Ago-RIP Sequencing Identifies New MicroRNA-449a-5p Target Genes Increasing Sorafenib Efficacy in Hepatocellular Carcinoma
Reinkens, Thea, Stalke, Amelie, Huge, Nicole, Vajen, Beate, Eilers, Marlies, Schäffer, Vera, Dittrich-Breiholz, Oliver, Schlegelberger, Brigitte, Illig, Thomas; Skawran, Britta.
Journal of Cancer. 2022.
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Single cell versus single nucleus: transcriptome differences in the murine kidney after ischemia-reperfusion injury
Gaedcke, Svenja, Sinning, Julius, Dittrich-Breiholz, Oliver, Haller, Hermann, Soerensen-Zender, Inga, Liao, Chieh Ming, Nordlohne, Alexandra, Sen, Payel, von Vietinghoff, Sibylle, DeLuca, David S.; Schmitt, Roland.
American Journal of Physiology-Renal Physiology. 2022.
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Meteorin-like promotes heart repair through endothelial KIT receptor tyrosine kinase
Reboll, Marc R., Klede, Stefanie, Taft, Manuel H., Cai, Chen-Leng, Field, Loren J., Lavine, Kory J., Koenig, Andrew L., Fleischauer, Jenni, Meyer, Johann, Schambach, Axel, Niessen, Hans W., Kosanke, Maike, van den Heuvel, Joop, Pich, Andreas, Bauersachs, Johann, Wu, Xuekun, Zheng, Linqun, Wang, Yong, Korf-Klingebiel, Mortimer, Polten, Felix; Wollert, Kai C..
Science. 2022.
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FC026: Chronic High Phosphate Level Impairs Cardiac Health
Grund, Andrea, Vogt, Isabel, Richter, Gloria Sophie, Richter, Beatrice, Trogisch, Felix, Garrido, Abel Martin, Heineke, Jörg, Dittrich-Breiholz, Oliver, Haffner, Dieter; Leifheit-Nestler, Maren.
Nephrology Dialysis Transplantation. 2022.
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MiR-129-5p exerts Wnt signaling-dependent tumor-suppressive functions in hepatocellular carcinoma by directly targeting hepatoma-derived growth factor HDGF
Huge, Nicole, Reinkens, Thea, Buurman, Reena, Sandbothe, Maria, Bergmann, Anke, Wallaschek, Hannah, Vajen, Beate, Stalke, Amelie, Decker, Melanie, Eilers, Marlies, Schäffer, Vera, Dittrich-Breiholz, Oliver, Gürlevik, Engin, Kühnel, Florian, Schlegelberger, Brigitte, Illig, Thomas; Skawran, Britta.
Cancer Cell International. 2022.
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Analysis of myocardial cellular gene expression during pressure overload reveals matrix based functional intercellular communication
Froese, Natali, Cordero, Julio, Abouissa, Aya, Trogisch, Felix A., Grein, Steve, Szaroszyk, Malgorzata, Wang, Yong, Gigina, Anna, Korf-Klingebiel, Mortimer, Bosnjak, Berislav, Davenport, Colin F., Wiehlmann, Lutz, Geffers, Robert, Riechert, Eva, Jürgensen, Lonny, Boileau, Etienne, Lin, Yanzhu, Dieterich, Christoph, Förster, Reinhold, Bauersachs, Johann, Ola, Roxana, Dobreva, Gergana, Völkers, Mirko; Heineke, Joerg.
iScience. 2022.
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Wochenende - modular and flexible alignment-based shotgun metagenome analysis
Rosenboom, Ilona, Scheithauer, Tobias, Friedrich, Fabian C., Pörtner, Sophia, Pust, Marie-Madlen, Sifakis, Konstantinos, Wehrbein, Tom, Rosenhahn, Bodo, Wiehlmann, Lutz, Chhatwal, Patrick, Tümmler, Burkhard; Davenport, Colin F..
2022.
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Direct RNA Nanopore Sequencing of Pseudomonas aeruginosa Clone C Transcriptomes
Pust, Marie-Madlen, Davenport, Colin Francis, Wiehlmann, Lutz; Tümmler, Burkhard.
Journal of Bacteriology. 2022.
