areas of research in the first funding period were, for example, the non-animal safety assessment of gene therapies or transplants from other species, the digestive tract - especially the oral mucosa, intestine
Transplant Engineering at the same institute. Professor Figueiredo is highly interested in cell and gene therapeutic approaches in the field of transfusion and transplantation. She has a long-term expertise
fibroblast growth factor receptor-2. In bile duct tumours, FGFR2 is fused, so to speak, with other genes due to a genetic malformation. These fusion rearrangements lead to a permanent activation of signalling
Scientific Focus Investigation of transcriptional, post-transcriptional and epigenetic regulation of gene expression during neurodevelopment and neurodegeneration Investigation and Development of new RNA-based
supported by Illumina, a manufacturer of genetic diagnostics equipment and a leader in the field of gene sequencing. The study will include 100 children and their parents within one year. These are families
Science Publishers Link Kirsten Haastert-Talini Editorial for special issue: Gene Therapy approaches for Neuroregeneration Curr Gene Ther 2011 in press (Vol 11 No 2, April 2011) Ratzka A, Baron O, Grothe C [...] hypothesis. Placenta 2007;28(4):353-60. Kirsten Haastert, Claudia Grothe Gene Therapy in Peripheral Nerve Reconstruction Approaches Curr Gene Ther, 2007 Jun, 7:221-228 Grothe C and Timmer M The physiological [...] Hayler D, Krueger A, Kubinski S, Claus P, Hammond S M, Wood M, Yáñez-Muñoz R, Bowerman M (2020): Gene Ther. 2019 Nov;27(10-11):505-515. doi: 10.1038/s41434-020-0146-8. Epub 2020 Apr 20. In Vivo and In
Tsiavaliaris, G., Hensel, N., Viero, G., Ponimaskin, E., and Claus P. (2024). The Spinal Muscular Atrophy gene product regulates actin dynamics. FASEB J. , https://doi.org/10.1096/fj.202300183R Küçükdogru, R.* [...] Hedtfeld, S, Steinemann, D., Tümmler, B., Tsiavaliaris, G., Stanke, F. (2016). Biochim. Biophys. Acta – Gene Regulatory Mechanisms , 1859, 1411-1428. DOI: https://10.1016/j.bbagrm.2016.09.002 Poorly understood [...] Tsiavaliaris, G. (2015). BioMed Res. Int. , review. DOI: https://10.1155/2015/245154 A novel Dock8 gene mutation confers diabetogenic susceptibility in the LEW.1AR1/Ztm-iddm rat, an animal model of human
antibodies with the help of a recombinant colour-tagged SARS-CoV-2 S protein and sequence their antibody genes. After selecting antibody sequences we express them as recombinant proteins and test them for their [...] Munich. The vaccine is based on the well-researched Modified-Vaccinia-Ankara-Virus, to which the gene information for a surface protein of SARS-CoV-2 has been inserted. A special feature of Modified-
lecture hall Q) ‘The future is here! The next generation of AAV vector as a foundation of cell and gene therapeutics of the future’ Prof. Leszek Lisowski, Translational Vectorology Research Unit, Children’s [...] Institut für Experimentelle Hämatologie, MHH: 'Tailoring Adeno-Associated Virus (AAV) Vectors for Gene Therapy' Scientific afternoon Scientific afternoons organized by the Department of Cardiothoracic
increased lifelong risk of a broad spectrum of cancers and is caused by pathogenic variants in the TP53 gene. A definition reflecting the broad disease spectrum has been lacking and factors leading to differences