leader Prof. Dr. Daniel P. Depledge Medizinische Hochschule Hannover (Hannover Medical School) Institute of Virology, OE5230 Carl-Neuberg-Str. 1 30625 Hannover Phone +49 (0) 511 532 4310 Departmental Secretary [...] modifications in viral infections. In 2019 he became an Assistant Professor at NYU before joining the Institute of Virology at the Hannover Medical School (MHH) in 2021 as a DZIF Associate Professor. Alumni of [...] - Selected articles, reviews, and book chapters: Depledge DP , Breuer J. Varicella-Zoster Virus-Genetics, Molecular Evolution and Recombination. Curr Top Microbiol Immunol. 2021. https://doi.org/10.10

Institute of Molecular Biology Research profile of the department In our institute independent groups address basic questions concerning organ and tissue development and cell differentiation using the [...] mouse as model organism and a variety of modern biochemical, molecular genetic, and transgenic methods and technologies. The institute participates in the following study programs: BSc Biology, Leibniz-University

Human heart-forming organoids recapitulate early heart and foregut development For the first time, MHH research group can use human stem cells to simulate early heart development in the cell culture dish [...] dish Scientists use so-called human pluripotent stem cells (hPSC) to study the early stages of embryonic development in the cell culture dish. These are cells with special properties that can be reproduced [...] the Hannover Medical School (MHH), succeeded in tracing the entire path to the early stages of a human heart in cell culture for the first time. The research work is published in the renowned journal Nature

after kidney transplant Further infomation: https://ntx360grad.de/ Copyright: NTX 360° Human genetics Human genetic studies Information will follow Lung Tx Lung-Tx For patients with the most severe end-stage [...] rapid processing of fresh human tissue and body fluids as well as biobanking and long-term storage. Quickly available, expertly assessed and extremely valuable tissue from human and animal hearts and lungs [...] network with the name BREATH , Hannover Medical School (MHH) applied together with the Fraunhofer Institute for Toxicology and Experimental Medicine (ITEM) and the Leibniz Universität Hannover to the BMBF

organoid for the first time. Robert Zweigerdt, Miriana Dardano, Lika Drakhlis (from left) How do human organs develop and what happens to them when they become diseased? To answer these questions, researchers [...] producing a heart-forming organoid (HFO) and reproducing the entire path to the early stage of a human heart in cell culture. One unsolved problem in science to date has been the development of a model [...] that simulates heart development and haematopoiesis in combination. Haematopoiesis begins in the human embryo after the fourth week in the aorta, close in time and location to the cardiac anlage. Building

cell-based therapies will provide innovative therapeutic strategies for the treatment of various genetic and acquired diseases. Recently, the possibility to reprogram normal somatic cells into induced [...] Martin - in collaboration with a group from Zürich - artificially introduced an ion channel into human iPS cells. Physiological occurrence of this ion channel is restricted to the thyroid and the stomach [...] Hoerstrup S, Luescher TF, Kaufmann PA, Landmesser U*, Martin U*: Transplantation and tracking of human-induced pluripotent stem cells in a pig model of myocardial infarction: assessment of cell survival

the first bioengineered rAAV to enter clinical evaluation. In 2012, he was recruited by the Salk Institute for Biological Studies to oversee their Gene Transfer, Targeting and Therapeutic (GT3) facility [...] facility. In 2015, he was recruited by the University of Sydney / Children’s Medical Research Institute (CMRI) to establish his independent research team, Translational Vectorology Research Unit (TVRU), and to [...] a number of gene therapy programs that aim to develop novel advanced therapeutics for paediatric genetic disorders affecting the CNS, lungs, liver and other organs.

Hochschule Hannover, the Fraunhofer Institute for Toxicology and Experimental Medicine, the Institute of Farm Animal Genetics of the Friedrich-Loeffler-Institute (FLI) Mariensee, the Helmholtz Centre [...] Centre for Infection Research Braunschweig and the Max Planck Institute for Molecular Biomedicine Münster. The consortium addresses some of the big questions in health research as well as the associated challenges [...] Structure of Organisation & Governance Coordinators Coordinator: Prof. Dr. Dr. Thomas Thum The Institute of Molecular and Translational Therapeutic Strategies (IMTTS) E-Mail: Thum.Thomas(at)mh-hannover

are also life threatening, e.g. Cystic Fibrosis (CF) and surfactant deficiencies (SD). CF is a genetic disease, resulting in a dysfunction of the „Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)“ [...] respiratory system. Cell replacement therapies could be used to regenerate normal lung function in both genetic and acquired pulmonary diseases. Pluripotent stem cells represent a suitable cell source due to their [...] huge impact for both the optimization of differentiation protocols as well as for drug-screening are human iPS reporter cell lines which are generated using TALEN-based homologues recombination ( RG Martin

and Toxicology human medicine, 3rd year of study Organized by: Prof. Dr. rer. nat. Harald Genth (Prof. Dr. med. Ingo Just), Institute of Toxicology Prof. Dr. med. Roland Seifert, Institut of Pharmacology [...] nutrition (anorexia and obesity) human Medicine, from the 3rd year of study Organized by: Prof. Dr. med. Roland Seifert, Institut of Pharmacology Dr. med. Bastian Schirmer, Institut of Pharmacology Curriculum [...] materials MSE_P_509 Clinical Pharmacology and Pharmacotherapy human medicine, 5rd year of study Organized by: Prof. Dr. med. Dirk.O. Stichtenoth, Institute of Clinical Pharmacology Curriculum more details MSE_P_312