Selected publications

Groß S, Jahn C, Cushman S, Bär C, Thum T. SARS-CoV-2 receptor ACE2-dependent

implications on the cardiovascular system: From basic science to clinical

implications. J Mol Cell Cardiol. 2020 Apr 30;144:47-53. doi:

10.1016/j.yjmcc.2020.04.031. Epub ahead of print. PMID: 32360703; PMCID:

PMC7191280.

 

Zacchigna S, Paldino A, Falcão-Pires I, Daskalopoulos EP, Dal Ferro M, Vodret

S, Lesizza P, Cannatà A, Miranda-Silva D, Lourenço AP, Pinamonti B, Sinagra G,

Weinberger F, Eschenhagen T, Carrier L, Kehat I, Tocchetti CG, Russo M, Ghigo A,

Cimino J, Hirsch E, Dawson D, Ciccarelli M, Oliveti M, Linke WA, Cuijpers I,

Heymans S, Hamdani N, de Boer M, Duncker D, Kuster D, van der Velden J, Beauloye

C, Bertrand L, Mayr M, Giacca M, Leuschner F, Backs J, Thum T; Working Group on

Myocardial Function of the European Society of Cardiology.. Toward

standardization of echocardiography for the evaluation of left ventricular

function in adult rodents: a position paper of the ESC Working Group on

Myocardial Function. Cardiovasc Res. 2020 May 4:cvaa110. doi:

10.1093/cvr/cvaa110. Epub ahead of print. PMID: 32365197.

 

Garg A, Foinquinos A, Jung M, Janssen-Peters H, Biss S, Bauersachs J, Gupta

SK, Thum T. MiRNA-181a is a novel regulator of aldosterone-mineralocorticoid

receptor-mediated cardiac remodelling. Eur J Heart Fail. 2020 Apr 18. doi:

10.1002/ejhf.1813. Epub ahead of print. PMID: 32304626.

 

Huang CK, Kafert-Kasting S, Thum T. Preclinical and Clinical Development of

Noncoding RNA Therapeutics for Cardiovascular Disease. Circ Res. 2020 Feb

28;126(5):663-678. doi: 10.1161/CIRCRESAHA.119.315856. Epub 2020 Feb 27. PMID:

32105576; PMCID: PMC7043728.

 

Foinquinos A, Batkai S, Genschel C, Viereck J, Rump S, Gyöngyösi M, Traxler

D, Riesenhuber M, Spannbauer A, Lukovic D, Weber N, Zlabinger K, Hašimbegović E,

Winkler J, Fiedler J, Dangwal S, Fischer M, de la Roche J, Wojciechowski D,

Kraft T, Garamvölgyi R, Neitzel S, Chatterjee S, Yin X, Bär C, Mayr M, Xiao K,

Thum T. Preclinical development of a miR-132 inhibitor for heart failure

treatment. Nat Commun. 2020 Jan 31;11(1):633. doi: 10.1038/s41467-020-14349-2.

PMID: 32005803; PMCID: PMC6994493.

 

Schimmel K, Jung M, Foinquinos A, José GS, Beaumont J, Bock K, Grote-Levi L,

Xiao K, Bär C, Pfanne A, Just A, Zimmer K, Ngoy S, López B, Ravassa S, Samolovac

S, Janssen-Peters H, Remke J, Scherf K, Dangwal S, Piccoli MT, Kleemiss F,

Kreutzer FP, Kenneweg F, Leonardy J, Hobuß L, Santer L, Do QT, Geffers R,

Braesen JH, Schmitz J, Brandenberger C, Müller DN, Wilck N, Kaever V, Bähre H,

Batkai S, Fiedler J, Alexander KM, Wertheim BM, Fisch S, Liao R, Diez J,

González A, Thum T. Natural Compound Library Screening Identifies New Molecules

for the Treatment of Cardiac Fibrosis and Diastolic Dysfunction. Circulation.