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Sequence diversity of the Pseudomonas aeruginosa population in loci that undergo microevolution in cystic fibrosis airways
Fischer, Sebastian, Klockgether, Jens, Sorribes, Marina Gonzalez, Dorda, Marie, Wiehlmann, Lutz; Tümmler, Burkhard.
Access Microbiology. 2021.
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The impact of stress on the transcriptomic signature of iNKT1 cells
Papadogianni, Georgia, Ravens, Inga, Hassan, Ahmed, Dittrich-Breiholz, Oliver, Bernhardt, Günter; Georgiev, Hristo.
Biochemistry and Biophysics Reports. 2021.
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A unique role of p53 haploinsufficiency or loss in the development of acute myeloid leukemia with FLT3-ITD mutation
Yang, Min, Pan, Zengkai, Huang, Kezhi, Büsche, Guntram, Liu, Hongyun, Göhring, Gudrun, Rumpel, Regina, Dittrich-Breiholz, Oliver, Talbot, Steven, Scherr, Michaela, Chaturvedi, Anuhar, Eder, Matthias, Skokowa, Julia, Zhou, Jianfeng, Welte, Karl, von Neuhoff, Nils, Liu, Ligen, Ganser, Arnold; Li, Zhixiong.
Leukemia. 2021.
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Intestinal Organoids in Colitis Research: Focusing on Variability and Cryopreservation
zur Bruegge, Talke F., Liese, Andrea, Donath, Sören, Kalies, Stefan, Kosanke, Maike, Dittrich-Breiholz, Oliver, Czech, Sandra, Bauer, Verena N., Bleich, André; Buettner, Manuela.
Stem Cells International. 2021.
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Novel aspects of regulatory T cell dysfunction as a therapeutic target in giant cell arteritis
Adriawan, Ignatius Ryan, Atschekzei, Faranaz, Dittrich-Breiholz, Oliver, Garantziotis, Panagiotis, Hirsch, Stefanie, Risser, Linus Maximillian, Kosanke, Maike, Schmidt, Reinhold Ernst, Witte, Torsten; Sogkas, Georgios.
Annals of the Rheumatic Diseases. 2021.
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Reprogramming enriches for somatic cell clones with small-scale mutations in cancer-associated genes
Kosanke, Maike, Osetek, Katarzyna, Haase, Alexandra, Wiehlmann, Lutz, Davenport, Colin, Schwarzer, Adrian, Adams, Felix, Kleppa, Marc-Jens, Schambach, Axel, Merkert, Sylvia, Wunderlich, Stephanie, Menke, Sandra, Dorda, Marie; Martin, Ulrich.
Molecular Therapy. 2021.
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Predicting genotoxicity of viral vectors for stem cell gene therapy using gene expression-based machine learning
Schwarzer, Adrian, Talbot, Steven R., Selich, Anton, Morgan, Michael, Schott, Juliane W., Dittrich-Breiholz, Oliver, Bastone, Antonella L., Weigel, Bettina, Ha, Teng Cheong, Dziadek, Violetta, Gijsbers, Rik, Thrasher, Adrian J., Staal, Frank J. T., Gaspar, Hubert B., Modlich, Ute, Schambach, Axel; Rothe, Michael.
Molecular Therapy. 2021.
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MicroRNA Profiles of Maternal and Neonatal Endothelial Progenitor Cells in Preeclampsia
Brodowski, Lars, Schröder-Heurich, Bianca, von Hardenberg, Sandra, Richter, Katja, von Kaisenberg, Constantin S., Dittrich-Breiholz, Oliver, Meyer, Nadia, Dörk, Thilo; von Versen-Höynck, Frauke.
International Journal of Molecular Sciences. 2021.
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Genome-Wide Methylation Mapping Using Nanopore Sequencing Technology Identifies Novel Tumor Suppressor Genes in Hepatocellular Carcinoma
Davenport, Colin F., Scheithauer, Tobias, Dunst, Alessia, Bahr, Frauke Sophie, Dorda, Marie, Wiehlmann, Lutz; Tran, Doan Duy Hai.
International Journal of Molecular Sciences. 2021.
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Ischemia Reperfusion Injury Triggers CXCL13 Release and B-Cell Recruitment After Allogenic Kidney Transplantation.
