Current Projects Molecular dissection of mutations in ACTB and ACTG1 causing non-muscle actinopathies Functional characterizations of mutations in non-muscle myosin-2A causing MYH9 -related disorders

inhibitor of RhoGAP class-IX myosins suppresses the metastatic features of cancer cells. Nat Commun . 15(1):9947. doi: 10.1038/s41467-024-54181-6 . Reinke, P. Y.A., Heiringhoff, R. S., Reindl, T., Baker, K. [...] R., Henn, A., Taft, M. H. #, and Manstein, D. J.# (2020) Mechanochemical properties of human myosin 1C are modulated by isoform-specific differences in the N-terminal extension. J Biol Chem. 296:100128 [...] Donato, N. (2018) Variants in exons 5 and 6 of ACTB cause syndromic thrombocytopenia. Nat. Commun. 9(1):4250 , doi: 10.1038/s41467-018-06713-0 Meiring, J. C. M., Bryce, N. S., Wang, Y., Taft, M. H. , Manstein

of German inpatient data. Strahlenther Onkol. 2022 Apr;198(4):334-345. doi:10.1007/s00066-021-01883-1. Epub 2022 Jan 7. Wulff A, Baier C, Ballout S, Tute E, Sommer KK, Kaase M. Sargeant A, Drenkhahn C, [...] of microbiology data into a standardised data representation using OpenEHR. Sci Rep. 2021 May 18;11(1):10556. doi:10.1038/s41598-021-89796-y. Wulff A, Mast M, Hassler M, Montag S, Marschollek M, Jack T [...] decision support systems and analysis of health care quality. BMC Med Inform Decis Mak. 2019 Sep 2;19(1):176. doi:10.1186/s12911-019-0902-0. Fiebeck J, Gietzelt M, Ballout S, Christmann M, Fradziak M, Laser

from you, we will contact you as soon as possible. Students of human medicine and dentistry for the 1st semester will receive confirmation of enrolment the day after the enrolment deadline that applies

Nikon Spinning Disk Nikon microcope with Andor/Yokogava Spinning disk X1. Spinning disk mode with 2 Andor EMCCD cameras for parallel recording of 2 channels. Nikon TIRF with 2 Andor EMCCD cameras for parallel

German Biobank Node (GBN). In total, 12.009.101 available tissue specimen, 8.080.183 liquid samples and 1.456 supporting research projects were ascertained by the GBN as key figures of the GBA for 2019. The

and work-up of neurotoxicity associated with CAR T cell therapy. Neurol Res Pract. 2022 Jan 10;4(1):1. doi: 10.1186/s42466-021-00166-5. PMID: 35000613; PMCID: PMC8744256. Penack O, Peczynski C, Mohty [...] Haferlach T, Platzbecker U, Heuser M. Impact of PPM1D mutations in patients with myelodysplastic syndrome and deletion of chromosome 5q. Am J Hematol. 2021 Jun 1;96(6):E207-E210. doi: 10.1002/ajh.26162. Epub [...] Ganser A, Koenecke C*, Pabst O*. VH1 Family Immunoglobulin Repertoire Sequencing after Allogeneic Hematopoietic Stem Cell Transplantation. PLoS One. 2017 Jan 17;12(1):e0168096. doi: 10.1371/journal.pone

HEK293T cells unveils disease-causing effects of Brugada mutation A735V of NaV1.5 sodium channels. Scientific reports. 2019;9(1):11173. Halloin C, Schwanke K, Lobel W, Franke A, Szepes M, Biswanath S, et [...] research project which is funded by the BMBF for a period of three years – officially started on April 1, 2017. In order to apply for the federal funding program “ Innovative Stem Cell Technologies in Personalized [...] barrier (Templin, C., Circulation 126, 2012. 4: 430; Kawamura, M., Circulation 127, 2012. 11 Suppl 1: S29). In contrast, recently published data (Chong, J.J., Nature, 2014. 510: 273) show that survival

remove bacteria from the blood stream: results of the first in human study. Crit Care. 2022 Jun 17;26(1):181. *Authors contributed equally. Vollmer Barbosa C, Lang H, Melk A, Schmidt BMW. Renal events in [...] Kraemer TD, Soerensen-Zender I, Memaran N, Haller H, Melk A, Schmidt BMW*, Schmitt R*. Changes in AZGP1 Serum Levels and Correlation With Pulse Wave Velocity After Kidney Transplantation. Front Cardiovasc [...] Disease after Transplantation – Causes and Prevention Förderer: BMBF (IFB Transplantation, Projekt CORE_1) Antragsteller: A. Melk, B.M.W. Schmidt, G. Beutel Cardiovascular risk profile in children and young

Toxins (Basel). 2013 Jan 11;5(1):106-19. Mg2+-free ATP Regulates Native Cytoplasmic Dynein’s Processivity, VA Behrens, WJ Walter, C Peters, T Wang , B Brenner1, MA Geeves4, T Scholz1,5, W Steffen. FEBS Lett [...] several myopathies including heart disorder Familial hypertrophic cardiomyopathy (FHC) that affects 1 in 200 individuals worldwide. Clinical phenotypes display a high variability ranging from being asymptomatic [...] filament is held between the optically trapped beads forming a dumbbell. Single myosin molecule (myosin S1) is shown bound on the 3rd bead on the surface of a flow chamber. The interaction between the actin