Pioneering work on the molecular genetic manipulation of the model organism Dictyostelium discoideum. Key contributions to the development and application of molecular genetics, transient kinetics, and hybrid [...] biohybrid devices. Structural characterization of the actomyosin complexes produced in Dictyostelium and human cells and elucidation of their involvement in cytokinesis and cell motility. Structure-based iden

Graduation 2023 Winter TACTiC Project Graduation 2022 Summer Generation of human induced pluripotent stem cell lines - Encoding for genetically encoded calcium indicators RCaMP1h and GCaMP6f COFONI - Covid-19 Research [...] organoids - New publication on a detailed protocol for the production of heart-forming organoids from human pluripotent stem cells Teaching Award of the Student Body 2021 - Outstanding Commitment in Teaching [...] research group can replicate early heart development in the cell culture dish for the first time using human stem cells Scalable Process for Differentiation of Pluripotent Stem Cells into Definitive Endoderm

caused by viruses, fungi and bacteria. A research team led by Dr Anna Christina Dragon from the Institute of Transfusion Medicine and Transplant Engineering at Hannover Medical School (MHH) is now developing [...] rejection," explains the young scientist. The structures on the surface of the body cells, the so-called human leukocyte antigens (HLA), are decisive for this. Based on these tissue characteristics, our immune [...] immune cells of the patient – the so-called T cells – which we convert into killer cells through genetic modification so that they precisely eliminate the responsible B cells that would otherwise produce

Projects Phylogeny and Function of Vγ9Vδ2 T cells: Human vs. Camelids (Prof. Dr. Thomas Herrmann) Plasticity of human gamma/delta T cells: (Epigenetic) Modulation by Vitamin C (Prof. Dr. Dietrich Kabelitz) [...] mechanism of γδ TCR activation, in order to enhance tumour killing (Prof. Dr. Wolfgang Schamel) Genetically engineered chicken models: novel tools to investigate lymphocyte development and function (Prof

Principal investigator PD Dr. Jens Bohne Medizinische Hochschule Hannover (Hannover Medical School) Institute of Virology, OE5230 Carl-Neuberg-Str. 1 30625 Hannover Phone +49 511 532 4307 Departmental Secretary [...] l RNA expression. On the cellular side we are interested in non-coding mutations causing various human diseases. Both areas follow our central idea: A deeper knowledge of both viral gene expression and [...] rescue of a non-coding variant suppressing factor 9 RNA biogenesis leading to hemophilia B. PLoS Genet. 2020 Apr 8;16(4):e1008690. 3. Krooss SA, Dai Z, Schmidt F, Rovai A, Fakhiri J, Dhingra A, Yuan Q

Jonathan Lühmann GERMANY Luehmann.Jonathan @ mh-hannover.de Supervisor: Prof. Dr. Doris Steinemann (Human Genetics) Project: Optical Mapping to detect structural genomic variants in cancer Jonathan was class [...] Thum / Dr. Christian Bär (IMTTS) Project: Screening and validation of natural compound libraries in human iPSC-cardiomyocytes for the treatment of Fabry disease Final exam June 2024 Bushra Khan INDIA khan [...] Sommer @ item.fraunhofer.de Supervisors: Prof. Dr. Armin Braun / Dr. Katherina Sewald (Fraunhofer Institute ITEM) Project: Immune-related mechanisms of IL-2-induced skin rash and lung toxicity Final exam

Status: 11 February 2021 On average, a human being consists of about 30 trillion body cells - and just as many bacteria. Without them, we would not be able to live. Not only in the intestine, on our skin [...] the renowned journal Biofilms and Microbiomes. Microorganisms form a community "Until recently, the human lower respiratory tract was considered sterile," explains Professor Tümmler. Therefore, most studies [...] assign it correctly. "The respective secretion samples contained only a few billionths of a gram of genetic material and about 90 per cent of that came from the children and only ten per cent from the mic

Interventional Radiology Institute of Human Genetics Institute for Radiation Therapy and Special Oncology Comprehensive Cancer Center (CCC) Hannover Center for Clinical Trials Clinic for Pediatric Pneumology [...] insights into the causes and course of diseases. Cooperating institutes and departments at the MHH Institutes and departments Peter L. Reichertz Institute for Medical Informatics of TU Braunschweig and Hannover [...] collection and cross-institutional exchange of medical data for health care and research. Research Research also benefits directly from the possibilities of exchanging data across institutions. On the one hand

clinics and institutes are also on board. These include experts from haematology, nephrology, gastroenterology, immunology, nuclear medicine, pathology, plastic surgery, paediatrics, human genetics and radiology

strong inhibitory and weak stimulatory signals in human immune cells when they interact with porcine tissues. Transgenic (tg) pigs expressing the human (h) inhibitory ligand hPD-L1 (CD274) and pigs lacking [...] vitro studies showed that SLA class I-deficient and hPD-L1 tg cells are only partially protected from human immune responses. We expect that hPD-L1 positive/SLA class I negative cells generated by combining [...] alleles with low stimulatory potential for the potential transplant recipient. Together with further "genetic engineering" in the context of ex vivo perfusion, it is thus possible to select or generate a xenograft