Current Projects

• Molecular dissection of mutations in ACTB and ACTG1 causing non-muscle actinopathies
• Functional characterizations of mutations in non-muscle myosin-2A causing MYH9-related disorders
• Characterization of SH3BGRL proteins, a group of newly discovered actin pointed-end capping proteins
• Structural and functional characterization of the non-canonical actin isoform ACTBL2
• Modulation of cytoskeletal actin dynamics by tropomyosin isoforms