speaker! Lily Sophie Rose , GERMANY, Rose.Lily@mh-hannover.de Supervisor: Prof. Dr. Ruthhild Weber (Human Genetics) Project: Ribosomal biogenesis genes and predisposition to brain tumors Tirthankar Saha , INDIA [...] Wilson.Agyapong @ mh-hannover.de Supervisor: Dr. Natalie Weber, PhD / Prof. Dr. Dr. Thomas Thum (Institute of Molecular and Translational Therapeutic Strategies IMTTS and Fraunhofer ITEM) Project: Investigation [...] zebrafish Sedef Ersoy, GERMANY, Ersoy.Sedef @ mh-hannover.de Supervisor: Prof. Dr. Christian Bär (Institute of Molecular and Translational Therapeutic Strategies, IMTTS) Project: Elucidating the role of circRNAs
Head of the Institute of Experimental Haematology at Hannover Medical School (MHH), and Prof. Dr Armin Braun, Head of Preclinical Pharmacology and Toxicology at the Fraunhofer Institute for Toxicology [...] successfully tested the efficacy and safety of our RNAi candidates on human lung tissue slices and in 3D cell cultures from human lung epithelium and animal models," explains Professor Dr Armin Braun, [...] place on the viral RNA, rendering it unreadable and initiating its degradation. As a result, the genetic blueprint it contains is not realised and virus replication is blocked. "We have now developed suitable
the same institute. Professor Figueiredo is highly interested in cell and gene therapeutic approaches in the field of transfusion and transplantation. She has a long-term expertise in the genetic engineering [...] 2008 Post-Doctoral training, Institute of Transfusion Medicine, Hannover Medical School, Germany Since 2008 Research Group Leader – Allogeneic Cell Therapy at the Institute of Transfusion Medicine and [...] strategies enabling the genetic modification of solid vascularized organs and vascular composite allografts. In addition, she is highly interested in the large-scale production of genetically engineered cells
the following institutions and companies involved: the Fraunhofer Institute for Toxicology and Experimental Medicine (ITEM) , the Institute of Mechatronic Systems (IMES) and the Institute of Quantum Optics(IQO) [...] application of human cardiac muscle cells, small animal models are unfortunately unsuitable, since the heart rate in these animals is much higher than in humans, and transplanted human muscle cells therefore [...] Ihler from the Institute for Mechatronic Systems (IMES), Prof. Dr. Alexander Heisterkamp and Prof. Dr. Stefan Kalies from the Institute of Quantum Optics (IQO). From the Fraunhofer Institute for Toxicology
Hannover Medical School (MHH) led by Professor Dr Hildegard Büning, AAV expert and deputy head of the Institute for Experimental Haematology, has developed two new AAV variants that are more effective and can [...] viral envelope, the so-called capsid, the AAV vectors dock onto the body cell and smuggle their genetic cargo into the cell interior. There it is read and converted into the corresponding protein according [...] library among more than one million AAV variants, which function both in mouse liver cells and in human liver cells. "This cross-species application possibility is very important for the development of
cardiac support system. With the help of induced pluripotent stem cells (iPS cells) from genetically reprogrammed human tissue cells, heart muscle cells can be produced. These should form the basic building [...] organoid for the first time. Robert Zweigerdt, Miriana Dardano, Lika Drakhlis (from left) How do human organs develop and what happens to them when they become diseased? To answer these questions, researchers [...] with more than six million euros, of which the Medical School Hannover (MHH) is the coordinating institution. This highly interdisciplinary network of academic and industrial scientists is composed of stem
cells are deposited, the so-called fibrosis. For years, Professor Dr. Dr. Thomas Thum, head of the Institute for Molecular and Translational Therapy Strategies at the Hannover Medical School (MHH), has been [...] research team are focusing on so-called long non-coding RNAs (lncRNA). These are building blocks of our genetic material that are not responsible for the production of proteins, but control certain processes in [...] team investigated whether the Meg3 inhibitor could also stop fibrosis and improve heart failure in human heart muscle cells and heart tissue. "Our revolutionary technology worked excellently," the cardiologist
Translational Medicine, Nature Genetics and the American Journal of Respiratory and Critical Care Medicine. After her medical doctoral thesis in the field of human genetics, she received her PhD in molecular [...] Vielzahl wissenschaftlicher Publikationen, unter anderem in Science Translational Medicine, Nature Genetics und dem American Journal of Respiratory and Critical Care Medicine. Nach ihrer medizinischen Do [...] Vorstand der „Young Investigators“ der Gesellschaft für Pädiatrische Pneumologie (GPP)“. studied human medicine in Leipzig, Munich, Sydney, Mendoza and Amsterdam. Since 2006, her pediatric training took
Translational Medicine, Nature Genetics and the American Journal of Respiratory and Critical Care Medicine. After her medical doctoral thesis in the field of human genetics, she received her PhD in molecular [...] Vielzahl wissenschaftlicher Publikationen, unter anderem in Science Translational Medicine, Nature Genetics und dem American Journal of Respiratory and Critical Care Medicine. Nach ihrer medizinischen Do [...] Vorstand der „Young Investigators“ der Gesellschaft für Pädiatrische Pneumologie (GPP)“. studied human medicine in Leipzig, Munich, Sydney, Mendoza and Amsterdam. Since 2006, her pediatric training took
for clinical application. These technologies were then combined for the generation of murine and human heart muscle tissue from embryonic and induced pluripotent stem cells. For clinical testing of bi [...] iCARE - Induced pluripotent stem cells for clinically applicable heart repair – with six partner institutions, coordinated by Prof. Dr. U. Martin and Prof. Dr. A. Haverich (LEBAO, HTTG , MHH ). The BMBF-funded [...] aims at the generation of a tube-shaped heart tissue, which is based on the contractile function of human pluripotent stem cell-derived cardiomyocytes. The tubular construct represents a single heart chamber