innate immune responses in acute-on-chronic liver failure Our group was committed to supporting the GRAFT trial (Granulocyte-colony stimulating factor (G-CSF) to treat acute-on-chronic liver failure: A [...] overall aim was to evaluate the clinical relevance of cellular and non-cellular immune responses in acute-on-chronic liver failure (ACLF). Clinical evaluations were complemented by experiments in the mouse

Acute and chronic damage of kidneys and kidney transplants Research Group Leader Prof. Dr. med. Wilfried Gwinner Dr. med. Robert Greite Research Assistants Dr. med. Julian Doricic Dr. rer. biol. hum. Irina [...] Nele-Sophie Heinz (Data Management) Scientific profile Our research focuses on various forms of acute and chronic kidney and kidney transplant injury. This includes the investigation of immunological [...] damage and mechanisms of renal tissue regeneration, which collectively determine the extent to which acute tissue damage can recover or progress to a chronic scarred state with permanent loss of function.

Clinical and epidemiological approaches in acute nephrology Research Group Leader Prof. Dr. med. Michael Haase Research Assistants Prof. Dr. rer. medic. Anja Haase-Fielitz cand. Dr. med. Martin Ernst, [...] epidemiological methods to further improve early diagnosis and quality-based treatment of patients with acute kidney or kidney transplant disease. We pay special attention to the exploitation, combination and [...] Serum creatinine and cystatin C-based estimates of glomerular filtration rate are misleading in acute heart failure. ESC Heart Failure, 8:3070-3081, 2021. Bagshaw S, Al-Khafaji A, Artigas A, Davison D

Medicine and Kidney International that show the molecular pattern of acute damage to human kidney cells. Direct zoom into the cell "Acute kidney damage is associated with a wide variety of diseases," says [...] the nephrologist. Approach for personalised therapy And that is important, because the problem of acute kidney damage is often underestimated. "It is associated with increased mortality, and patients can [...] molecular patterns that occurred individually at different frequencies in all those affected with acute kidney injury," says Dr Hinze. "In future, these findings could help to better assess risks for severe

short chromosome ends Acute lung damage or acute respiratory distress syndrome increase the risk of a heart attack. Conversely, a heart attack or chronic heart failure can lead to acute lung problems. Age [...] heart and lungs, affects a heart attack and lung damage. In addition, they want to demonstrate how acute lung damage develops when the heart is already damaged by a heart attack and what damage a heart attack

signalling in acute disease and in long- and post-COVID. They also want to clarify how acute corona infection causes heart muscle cells to die. "The upregulation of myocardial cell death during acute infection [...] the heart muscle cells. "These data will then form the basis for developing new treatments against acute SARS-CoV-2 infection as well as long and post-COVID," Dr Amanakis hopes. The project is taking place

(General pneumology) In our outpatient clinic we offer competent diagnostics and treatment of all acute and chronic diseases of the lungs and respiratory tract of children and adolescents. We have comprehensive [...] children's ward offers inpatient examination and treatment of infants, children and adolescents with acute and chronic lung and respiratory tract diseases. Important information for your visit to the outpatient

IDH1-Mutated Acute Myeloid Leukemia" can be found here . The publication on the investigations in the mouse model "Synergistic activity of IDH1 inhibitor BAY1436032 with azacitidine in IDH1 mutant acute myeloid [...] 31.05.2022 Acute myeloid leukaemia (AML) is a malignant disease in which the precursor cells of the haematopoietic system multiply uncontrollably. This form of blood cancer is caused by genetic changes

Extracorporeal therapies are increasingly used not only in the treatment of septic complications such as acute renal failure requiring dialysis, but are also being investigated for immunomodulation and pathogen [...] care treatment of special nephrological patient groups (kidney transplant patients, patients with acute renal failure). Selected publications Eden G, Schmidt JJ, Büttner S, Kümpers P, Hafer C, Rovas A, [...] and multiple-dose pharmacokinetics and total removal of colistin in critically ill patients with acute kidney injury undergoing prolonged intermittent renal replacement therapy. J Antimicrob Chemother

from various fields and provides comprehensive, interdisciplinary care for patients with chronic and acute kidney diseases, as well as hypertension. In addition to clinical care, the department also has a [...] clinical and experimental research. Key areas of focus at the department include the treatment of acute kidney injury, chronic kidney disease, kidney transplantation, and glomerulonephritis, as well as