2020 Mar 3;141(9):751-767. doi: 10.1161/CIRCULATIONAHA.119.042559. Epub 2020 Jan

17. PMID: 31948273; PMCID: PMC7050799.

 

Stojanović SD, Fiedler J, Bauersachs J, Thum T, Sedding DG. Senescence-

induced inflammation: an important player and key therapeutic target in

atherosclerosis. Eur Heart J. 2020 Jan 3:ehz919. doi: 10.1093/eurheartj/ehz919.

Epub ahead of print. PMID: 31898722.

 

Kenneweg F, Bang C, Xiao K, Boulanger CM, Loyer X, Mazlan S, Schroen B,

Hermans-Beijnsberger S, Foinquinos A, Hirt MN, Eschenhagen T, Funcke S,

Stojanovic S, Genschel C, Schimmel K, Just A, Pfanne A, Scherf K, Dehmel S,

Raemon-Buettner SM, Fiedler J, Thum T. Long Noncoding RNA-Enriched Vesicles

Secreted by Hypoxic Cardiomyocytes Drive Cardiac Fibrosis. Mol Ther Nucleic

Acids. 2019 Dec 6;18:363-374. doi: 10.1016/j.omtn.2019.09.003. Epub 2019 Sep 13.

PMID: 31634682; PMCID: PMC6807307.

 

Santer L, Bär C, Thum T. Circular RNAs: A Novel Class of Functional RNA

Molecules with a Therapeutic Perspective. Mol Ther. 2019 Aug 7;27(8):1350-1363.

doi: 10.1016/j.ymthe.2019.07.001. Epub 2019 Jul 9. PMID: 31324392; PMCID:

PMC6697450.

 

Lu D, Thum T. RNA-based diagnostic and therapeutic strategies for

cardiovascular disease. Nat Rev Cardiol. 2019 Nov;16(11):661-674. doi:

10.1038/s41569-019-0218-x. Epub 2019 Jun 11. PMID: 31186539.

 

miR-212/132 Cluster Modulation Prevents Doxorubicin-Mediated Atrophy and Cardiotoxicity.

Gupta SK, Garg A, Avramopoulos P, Engelhardt S, Streckfuss-Bömeke K, Batkai S, Thum T (2018).

Mol Ther. 2019 Jan 2;27(1):17-28. Epub 2018 Nov 13

 

Quaking inhibits Doxorubicin-mediated cardiotoxicity through regulation of cardiac circular RNA expression.

Gupta SK, Garg A, Bär C, Chatterjee S, Foinquinos A, Milting H, Streckfuß-Bömeke K, Fiedler J, Thum T (2018)

Circ Res. 122(2):246-254. [Epub 2017 Nov 13]

 

Cardiac myocyte miR-29 promotes pathological remodeling of the heart by activating Wnt signaling.

Sassi Y, Avramopoulos P, Ramanujam D, Grüter L, Werfel S, Giosele S, Brunner AD, Esfandyari D, Papadopoulou AS, De Strooper B, Hübner N, Kumarswamy R, Thum T, Yin X, Mayr M, Laggerbauer B, Engelhardt S (2017).

Nat Commun. 8(1):1614.

 

A large shRNA library approach identifies lncRNA Ntep as an essential regulator of cell proliferation.

Beermann J, Kirste D, Iwanov K, Lu D, Kleemiß F, Kumarswamy R, Schimmel K, Bär C, Thum T (2017).

Cell Death Differ. 25(2):307-318. [Epub 2017 Nov 3]

 

Circulating microRNA-132 levels improve risk prediction for heart failure hospitalization in patients with chronic heart failure.

Masson S, Batkai S, Beermann J, Bär C, Pfanne A, Thum S, Magnoli M, Balconi G, Nicolosi GL, Tavazzi L, Latini R, Thum T (2017).

Eur J Heart Fail. 20(1):78-85 [Epub 2017 Oct 12]

 

Antagonism of profibrotic microRNA-21 improves outcome of murine chronic renal allograft dysfunction.

