g communities in humans: an overview using Omics data. mSystems 00130-17. Rath S, Heidrich B, Pieper DH, Vital M (2017). Uncovering the trimethylamine-producing bacteria of the human gut microbiota. Microbiome [...] are colonized by a myriad of microorganisms including bacteria, fungi and viruses – the so-called “human microbiota”. Research efforts in the last decade revealed an important role of microbiota for our [...] we apply “Next- and Third-Generation” Sequencing (NGS) techniques aiming to elucidate the role of human microbiota in health and disease. Bioinformatics and statistical analyses are in focus and coupled

Pharmacology and Toxicology organizes/holds the following courses: MSE_P_301 Pharmacology and Toxicology human medicine, 3rd year of study Organized by: Prof. Dr. rer. nat. Harald Genth (Prof. Dr. med. Ingo Just) [...] of Pharmacology Curriculum Lecture materials MSE_P_509 Clinical Pharmacology and Pharmacotherapy human medicine, 5rd year of study Organized by: Prof. Dr. med. Dirk.O. Stichtenoth, Institute of Clinical [...] Clinical Pharmacology Curriculum more details MSE_P_312 Block internship in internal medicine human medicine, 3rd year of study Organized by: Prof. Dr. Kai Schmidt-Ott, OE 6840, Department of Nephrology and

MZP Cardiomyocytes from human induced pluripotent stem cells as a cellular model for hypertrophic cardiomyopathy Researc h focus The focus of our research is the analysis of human induced pluripotent stem [...] β-Myosin heavy chain isoform-expressing myofibrils within human ESC-derived cardiomyocytes recapitulate the contractile features of adult human ventricular myofibrils?, J. Muscle Res. Cell. Motil., 2017 [...] Martin U, Zweigerdt R, Kraft T , Brenner B. Differences in Contractile Function of Myofibrils within Human Embryonic Stem Cell-Derived Cardiomyocytes vs. Adult Ventricular Myofibrils Are Related to Distinct

composition of sarcomeric proteins. Subcellular myofibrils can be obtained from human (e.g., biopsies), human-derived and non-human cardiac and skeletal small muscle samples (e.g., mouse, rat, rabbit, zebrafish [...] maturation of human pluripotent stem cell-derived cardiomyocytes; (2) Understanding the effects of missense mutations in sarcomeric proteins on the subcellular and cellular contractile function in human cardiac [...] School; Research topics: Force-related kinetic studies with subcellular myofibrils using human myocardial samples and human embryonic/induced pluripotent stem cell-derived cardiomyocytes. 2011-2013 : Junior

Paper in European Heart Journal Murine and human pluripotent stem cell-derived cardiac bodies form contractile myocardial tissue in vitro, European Heart Journal 2013 For the first time, the team of Ina [...] dimensional cardiomyocyte aggregates, so-called cardiac bodies (CBs), that are based on murine and human pluripotent stem cells. The LEBAO team optimized the processes and investigated the role of fibroblasts [...] S., Krause, A., Drager, G., Ochs, M., Haverich, A., Gruh, I.#, and Martin, U.#. 2013. Murine and human pluripotent stem cell-derived cardiac bodies form contractile myocardial tissue in vitro. European

for his research on human macrophages in the amount of 1.5 million euros over five years. Human immune cells - produced in the laboratory Professor Lachmann's method is based on human cells of the immune [...] adequately reflect human physiology in some cases and because the European authorities will no longer accept them from 2026. The MAT based on donated blood cells better reflects human physiology, but is

Toxicology and Experimental Medicine ITEM. Standardised production of mature immune cells The demand for human immune cells is high and growing daily. So far, however, it has been difficult to provide cells in [...] meet the steadily growing demand, biomedical research is therefore trying to obtain and multiply human immune cells through novel bioprocesses. The Attract group leader and his team have already laid a [...] researching and evaluating drug candidates because we can test their efficacy and safety directly on the human targets," says the scientist. The construction and testing of these tests will be advanced within

three-dimensional X-ray images of the human body possible. With a maximum resolution of up to 300 nanometres, they are equivalent to one tenth of the diameter of a human hair. "The networking between radiology [...] synchrotron particle accelerators. The international team of this worldwide unique project entitled "Human Organ Project" is composed of physicians from the European Synchrotron Facility ESRF in Grenoble and [...] and currently the brightest X-ray source in the world. The project promises images of the entire human body with a resolution of two micrometres, over a hundred times better than a CT scanner. "We were

Research at the Department of Human Genetics Our scientific findings make an important contribution to the understanding of ultra-rare genetic diseases, the identification of risk factors for cancer and [...] valuable tool for advances in our field. Find out more about the research groups at the Department of Human Genetics!

mechanisms. The second part of this project deals with human γδ T cells. We and other could recently show by next generation sequencing of human γδ TCRs that the adult, but not neonatal, γδ TCR repertoires [...] factors might fine-tune the development, organ-specificity and functional adaptation of murine and human γδ T cells. Murine IL-17 producing Vγ6 and Vγ4 T cells develop within an embryonic thymus and are