Regenerative Medizin und Experimentelle Chirurgie
There is a long history of organ transplantation and visceral surgery at the Department for General, Visceral and Transplantation Surgery at the Hannover Medical School. This research group is an association of young surgeons and scientists who are interested in basic and clinical research in the field of experimental surgery and regenerative medicine. Besides applying latest treatment strategies we aim at gaining further insight into the mechanisms of disease and to develop innovative therapy concepts for the benefit of our patients.
Please take a look at our current projects and feel free to contact us!
Contact
Prof. Dr. med. Florian F.W. Vondran
Work Group Leader
☎ 0511-532 4194
Remedies@mh-hannover.de
Vondran.Florian@mh-hannover.de
Team
Projekte
2020
- Beetz O, Bajunaid A, Meißler L, Vondran FWR, Kleine M, Cammann S, Hanke JS, Schmitto JD, Haverich A, Klempnauer J, Ringe KI, Oldhafer F, Timrott K.
Abdominal Surgery in Patients with Ventricular Assist Devices: a Single-Center Report.
ASAIO J. 2020 Aug;66(8):890-898.
- Wandrer F, Frangež Ž, Liebig S, John K, Vondran F, Wedemeyer H, Veltmann C, Pfeffer TJ, Shibolet O, Schulze-Osthoff K, Simon HU, Bantel H.
Autophagy alleviates amiodarone-induced hepatotoxicity.
Arch Toxicol. 2020 Jul 10. doi: 10.1007/s00204-020-02837-9. Epub ahead of print
- Stahl K, Busch M, Fuge J, Schneider A, Manns MP, Seeliger B, Schmidt JJ, Wiesner O, Schmidt BMW, Taubert R, Vondran FWR, Hoeper MM, David S.
Therapeutic plasma exchange in acute on chronic liver failure.
J Clin Apher. 2020 Jun 24. doi: 10.1002/jca.21799. Epub ahead of print.
- Vieyres G, Reichert I, Carpentier A, Vondran FWR, Pietschmann T.
The ATGL lipase cooperates with ABHD5 to mobilize lipids for hepatitis C virus assembly.
PLoS Pathog. 2020 Jun 15;16(6):e1008554. doi: 10.1371
- Bahlmann J, Madrahimov N, Daniel F, Theidel D, DeTemple DE, Buettner M, Bleich A, Haverich A, Heisterkamp A, Kalies S.
Establishment of a guided, in vivo, multi-channel, abdominal, tissue imaging approach.
Sci Rep. 2020 Jun 8;10(1):9224.
- Lauterbach-Rivière L, Bergez M, Mönch S, Qu B, Riess M, Vondran FWR, Liese J, Hornung V, Urban S, König R.
Hepatitis B Virus DNA is a Substrate for the cGAS/STING Pathway but is not sensed in Infected Hepatocytes.
Viruses. 2020 May 29;12(6):592.
- Timrott K, Beetz O, Oldhafer F, Klempnauer J, Vondran FWR, Jäger MD.
The importance of MHC class II in allogeneic bone marrow transplantation andchimerism-based solid organ tolerance in a rat model.
PLoS One. 2020 May 22;15(5):e0233497.
- Weigle CA, Lieke T, Vondran FWR, Timrott K, Klempnauer J, Beetz O.
An Immunological Model for Heterotopic Heart and Cardiac Muscle Cell
Transplantation in Rats. J Vis Exp. 2020 May 8;(159). doi: 10.3791/60956
- Bojkova D, Westhaus S, Costa R, Timmer L, Funkenberg N, Korencak M, Streeck H, Vondran F, Broering R, Heinrichs S, Lang KS, Ciesek S.
Sofosbuvir Activates EGFR-Dependent Pathways in Hepatoma Cells with Implications for Liver-Related Pathological Processes.
Cells. 2020 Apr 17;9(4):1003.
- Kinast V, Plociennikowska A, Anggakusuma, Bracht T, Todt D, Brown RJP, Boldanova T, Zhang Y, Brüggemann Y, Friesland M, Engelmann M, Vieyres G, Broering R, Vondran FWR, Heim MH, Sitek B, Bartenschlager R, Pietschmann T, Steinmann E.
C19orf66 is an interferon-induced inhibitor of HCV replication that restricts formation of the viral replication organelle.
J Hepatol. 2020 Apr 12:S0168-8278(20)30209-9.
- Oldhafer F, Wittauer EM, Beetz O, Vondran FWR.
Long-term Functional Maintenance of Exteriorized Portal Venous Catheters in a Porcine Animal Model.
J Surg Res. 2020 Jul;251:187-194.
- Carpentier A, Sheldon J, Vondran FWR, Brown RJ, Pietschmann T.
Efficient acute and chronic infection of stem cell-derived hepatocytes by hepatitis C virus.
Gut. 2020 Sep;69(9):1659-1666.
- Wiesener A, Knaup KX, Büttner-Herold M, Dieterle A, Stoeckert J, Riedl B, Morath C, Wald A, Vondran F, Braun F, Schödel J, Schueler M, Schiffer M, Amann K, Reis A, Kraus C, Wiesener MS.
Molecular diagnosis of kidney transplant failure based on urine.
Am J Transplant. 2020 May;20(5):1410-1416.
- Beetz O, Söffker R, Cammann S, Oldhafer F, Vondran FWR, Imkamp F, Klempnauer J, Kleine M.
Extended hepatic metastasectomy for renal cell carcinoma-new aspects in times of targeted therapy: a single-center experience over three decades.
