the research group "Systems Biology of Microbial Communities" at the Institute of Molecular Bacteriology of TWINCORE. Significant genetic differences between harmless and dangerous bacteria The team examined [...] Escherichia coli bacteria live in the intestines of humans and play an important role there for normal intestinal function as well as for a functioning immune system. These intestinal inhabitants do not [...] Marco Galardinis team has studied this in more detail and found that E. coli has a significant genetic variation that contributes to the transition between the harmless life in the intestine (commensalism)

explains Professor Dr. Constanca Figueiredo, senior scientist at the Institute and deputy project leader. In addition, the scientist genetically modified the iPSC and also switched off the HLA characteristics [...] consumption of blood products. A research team led by Professor Dr Rainer Blasczyk, head of the Institute for Transfusion Medicine and Transplant Engineering at the Medical School (MHH), wants to solve [...] groups that have to be taken into account in a transfusion. Tissue characteristics, the so-called human leukocyte antigens (HLA), also play a role. These molecules on the surface of body cells are comparable

nal cohorts could enable more accurate cancer risk prediction," says Penkert from the Institute of Human Genetics, who is currently conducting research in Professor Kratz's team. A total of 141 people [...] and is associated with a massively increased cancer risk. It represents one of the most important genetic causes of cancer in children and adults. Modern DNA sequencing methods are repeatedly uncovering

Vice Director of the MHH Institute for Experimental Haematology . The AAV vectors dock onto the body cell via the vector envelope, the so-called capsid, and transfer their genetic cargo into the cell interior [...] culture with human blood plasma. The two AAV variants also survived this test. They were then loaded with a biomolecule called H19, which has already been successfully tested at the Institute for the treatment [...] "We had several winners in the running and then tested how strongly they were intercepted by the human immune system." Not all gene taxis reach their target Not all vectors that target specific body cells

Professor Dr. Dr. Axel Schambach, head of the Institute for Experimental Haematology at the Hannover Medical School (MHH), in cooperation with the Fraunhofer Institute for Toxicology and Experimental Medicine [...] affected by the virus. The efficacy of the drug is being tested on human lung tissue sections as well as in 3-D cell cultures from human lung epithelium. "If all this works, we will be able to use our iGUARD [...] 08.12.2021 Viruses are a major problem for human health worldwide - and not just since the outbreak of the SARS-CoV2 pandemic. Despite successful vaccine development, there are still no effective drugs

medicine. Prof. Konstanze Döhner studied human medicine in Heidelberg and has been a senior clinical physician and head of the Laboratory for Cytogenetic and Molecular Genetic Diagnostics at the Department of [...] Hartmut Döhner. Professor Konstanze Döhner has been Clinical Senior Physician and Head of Molecular Genetic Diagnostics of Acute Myeloid Leukemias (AML) in the Department of Internal Medicine III at Ulm University [...] outstanding scientists is in recognition of their research in the field of characterization of genetic alterations in AML and the development of personalized treatment concepts for this form of leukemia

working group is based at the Fraunhofer Institute for Toxicology and Experimental Medicine ITEM. Standardised production of mature immune cells The demand for human immune cells is high and growing daily [...] meet the steadily growing demand, biomedical research is therefore trying to obtain and multiply human immune cells through novel bioprocesses. The Attract group leader and his team have already laid a [...] researching and evaluating drug candidates because we can test their efficacy and safety directly on the human targets," says the scientist. The construction and testing of these tests will be advanced within

and basic researchers; there are about 50 teams from six institutions. RESIST spokesperson is Professor Dr Thomas Schulz, head of the MHH Institute of Virology. RESIST is funded by the German Research Foundation [...] susceptibility to infection? Professor Dr. Sarina Ravens is investigating these questions at the MHH Institute of Immunology. The scientist is focusing on certain white blood cells of the immune system (B and [...] find new starting points for the development of drugs and vaccines, Professor Schreiner at the MHH Institute of Virology is investigating how the virus multiplies in the cell. Professor Dr Nico Lachmann's

head of the Institute for Experimental Haematology at the Hannover Medical School (MHH), is developing RNA-based drugs to combat viral diseases in cooperation with the Fraunhofer Institute for Toxicology [...] "We have successfully tested the efficacy of our RNAi candidates on human lung tissue sections as well as in 3D cell cultures from human lung epithelium," explains Professor Dr. Armin Braun, Head of Preclinical [...] place on the viral RNA, thus making it unreadable and initiating its degradation. The result: the genetic blueprint packed in it is not implemented and virus replication is blocked. "In the meantime, we

therapy. Professor Dr. Dr. Axel Schambach, head of the Institute of Experimental Haematology at the Hannover Medical School (MHH), wants to genetically modify the immune cells in such a way that they detect [...] in the laboratory from “reprogrammed” adult body cells and can then produce any cell type in the human body – including NK cells of the innate immune system. The advantage: the NK cells can be produced [...] transplanted quickly and in unlimited numbers. But that is not enough. “The NK cells need to be genetically modified and put into a hyperactive and more targeted state, so that they can ensure greater targeting