t dyes, time-lapse confocal imaging, multiphoton laser scanning microscopy and the influencing of gene expression by small interfering RNA are being developed as new techniques for investigating such processes

EdinburghBelén Shruti Chopra Research Topic: Identification and characterisation of new possible risk genes for eczema herpeticum Supervisor: Prof. Dr. Thomas Werfel, Dept. Dermatology and Allergy, Division [...] Biology and Biomedical Sciences, TiHo Dilfuza Djamalova Research Topic: Pangenome wide prediction of gene function Supervisor: Prof. Dr. Marco Galardini, Institute of Molecular Bacteriology, Twincore Academic [...] Agricultural Sciences Nahuel Villarreal Research Topic: Characterization of the colitogenic candidate gene Alpk1 during infection Supervisor: Prof. André Bleich, PhD, Institute for Laboratory Animal Science

non-replicative state, during which no new viral progeny is produced and only a very limited set of viral genes is expressed. This latent state is found in infected B- and endothelial cells and can alternate with [...] sarcoma-associated herpesvirus vIRF2 protein utilizes an IFN-dependent pathway to regulate viral early gene expression. PLoS Pathogens 2019; 15(5):e1007743 Abere B, Samarina N, Gramolelli S, Rückert J, Gerold [...] inhibitory protein, vFLIP, from the viral genome compromises the activation of STAT1-responsive cellular genes and spindle cell formation in endothelial cells. J. Virol. 2011; 85:10375-88. Pietrek M, Brinkmann

Using the CRISPR/Cas9-GMNN Fusion Gene.,Gerlach M, Kraft T, Brenner B, Petersen B, Niemann H, Montag J. , Genes (Basel). 2018 Jun 13;9(6). pii: E296. doi: 10.3390/genes9060296, Journal High Intensity High [...] induces cachexia by impeding transcriptional signaling of the SET1/MLL complex on muscle-specific genes, Bushra Khan , Chiara Lanzuolo, Valentina Rosti, Philina Santarelli, Andreas Pich, Theresia Kraft [...] Nayak , Christian Hartmann, Wolfram S. Kunz, Amir Samii, Helmut Bertalanffy, Saverio Francesco Retta, Genes & Diseases , Available online 3 April 2023 ScienceDirect, doi.org/10.1016/j.gendis.2023.02.045 , PubMed

Cardiomyogenic Differentiation and Transdifferentiation By Ectopic Gene Expression - Direct Transition Or Reprogramming Detour? Curr Gene Ther 16, no. 1:14. https://doi.org/10.2174/1566523216666160104141522 [...] human iPSC line, from a Cystic Fibrosis patient specific line with p.Phe508del mutation and from the gene corrected iPSC line. Stem Cell Res 64:102918. #authors contributed equally. https://doi.org/10.1016/j [...] Zweigerdt, R. , and Martin, U. 2022. Targeted biallelic integration of an inducible Caspase 9 suicide gene in iPSCs for safer therapies. Mol Ther Methods Clin Dev 26:84. https://doi.org/10.1016/j.omtm.2022

sample. It is a kind of special camera that visualises their transcriptome - the entirety of all genes that are read and transcribed into RNA at a specific point in time. This makes it possible to better

technologies of regenerative medicine to repair tissues and organs, such as stem cell-based therapies and gene therapies," describes Professor Dr Nico Lachmann. The researcher at the MHH Clinic for Paediatric

pathologic gene-expression after myocardial infarction in mice. J Mol Cell Cardiol. 2018. www.ncbi.nlm.nih.gov/pubmed/30118791 Bauersachs J, Heymans S. Scientific updates on the interaction of genes, epigenetics [...] Jara-Avaca M, Gruh I, Martin U, Wollert KC, Gohla A, Katus HA, Muller OJ, Bauersachs J, Heineke J. A gene therapeutic approach to inhibit CIB1 ameliorates maladaptive remodeling in pressure overload. Cardiovasc

in a particular cell is indicated, among other things, by its transcriptome - the totality of all genes that are read and transcribed into RNA at a specific point in time. With the help of single-cell RNA

field include electrophysiological disorders (e.g. Brugada Syndrome due to mutations in the SCN5A gene), disruption of cardiac transcription factors (e.g. NKX2.5 Knock Out in HFOs), and studying cardiac [...] to play a pivotal role in heart development and homeostasis. In spite of their ubiquitous role in gene networks regulation, systematic studies in heart development and diseases are missing. We are specifically [...] approach include electrophysiological disorders (e.g. Brugada Syndrome due to mutations in the SCN5A gene), disruption of cardiac transcription factors (e.g. NKX2.5 knock-out in HFOs), and most recent in