Publications - Prof. Dr. Georgios Tsiavaliaris
- Al-Samir, S., Itel, F., Hegermann, J., Gros, G., Tsiavaliaris, G., and Endeward, V. (2021). O2 permeability of lipid bilayers is low, but increases with membrane cholesterol. Cell. Mol. Life Sci. doi: https://10.1007/s00018-021-03974-9.
- Franz, P., Ewert, W., Preller, M. and Tsiavaliaris, G. (2021). Unravelling a force-generating allosteric pathway of actomyosin communication associated with ADP and Pi release. Int. J. Mol. Sci. 22(1), 104; https://doi.org/10.3390/ijms22010104.
- Franz, P., Gassl, V., Topf, A., Eckelmann, L., Iorga, B., and Tsiavaliaris, G. (2020). A thermophoresis-based biosensor for real-time detection of inorganic phosphate during enzymatic reactions. Biosens. Bioelectron. 169:112616. doi: https://doi.org/10.1016/j.bios.2020.112616.
- Ewert, W., Franz, P., Tsiavaliaris, G., and Preller, M. (2020). Structural and computational insights into a blebbistatin-bound myosin·ADP complex with characteristics of an ADP-Release conformation along the two-step myosin power stoke. Int. J. Mol. Sci.; 21(19):7417. doi: https://10.3390/ijms21197417.
- Nayak, A., Wang, T., Franz, P., Steffen, W., Chizhov, I., Tsiavaliaris, G., and Amrute-Nayak, M. (2020). Single-molecule analysis reveals that regulatory light chains fine-tune skeletal myosin II function. J. Biol. Chem. 15; 295(20): 7046-7059. doi: https://10.1074/jbc.RA120.012774
- Roeles, J. and Tsiavaliaris, G. (2019). Actin-microtubule interplay coordinates spindle assembly in human oocytes. Nat. Comm. 10:4651. https://doi.org/10.1038/s41467-019-12674-9.
- Transformation of the nonprocessive fast skeletal myosin II into a processive motor. Amrute-Nayak, M., Nayak, A., Steffen, W., Tsiavaliaris, G., Scholz, T., and Brenner, B. (2019). Small, 15, 1804313. doi: https://10.1002/smll.201804313.
- Profilin2a-phosphorylation as a regulatory mechanism for actin dynamics. Walter, L.S., Franz, P. Lindner, R., Tsiavaliaris, G., Hensel, N., and Claus, P. (2019). FASEB J., https://doi.org/10.1096/fj.201901883R.
- MicroScale Thermophoresis (MST) for studying actin polymerization kinetics. Topf., A., Franz, P., and Tsiavaliaris, G. (2017). BioTechniques. 63 (4), 187-190. doi: https://10.2144/000114599
- Diatrack particle tracking software: review of applications and performance evaluation. Vallotton, P., van Oijen, A.M., Whitchurch, C.B., Gelfand, V., Yeo, L., Tsiavaliaris, G., Heinrich, S., Dultz, E., Weis, K., and Grünwald, D. (2017). Traffic 18(12):840-852, review. doi: https://10.1111/tra.12530
- CO2 and HCO3- permeability of the rat liver mitochondrial membrane. Arias-Hidalgo, M., Hegermann, J., Tsiavaliaris, G., Carta, F., Supuran, C.T., Gros, G., Endeward, V. (2016). Cell. Physiol. Biochem., 39, 2014-2024. doi: https://doi.org/10.1159/000447897
- Mechanism of allele specific assembly and disruption of master regulator transcription factor complexes of NF-KBp50, NF-KBp65 and HIF1a on a non-coding FAS SNP. Awah, C.U., Tamm, S., Hedtfeld, S, Steinemann, D., Tümmler, B., Tsiavaliaris, G., Stanke, F. (2016). Biochim. Biophys. Acta – Gene Regulatory Mechanisms, 1859, 1411-1428. DOI: https://10.1016/j.bbagrm.2016.09.002
- Poorly understood aspects of striated muscle contraction. Månsson, A., Dilson, R., and Tsiavaliaris, G. (2015). BioMed Res. Int., review. DOI: https://10.1155/2015/245154
- A novel Dock8 gene mutation confers diabetogenic susceptibility in the LEW.1AR1/Ztm-iddm rat, an animal model of human type 1 diabetes. Arndt, T., Wedekind, D., Jörns, A., Tsiavaliaris, G., Cuppen, E., Hedrich, H.-J., and Lenzen, S. (2015). Diabetologia, 58, 2800-2809. DOI: https://10.1007/s00125-015-3757-7
