SUMO proteomics, CRISPR/Cas9-mediated genome editing tools to check chromatin events of a single gene, epigenomics (ChIPseq, chromosome conformation capture etc.), cell contractility assay, measurement [...] induces cachexia by impeding transcriptional signaling of the SET1/MLL complex on muscle-specific genes . iScience 27: 110913 Wang T, Nayak A , Kraft T, Amrute-Nayak M (2024) Single-Molecule Investigation [...] S (2017) Flightless-I governs cell fate by recruiting the SUMO isopeptidase SENP3 to distinct HOX genes. Epigenetics Chromatin 10: 15 Jung J, Nayak A , Schaeffer V, Starzetz T, Kirsch AK, Muller S, Dikic

for gene therapy of inner ear disorders Final exam November 2024 Philip Mausberg GERMANY Mausberg.Philip @ mh-hannover.de Supervisor: Prof. Dr. Britta Eiz-Vesper (Transfusionmedicine) Project: Gene engineered [...] Hildegard Büning / Prof. Dr. Axel Schambach (Experimental Hematology) Project: Tailoring AAV vectors for gene therapy of inner ear disorders by directed evolution Hanna L. Redeker, nee Martin GERMANY Martin.Hanna

Azacitidine, which have so far been used individually against AML. While the first inhibits a certain gene-modified enzyme called IDH1, which promotes the development of blood cancer cells, the second prevents [...] researchers were now also able to demonstrate this effect in humans who had newly diagnosed AML with gene alterations in the IDH1 enzyme. "We were surprised that the effect was so strong," emphasises the

approved gamma-emitting radiopharmaceuticals after individual consultation. Use of reporter gene imaging and to record gene expression and cell tracking techniques to record cell-specific signals. Simultaneous

Structural Analysis of microRNAs in Myeloid Cancer Reveals Consensus Motifs. Genes 13, 1152. https://doi.org/10.3390/genes13071152 2020 Karatas, M., Dogan, S., Spahiu, E. , Ašić, A., Bešić, L., Turan,

the Aurealis Therapeutics study on AUP-16. In this first-in-human phase 1 clinical trial, the live gene therapy biotherapeutic drug was shown to accelerate the healing of diabetic foot ulcers.

Mutation in Porcine Fibroblasts Using the CRISPR/Cas9-GMNN Fusion Gene; Gerlach M, Kraft T, Brenner B, Petersen B, Niemann H, Montag J .. Genes (Basel):13;9(6); 2018 Jun Burst-like transcription of mutant and [...] animal model for hypertrophic cardiomyopathy Analysis of burst-like transcription of HCM-associated genes Molecular basis of allelic imbalance at tissue level in heterozygous HCM-patients Analysis of allelic [...] Physiol: 9:359. 2018 Apr Successful knock-in of Hypertrophic Cardiomyopathy-mutation R723G into the MYH7 gene mimics HCM pathology in pigs; Montag J , Petersen B, Lucas-Hahn A, Becker E, Harries D, Niemeier H

induces cachexia by impeding transcriptional signaling of the SET1/MLL complex on muscle-specific genes, Bushra Khan , Chiara Lanzuolo, Valentina Rosti, Philina Santarelli, Andreas Pich, Theresia Kraft [...] Nayak , Christian Hartmann, Wolfram S. Kunz, Amir Samii, Helmut Bertalanffy, Saverio Francesco Retta, Genes & Diseases , Available online 3 April 2023 ScienceDirect, doi.org/10.1016/j.gendis.2023.02.045 , PubMed

combined the active ingredients ivosidenib and azacitidine. While the former inhibits a specific gene-modified enzyme called IDH1 that promotes the development of blood cancer cells, the latter prevents [...] growing. The combination of the two drugs improved survival in people newly diagnosed with AML that had gene alterations in the IDH1 enzyme. However, the standard treatment is currently still either chemotherapy

providing scientists without previous microarray experience with an early insight into the most prominent gene expression changes and overall data reliability. By supplying clients with a “first impression” of [...] individual spots PDF Supplemental materials for publications Microarray-based mRNA expression analysis - Gene regulation by mRNA export protein, THOC5 PDF C/EBPβ is a transciptional key regulator of IL-36α in