Investigations of human, human pluripotent stem cell-derived cardiomyocytes and animal contractile models in non-pathologic and pathologic conditions Address: Apl. Prof. Dr. Bogdan Iorga Institute for Molecular [...] composition of sarcomeric proteins. Subcellular myofibrils can be obtained from human (e.g., biopsies), human-derived and non-human cardiac and skeletal small muscle samples (e.g., mouse, rat, rabbit, zebrafish [...] and from human stem cells AG Dr. Sarah Konze Cardiomyocytes from human induced pluripotent stem cells as a cellular model for hypertrophic cardiomyopathy Address Dr. rer. nat. Sarah Konze Institute for Molecular

Pioneering work on the molecular genetic manipulation of the model organism Dictyostelium discoideum. Key contributions to the development and application of molecular genetics, transient kinetics, and hybrid [...] biohybrid devices. Structural characterization of the actomyosin complexes produced in Dictyostelium and human cells and elucidation of their involvement in cytokinesis and cell motility. Structure-based iden

Graduation 2023 Winter TACTiC Project Graduation 2022 Summer Generation of human induced pluripotent stem cell lines - Encoding for genetically encoded calcium indicators RCaMP1h and GCaMP6f COFONI - Covid-19 Research [...] organoids - New publication on a detailed protocol for the production of heart-forming organoids from human pluripotent stem cells Teaching Award of the Student Body 2021 - Outstanding Commitment in Teaching [...] research group can replicate early heart development in the cell culture dish for the first time using human stem cells Scalable Process for Differentiation of Pluripotent Stem Cells into Definitive Endoderm

Projects Phylogeny and Function of Vγ9Vδ2 T cells: Human vs. Camelids (Prof. Dr. Thomas Herrmann) Plasticity of human gamma/delta T cells: (Epigenetic) Modulation by Vitamin C (Prof. Dr. Dietrich Kabelitz) [...] mechanism of γδ TCR activation, in order to enhance tumour killing (Prof. Dr. Wolfgang Schamel) Genetically engineered chicken models: novel tools to investigate lymphocyte development and function (Prof

Principal investigator PD Dr. Jens Bohne Medizinische Hochschule Hannover (Hannover Medical School) Institute of Virology, OE5230 Carl-Neuberg-Str. 1 30625 Hannover Phone +49 511 532 4307 Departmental Secretary [...] l RNA expression. On the cellular side we are interested in non-coding mutations causing various human diseases. Both areas follow our central idea: A deeper knowledge of both viral gene expression and [...] rescue of a non-coding variant suppressing factor 9 RNA biogenesis leading to hemophilia B. PLoS Genet. 2020 Apr 8;16(4):e1008690. 3. Krooss SA, Dai Z, Schmidt F, Rovai A, Fakhiri J, Dhingra A, Yuan Q

Jonathan Lühmann GERMANY Luehmann.Jonathan @ mh-hannover.de Supervisor: Prof. Dr. Doris Steinemann (Human Genetics) Project: Optical Mapping to detect structural genomic variants in cancer Jonathan was class [...] Thum / Dr. Christian Bär (IMTTS) Project: Screening and validation of natural compound libraries in human iPSC-cardiomyocytes for the treatment of Fabry disease Final exam June 2024 Bushra Khan INDIA khan [...] Sommer @ item.fraunhofer.de Supervisors: Prof. Dr. Armin Braun / Dr. Katherina Sewald (Fraunhofer Institute ITEM) Project: Immune-related mechanisms of IL-2-induced skin rash and lung toxicity Final exam

Interventional Radiology Institute of Human Genetics Institute for Radiation Therapy and Special Oncology Comprehensive Cancer Center (CCC) Hannover Center for Clinical Trials Clinic for Pediatric Pneumology [...] insights into the causes and course of diseases. Cooperating institutes and departments at the MHH Institutes and departments Peter L. Reichertz Institute for Medical Informatics of TU Braunschweig and Hannover [...] collection and cross-institutional exchange of medical data for health care and research. Research Research also benefits directly from the possibilities of exchanging data across institutions. On the one hand

strong inhibitory and weak stimulatory signals in human immune cells when they interact with porcine tissues. Transgenic (tg) pigs expressing the human (h) inhibitory ligand hPD-L1 (CD274) and pigs lacking [...] vitro studies showed that SLA class I-deficient and hPD-L1 tg cells are only partially protected from human immune responses. We expect that hPD-L1 positive/SLA class I negative cells generated by combining [...] alleles with low stimulatory potential for the potential transplant recipient. Together with further "genetic engineering" in the context of ex vivo perfusion, it is thus possible to select or generate a xenograft

is to vascularize organoids and to produce functional kidney tissue from human stem cells. We use zebrafish embryos with genetic markers for renal cells, macrophages and endothelium and LSM microscopy to [...] mechanisms of vasculogenesis. In parallel, we are studying new vessel formation in human renal organoids. We have discovered that human macrophages strongly influence vascularization and endothelial differentiation [...] hypothesis is that impaired signal transduction of VEGF is responsible for aging and that targeted genetic manipulation can arrest these aging and dedifferentiation processes. Our second research project

Theories of the State JC Political Institutions and Public Administration JF Political Institutions and Public Administration (North America) JJ Political Institutions and Public Administration (United [...] g QT 34-37 Human Physiology QT 104-172 Physiology, Hygiene QT 180-245 Leisure Activities, Sports Medicine QT 250-275 Zeitschriften / Periodicals QU - Biochemistry, Cell Biology and Genetics Reference Works [...] Carbohydrates, Lipids QU 75-99 Biochemistry of the Human Body QU 100-133 Enzymes QU 135-144 Nutrition, Vitamins QU 145-220 Cells QU 300-375 Genetics QU 450-560 Zeitschriften / Periodicals QV - Pharmacology