- Low CO2 permeability of cholesterol-containing liposomes detected by stopped-flow fluorescence spectroscopy. Tsiavaliaris, G., Itel, F., Hedfalk, K., Al-Samir, S., Meier, W., Gros, G., and Endeward, V. (2015). FASEB J., 29, 1780-1793. DOI: https://10.1096/fj.14-263988
- Kinetic mechanism of Nicotiana tabacum myosin-11 defines a new type of a processive motor. Diensthuber, R.P., Tominaga, M., Preller, M., Hartmann, F.K., Orii, H., Chizhov, I., Oiwa, K., and Tsiavaliaris, G. (2015). FASEB J., 29, 81-94. DOI: https://10.1096/fj.14-254763
- A pivotal role of nonmuscle myosin II during microglial activation. Janssen, S., Gudi, V., Prajeeth, C.K., Singh, V., Stahl, K., Heckers, S., Skripuletz, T., Pul, R., Trebst, C., Tsiavaliaris, G., and Stangel, M. (2014). Exp. Neurol., 261, 666-676. DOI: https://10.1016/j.expneurol.2014.08.010
- ATP-turnover by individual myosin molecules hints at two conformers of the myosin active site. Amrute-Nayaka, M., Lambecka,K.-A., Huhnt, H., Scholz, T., Radocaja, A., Tsiavaliaris, G., Walter, W.J., and Brenner, B. (2014). PNAS U.S.A., 111 (7), 2536-2541. DOI: https://10.1073/pnas.1316390111
- Inactivation of hepatitis C virus infectivity by human breast milk. Pfaender, S., Heyden, J., Friesland, M., Ciesek, S., Ejaz, A., Steinmann, J., Steinmann, J., Malarski, A., Stoiber, H., Tsiavaliaris, G., Bader, W., Jahreis, G., Pietschmann, T., Steinmann, E. (2013). J. Infect. Dis., 208 (12), 1943-1952. DOI: https://10.1093/infdis/jit519
- Global fit analysis of myosin-5b motility reveals thermodynamics of magnesium-sensitive acto-myosin-ADP states. Chizhov, I., Hartmann, F.K., Hundt, N., and Tsiavaliaris, G. (2013). PLoS One, 8(5):e64797. doi: https://10.1371/journal.pone.0064797
- Myosin-1C associates with microtubules and stabilizes the mitotic spindle during cell division. Rump, A., Scholz, T., Thiel, C., Hartmann, F. K., Uta, P., Hinrichs, M. H., Taft, M.H. and Tsiavaliaris, G. (2011). J. Cell Sci., 124, 2521-2528. DOI: https://10.1242/jcs.084335
- Mechanism and specificity of pentachloropseudilin-mediated inhibition of myosin motor activity. Chinthalapudi, K., Taft, M. H., Martin, R., Heissler, S. M., Preller, M., Hartmann, F. K., Brandstaetter, H., Kendrick-Jones, J., Tsiavaliaris, G., Gutzeit, H. O., Fedorov, R., Buss, F., Knolker, H. J., Coluccio, L. M., and Manstein, D. J. (2011). J. Biol. Chem., 286, 29700-29708. DOI: https://10.1074/jbc.M111.239210
- Targeted optimization of a protein nanomachine for operation in biohybrid devices. Amrute-Nayak, M., Diensthuber, R.P., Steffen, W., Kathmann, D., Hartmann, F.K., Fedorov, R., Urbanke, C., Manstein, D.J., Brenner, B., and Tsiavaliaris, G. (2010). Angew. Chem. Int. Ed. Engl., 49, 312-316. DOI: https://10.1002/anie.200905200
- A myosin IK-Abp1-PakB circuit acts as a switch to regulate phagocytosis efficiency. Dieckmann, R., von Heyden, Y., Kistler, C., Gopaldass, N., Hausherr, S., Crawley, S.W., Schwarz, E.C., Diensthuber, R.P., Côté, G.P., Tsiavaliaris, G., and Soldati T., (2010). Mol. Biol. Cell, 21, 1505-1518. DOI: https://10.1091/mbc.e09-06-0485
- Total synthesis of biologically active alkaloids using transition metals. Forke, R., Gruner, K. K., Knott, K. E., Auschill, S., Agarwal, S., Martin, R., Böhl, M., Richter, S., Tsiavaliaris, G., Fedorov, R., Manstein, D. J., Gutzeit, H. O., Knölker, H.-J. (2010). Pure Appl. Chem., 82. No. 11, 1975-1991. doi: https://10.1351/PAC-CON-09-12-15
- Specific Inhibitors of Myosin ATPase via Silver-Catalyzed Synthesis of Pyrroles. The Chemistry and Biological Activity of Synthetic and Natural Compounds – Modern Aspects of Chemistry of Heterocycles. Martin, R., Agarwal, S., Jäger, A., Böhl, M., Richter, S., Tsiavaliaris, G., Fedorov, R., Manstein, D. J., Gutzeit, H. O., Knölker, H.-J. (2010). V. G. Kartsev, Ed.; ICSPF Press, Moscow; Vol. 1, 110-117. (Book Chapter).
