expression and contractile function are altered by replating stem cell–derived cardiomyocytes, (2023), J Gen Physiol (2023) 155 (11): e202313377, https://doi.org/10.1085/jgp.202313377 , Online ahead of print [...] protein kinases mediate recruitment of CREB-binding protein to preserve fast myosin heavy chain IId/x gene activity in myotubes. J. Biol. Chem., 282, 7265-7275. da Costa, N., Edgar, J., Ooi, P.-T., Su, Y. [...] Meissner, J.D. , and Chang, K.-C., 2007. Calcineurin differentially regulates fast myosin heavy chain genes in oxidative muscle fibre type conversion. Cell Tissue Res., 329, 515-27. Hanke, N., Meissner, J.D

J, Klein C, Schambach A „Lentiviral Gene Therapy and Vitamin B3 Treatment Enable Granulocytic Differentiation of G6PC3-deficient Induced Pluripotent Stem Cells“ Gene Ther 2020 Feb 12 [Online ahead of print] [...] Moritz T, Trapnell BC, Lachmann N. “Function and Safety of Lentivirus-Mediated Gene Transfer for CSF2RA-Deficiency” Hum Gene Ther Methods . 2017 Dec;28(6):318-329 Ackermann M, Kuhn A, Kunkiel J, Merkert [...] Moritz T. „Chemoprotection of murine hematopoietic cells by combined gene transfer of cytidine deaminase (CDD) and multidrug resistance 1 gene (MDR1).“ J Exp Clin Cancer Res . 2015 Dec 12;34:148 Dreyer AK, Hoffmann

Rahav G, Grassl GA, Gal-Mor O. The emerging Salmonella infantis expresses lower levels of SPI-1 genes and causes milder colitis in mice and lower rates of invasive disease in humans than Salmonella T [...] The core genome m5C methyltransferase JHP1050 (M.Hpy99III) plays an important role in orchestrating gene expression in Helicobacter pylori . Nucleic Acids Res 2019; 47(5):2336-2348. Farowski F, Solbach P [...] 309(6):151336. Selvakumar, Tharini Ashtalakshmi (Dr. rer. nat.). Interferon mediated intestinal epithelial gene expression under homeostatic and inducible conditions. - 201 Blätter: Illustrationen, Diagramme. Suwandi

CRISPR/Cas9-vermittelte Genom-Editing-Tools zur Überprüfung von Chromatin-Ereignissen eines einzelnen Gens, Epigenomik (ChIPseq, Chromosomenkonformationserfassung usw.), Zellschrittmacherexperimente, Messung [...] induces cachexia by impeding transcriptional signaling of the SET1/MLL complex on muscle-specific genes . iScience 27: 110913 Wang T, Nayak A , Kraft T, Amrute-Nayak M (2024) Single-Molecule Investigation [...] S (2017) Flightless-I governs cell fate by recruiting the SUMO isopeptidase SENP3 to distinct HOX genes. Epigenetics Chromatin 10: 15 Jung J, Nayak A , Schaeffer V, Starzetz T, Kirsch AK, Muller S, Dikic

killer (NK) cells. A few E3 genes are unique to a particular species and hence may allow for species-specific immunomodulation and differential disease outcome. One of these genes, designated E3/49K, is only [...] infections. E3 is one of the most divergent regions of the Ad genome, differing considerably in size, gene composition and sequence between and within an Ad species. Species D Ads have the largest E3 region

Wageningen University & Research, The Netherlands Xiangming Han Research Topic : Cell type-specific HCMV gene expression and its consequences for the MHC-I immunopeptidome Supervisor : Prof. Dr. Lars Dölken, [...] Research Topic : Development of a screening platform for fine mapping of functional herpes simplex virus gene elements by MuA transposon mutagenesis Supervisor: Prof. Dr. Lars Dölken, Institute of Virology, MHH [...] Immunology, Philipps University Marburg Yan Zheng Research Topic : Functional analysis of cytomegalovirus gene products and cellular effectors during lytic infection Supervisor: Prof. Dr. Lars Dölken, Institute

microRNAs in the inhibition of fibrosis is due to the fact that a single miRNA can regulate multiple genes and pathways involved in the development of fibrosis, and therefore using only two microRNAs for therapy [...] therapy of liver fibrosis is advantageous instead of sequentially or simultaneously modulating several genes”. Prof. Sharma states, “we are very excited about the anti-fibrotic potential of miR-190b-5p and

induces cachexia by impeding transcriptional signaling of the SET1/MLL complex on muscle-specific genes, Bushra Khan , Chiara Lanzuolo, Valentina Rosti, Philina Santarelli, Andreas Pich, Theresia Kraft [...] Nayak , Christian Hartmann, Wolfram S. Kunz, Amir Samii, Helmut Bertalanffy, Saverio Francesco Retta, Genes & Diseases , Available online 3 April 2023 ScienceDirect, doi.org/10.1016/j.gendis.2023.02.045 , PubMed

single miR validation TaqMan Real-time PCR - miR target and promoter validation: luciferase reporter gene assays - Ago2 RNA immunoprecipitation for targetome analysis - functional studies: vascular phenotyping [...] analysis - Western blotting and proteome profiling - lentiviral cloning and viral transduction - miR or gene modulation via specific precursors/viruses or antagonists/siRNAs/shRNAs - antigen or ncRNA detection

Molekularbiologie Teil 1 (Download, pdf) Skript Molekularbiologie Teil 2 ( Download , pdf) GenTG ( Download , pdf) GenDG ( Download , pdf) 6. Semester Fragenkatalog Examen (schriftl.) 2010 ( Download , pdf)