Selected publications
Groß S, Jahn C, Cushman S, Bär C, Thum T. SARS-CoV-2 receptor ACE2-dependent
implications on the cardiovascular system: From basic science to clinical
implications. J Mol Cell Cardiol. 2020 Apr 30;144:47-53. doi:
10.1016/j.yjmcc.2020.04.031. Epub ahead of print. PMID: 32360703; PMCID:
PMC7191280.
Zacchigna S, Paldino A, Falcão-Pires I, Daskalopoulos EP, Dal Ferro M, Vodret
S, Lesizza P, Cannatà A, Miranda-Silva D, Lourenço AP, Pinamonti B, Sinagra G,
Weinberger F, Eschenhagen T, Carrier L, Kehat I, Tocchetti CG, Russo M, Ghigo A,
Cimino J, Hirsch E, Dawson D, Ciccarelli M, Oliveti M, Linke WA, Cuijpers I,
Heymans S, Hamdani N, de Boer M, Duncker D, Kuster D, van der Velden J, Beauloye
C, Bertrand L, Mayr M, Giacca M, Leuschner F, Backs J, Thum T; Working Group on
Myocardial Function of the European Society of Cardiology.. Toward
standardization of echocardiography for the evaluation of left ventricular
function in adult rodents: a position paper of the ESC Working Group on
Myocardial Function. Cardiovasc Res. 2020 May 4:cvaa110. doi:
10.1093/cvr/cvaa110. Epub ahead of print. PMID: 32365197.
Garg A, Foinquinos A, Jung M, Janssen-Peters H, Biss S, Bauersachs J, Gupta
SK, Thum T. MiRNA-181a is a novel regulator of aldosterone-mineralocorticoid
receptor-mediated cardiac remodelling. Eur J Heart Fail. 2020 Apr 18. doi:
10.1002/ejhf.1813. Epub ahead of print. PMID: 32304626.
Huang CK, Kafert-Kasting S, Thum T. Preclinical and Clinical Development of
Noncoding RNA Therapeutics for Cardiovascular Disease. Circ Res. 2020 Feb
28;126(5):663-678. doi: 10.1161/CIRCRESAHA.119.315856. Epub 2020 Feb 27. PMID:
32105576; PMCID: PMC7043728.
Foinquinos A, Batkai S, Genschel C, Viereck J, Rump S, Gyöngyösi M, Traxler
D, Riesenhuber M, Spannbauer A, Lukovic D, Weber N, Zlabinger K, Hašimbegović E,
Winkler J, Fiedler J, Dangwal S, Fischer M, de la Roche J, Wojciechowski D,
Kraft T, Garamvölgyi R, Neitzel S, Chatterjee S, Yin X, Bär C, Mayr M, Xiao K,
Thum T. Preclinical development of a miR-132 inhibitor for heart failure
treatment. Nat Commun. 2020 Jan 31;11(1):633. doi: 10.1038/s41467-020-14349-2.
PMID: 32005803; PMCID: PMC6994493.
Schimmel K, Jung M, Foinquinos A, José GS, Beaumont J, Bock K, Grote-Levi L,
Xiao K, Bär C, Pfanne A, Just A, Zimmer K, Ngoy S, López B, Ravassa S, Samolovac
S, Janssen-Peters H, Remke J, Scherf K, Dangwal S, Piccoli MT, Kleemiss F,
Kreutzer FP, Kenneweg F, Leonardy J, Hobuß L, Santer L, Do QT, Geffers R,
Braesen JH, Schmitz J, Brandenberger C, Müller DN, Wilck N, Kaever V, Bähre H,
Batkai S, Fiedler J, Alexander KM, Wertheim BM, Fisch S, Liao R, Diez J,
González A, Thum T. Natural Compound Library Screening Identifies New Molecules
for the Treatment of Cardiac Fibrosis and Diastolic Dysfunction. Circulation.
2020 Mar 3;141(9):751-767. doi: 10.1161/CIRCULATIONAHA.119.042559. Epub 2020 Jan
17. PMID: 31948273; PMCID: PMC7050799.
Stojanović SD, Fiedler J, Bauersachs J, Thum T, Sedding DG. Senescence-
induced inflammation: an important player and key therapeutic target in
atherosclerosis. Eur Heart J. 2020 Jan 3:ehz919. doi: 10.1093/eurheartj/ehz919.
Epub ahead of print. PMID: 31898722.