Kreimann, Kirill, Jang, Mi-Sun, Rong, Song, Greite, Robert, von Vietinghoff, Sibylle, Schmitt, Roland, Bräsen, Jan Hinrich, Schiffer, Lena, Gerstenberg, Jessica, Vijayan, Vijith, Dittrich-Breiholz, Oliver, Wang, Li, Karsten, Christian M., Gwinner, Wilfried, Haller, Hermann, Immenschuh, Stephan; Gueler, Faikah.
Frontiers in immunology. 2020.
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The human respiratory tract microbial community structures in healthy and cystic fibrosis infants
Pust, Marie-Madlen, Wiehlmann, Lutz, Davenport, Colin, Rudolf, Isa, Dittrich, Anna-Maria; Tümmler, Burkhard.
npj Biofilms and Microbiomes. 2020.
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Impact of Aging on the Phenotype of Invariant Natural Killer T Cells in Mouse Thymus
Papadogianni, Georgia, Ravens, Inga, Dittrich-Breiholz, Oliver, Bernhardt, Günter; Georgiev, Hristo.
Frontiers in Immunology. 2020.
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Aging impairs alveolar epithelial type II cell function in acute lung injury.
Yazicioglu, Tolga, Mühlfeld, Christian, Autilio, Chiara, Huang, Cheng-Kai, Bär, Christian, Dittrich-Breiholz, Oliver, Thum, Thomas, Perez-Gil, Jesus, Schmiedl, Andreas; Brandenberger, Christina.
American journal of physiology. Lung cellular and molecular physiology. 2020.
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Dietary lipids accumulate in macrophages and stromal cells and change the microarchitecture of mesenteric lymph nodes.
Streich, Katharina, Smoczek, Margarethe, Hegermann, Jan, Dittrich-Breiholz, Oliver, Bornemann, Melanie, Siebert, Anja, Bleich, Andre; Buettner, Manuela.
Journal of advanced research. 2020.
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IL-17 regulates DC migration to the peribronchial LNs and allergen presentation in experimental allergic asthma.
Jirmo, Adan Chari, Busse, Mandy, Happle, Christine, Skuljec, Jelena, Dalüge, Kathleen, Habener, Anika, Grychtol, Ruth, DeLuca, David S., Breiholz, Oliver D., Prinz, Immo; Hansen, Gesine.
European journal of immunology. 2020.
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Intraclonal competitive fitness of longitudinal cystic fibrosis Pseudomonas aeruginosa airway isolates in liquid cultures.
Cramer, Nina, Fischer, Sebastian, Hedtfeld, Silke, Dorda, Marie; Tümmler, Burkhard.
Environmental microbiology. 2020.
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Novel candidate genes for ECT response prediction-a pilot study analyzing the DNA methylome of depressed patients receiving electroconvulsive therapy.
Moschny, Nicole, Zindler, Tristan, Jahn, Kirsten, Dorda, Marie, Davenport, Colin F., Wiehlmann, Lutz, Maier, Hannah B., Eberle, Franziska, Bleich, Stefan, Neyazi, Alexandra; Frieling, Helge.
Clinical epigenetics. 2020.
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Transcriptome profiling identifies TIGIT as a marker of T cell exhaustion in liver cancer.
Ostroumov, Dmitrij, Duong, Steven, Wingerath, Jessica, Woller, Norman, Manns, Michael P., Timrott, Kai, Kleine, Moritz, Ramackers, Wolf, Roessler, Stephanie, Nahnsen, Sven, Czemmel, Stefan, Dittrich-Breiholz, Oliver, Eggert, Tobias, Kühnel, Florian; Wirth, Thomas C..
Hepatology (Baltimore, Md.). 2020.
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Heparin Anticoagulant for Human Bone Marrow Does Not Influence In Vitro Performance of Human Mesenchymal Stromal Cells.
Roger, Yvonne, Burmeister, Laura, Hamm, Anika, Elger, Kirsten, Dittrich-Breiholz, Oliver, Flörkemeier, Thilo; Hoffmann, Andrea.
Cells. 2020.
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Immunotyping of clinically divergent p.Phe508del homozygous monozygous cystic fibrosis twins.
