hypertrophy in hPSC-derived cardiomyocytes based on pharmacological stimuli or genetic mutations e.g. in the MYH7 or MYBPC3 genetic loci (DFG project cMyBP-C-Mutationen FKZ: ZW 64/4-2). This research strongly [...] HFOs), and studying cardiac hypertrophy in hPSC-cardiomyocytes based on pharmacological stimuli or genetic mutations (e.g. in MYH7 or MYBPC3). Collaboration with Industry : Besides academic partners (within [...] Birgit Andree, Andreas Martens, and Thomas Aper in the 3D-Heart-2B project, aiming at the in vitro engineering of multilayered, vascularized, linear heart-tube tissue construct ( LINK ). Another important
Science (NCCS), India. 1999-2001: Master in Zoology (specialization in Molecular, Applied and Clinical Genetics) in BHU, in Banaras Hindu University India. 1996-1999: Bachelor in Zoology (with Chemistry and Botany) [...] Industrial Research)- NET (National Eligibility Test), India. GATE (Graduate Aptitude Test for Engineering) fellowship. Junior research fellowship by NCCS Pune, India. National Talent Search scholarship
Leon Budde, Ulrich Martin, Andreas Martens und Thomas Seel , Current Directions in Biomedical Engineering ( https://doi.org/10.1515/cdbme-2024-2109 ). Standardized production of hPSC-derived cardiomyocyte [...] doi: 10.1093/cvr/cvae118. Generation of human induced pluripotent stem cell line encoding for a genetically encoded voltage indicator Arclight A242. Vivekanandan R, Szepes M, Ricci Signorini ME, Kravchenko
and Martin, U. 2019. High-Throughput Screening for Modulators of CFTR Activity Based on Genetically Engineered Cystic Fibrosis Disease-Specific iPSCs. Stem Cell Reports 12, no. 6:1389. * authors contributed [...] hypothermic storage: potential application for cardiac surgery and myocardial tissue engineering. Biomedical Physics & Engineering Express 4, no. 3:035010. * authors contributed equally. http://stacks.iop.org [...] und Tissue Engineering: Aktuelle Entwicklungen und klinische Perspektiven. Laborwelt, no. 1:4. Mertsching, H., and Martin, U. 2001. Zelltransplantation und Gewebezucht-Tissue-Engineering künstlicher Organe
Brenner, B., Manstein, D.J. & Meyhöfer, E. (2001) Single-molecule tracking of myosins with genetically engineered amplifier domains Nature Struct. Biol ., 8 , 226-229. ( Abstract ) ( pdf , 590 kB) Niemann [...] Kliche, W., Fujita-Becker, S., Kollmar, M., Manstein, D.J. & Kull, F.J. (2001) Structure of a genetically engineered molecular motor EMBO J ., 20 , 40-46. ( Abstract ) ( pdf ) Ponomarev, M.A., Furch, M., Levitsky [...] Motil . 25, 527-537 ( pdf ) Tsiavaliaris, G., Fujita-Becker, S. & Manstein, D.J. (2004) Molecular engineering of a backwards moving myosin motor Nature 427 , 558-561, rdcu.be/mD1F , ( Abstract )( pdf ) Schlosser
(hPSC-CMs) hold great potential for the treatment of cardiovascular diseases by cell transplantation or engineered cardiac tissue, for assessing efficiency and toxicity of pharmacological compounds, or to be used [...] (cMyBP-C). Mutations in cMyBP-C are besides mutations in beta-cardiac myosin (MyHC) the most frequent genetic cause for hypertrophic cardiomyopathy (HCM). HCM is a severe disease of the heart, which is mostly
2019. Publisher's page High-Throughput Screening for Modulators of CFTR Activity Based on Genetically Engineered Cystic Fibrosis Disease-Specific iPSCs Merkert, Sylvia, Schubert, Madline, Olmer, Ruth, Engels [...] Stalke, Amelie, Decker, Melanie, Eilers, Marlies, Schäffer, Vera, Dittrich-Breiholz, Oliver, Gürlevik, Engin, Kühnel, Florian, Schlegelberger, Brigitte, Illig, Thomas; Skawran, Britta. Cancer Cell International [...] Nina; Tümmler, Burkhard. Journal of Cystic Fibrosis. 2017. Publisher's page Impact of Molecular Genetics on Outcome in Myelofibrosis Patients after Allogeneic Stem Cell Transplantation Kröger, Nicolaus
Stanke F, Witte T, Forster R. Genetic variants of chemokine receptor CCR7 in patients with systemic lupus erythematosus, Sjogren's syndrome and systemic sclerosis. BMC Genet. 2007;8:33. Tischer S, Kaireit [...] multisomatoform disorder in a group of German multisomatoform disorder patients and healthy controls. Genet Test Mol Biomarkers. 2010 Jun;14(3):293-7. Jörgens G , Bange FC, Mühlradt PF, Pabst R, Maus UA, Tschernig [...] modifying genes: STAT3, IL1B and IFNGR1 determine cystic fibrosis disease manifestation. Eur J Hum Genet. 2011 Dec;19(12):1281-8. Amrute-Nayak, M.*, Lambeck, K.* , Radocaj, A., Huhnt, H., Scholz, T., Hahn
supramaximal care In addition to the research topics on Transplantation and Regeneration or Biomedical Engineering as well as Implants, the Hannover Medical School (MHH) is also well-known for the Infection Research [...] 019 Derda AA, Garg A, Bär C, Thum T. Reply to 'COVID-19 severity, miR-21 targets, and common human genetic variation'. Eur J Heart Fail 2021 DOI: 10.1002/ejhf.2322 Rand U, Kupke SY, Shkarlet H, Hein MD, Hirsch [...] Mourits VP, de Bree LCJ, de Mast Q, van de Veerdonk FL, Joosten LAB, Li Y, Netea MG, Xu CJ. The Genetic Risk for COVID-19 Severity Is Associated With Defective Immune Responses. Front Immunol 2022;13:859387