Kenneweg F, Bang C, Xiao K, Boulanger CM, Loyer X, Mazlan S, Schroen B,
Hermans-Beijnsberger S, Foinquinos A, Hirt MN, Eschenhagen T, Funcke S,
Stojanovic S, Genschel C, Schimmel K, Just A, Pfanne A, Scherf K, Dehmel S,
Raemon-Buettner SM, Fiedler J, Thum T. Long Noncoding RNA-Enriched Vesicles
Secreted by Hypoxic Cardiomyocytes Drive Cardiac Fibrosis. Mol Ther Nucleic
Acids. 2019 Dec 6;18:363-374. doi: 10.1016/j.omtn.2019.09.003. Epub 2019 Sep 13.
PMID: 31634682; PMCID: PMC6807307.
Santer L, Bär C, Thum T. Circular RNAs: A Novel Class of Functional RNA
Molecules with a Therapeutic Perspective. Mol Ther. 2019 Aug 7;27(8):1350-1363.
doi: 10.1016/j.ymthe.2019.07.001. Epub 2019 Jul 9. PMID: 31324392; PMCID:
PMC6697450.
Lu D, Thum T. RNA-based diagnostic and therapeutic strategies for
cardiovascular disease. Nat Rev Cardiol. 2019 Nov;16(11):661-674. doi:
10.1038/s41569-019-0218-x. Epub 2019 Jun 11. PMID: 31186539.
miR-212/132 Cluster Modulation Prevents Doxorubicin-Mediated Atrophy and Cardiotoxicity.
Gupta SK, Garg A, Avramopoulos P, Engelhardt S, Streckfuss-Bömeke K, Batkai S, Thum T (2018).
Mol Ther. 2019 Jan 2;27(1):17-28. Epub 2018 Nov 13
Gupta SK, Garg A, Bär C, Chatterjee S, Foinquinos A, Milting H, Streckfuß-Bömeke K, Fiedler J, Thum T (2018)
Circ Res. 122(2):246-254. [Epub 2017 Nov 13]
Cardiac myocyte miR-29 promotes pathological remodeling of the heart by activating Wnt signaling.
Sassi Y, Avramopoulos P, Ramanujam D, Grüter L, Werfel S, Giosele S, Brunner AD, Esfandyari D, Papadopoulou AS, De Strooper B, Hübner N, Kumarswamy R, Thum T, Yin X, Mayr M, Laggerbauer B, Engelhardt S (2017).
Nat Commun. 8(1):1614.
Beermann J, Kirste D, Iwanov K, Lu D, Kleemiß F, Kumarswamy R, Schimmel K, Bär C, Thum T (2017).
Cell Death Differ. 25(2):307-318. [Epub 2017 Nov 3]
Masson S, Batkai S, Beermann J, Bär C, Pfanne A, Thum S, Magnoli M, Balconi G, Nicolosi GL, Tavazzi L, Latini R, Thum T (2017).
Eur J Heart Fail. 20(1):78-85 [Epub 2017 Oct 12]
Schauerte C, Hübner A, Rong S, Wang S, Shushakova N, Mengel M, Dettling A, Bang C, Scherf K, Koelling M, Melk A, Haller H, Thum T, Lorenzen JM (2017).
Kidney Int. 92(3):646-656.
Piccoli MT, Gupta SK, Viereck J, Foinquinos A, Samolovac S, Kramer FL, Garg A, Remke J, Zimmer K, Batkai S, Thum T.
Circ Res. 2017 Aug 18;121(5):575-583. doi: 10.1161/CIRCRESAHA.117.310624. Epub 2017 Jun 19.
Therapeutic miR-21 Silencing Ameliorates Diabetic Kidney Disease in Mice.
Kölling M, Kaucsar T, Schauerte C, Hübner A, Dettling A, Park JK, Busch M, Wulff X, Meier M, Scherf K, Bukosza N, Szénási G, Godó M, Sharma A, Heuser M, Hamar P, Bang C, Haller H, Thum T, Lorenzen JM (2017).
Mol Ther. 25(1):165-180.
de Gonzalo-Calvo D, Kenneweg F, Bang C, Toro R, van der Meer RW, Rijzewijk LJ, Smit JW, Lamb HJ, Llorente-Cortes V, Thum T.
Sci Rep. 2016 Nov 22;6:37354. doi: 10.1038/srep37354.
Long Noncoding RNAs in Cardiovascular Pathology, Diagnosis, and Therapy.