Schauerte C, Hübner A, Rong S, Wang S, Shushakova N, Mengel M, Dettling A, Bang C, Scherf K, Koelling M, Melk A, Haller H, Thum T, Lorenzen JM (2017).

Kidney Int. 92(3):646-656.

 

Inhibition of the Cardiac Fibroblast-Enriched lncRNA Meg3 Prevents Cardiac Fibrosis and Diastolic Dysfunction.

Piccoli MT, Gupta SK, Viereck J, Foinquinos A, Samolovac S, Kramer FL, Garg A, Remke J, Zimmer K, Batkai S, Thum T.

Circ Res. 2017 Aug 18;121(5):575-583. doi: 10.1161/CIRCRESAHA.117.310624. Epub 2017 Jun 19.

 

Therapeutic miR-21 Silencing Ameliorates Diabetic Kidney Disease in Mice.

Kölling M, Kaucsar T, Schauerte C, Hübner A, Dettling A, Park JK, Busch M, Wulff X, Meier M, Scherf K, Bukosza N, Szénási G, Godó M, Sharma A, Heuser M, Hamar P, Bang C, Haller H, Thum T, Lorenzen JM (2017).

Mol Ther. 25(1):165-180.

 

Circulating long-non coding RNAs as biomarkers of left ventricular diastolic function and remodelling in patients with well-controlled type 2 diabetes.

de Gonzalo-Calvo D, Kenneweg F, Bang C, Toro R, van der Meer RW, Rijzewijk LJ, Smit JW, Lamb HJ, Llorente-Cortes V, Thum T.

Sci Rep. 2016 Nov 22;6:37354. doi: 10.1038/srep37354.

 

Long Noncoding RNAs in Cardiovascular Pathology, Diagnosis, and Therapy.

Bär C, Chatterjee S, Thum T.

Circulation. 2016 Nov 8; 134(19):1484-1499.

 

MicroRNA-based Therapy of Gata2-deficient Vascular Disease.

Hartmann D, Fiedler J, Sonnenschein K, Just A, Pfanne A, Zimmer K, Remke J, Foinquinos A, Butzlaff M, Schimmel K, Maegdefessel L, Hilfiker-Kleiner D, Lachmann N, Schober A, Froese N, Heineke J, Bauersachs J, Batkai S, Thum T.

Circulation. 2016 Oct 25. pii: CIRCULATIONAHA.116.022478. [Epub ahead of print]

 

Non-coding RNAs in Development and Disease: Background, Mechanisms, and Therapeutic Approaches.

Beermann J, Piccoli MT, Viereck J, Thum T.

Physiol Rev. 2016 Oct; 96(4):1297-325. doi: 10.1152/physrev.00041.2015.

 

Preclinical Development of a MicroRNA-Based Therapy for Elderly Patients With Myocardial Infarction.

Gupta SK, Foinquinos A, Thum S, Remke J, Zimmer K, Bauters C, de Groote P, Boon RA, de Windt LJ, Preissl S, Hein L, Batkai S, Pinet F, Thum T.

J Am Coll Cardiol. 2016 Oct 4;68(14):1557-71. doi: 10.1016/j.jacc.2016.07.739.

 

Identification of miR-126 as a new regulator of skin aging.

Fiedler J, Grönniger E, Pfanne A, Brönneke S, Schmidt K, Falk CS, Wenck H, Terstegen L, Thum T, Winnefeld M.

Exp Dermatol. 2016 Aug 30. doi: 10.1111/exd.13173. [Epub ahead of print]

 

Long noncoding RNA Chast promotes cardiac remodeling.

Viereck J, Kumarswamy R, Foinquinos A, Xiao K, Avramopoulos P, Kunz M, Dittrich M, Maetzig T, Zimmer K, Remke J, Just A, Fendrich J, Scherf K, Bolesani E, Schambach A, Weidemann F, Zweigerdt R, de Windt LJ, Engelhardt S, Dandekar T, Batkai S, Thum T.