Schamschula, Esther, Hagmann, Wolfgang, Assenov, Yassen, Hedtfeld, Silke, Farag, Ahmed K., Roesner, Lennart M., Wiehlmann, Lutz, Stanke, Frauke, Fischer, Sebastian, Risch, Angela; Tümmler, Burkhard.
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society. 2020.
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Implementation of RNA sequencing and array CGH in the diagnostic workflow of the AIEOP-BFM ALL 2017 trial on acute lymphoblastic leukemia.
Schieck, Maximilian, Lentes, Jana, Thomay, Kathrin, Hofmann, Winfried, Behrens, Yvonne Lisa, Hagedorn, Maike, Ebersold, Juliane, Davenport, Colin F., Fazio, Grazia, Möricke, Anja, Buchmann, Swantje, Alten, Julia, Cario, Gunnar, Schrappe, Martin, Bergmann, Anke Katharina, Stanulla, Martin, Steinemann, Doris, Schlegelberger, Brigitte, Cazzaniga, Giovanni; Göhring, Gudrun.
Annals of hematology. 2020.
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Distinct IL-1α-responsive enhancers promote acute and coordinated changes in chromatin topology in a hierarchical manner.
Weiterer, Sinah-Sophia, Meier-Soelch, Johanna, Georgomanolis, Theodore, Mizi, Athanasia, Beyerlein, Anna, Weiser, Hendrik, Brant, Lilija, Mayr-Buro, Christin, Jurida, Liane, Beuerlein, Knut, Müller, Helmut, Weber, Axel, Tenekeci, Ulas, Dittrich-Breiholz, Oliver, Bartkuhn, Marek, Nist, Andrea, Stiewe, Thorsten, van IJcken, Wilfred Fj, Riedlinger, Tabea, Schmitz, M. Lienhard, Papantonis, Argyris; Kracht, Michael.
The EMBO journal. 2020.
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Transcriptome-wide Profiling of Cerebral Cavernous Malformations Patients Reveal Important Long noncoding RNA molecular signatures.
Subhash, Santhilal, Kalmbach, Norman, Wegner, Florian, Petri, Susanne, Glomb, Torsten, Dittrich-Breiholz, Oliver, Huang, Caiquan, Bali, Kiran Kumar, Kunz, Wolfram S., Samii, Amir, Bertalanffy, Helmut, Kanduri, Chandrasekhar; Kar, Souvik.
Scientific reports. 2019.
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Myc/Max dependent intronic long antisense noncoding RNA, EVA1A-AS, suppresses the expression of Myc/Max dependent anti-proliferating gene EVA1A in a U2 dependent manner
Niehus, Svenja E., Allister, Aldrige B., Hoffmann, Andrea, Wiehlmann, Lutz, Tamura, Teruko; Tran, Doan Duy Hai.
Scientific Reports. 2019.
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Umbilical cord as a long-term source of activatable mesenchymal stromal cells for immunomodulation
Selich, Anton, Zimmermann, Katharina, Tenspolde, Michel, Dittrich-Breiholz, Oliver, von Kaisenberg, Constantin, Schambach, Axel; Rothe, Michael.
Stem Cell Research & Therapy. 2019.
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The identification of pathogenic variants in BRCA1/2 negative, high risk, hereditary breast and/or ovarian cancer patients: High frequency of FANCM pathogenic variants.
Schubert, Stephanie, van Luttikhuizen, Jana L., Auber, Bernd, Schmidt, Gunnar, Hofmann, Winfried, Penkert, Judith, Davenport, Colin F., Hille-Betz, Ursula, Wendeburg, Lena, Bublitz, Janin, Tauscher, Marcel, Hackmann, Karl, Schröck, Evelin, Scholz, Caroline, Wallaschek, Hannah, Schlegelberger, Brigitte, Illig, Thomas; Steinemann, Doris.
International journal of cancer. 2019.
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IFN-γ Producing Th1 Cells Induce Different Transcriptional Profiles in Microglia and Astrocytes.
Prajeeth, Chittappen K., Dittrich-Breiholz, Oliver, Talbot, Steven R., Robert, Philippe A., Huehn, Jochen; Stangel, Martin.
Frontiers in cellular neuroscience. 2018.