Bär C, Chatterjee S, Thum T.
Circulation. 2016 Nov 8; 134(19):1484-1499.
MicroRNA-based Therapy of Gata2-deficient Vascular Disease.
Hartmann D, Fiedler J, Sonnenschein K, Just A, Pfanne A, Zimmer K, Remke J, Foinquinos A, Butzlaff M, Schimmel K, Maegdefessel L, Hilfiker-Kleiner D, Lachmann N, Schober A, Froese N, Heineke J, Bauersachs J, Batkai S, Thum T.
Circulation. 2016 Oct 25. pii: CIRCULATIONAHA.116.022478. [Epub ahead of print]
Non-coding RNAs in Development and Disease: Background, Mechanisms, and Therapeutic Approaches.
Beermann J, Piccoli MT, Viereck J, Thum T.
Physiol Rev. 2016 Oct; 96(4):1297-325. doi: 10.1152/physrev.00041.2015.
Preclinical Development of a MicroRNA-Based Therapy for Elderly Patients With Myocardial Infarction.
Gupta SK, Foinquinos A, Thum S, Remke J, Zimmer K, Bauters C, de Groote P, Boon RA, de Windt LJ, Preissl S, Hein L, Batkai S, Pinet F, Thum T.
J Am Coll Cardiol. 2016 Oct 4;68(14):1557-71. doi: 10.1016/j.jacc.2016.07.739.
Identification of miR-126 as a new regulator of skin aging.
Fiedler J, Grönniger E, Pfanne A, Brönneke S, Schmidt K, Falk CS, Wenck H, Terstegen L, Thum T, Winnefeld M.
Exp Dermatol. 2016 Aug 30. doi: 10.1111/exd.13173. [Epub ahead of print]
Long noncoding RNA Chast promotes cardiac remodeling.
Viereck J, Kumarswamy R, Foinquinos A, Xiao K, Avramopoulos P, Kunz M, Dittrich M, Maetzig T, Zimmer K, Remke J, Just A, Fendrich J, Scherf K, Bolesani E, Schambach A, Weidemann F, Zweigerdt R, de Windt LJ, Engelhardt S, Dandekar T, Batkai S, Thum T.
Sci Transl Med. 2016 Feb 17;8(326):326ra22. doi: 10.1126/scitranslmed.aaf1475.
Li XG, Roivainen A, Bergman J, Heinonen A, Bengel F, Thum T, Knuuti J.
Chem Commun (Camb). 2015 Jun 2;51(48):9821-4.
Lorenzen JM, Schauerte C, Hübner A, Kölling M, Martino F, Scherf K, Batkai S, Zimmer K, Foinquinos A, Kaucsar T, Fiedler J, Kumarswamy R, Bang C, Hartmann D, Gupta SK, Kielstein J, Jungmann A, Katus HA, Weidemann F, Müller OJ, Haller H, Thum T.
Eur Heart J. 2015 Apr 21. pii: ehv109.
Long noncoding RNAs in cardiac development and ageing.
Devaux Y, Zangrando J, Schroen B, Creemers EE, Pedrazzini T, Chang CP, Dorn GW 2nd, Thum T, Heymans S; Cardiolinc network.
Nat Rev Cardiol. 2015 Apr 7. doi: 10.1038/nrcardio.2015.55
Dangwal S, Stratmann B, Bang C, Lorenzen JM, Kumarswamy R, Fiedler J, Falk CS, Scholz CJ, Thum T, Tschoepe D.
Arterioscler Thromb Vasc Biol. 2015 Jun;35(6):1480-8.
MicroRNA signatures differentiate preserved from reduced ejection fraction heart failure.
Watson CJ, Gupta SK, O'Connell E, Thum S, Glezeva N, Fendrich J, Gallagher J, Ledwidge M, Grote-Levi L, McDonald K, Thum T.
Eur J Heart Fail. 2015 Apr;17(4):405-15.
Long noncoding RNAs and microRNAs in cardiovascular pathophysiology.
Thum T, Condorelli G.
Circ Res. 2015 Feb 13;116(4):751-62.
Bang C, Batkai S, Dangwal S, Gupta SK, Foinquinos A, Holzmann A, Just A, Remke J, Zimmer K, Zeug A, Ponimaskin E, Schmiedl A, Yin X, Mayr M, Halder R, Fischer A, Engelhardt S, Wei Y, Schober A, Fiedler J, Thum T.
