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A novel Dock8 gene mutation confers diabetogenic susceptibility in the LEW.1AR1/Ztm-iddm rat, an animal model of human type 1 diabetes. Arndt, T., Wedekind, D., Jörns, A., Tsiavaliaris, G., Cuppen, E.
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for development of new pharmacologically active ingredients, and finding alternative methods to animal experiments. Therefore, the following research areas are addressed in the RG Martin: 1. Reprogramming
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Tocchetti, C. G., Vlasman, P., Yeung, K. K., Zacchigna, S., Zwaagman, D., and Thum, T. 2022. Animal models and animal-free innovations for cardiovascular research: current status and routes to be explored. [...] and Martin, U. 2017. Generation of non-transgenic iPS cells from human cord blood CD34+ cells under animal component-free conditions. Stem Cell Research 21:71. https://doi.org/10.1016/j.scr.2017.03.022 .
long-term storage. Quickly available, expertly assessed and extremely valuable tissue from human and animal hearts and lungs as well as standardized liquid samples are generated and thus added value for the
Vondran FWR . Long-term Functional Maintenance of Exteriorized Portal Venous Catheters in a Porcine Animal Model. J Surg Res. 2020 Jul;251:187-194. doi: 10.1016/j.jss.2020.02.003. Epub 2020 Mar 9. PMID: 32163793 [...] influence of xenoreactive antibodies on activation of complement and coagulation in an ex vivo perfusion animal study using porcine kidneys. Transpl Int. 2019 May;32(5):546-556. doi: 10.1111/tri.13396. Epub 2019
G, Nave H. Altered Phenotype of NK Cells From Obese Rats Can Be Normalized by Transfer Into Lean Animals. Obesity (Silver Spring). 2009; 17(10):1848-55. Wrann CD, Ehmer U, Lautenbach A , Kuhlmann S, Nave
N, Struve B, Zur Brügge TF, Bleich A, Leenaars CHC. Extracting data from graphs: A case-study on animal research with implications for meta-analyses. Res Synth Methods 2021;12(6):701-710. Welsh J , Gross