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Airway microbial metagenomics
Pienkowska, Katarzyna, Wiehlmann, Lutz; Tümmler, Burkhard.
Microbes and Infection. 2018.
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Long-Term Microevolution of Pseudomonas aeruginosa Differs between Mildly and Severely Affected Cystic Fibrosis Lungs.
Klockgether, Jens, Cramer, Nina, Fischer, Sebastian, Wiehlmann, Lutz; Tümmler, Burkhard.
American journal of respiratory cell and molecular biology. 2018.
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Pulmonary Transplantation of Human Induced Pluripotent Stem Cell–derived Macrophages Ameliorates Pulmonary Alveolar Proteinosis
Happle, Christine, Lachmann, Nico, Ackermann, Mania, Mirenska, Anja, Göhring, Gudrun, Thomay, Kathrin, Mucci, Adele, Hetzel, Miriam, Glomb, Torsten, Suzuki, Takuji, Chalk, Claudia, Glage, Silke, Dittrich-Breiholz, Oliver, Trapnell, Bruce, Moritz, Thomas; Hansen, Gesine.
American Journal of Respiratory and Critical Care Medicine. 2018.
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Effects of Lumacaftor–Ivacaftor Therapy on Cystic Fibrosis Transmembrane Conductance Regulator Function in Phe508del Homozygous Patients with Cystic Fibrosis
Graeber, Simon Y., Dopfer, Christian, Naehrlich, Lutz, Gyulumyan, Lena, Scheuermann, Heike, Hirtz, Stephanie, Wege, Sabine, Mairbäurl, Heimo, Dorda, Marie, Hyde, Rebecca, Bagheri-Hanson, Azadeh, Rueckes-Nilges, Claudia, Fischer, Sebastian, Mall, Marcus A.; Tümmler, Burkhard.
American Journal of Respiratory and Critical Care Medicine. 2018.
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Functional characterization of the mouse Serpina1 paralog DOM-7
Jülicher, Karen, Wähner, Annabell, Haase, Kerstin, Barbour, Karen W., Berger, Franklin G., Wiehlmann, Lutz, Davenport, Colin, Schuster-Gossler, Karin, Stitz, Jörn, Cantz, Tobias; Eggenschwiler, Reto.
Biological Chemistry. 2018.
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Expansion of functional personalized cells with specific transgene combinations.
Lipps, Christoph, Klein, Franziska, Wahlicht, Tom, Seiffert, Virginia, Butueva, Milada, Zauers, Jeannette, Truschel, Theresa, Luckner, Martin, Köster, Mario, MacLeod, Roderick, Pezoldt, Jörn, Hühn, Jochen, Yuan, Qinggong, Müller, Peter Paul, Kempf, Henning, Zweigerdt, Robert, Dittrich-Breiholz, Oliver, Pufe, Thomas, Beckmann, Rainer, Drescher, Wolf, Riancho, Jose, Sañudo, Carolina, Korff, Thomas, Opalka, Bertram, Rebmann, Vera, Göthert, Joachim R., Alves, Paula M., Ott, Michael, Schucht, Roland, Hauser, Hansjörg, Wirth, Dagmar; May, Tobias.
Nature communications. 2018.
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Inflammatory marker analysis in psoriatic skin under topical phosphodiesterase 4 inhibitor treatment
Roesner, Lennart M., Kienlin, Petra, Begemann, Gabriele, Dittrich-Breiholz, Oliver; Werfel, Thomas.
Journal of Allergy and Clinical Immunology. 2017.
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TNF phase III signalling in tolerant cells is tightly controlled by A20 and CYLD
Bikker, Rolf, Christmann, Martin, Preuß, Katharina, Welz, Bastian, Friesenhagen, Judith, Dittrich-Breiholz, Oliver, Huber, René; Brand, Korbinian.
Cellular Signalling. 2017.
