2022

• Transcriptional bursts and heterogeneity among cardiomyocytes in hypertrophic cardiomyopathy, Valentin Burkart, Kathrin Kowalski, David Aldag-Niebling, Julia Beck, Dirk Alexander Frick, Tim Holler, Ante Radocaj, Birgit Piep, Andre Zeug, Denise Hilfiker-Kleiner, Cristobal G. dos Remedios, Jolanda van der Velden, Judith Montag and Theresia Kraft, Front. Cardiovasc. Med.,  August 2022, Sec. Cardiovascular Biologics and Regenerative Medicin, doi: 10.3389/fcvm.2022.987889

2020

• Advanced single cell mapping reveals that in hESC-cardiomyocytes contraction kinetics and action potential are independent of myosin isoform, accepted 2020, Stem Cell Reports, * gleichwertiger Beitrag der Autoren, Weber N.*, Kowalski K.*, Holler H., Radocaj A., Fischer M., Thiemann S., de la Roche J., Schwanke K., Piep B., Krumm U., Lingk A., Wendland M., Greten S., Schmitto J. D., Ismail I., Warnecke G., Zywietz U., Chichkov B., Haverich A., Martin U., Brenner B., Zweigerdt R., Kraft T. PubMed

2018

• Burst-Like Transcription of Mutant and Wildtype MYH7 -Alleles as Possible Origin of Cell-to-Cell Contractile Imbalance in Hypertrophic Cardiomyopathy, Montag, J., Kowalski, K., Makul, M., Ernstberger, P., Radocaj, A., Beck, J., Becker, E., Tripathi, S., Keyser, B., Mühlfeld, C., Wissel, K., Pich, A., van der Velden, J., dos Remedios, C. G., Perrot, A., Francino, A., Navarro-López, F., Brenner, B., & Kraft, T. (2018). Front. Physiol. 9, 1–15. doi:10.3389/fphys.2018.00359

Abstructs and Awards

2019

• Myosin and cMyBP-C-mutations in Hypertrophic cardiomyopathy: Variable effects on calcium sensitivity and contractile imbalance from cell-to-cell, Makul M., Radocaj A., Ernstberger P., Montag J., Kowalski K., Keyser B., Perrot A., dos Remedios C. G., Brenner B., Kraft T., 2019, Biophysical Society Journal, Vol.116, Issue 3, Suppl. 1, 262A
• In human embryonic stem cell-derived cardiomyocytes twitsch kinetics, action potential parameters and MyH-mRNA fractions are independent of the expressed myosin heavy chain isoform, Weber N.*, Kowalski K.*, Holler T., Radocaj A., Fischer M., de la Roche J., Thiemann S., Schwanke K., Lingk A., Krumm U., Piep B., Martin U., Zweigerdt R., Brenner B., Kraft T., , 2019, Biophysical Society Journal, Vol.116, Issue 3, Suppl. 1, 118A * gleichwertiger Beitrag der Autoren

2018

• Human embryonic stem-cell derived cardiomyocytes: Single-Cell Mapping to relate twitch kinetics to myosin heavy chain protein and mRNA-expression, Weber N.*, Kowalski K.*, Holler T., Radocaj A., Schwanke K., Lingk A., Krumm U., Wendland M., Zywietz U., Chickov B., Ulrich M., Zweigerdt R., Brenner B., Kraft T., 2018, Biophysical Journal, Vol.114, Issue 3, p.549a * gleichwertiger Beitrag der Autoren
• Poster Award 2. Platz beim 1. PhD Symposium des IRTG1902 und SFB1116 in Düsseldorf 2018 für Analysis of active transcription sites in human ventricular cardiomyocytes indicates burst-like transcription of MYH7, Kowalski K.

2017

• Independent, stochastic, burst-like transcription of mutant and wildtype MYH7-alleles. A mechanism for functional and transcriptional variability among HCM (hypertrophic cardiomyopathy) cardiomyocytes, Radocaj A, Kowalski K., Montag J, Kraft T, Brenner B., 2017, Acta Physiol. 219(S711):132
• Independent Stochastic Burst-like Transcription of Mutant and Wildtype Alleles as Mechanism for Cell-to-Cell Functional Imbalance in Hypertrophic Cardiomyopathy, Radocaj A, Kowalski K., Montag J, Kraft T, Brenner B., 2017, Biophysical Journal, Vol. 112, Issue 3, p164a
• Model of independent stochastic burst-like transcription can explain observed functional and transcriptional variability among cardiomyocytes from Hypertrophic Cardiomyopathy patients, Radocaj A, Kowalski K., Montag J, Kraft T, Brenner B., 2017, J Muscle Res Cell Motil 38:362
• Singe cell mapping used to assign mRNA and protein expression of cardiac myosin heavy chain to twitch kinetics of the same human embryonic stem cell-derived cardiomyocyte, Weber N., Kowalski K., Holler T., Lingk A., Radocaj A., Krumm U., Wendland M., Zywietz U., Chichkov B., Schwanke K., Martin U., Zweigerdt R., Brenner B., Kraft T., 2017, J Muscle Res Cell Motil 38:344
• Analysis of active transcription sites in single human cardiomyocytes reveals burst-like transcription of MYH7, Kowalski K., Radocaj A., Francino A., Navarrto.López F., dos Remedios C. G., Kraft T., Brenner B., . 2017, J Muscle Res Cell Motil 38:360
• Detection of transcription sites in FHC patients indicating a burst-like transcription concept for MYH7, Kowalski K., Radocaj A., Francino A., Navarro-López f., dos Remedios C. G., Kraft T., Brenner B., 2017, Acta Physiol. 219 (S711):47
• Visualization of active transcription sites in human cardiomyocytes supports the concept of burst-like transcription of MYH7, Kowalski K., Radocaj A., Francino A., Navarro-López F., dos Remedios C. G., Kraft T., Brenner B., 2017, Biophysical Journal Vol. 112, Issue 3, Supplement 1, 210a

2016

• Hypertrophic Cardiomyopathy: Random burst-like transcription of wildtype and mutated allele as trigger for phenotype development, Kraft T., Kowalski K., Montag J., Radocaj A., Makul M., Ernstberger P., Perrot A., Francino A., Navarro-López F., Brenner B., 2016, Cicrulation, Vol. 134, Issue suppl_1