important effector cells of the innate immune system in nearly all mammals. We also investigate murine NK cells and although human and murine have many features [...] innate Immunity Natural killer (NK) cells comprise about 10-15% of the peripheral lymphocytes in human blood. NK cells are part of the innate immune system as they are able to spontaneously lyse tumors

School (MHH), those affected and those seeking advice are cared for by an interdisciplinary team from Human Genetics, the Breast Centre, the Gynaecological Cancer Centre, Radiology and Pathology. After a c [...] directly," says Professor Brigitte Schlegelberger, head of the FBREK Centre and the Institute of Human Genetics at the MHH. Professor Dr. Peter Hillemanns, Director of the Comprehensive Cancer Center (CCC) [...] individual steps from genetic diagnostics to treatment and aftercare can be well coordinated," says human genetics specialist Dr Hannah Wallaschek, coordinator of the FBREK Centre. Those affected also find