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Impact of Molecular Genetics on Outcome in Myelofibrosis Patients after Allogeneic Stem Cell Transplantation
Kröger, Nicolaus, Panagiota, Victoria, Badbaran, Anita, Zabelina, Tatjana, Triviai, Ioanna, Cruz, Michelle Maria Araujo, Shahswar, Rabia, Ayuk, Francis, Gehlhaar, Marten, Wolschke, Christine, Bollin, Robin, Walter, Carolin, Dugas, Martin, Wiehlmann, Lutz, Lehmann, Ulrich, Koenecke, Christian, Chaturvedi, Anuhar, Alchalby, Haefaa, Stadler, Michael, Eder, Matthias, Christopeit, Max, Göhring, Gudrun, Koenigsmann, Michael, Schlegelberger, Brigitte, Kreipe, Hans-Heinrich, Ganser, Arnold, Stocking, Carol, Fehse, Boris, Thol, Felicitas; Heuser, Michael.
Biology of Blood and Marrow Transplantation. 2017.
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Impact of sample processing on human airways microbial metagenomes
Wiehlmann, Lutz, Pienkowska, Katarzyna, Hedtfeld, Silke, Dorda, Marie; Tümmler, Burkhard.
Journal of Biotechnology. 2017.
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Multilocus amplicon sequencing of Pseudomonas aeruginosa cystic fibrosis airways isolates collected prior to and after early antipseudomonal chemotherapy
Fischer, Sebastian, Greipel, Leonie, Klockgether, Jens, Dorda, Marie, Wiehlmann, Lutz, Cramer, Nina; Tümmler, Burkhard.
Journal of Cystic Fibrosis. 2017.
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Identification of FOXJ1 effectors during ciliogenesis in the foetal respiratory epithelium and embryonic left-right organiser of the mouse
Stauber, Michael, Weidemann, Marina, Dittrich-Breiholz, Oliver, Lobschat, Katharina, Alten, Leonie, Mai, Michaela, Beckers, Anja, Kracht, Michael; Gossler, Achim.
Developmental Biology. 2017.
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Bacterial low-abundant taxa are key determinants of a healthy airway metagenome in the early years of human life
Pust, Marie-Madlen; Tümmler, Burkhard.
Computational and Structural Biotechnology Journal. 2022.
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Polarization of human iPSC-derived macrophages directs their immunological response to secondary pro-inflammatory stimuli
Schinke, Maximilian, Meyer, Greta, Hashtchin, Anna Rafiei, Hetzel, Miriam, Abdin, Shifaa M., Wegner, Tim, Schwarzer, Adrian, Hansen, Gesine, Schambach, Axel, Lachmann, Nico; Ackermann, Mania.
Journal of Immunology and Regenerative Medicine. 2022.
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ISG15 deficiency features a complex cellular phenotype that responds to treatment with itaconate and derivatives
Waqas, Syed Fakhar-ul-Hassnain, Sohail, Aaqib, Nguyen, Ariane Hai Ha, Usman, Abdulai, Ludwig, Tobias, Wegner, Andre, Malik, Muhammad Nasir Hayat, Schuchardt, Sven, Geffers, Robert, Winterhoff, Moritz, Merkert, Sylvia, Martin, Ulrich, Olmer, Ruth, Lachmann, Nico; Pessler, Frank.
Clinical and Translational Medicine. 2022.
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Human umbilical cord mesenchymal stem cell-derived treatment of severe pulmonary arterial hypertension
Hansmann, Georg, Chouvarine, Philippe, Diekmann, Franziska, Giera, Martin, Ralser, Markus, Mülleder, Michael, von Kaisenberg, Constantin, Bertram, Harald, Legchenko, Ekaterina; Hass, Ralf.
Nature Cardiovascular Research. 2022.
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Human umbilical cord mesenchymal stem cell-derived treatment of severe pulmonary arterial hypertension
Hansmann, Georg, Chouvarine, Philippe, Diekmann, Franziska, Giera, Martin, Ralser, Markus, Mülleder, Michael, von Kaisenberg, Constantin, Bertram, Harald, Legchenko, Ekaterina; Hass, Ralf.
Nature Cardiovascular Research. 2022.
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Molecular characterization of a bovine adenovirus type 7 (Bovine Atadenovirus F) strain isolated from a systemically infected calf in Germany
Jesse, Sonja T., Ciurkiewicz, Malgorzata, Siesenop, Ute, Spitzbarth, Ingo, Osterhaus, A. D. M. E., Baumgärtner, Wolfgang; Ludlow, Martin.
Virology Journal. 2022.