- The mechanism of pentabromopseudilin inhibition of myosin motor activity. Fedorov, R., Böhl, M., Tsiavaliaris, G., Hartmann, F.K., Taft, M.H., Baruch, P., Brenner, B., Martin, R., Knölker, H.J., Gutzeit, H.O., and Manstein, D.J. (2009). Nat. Struct. Mol. Biol., 16, 80 - 87. DOI: https://10.1038/nsmb.1542
- Myosine - Molekulare Motoren als moderne Werkzeuge und Ziele in der humanen Wirkstoffentwicklung. Furch, M., Manstein, D.J., and Tsiavaliaris, G. (2009). Labor&More, Jahr 2009, Heft 4. (Zeitschriftenbeitrag).
- Dictyostelium myosin-5b is a conditional processive motor. Taft, M.H., Hartmann, F.K., Rump, A., Keller H., Chizhov, I., Manstein, D.J., and Tsiavaliaris, G. (2008). J. Biol. Chem., 283, 26902-26910. DOI: https://10.1074/jbc.M802957200
- Mechanism, regulation, and functional properties of Dictyostelium myosin-1B. Tsiavaliaris, G., Fujita-Becker, S., Dürrwang, U., Diensthuber, R.P., Geeves, M.A., and Manstein D.J. (2008). J. Biol. Chem., 283, 4520-4527. DOI: https://10.1074/jbc.M708113200
- Functional characterization of the N-terminal region of myosin-2. Fujita-Becker, S., Tsiavaliaris, G., Ohkura, R., Shimada, T., Manstein, D.J., and Sutoh, K., (2006). J. Biol. Chem., 281, 36102-36109. DOI: https://10.1074/jbc.M605171200
- Dictyostelium myosin-1E is a fast molecular motor involved in phagocytosis. Dürrwang, U., Fujita-Becker, S., Erent, M., Kull, F.J., Tsiavaliaris, G., Geeves, M.A., and Manstein, D.J. (2006). J. Cell Sci., 119, 550-558. DOI: https://10.1242/jcs.02774
- Molecular engineering of a backwards-moving myosin motor. Tsiavaliaris, G., Fujita-Becker, S., and Manstein, D.J. (2004). Nature, 427, 558-561. DOI: https://10.1038/nature02303
- TIRF-Mikroskopie und ihre Anwendung in der Biologie. Tsiavaliaris, G. and Manstein, D.J. (2003). Biospektrum, 596-600. (Zeitschriftenbeitrag)
- Expression vectors for studying cytoskeletal proteins in Dictyostelium discoideum. Knetsch, M.L.W., Tsiavaliaris, G., Zimmermann, S., Rühl U., and Manstein, D.J. (2003). J. Muscle Res. Cell Mot., 605-611. DOI: https://10.1023/a:1024498805771
- Mutations in the relay loop region result in dominant-negative inhibition of myosin II function in Dictyostelium. Tsiavaliaris, G., Fujita-Becker, S., Batra, R., Levitsky, D.I., Kull, F.J., Geeves, M.A., and Manstein, D.J. (2002). EMBO Reports, 3, 1099-1105. DOI: https://10.1093/embo-reports/kvf214
- New bifunctional chelating phosphine ligands for immobilization of metal complexes on oxidic supports. Tsiavaliaris, G., Haubrich, S., Merckle, C., and Blümel, J. (2001). Synlett, 391-394. DOI: https://10.1055/s-2001-11386
Dietmar J. Manstein, Roman Fedorov, Georgios Tsiavaliaris, Hans-Joachim Knölker, René Martin, Juliane Kirst, Herwig O. Gutzeit, Markus Böhl, Marcus Furch.
Means for treating myosin-related diseases.
(WO/2009/065600), International Application No.: PCT/EP2008/009891; Publication Date: 28.05.2008; International Filling Date: 21.11. 2008.