Sci Transl Med. 2016 Feb 17;8(326):326ra22. doi: 10.1126/scitranslmed.aaf1475.

 

Enabling [(18)F]-bicyclo[6.1.0]nonyne for oligonucleotide conjugation for positron emission tomography applications: [(18)F]-anti-microRNA-21 as an example.

Li XG, Roivainen A, Bergman J, Heinonen A, Bengel F, Thum T, Knuuti J.

Chem Commun (Camb). 2015 Jun 2;51(48):9821-4.

 

Osteopontin is indispensible for AP1-mediated angiotensin II-related miR-21 transcription during cardiac fibrosis.

Lorenzen JM, Schauerte C, Hübner A, Kölling M, Martino F, Scherf K, Batkai S, Zimmer K, Foinquinos A, Kaucsar T, Fiedler J, Kumarswamy R, Bang C, Hartmann D, Gupta SK, Kielstein J, Jungmann A, Katus HA, Weidemann F, Müller OJ, Haller H, Thum T.

Eur Heart J. 2015 Apr 21. pii: ehv109.

 

Long noncoding RNAs in cardiac development and ageing.

Devaux Y, Zangrando J, Schroen B, Creemers EE, Pedrazzini T, Chang CP, Dorn GW 2nd, Thum T, Heymans S; Cardiolinc network.

Nat Rev Cardiol. 2015 Apr 7. doi: 10.1038/nrcardio.2015.55

 

Impairment of Wound Healing in Patients With Type 2 Diabetes Mellitus Influences Circulating MicroRNA Patterns via Inflammatory Cytokines.

Dangwal S, Stratmann B, Bang C, Lorenzen JM, Kumarswamy R, Fiedler J, Falk CS, Scholz CJ, Thum T, Tschoepe D.

Arterioscler Thromb Vasc Biol. 2015 Jun;35(6):1480-8.

 

MicroRNA signatures differentiate preserved from reduced ejection fraction heart failure.

Watson CJ, Gupta SK, O'Connell E, Thum S, Glezeva N, Fendrich J, Gallagher J, Ledwidge M, Grote-Levi L, McDonald K, Thum T.

Eur J Heart Fail. 2015 Apr;17(4):405-15.

 

Long noncoding RNAs and microRNAs in cardiovascular pathophysiology.

Thum T, Condorelli G.

Circ Res. 2015 Feb 13;116(4):751-62.

 

Cardiac fibroblast-derived microRNA passenger strand-enriched exosomes mediate cardiomyocyte hypertrophy.

Bang C, Batkai S, Dangwal S, Gupta SK, Foinquinos A, Holzmann A, Just A, Remke J, Zimmer K, Zeug A, Ponimaskin E, Schmiedl A, Yin X, Mayr M, Halder R, Fischer A, Engelhardt S, Wei Y, Schober A, Fiedler J, Thum T. 

J Clin Invest. 2014;124:2136-2146.

 

Functional MicroRNA library screening identifies the HypoxaMiR MiR-24 as a potent regulator of smooth muscle cell proliferation and vascularization.

Fiedler J, Stohr A, Gupta SK, Hartmann D, Holzmann A, Just A, Hansen A, Hilfiker-Kleiner D, Eschenhagen T, Thum T. 

Antioxid Redox Signal. 2014;21:1167-1176.

 

Circulating long noncoding RNA, LIPCAR, predicts survival in patients with heart failure.

Kumarswamy R, Bauters C, Volkmann I, Maury F, Fetisch J, Holzmann A, Lemesle G, de Groote P, Pinet F, Thum T. 

Circ Res. 2014;114:1569-1575.

 

MicroRNA-24 antagonism prevents renal ischemia reperfusion injury.

Lorenzen JM, Kaucsar T, Schauerte C, Schmitt R, Rong S, Hubner A, Scherf K, Fiedler J, Martino F, Kumarswamy R, Kolling M, Sorensen I, Hinz H, Heineke J, van Rooij E, Haller H, Thum T.

