Innate Immunity - Natural killer cells

Prof. Dr. Roland Jacobs

A portrait photograph of the working group leader Professor Jacobs is shown. Copyright: Wyrwa, Christian.
Copyright: Wyrwa, Christian. Working group leader Prof. Jacobs

We are mainly working on innate immunity and particularly NK cells. These cells are of outstanding importance in defending virus infections and tumor genesis. NK cells do not require prior sensitization to efficiently kill virus-infected and tumor cells enabling them to immediately control until lymphocytes of the adopted immune system overtake and terminate infection and tumorigenesis. In addition to their cytolytic properties, NK cells can produce several cytokines such as IFN-γ, TNF-α, GM-CSF and IP10 allowing them to also control and regulate immune functions by soluble factors.

Other areas of research: innate immunity, immunodeficiencies, CD20+ T cells

This map shows the buildings of MHH. The blue circle indicates the location of the Jacobs' lab. Copyright: IGM - Infrastrukturelles Gebäudemanagement/MHH (modified)
Copyright: IGM - Infrastrukturelles Gebäudemanagement/MHH (modified). The blue circle indicates the Jacobs' lab in building K5.


This working group comprises:

Leader: Prof. Dr. Roland Jacobs


Sabine Buyny, technician



Rheumatology and Clinical Immunology


Hannover Medical School

Carl-Neuberg-Str. 1

30625 Hannover

Tel.: 0511 532 3581

E-Mail: Prof. Dr. Roland Jacobs