Filipczyk AA, Halle S, Klump H, Schöler HR, Baum C, Schroeder T, Schambach A. Lentiviral vector design and imaging approaches to visualize the early stages of cellular reprogramming. Mol Ther. 2011 A
(special focus: RNA expression analyses, miRNAs, cloning, single cell analysis, , genome editing using designer nucleases TALEN and CRISPR/Cas9), cell culture techniques virological methods and handling of pathogens
the motor proteins. read more .... Projects Modulatory roles of sub-components of motor proteins Designing new nano-biohybrid motors based on natural building blocks Single molecule analysis of mutant myosin
K., and Hilgenfeld, R. (2020) Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved alpha-ketoamide inhibitors. Science 368, 409-412. Bogutzki, A., Naue, N., Litz, L., Pich
Daly D, Begley C, Putman K. Health economic analysis of a cluster-randomised trial (OptiBIRTH) designed to increase rates of vaginal birth after caesarean section. BJOG. 2019;126(8):1043-1051. Grylka [...] Begley C. Process evaluation for OptiBIRTH, a randomised controlled trial of a complex intervention designed to increase rates of vaginal birth after caesarean section. Trials. 2018 Jan 5;19(1):9. Doi: 10 [...] A systematic literature review of computer-based behavioural change interventions to inform the design of an online VBAC intervention for the OptiBIRTH european randomized trial. Evidence Based Midwifery
ures, in particular the NUM Clinical Epidemiology and Studies Platform (NUKLEUS). NAPKON-TIP is designed as a platform for adaptive clinical trials to facilitate the ongoing evaluation of new therapies [...] developing new endpoints and better monitoring approaches for immune function tests, and (iii) designing cellular and molecular biomarkers for early detection of adverse effects. The platform imSAVAR will
Germ-free rederivation of rodent models Maintenance of gnotobiotic models Assistance with study design involving gnotobiotic mice Support and execution of collaborative gnotobiotic experiments Training
Microbiology, Leibniz University Hannover Hannes Sommer Research Topic: Computational methods for the design of diagnostics and treatment oligonucleotides Supervisor: Prof. Dr. Marco Galardini, Institute of [...] Biology, Technical University Braunschweig, Germany Julia Schneider Research Topic: Structure-based design of specific inhibitors for Apicomplexa myosins Supervisor: Prof. Dr. Dietmar Manstein, Institute
org/10.5966/sctm.2015-0253 . Merkert, S., and Martin, U. 2016. Targeted genome engineering using designer nucleases: State of the art and practical guidance for application in human pluripotent stem cells [...] Dreyer, A.-K., Schwanke, K., Meyer, J., Göhring, G., Cathomen, T., and Martin, U. 2014. Efficient designer nuclease-based homologous recombination enables direct PCR screening for footprint less targeted
Becker S, Rox K, Hilgenfeld R. Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved alpha-ketoamide inhibitors. Science 2020;368(6489):409-412 DOI: 10.1126/science.abb3405 [...] Embedded Multifactorial Adaptive Platform for Community-acquired Pneumonia) Study. Rationale and Design. Ann Am Thorac Soc 2020;17(7):879-891 DOI: 10.1513/AnnalsATS.202003-192SD Boettler T, Newsome PN [...] collaborative outcomes study on health and functioning during infection times in adults (COH-FIT-Adults): Design and methods of an international online survey targeting physical and mental health effects of the