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Myeloid CCR2 Promotes Atherosclerosis after AKI
Hüsing, Anne M., Wulfmeyer, Vera C., Gaedcke, Svenja, Fleig, Susanne V., Rong, Song, DeLuca, David, Haller, Hermann, Schmitt, Roland; von Vietinghoff, Sibylle.
Journal of the American Society of Nephrology. 2022.
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B Cells Are Not Involved in the Regulation of Adenoviral TGF-upbeta1– or Bleomycin-Induced Lung Fibrosis in Mice
Moog, Marie T., Hinze, Christopher, Bormann, Tina, Aschenbrenner, Franziska, Knudsen, Lars, DeLuca, David S., Jonigk, Danny, Neubert, Lavinia, Welte, Tobias, Gauldie, Jack, Kolb, Martin; Maus, Ulrich A..
The Journal of Immunology. 2022.
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Proinflammatory cytokines induce rapid, NO-independent apoptosis, expression of chemotactic mediators and interleukin-32 secretion in human pluripotent stem cell-derived beta cells
Dettmer, Rabea, Niwolik, Isabell, Cirksena, Karsten, Yoshimoto, Toshiaki, Tang, Yadi, Mehmeti, Ilir, Gurgul-Convey, Ewa; Naujok, Ortwin.
Diabetologia. 2022.
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FGFR2 signaling enhances the SHH-BMP4 signaling axis in early ureter development
Meuser, Max, Deuper, Lena, Rudat, Carsten, Aydoğdu, Nurullah, Thiesler, Hauke, Zarnovican, Patricia, Hildebrandt, Herbert, Trowe, Mark-Oliver; Kispert, Andreas.
Development. 2022.
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Human iPSC-derived macrophages for efficient Staphylococcus aureus clearance in a murine pulmonary infection model
Hashtchin, Anna Rafiei, Fehlhaber, Beate, Hetzel, Miriam, Manstein, Felix, Stalp, Jan Lennart, Glage, Silke, Abeln, Markus, Zweigerdt, Robert, Munder, Antje, Viemann, Dorothee, Ackermann, Mania; Lachmann, Nico.
Blood Advances. 2021.
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Anthracycline-free tumor elimination in mice leads to functional and molecular cardiac recovery from cancer-induced alterations in contrast to long-lasting doxorubicin treatment effects
Pietzsch, Stefan, Wohlan, Katharina, Thackeray, James T., Heimerl, Maren, Schuchardt, Sven, Scherr, Michaela, Ricke-Hoch, Melanie; Hilfiker-Kleiner, Denise.
Basic Research in Cardiology. 2021.
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Expression of ACKR4 demarcates the “peri-marginal sinus,” a specialized vascular compartment of the splenic red pulp
Werth, Kathrin, Hub, Elin, Gutjahr, Julia Christine, Bosjnak, Berislav, Zheng, Xiang, Bubke, Anja, Russo, Stefan, Rot, Antal; Förster, Reinhold.
Cell Reports. 2021.
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Dextran-based scaffolds for in-situ hydrogelation: Use for next generation of bioartificial cardiac tissues
Banerjee, Samhita, Szepes, Monika, Dibbert, Nick, Rios-Camacho, Julio-Cesar, Kirschning, Andreas, Gruh, Ina; Dräger, Gerald.
Carbohydrate Polymers. 2021.
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The highly conserved FOXJ1 target CFAP161 is dispensable for motile ciliary function in mouse and Xenopus
Beckers, Anja, Fuhl, Franziska, Ott, Tim, Boldt, Karsten, Brislinger, Magdalena Maria, Walentek, Peter, Schuster-Gossler, Karin, Hegermann, Jan, Alten, Leonie, Kremmer, Elisabeth, Przykopanski, Adina, Serth, Katrin, Ueffing, Marius, Blum, Martin; Gossler, Achim.
Scientific Reports. 2021.
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Combined genomic and proteomic approaches reveal DNA binding sites and interaction partners of TBX2 in the developing lung
Lüdtke, Timo H., Wojahn, Irina, Kleppa, Marc-Jens, Schierstaedt, Jasper, Christoffels, Vincent M., Künzler, Patrick; Kispert, Andreas.
Respiratory Research. 2021.
