interaction, size-exclusion chromatography) Time-resolved spectroscopy Transient kinetics (stopped-flow, quenched-flow, flash photolysis of caged compounds, IR-laser induced temperature-jump) Circular dichroism [...] for integrated structural biology and hybrid methods Computer-assisted drug-design (3D-workstations, High-Performance Computing Cluster)

expression systems Protein purification Steady-state and transient kinetics (high-throughput plate-reader assays, stopped-flow) Characterization of proteins and protein complexes by Differential Scanning

patient survival. MRD can be measured by conventional multicolor flow cytometry (Flow-MRD, 8-10 colors), PCR, or next generation sequencing. Flow-MRD relies on the aberrant expression of surface marker combinations [...] However, Spectral Flow Cytometry gives rise to large, high-dimensional datasets which are increasingly difficult to analyze by manual gating. Therefore, frameworks for computational flow-cytometry have to [...] conventional and spectral flow cytometry on bone marrow samples and an informatics master student who will develop the computational pipeline to analyze high dimensional Flow-MRD datasets. Projektleitung:

ilung legt besonderen Wert und Fokus auf die Beurteilung der Nieren und Nierenarterien. Mit einem High-End-Ultraschallgerät bieten wir Ihnen neben den üblichen Untersuchungsmethoden auch moderne Dopplermodi [...] Dialyseshunts Untersuchungsmethoden B-Bild Sonographie Farb-, Power-, PW-Doppler, ADF (Advanced Dynamic Flow), SMI-Modi (Superb Microvascular Imaging) Elastographie CEUS (Contrast Enhanced Ultrasound, Kontr

Advanced Analytical Image Processing and Analysis Strategies ML-Based Image Processing Access to the MHH High-Performance Computing (HPC) Cluster Your Role: As a Master's thesis candidate, you will build upon [...] programming languages such as Python or Matlab Expertise in ML application frameworks such as TensorFlow or PyTorch Flourish in a collaborative, team-oriented, and international research environment Application [...] and motivation A concise CV (1 page) A copy of your Bachelor's degree certificate A copy of your high school certificate Application Process: Feel free to submit your application anytime via email to:

nagement Trachealkanülenmanagement Sauerstofftherapie Begleitung des Beatmungsweanings NIV und High-Flow-Therapie Notfallmanagement Schluckdiagnostik Schulung von Patienten und Angehörigen Fortbildung

enzymatic digest Sequencing (Sanger) Next-Generation-Sequencing SNP genotyping High Resolution Melting Gene expression (Q-RT PCR and high throughput microfluidic systems) Transcript isoform analysis Protein tools [...] 2D SDS PAG Cell tools Life cell imaging Cells immortalization (EBV, SV40, hTERT) Molecular cloning Flow cytometry (Cell cycle) siRNA technology Real-time noninvasive monitoring of cell viability, proliferation

können mit Theo den Raum wechseln, ohne große Sauerstoffcontainer hinter uns herzuschieben oder den High Flow vorheizen zu müssen. Wir können ihn einfach in den Kinderwagen packen und mit ihm rausgehen. Er [...] Mithilfe eines fabelhaften ambulanten Pflegeteams war das möglich. Theo hatte einen Highflow mit 15 Liter Flow und zusätzlich 15 Liter Sauerstoff pro Minute. Ein Kind wie Theo war eigentlich nicht zuhause. Weil

denen MRD als Surrogatendpunkt oder Ausgangspunkt verwendet wird? TOP 2 Wie kann eine standardisierte Flow-MRD-Bewertung von AML in ganz Europa erreicht werden? TOP 3 Wie kann man einen Konsens über die M [...] progression (40-50% and 45%, respectively), meaning CR is insufficient to identify patients with a high risk of relapse. Current treatment guidelines for acute leukemias therefore recommend quantification [...] residual disease (measurable residual disease, or MRD) using the sensitive technique of multi-color flow cytometry (MFC) or qPCR to better predict prognosis. While MRD is widely utilized in leukemia diagnosis

genome sequencing has proven to be of great clinical value in pediatric precision medicine, offering a high diagnostic rate and a short median time to diagnosis in several healthcare systems, including those [...] the only possiblity to diagnose critically ill children in a timely manner. ... shows consistently high diagnostic yield and impact on patient management. ... should be available for every critically ill [...] all patients an their families. ... to all participating clinicians. ... to Illumina for providing flow cells, software and DRAGEN pipeline access for the Baby Lion study.