extent of functional changes caused by HCM mutations in cardiomyocytes of affected heterozygous patients is very different among cardiomyocytes isolated from the same tissue. For example, some cardiomyocytes [...] show for β-cardiac myosin heavy chain (β-MyHC) and cardiac troponin I (cTnI) that in each of the patients studied, individual cardiomyocytes from the same tissue express very different proportions of mutated [...] molecular level and to characterize them from cell to cell by investigating myocardial tissue from HCM patients. Furthermore, we analyze changes in signaling pathways at the single cell level, which are induced
situation. After significant accidents, the patient is taken over to the central emergency room, and computed tomography performs holistic imaging. If necessary, the patients are transferred to the intensive care [...] tumours that require follow-up treatment and tumour follow-up in our neurosurgical outpatient clinic, patients are also cared for on an interdisciplinary basis as part of the CNS tumour board. The interdisciplinary [...] course. The progress of the healing is discussed in interdisciplinary conferences. Upon recovery, the patient is discharged home through the regular ward. Otherwise, a rehabilitation procedure and transfer to
Kraft T., Montag J. Burst-like transcription of MYH7 in Hypertrophic Cardiomyopathy patients is mimicked in patient-derived hPSC-CMs; Acta Biochimica Polonica, Vol. 68 No. S1, 57; 2021 Burkart V., Kowalski [...] level 03, room 1320 Publications and Abstracts Scientific articles in peer-reviewed journals 2025 Patient-specific hiPSC-derived cardiomyocytes indicate allelic and contractile imbalance as pathogenic factor [...] decay factor UPF3B is associated with cMyBP-C haploinsufficiency in hypertrophic cardiomyopathy patients, Valentin Burkart, Kathrin Kowalski, Alina Disch, Denise Hilfiker-Kleiner , Sean Lal , Cristobal
transplantation is the treatment of choice for many patients. Our Department of Nephrology and Hypertension is responsible for the evaluation of patients for kidney transplantation. We also provide medical
in workshops, a panel discussion, and through personal statements from our fellows: Patient Communication / Patient & Public Involvement Communication with Professional Societies Communication with the
well as the Helmholtz Center for Infectious Disease is planning the establishment of a COVID-19 patient cohort and subsequent thorough molecular characterization of the cohort. The cohort enables the [...] corresponding metabolic pathways and therapy options. The COVID-19 cohort will encompass a total of 1000 patients with different disease severities and healthy controls. Samples of blood, live blood cells, plasma
nal exchange and cooperations with universities from abroad International Patient Office Contact and information for patients from abroad EU Office All about EU research grants and grant application (in
the death of the patient. Modern transfusion medicine makes use of the different functions by breaking down the whole blood into individual components and then providing each patient with the component
cancer prevention, diagnosis and treatment in the Member States in order to improve care for all patients in the EU. The project focuses on measures of personalized medicine. Genomics is an important c [...] specialised centers. This would allow identical therapeutic approaches to be applied across the EU to patients with similar cancer profiles. The project builds on the findings from comprehensive genomic projects [...] training and education to raise awareness of the importance of genomics in healthcare professionals, patients and the general public. The aim of the project is to develop recommendations for initiatives in
risk of cancer in the affected children compared to the general population. Study results support patient counselling "Based on our results, the risk of developing cancer before the age of 18 is 11 per cent [...] Prevention/Predisposition at the Comprehensive Cancer Center (CCC) Hannover of MHH. Data from 581 patients analysed In total, data from 581 affected individuals diagnosed between the years 1973 and 2020 [...] disorders in Würzburg (FA and AT) and Hannover (AT) were analysed. The researchers identified 421 patients with FA and 160 with AT. With the help of an encryption algorithm to pseudonymise the data, a comparison