GMP-compliant large scale animal serum-free human mesenchymal stem cell (MSC) propagation Main tasks Work Package 7 - Advancing the processes for primary human MSC expansion: GMP-grade, animal serum-free and safe [...] tissues with superior efficiency adapted to TECHNOBEAT requirements - Providing fully characterized, animal serum-free MSCs of highest quality for advanced µ-tissue engineering and transplantation - Elucidating

für die Teilnahme am praktischen Grundmodul „Tierexperimentelle Techniken“ bzw. „Basic Laboratory Animal Module“ (BMC WP 19c). Kompetenzen Die Studierenden verfügen nach erfolgreichem Abschluss der Vorlesung [...] dieser Veranstaltung das praktische Grundmodul „Tierexperimentelle Techniken“ bzw. „Basic Laboratory Animal Module“ absolviert, verfügen die Teilnehmer über eine Basis-Sachkunde, die für die Mitarbeit in [...] apier der “National Competent Authorities for the implementation 2010/63EU on the protection of animals used for scientific purposes“.

Bioethics 44:567-587 Selter F, Hetzel T, Kahrass H, Mertz M (2023) Animal research ethics as interaction of research ethics, animal ethics, and (animal protection) law . Tagungsbericht. ALTEX 40(3):541-544 Beigel [...] V*, Todorović Z*, Kahrass H, Selter F (2024) Interdisciplinary animal research ethics – challenges, opportunities, and perspectives . Animals 14(19):2896 (* gleichwertiger Beitrag) Kühlmeyer K, Jansky B [...] (2024) Why do I choose an animal model or an alternative method in basic and preclinical biomedical research? A spectrum of ethically relevant reasons and their evaluation . Animals 14(4):651 2023 Kahrass

restoration of the beta cell function by regaining normoglycaemia in an infiltration-free pancreas. Animal models of human T1DM and T2DM are of particular importance in diabetes research to systematically [...] pancreatic samples were used to correlate the pathophysiological findings observed especially in this animal model in the context of similarities to the human situation under age-matched non-diabetic and diabetic [...] manifestation. This is important for a potential transfer of diabetes prevention strategies developed in animal models to humans after disease onset. The immune cell composition and the cytokine pattern of the

Dr. Franziska E. Müller Methods and Expertise AAV-production and application Animal management Animal surgery including stereotactic injection and cranial window implantation Cell morphology analysis Molecular

health problem worldwide. Development of therapeutic approaches depends on suitable small and large animal models that replicate pathogenesis in humans. Non-coding RNAs are novel therapeutic targets as master [...] therapy of heart failure We aim to develop and test noncoding RNA-based therapies in small and large animal models of myocardial infarction and heart failure. 2. Antisense oligo pharmacology Pharmacological

Medical Center Utrecht these tissues are transplanted for preclinical testing into damaged hearts in animal models. Monitoring the (electro-) physiological integration of the transplanted cells is another [...] Endothelial cells (ECs) and pericytes (PCs) differentiation WP 7 Mesenchymal Stem Cells (MSC) WP 8 Large animal model, in vivo cell monitoring and function WP 9 Regulatory compliance and exploitation WP 10 Management

the accommodation and care of animals used for experimental and other scientific purposes. Based on the revised appendix A of the european convention ETS123 Design of Animal Experiments Festing Versuchstierkunde [...] Lodish WP3 - Organogenese und Regeneration Principles of development Wolpert Molecular principles of animal development Martinez Arias WP4 - Stammzellforschung und Tissue Engineering Molecular Biology of the

Kunzmann P (2020) "Philosophy of a “Good Death” in Small Animals and Consequences for Euthanasia in Animal Law and Veterinary Practice." In: Animals 2020, 10 , 124. Oktober 2019 Neitzke G. (2019) "Ethik in

André (Prof., PhD) DFG research unit 2591 – Defining a Severity Assessment framework for laboratory animals www.severity-assessment.de Projektleitung: Bleich, André (Prof., PhD), Tolba, Réné (Prof. Dr.; RWTH [...] Alternativmethoden – Verbundprojekt:EMBARC - Extent, Predictors and Management of Publication Bias in Animal Research, TP01 Projektleitung: Bleich, André (Prof., PhD) Förderung: BMBF, 031LO131A Forschungsprojekte [...] ng: Dorsch, Martina (PD Dr. rer. nat.), Glage, Silke (Dr. med. vet., DipECLAM) Histopathology of Animal Models and Teratoma – Veterinary Pathology Projektleitung: Glage, Silke (Dr. med. vet., DipECLAM)