J Clin Invest. 2014;124:2136-2146.
Fiedler J, Stohr A, Gupta SK, Hartmann D, Holzmann A, Just A, Hansen A, Hilfiker-Kleiner D, Eschenhagen T, Thum T.
Antioxid Redox Signal. 2014;21:1167-1176.
Circulating long noncoding RNA, LIPCAR, predicts survival in patients with heart failure.
Kumarswamy R, Bauters C, Volkmann I, Maury F, Fetisch J, Holzmann A, Lemesle G, de Groote P, Pinet F, Thum T.
Circ Res. 2014;114:1569-1575.
MicroRNA-24 antagonism prevents renal ischemia reperfusion injury.
Lorenzen JM, Kaucsar T, Schauerte C, Schmitt R, Rong S, Hubner A, Scherf K, Fiedler J, Martino F, Kumarswamy R, Kolling M, Sorensen I, Hinz H, Heineke J, van Rooij E, Haller H, Thum T.
J Am Soc Nephrol. 2014.
MicroRNA-22 increases senescence and activates cardiac fibroblasts in the aging heart.
Jazbutyte V, Fiedler J, Kneitz S, Galuppo P, Just A, Holzmann A, Bauersachs J, Thum T.
Age (Dordr). 2013;35:747-762.
The miRNA-212/132 family regulates both cardiac hypertrophy and cardiomyocyte autophagy.
Ucar A, Gupta SK, Fiedler J, Erikci E, Kardasinski M, Batkai S, Dangwal S, Kumarswamy R, Bang C, Holzmann A, Remke J, Caprio M, Jentzsch C, Engelhardt S, Geisendorf S, Glas C, Hofmann TG, Nessling M, Richter K, Schiffer M, Carrier L, Napp LC, Bauersachs J, Chowdhury K, Thum T.
Nat Commun. 2012;3:1078.
MicroRNA-24 regulates vascularity after myocardial infarction.
Fiedler J, Jazbutyte V, Kirchmaier BC, Gupta SK, Lorenzen J, Hartmann D, Galuppo P, Kneitz S, Pena JT, Sohn-Lee C, Loyer X, Soutschek J, Brand T, Tuschl T, Heineke J, Martin U, Schulte-Merker S, Ertl G, Engelhardt S, Bauersachs J, Thum T.
Circulation. 2011;124:720-730.
miRNA screening reveals a new miRNA family stimulating iPS cell generation via regulation of Meox2.
Pfaff N, Fiedler J, Holzmann A, Schambach A, Moritz T, Cantz T, Thum T.
EMBO Rep. 2011;12:1153-1159.
Comparison of different miR-21 inhibitor chemistries in a cardiac disease model.
Thum T, Chau N, Bhat B, Gupta SK, Linsley PS, Bauersachs J, Engelhardt S.
J Clin Invest. 2011;121:461-2; author reply 462-3.
Thum T, Schmitter K, Fleissner F, Wiebking V, Dietrich B, Widder JD, Jazbutyte V, Hahner S, Ertl G, Bauersachs J.
Eur Heart J. 2011;32:1275-1286.
Ucar A, Vafaizadeh V, Jarry H, Fiedler J, Klemmt PA, Thum T, Groner B, Chowdhury K.
Nat Genet. 2010;42:1101-1108.
MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts.
Thum T, Gross C, Fiedler J, Fischer T, Kissler S, Bussen M, Galuppo P, Just S, Rottbauer W, Frantz S, Castoldi M, Soutschek J, Koteliansky V, Rosenwald A, Basson MA, Licht JD, Pena JT, Rouhanifard SH, Muckenthaler MU, Tuschl T, Martin GR, Bauersachs J, Engelhardt S.
Nature. 2008;456:980-984.
MicroRNAs in the human heart: A clue to fetal gene reprogramming in heart failure.
Thum T, Galuppo P, Wolf C, Fiedler J, Kneitz S, van Laake LW, Doevendans PA, Mummery CL, Borlak J, Haverich A, Gross C, Engelhardt S, Ertl G, Bauersachs J.
Circulation. 2007;116:258-267.
Thum T, Hoeber S, Froese S, Klink I, Stichtenoth DO, Galuppo P, Jakob M, Tsikas D, Anker SD, Poole-Wilson PA, Borlak J, Ertl G, Bauersachs J.
Circ Res. 2007;100:434-443.
For a complete list of publications please go to PubMed.