, M., Klimenkova, O., Lan, D., Gupta, K., Hussein, K., et al (2012) Interactions among HCLS1, HAX1 and LEF-1 proteins are essential for G-CSF-triggered granulopoiesis. Nat Med 18: 1550-1559. 144. Vallabhaneni [...] Menon, M. B., Tachibana, K., Doi, T., and Seidler, U. E. (2017). IL-1beta-Induced Downregulation of the Multifunctional PDZ Adaptor PDZK1 Is Attenuated by ERK Inhibition, RXRalpha, or PPARalpha Stimulation [...] Preusse, K., Madlung, J., et al (2014) S/T phosphorylation of DLL1 is required for full ligand activity in vitro but dispensable for DLL1 function in vivo during embryonic patterning and marginal zone B
Completed Projects of the Georgiev Group 05/2018 – 04/2020 Research Stipends GE 3062/1-1 Deciphering endogenous and environmental factors impacting on development and function of iNKT cell subsets.
detail for the NOD protein Apaf-1, the key switch in the mitochondrial pathway of apoptosis. Combining structural information from the X-ray structure of auto-inhibited Apaf-1 and the cryo-EM structure of [...] speck-like protein containing a caspase activation and recruitment domain ), and the effector pro-caspase 1. The transition from inactive monomer to active oligomer is characteristic for NOD proteins, to which [...] of the apoptosome, we depicted the conformational changes of Apaf-1, which eventually lead to the transduction of the cellular death signal. To understand the dynamics of the activation of NLRPs, we structurally
assembly and egress? Our focus is to analyze all virus-host interactions of Herpes Simplex Virus Type 1 (HSV-1) in cell types that it also interacts with in the human host: epithelial cells, neurons and immune [...] interactions that are required for efficient HSV1 cell entry, nuclear targeting of the viral genome, viral gene expression, virus assembly, egress and spread. We use HSV1 mutants as well as state-of-the-art biochemical [...] biochemical, life-cell imaging approaches and electron microscopy to characterize how HSV1 activates cellular signal transduction cascades to utilize the actin cytoskeleton, the microtubule transport machinery
Apr;85(1):1-13. Erratum in: J Biomed Mater Res A. 2008 Apr; 85(1):284 Petri S, Krampfl K, Kuhlemann K, Dengler R, Grothe C Preserved expression of fibroblast growth factor (FGF)-2 and FGF receptor 1 in brain [...] 25;29(24):3935-3944. doi: 10.1093/hmg/ddaa275. Low Density Lipoprotein Receptor-Related Protein-1 (LRP1) Is Involved in the Uptake of Clostridioides difficile Toxin A and Serves as an Internalizing Receptor [...] survival and gene expression in SOD1G93A amyotrophic lateral sclerosis mice. Eur J Neurosci. 2019 Mar 18. doi: 10.1111/ejn.14405. [Epub ahead of print] Ekaterini Kefalakes1, Sebastian Boeselt, Anastasia Sarikidi
511 532 -2759 (office), -3654 (lab) Fax: +49 511 532-161215 address: 30625 Hannover, Carl-Neuberg-Str.1, Germany Building J03, level 03, room 1320 Publications and Abstracts Scientific articles in peer-reviewed [...] , Perrot, A., Francino, A., Navarro-López, F., Brenner, B., & Kraft, T. (2018). Front. Physiol. 9, 1–15. doi:10.3389/fphys.2018.00359 Publication Abstracts for Lectures Burkart V., Kowalski K. , Holler [...] cardiomyopathy patients with truncation mutations. 2022, Biophysical Journal, Vol.121, Issue 3, Suppl., 1, 435a Kowalski K. , Mayer A.-K., Piep B., Zweigerdt R., Schwanke K., Kraft T., Montag J. Burst-like
(Kopie 1) ICBT - Registration Form 1 Personal information 2 Different invoice address Salutation: Mr Ms Title: First name: * Last name: * Organization: * Department: * Address: * Postal code: * City: *
Medizinische Hochschule Hannover (Hannover Medical School) Institute of Virology, OE5230 Carl-Neuberg-Str. 1 30625 Hannover Phone +49 511 532 4307 Departmental Secretary +49 511 532 6736 Laboratory +49 511 532 [...] Publications in peer-reviewed journals, Reviews, Book chapters, Comments etc. Ten most recent Publications: 1. Wachs AS, Bohne J. Two sides of the same medal: Noncoding mutations reveal new pathological mechanisms [...] mechanisms and insights into the regulation of gene expression. Wiley Interdiscip Rev RNA. 2021 Jan;12(1):e1616. Review. 2. Krooss S, Werwitzke S, Kopp J, Rovai A, Varnholt D, Wachs AS, Goyenvalle A, Aarstma-Rus
the cellular phospholipase PLCg1 and downstream signaling pathways activated by PLCg1. We try to understand how pK15 promotes the phosphorylation and activation of PLCg1 by cellular tyrosine kinases. Based [...] Herpesvirus K15 protein contributes to virus-induced angiogenesis by recruiting PLCg1 and activating NFAT1-dependent RCAN1 expression. PLoS Pathogens 2012; 8:e1002927. doi: 10.1371 Jäger W, Santag S, Wei [...] Kaposi's Sarcoma-associated herpesvirus latency-associated nuclear antigen 1 (LANA-1) that is required for multiple functions of LANA-1. J Virol. 2005; 79:13618-29. Dedicoat M, Newton R, Alkharsah K.R, Sheldon
treatment of a large maximum care hospital. We employ more than 10.000 people, 1.164 of them in medical service and about 1.929 in nursing service. The clinic with its focus on pediatric pneumology and [...] the adjacent subjects of immunology which is recognized worldwide. Besides the Perinatal Center Level 1, one of the largest cystic fibrosis centers in Germany is part of our department. Further focal points