Langenbecks Arch Surg. 2020 Feb;405(1):97-106.
- Todt D, Friesland M, Moeller N, Praditya D, Kinast V, Brüggemann Y, Knegendorf L, Burkard T, Steinmann J, Burm R, Verhoye L, Wahid A, Meister TL, Engelmann M, Pfankuche VM, Puff C, Vondran FWR, Baumgärtner W, Meuleman P, Behrendt P, Steinmann E.
Robust hepatitis E virus infection and transcriptional response in human hepatocytes.
Proc Natl Acad Sci U S A. 2020 Jan 21;117(3):1731-1741.
2019
- Ko C, Bester R, Zhou X, Xu Z, Blossey C, Sacherl J, Vondran FWR, Gao L, Protzer U.
A New Role for Capsid Assembly Modulators To Target Mature Hepatitis B Virus Capsids and Prevent Virus Infection.
Antimicrob Agents Chemother. 2019 Dec 20;64(1):e01440-19.
- Beetz O, Bajunaid A, Meißler L, Vondran FWR, Kleine M, Cammann S, Hanke JS, Schmitto JD, Haverich A, Klempnauer J, Ringe KI, Oldhafer F, Timrott K.
Abdominal Surgery in Patients with Ventricular Assist Devices: a Single-Center Report.
ASAIO J. 2019 Oct 23. doi: 10.1097/MAT.0000000000001085. Epub ahead of print.
- Beetz O, Kolb J, Buck B, Trautewig B, Timrott K, Vondran FWR, Meder I, Löbbert C, Hundrieser J, Klempnauer J, Bektaş H, Lieke T.
Recipient natural killer cells alter the course of rejection of allogeneic heart grafts in rats.
PLoS One. 2019 Aug 22;14(8):e0220546
- Oldhafer F, Wittauer EM, Falk CS, DeTemple DE, Beetz O, Timrott K, Kleine M, Vondran FWR.
Alloresponses of Mixed Lymphocyte Hepatocyte Culture to Immunosuppressive Drugs as an In-Vitro Model of Hepatocyte Transplantation.
Ann Transplant. 2019 Aug 13;24:472-480.
- Oldhafer F, Ringe KI, Timrott K, Kleine M, Beetz O, Ramackers W, Cammann S, Klempnauer J, Bektas H, Vondran FWR.
Response to "Critical appraisal of the modified ante situm liver resection-is the original method the better choice?".
Langenbecks Arch Surg. 2019 Aug;404(5):649-651.
- Gwiasda J, Qu Z, Schrem H, Oldhafer F, Winny M, Klempnauer J, Grannas G, Kaltenborn A.
Prediction of survival after left-sided pancreatic resection for adenocarcinoma: Introduction of a new prognostic score. Hepatobiliary Pancreat
Dis Int. 2019 Dec;18(6):569-575.
- Kinast V, Leber SL, Brown RJP, Vieyres G, Behrendt P, Eßbach C, Strnad P, Vondran FWR, Cornberg M, Wex C, Pietschmann T, Haybaeck J, Todt D, Steinmann E.
Identification of Keratin 23 as a Hepatitis C Virus-Induced Host Factor in the Human Liver.
Cells. 2019 Jun 18;8(6):610.
- Echtermeyer F, Eberhardt M, Risser L, Herzog C, Gueler F, Khalil M, Engel M, Vondran F, Leffler A.
Acetaminophen-induced liver injury is mediated by the ion channel TRPV4.
FASEB J. 2019 Sep;33(9):10257-10268.
- Figueiredo C, Oldhafer F, Wittauer EM, Carvalho-Oliveira M, Akhdar A, Beetz O, Chen-Wacker C, Yuzefovych Y, Falk CS, Blasczyk R, Vondran FWR.
Silencing of HLA class I on primary human hepatocytes as a novel strategy for reduction in alloreactivity.
J Cell Mol Med. 2019 Aug;23(8):5705-5714.
- Wittauer EM, Oldhafer F, Augstein E, Beetz O, Kleine M, Schumacher C, Sieg L, Eismann H, Johanning K, Bleich A, Vondran FWR.
Porcine model for the study of liver regeneration enhanced by non-invasive 13C-methacetin breath test (LiMAx test) and permanent portal venous access.
PLoS One. 2019 May 31;14(5):e0217488
- Strowitzki MJ, Radhakrishnan P, Pavicevic S, Scheer J, Kimmer G, Ritter AS, Tuffs C, Volz C, Vondran F, Harnoss JM, Klose J, Schmidt T, Schneider M.
High hepatic expression of PDK4 improves survival upon multimodal treatment of colorectal liver metastases.
Br J Cancer. 2019 Apr;120(7):675-688
- Mederacke YS, Vondran FW, Kollrich S, Schulde E, Schmitt R, Manns MP, Klempnauer J, Schwinzer R, Noyan F, Jaeckel E.
Transient increase of activated regulatory T cells early after kidney transplantation.
Sci Rep. 2019 Jan 31;9(1):1021
- Tsay HC, Yuan Q, Balakrishnan A, Kaiser M, Möbus S, Kozdrowska E, Farid M, Tegtmeyer PK, Borst K, Vondran FWR, Kalinke U, Kispert A, Manns MP, Ott M, Sharma AD.
Hepatocyte-specific suppression of microRNA-221-3p mitigates liver fibrosis.
J Hepatol. 2019 Apr;70(4):722-734
2018
2017
2016
Publikationen
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