 J Am Soc Nephrol. 2014.

 

MicroRNA-22 increases senescence and activates cardiac fibroblasts in the aging heart.

Jazbutyte V, Fiedler J, Kneitz S, Galuppo P, Just A, Holzmann A, Bauersachs J, Thum T. 

Age (Dordr). 2013;35:747-762.

 

The miRNA-212/132 family regulates both cardiac hypertrophy and cardiomyocyte autophagy.

Ucar A, Gupta SK, Fiedler J, Erikci E, Kardasinski M, Batkai S, Dangwal S, Kumarswamy R, Bang C, Holzmann A, Remke J, Caprio M, Jentzsch C, Engelhardt S, Geisendorf S, Glas C, Hofmann TG, Nessling M, Richter K, Schiffer M, Carrier L, Napp LC, Bauersachs J, Chowdhury K, Thum T. 

Nat Commun. 2012;3:1078.

 

MicroRNA-24 regulates vascularity after myocardial infarction.

Fiedler J, Jazbutyte V, Kirchmaier BC, Gupta SK, Lorenzen J, Hartmann D, Galuppo P, Kneitz S, Pena JT, Sohn-Lee C, Loyer X, Soutschek J, Brand T, Tuschl T, Heineke J, Martin U, Schulte-Merker S, Ertl G, Engelhardt S, Bauersachs J, Thum T. 

Circulation. 2011;124:720-730.

 

miRNA screening reveals a new miRNA family stimulating iPS cell generation via regulation of Meox2.

Pfaff N, Fiedler J, Holzmann A, Schambach A, Moritz T, Cantz T, Thum T. 

EMBO Rep. 2011;12:1153-1159.

 

Comparison of different miR-21 inhibitor chemistries in a cardiac disease model.

Thum T, Chau N, Bhat B, Gupta SK, Linsley PS, Bauersachs J, Engelhardt S. 

J Clin Invest. 2011;121:461-2; author reply 462-3.

 

Impairment of endothelial progenitor cell function and vascularization capacity by aldosterone in mice and humans.

Thum T, Schmitter K, Fleissner F, Wiebking V, Dietrich B, Widder JD, Jazbutyte V, Hahner S, Ertl G, Bauersachs J.

Eur Heart J. 2011;32:1275-1286.

 

miR-212 and miR-132 are required for epithelial stromal interactions necessary for mouse mammary gland development.

Ucar A, Vafaizadeh V, Jarry H, Fiedler J, Klemmt PA, Thum T, Groner B, Chowdhury K.

Nat Genet. 2010;42:1101-1108.

 

MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts.

Thum T, Gross C, Fiedler J, Fischer T, Kissler S, Bussen M, Galuppo P, Just S, Rottbauer W, Frantz S, Castoldi M, Soutschek J, Koteliansky V, Rosenwald A, Basson MA, Licht JD, Pena JT, Rouhanifard SH, Muckenthaler MU, Tuschl T, Martin GR, Bauersachs J, Engelhardt S.

Nature. 2008;456:980-984.

 

MicroRNAs in the human heart: A clue to fetal gene reprogramming in heart failure.

Thum T,  Galuppo P, Wolf C, Fiedler J, Kneitz S, van Laake LW, Doevendans PA, Mummery CL, Borlak J, Haverich A, Gross C, Engelhardt S, Ertl G, Bauersachs J.

Circulation. 2007;116:258-267.

 

Age-dependent impairment of endothelial progenitor cells is corrected by growth-hormone-mediated increase of insulin-like growth-factor-1.

Thum T, Hoeber S, Froese S, Klink I, Stichtenoth DO, Galuppo P, Jakob M, Tsikas D, Anker SD, Poole-Wilson PA, Borlak J, Ertl G, Bauersachs J.

Circ Res. 2007;100:434-443.

 

 

For a complete list of publications please go to PubMed.