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Remodelling of adult cardiac tissue subjected to physiological and pathological mechanical load in vitro
Pitoulis, Fotios G., Nunez-Toldra, Raquel, Xiao, Ke, Kit-Anan, Worrapong, Mitzka, Saskia, Jabbour, Richard J., Harding, Sian E., Perbellini, Filippo, Thum, Thomas, de Tombe, Pieter P.; Terracciano, Cesare M..
Cardiovascular Research. 2021.
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Human heart-forming organoids recapitulate early heart and foregut development
Drakhlis, Lika, Biswanath, Santoshi, Farr, Clara-Milena, Lupanow, Victoria, Teske, Jana, Ritzenhoff, Katharina, Franke, Annika, Manstein, Felix, Bolesani, Emiliano, Kempf, Henning, Liebscher, Simone, Schenke-Layland, Katja, Hegermann, Jan, Nolte, Lena, Meyer, Heiko, de la Roche, Jeanne, Thiemann, Stefan, Wahl-Schott, Christian, Martin, Ulrich; Zweigerdt, Robert.
Nature Biotechnology. 2021.
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Blood-based protein profiling identifies serum protein c-KIT as a novel biomarker for hypertrophic cardiomyopathy
Sonnenschein, Kristina, Fiedler, Jan, de Gonzalo-Calvo, David, Xiao, Ke, Pfanne, Angelika, Just, Annette, Zwadlo, Carolin, Soltani, Samira, Bavendiek, Udo, Kraft, Theresia, Remedios, Cristobal Dos, Cebotari, Serghei, Bauersachs, Johann; Thum, Thomas.
Scientific Reports. 2021.
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Efficient IL-2R signaling differentially affects the stability, function, and composition of the regulatory T-cell pool
Permanyer, Marc, Bošnjak, Berislav, Glage, Silke, Friedrichsen, Michaela, Floess, Stefan, Huehn, Jochen, Patzer, Gwendolyn E., Odak, Ivan, Eckert, Nadine, Zargari, Razieh, Ospina-Quintero, Laura, Georgiev, Hristo; Förster, Reinhold.
Cellular & Molecular Immunology. 2021.
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Liver-expressed Cd302 and Cr1l limit hepatitis C virus cross-species transmission to mice
Brown, Richard J. P., Tegtmeyer, Birthe, Sheldon, Julie, Khera, Tanvi, Anggakusuma, Todt, Daniel, Vieyres, Gabrielle, Weller, Romy, Joecks, Sebastian, Zhang, Yudi, Sake, Svenja, Bankwitz, Dorothea, Welsch, Kathrin, Ginkel, Corinne, Engelmann, Michael, Gerold, Gisa, Steinmann, Eike, Yuan, Qinggong, Ott, Michael, Vondran, Florian W. R., Krey, Thomas, Ströh, Luisa J., Miskey, Csaba, Ivics, Zoltán, Herder, Vanessa, Baumgärtner, Wolfgang, Lauber, Chris, Seifert, Michael, Tarr, Alexander W., McClure, C. Patrick, Randall, Glenn, Baktash, Yasmine, Ploss, Alexander, Thi, Viet Loan Dao, Michailidis, Eleftherios, Saeed, Mohsan, Verhoye, Lieven, Meuleman, Philip, Goedecke, Natascha, Wirth, Dagmar, Rice, Charles M.; Pietschmann, Thomas.
Science Advances. 2020.
Publisher's page
Multiple genes surrounding Bcl-xL, a common retroviral insertion site, can influence hematopoiesis individually or in concert
Ha, Teng-Cheong, Stahlhut, Maike, Rothe, Michael, Paul, Gabi, Dziadek, Violetta, Morgan, Michael A., Brugman, Martijn, Fehse, Boris, Kustikova, Olga, Schambach, Axel; Baum, Christopher.
Human Gene Therapy. 2020.
Publisher's page
Neuraminidase-1 promotes heart failure after ischemia/reperfusion injury by affecting cardiomyocytes and invading monocytes/macrophages
Heimerl, Maren, Sieve, Irina, Ricke-Hoch, Melanie, Erschow, Sergej, Battmer, Karin, Scherr, Michaela; Hilfiker-Kleiner, Denise.
Basic Research in Cardiology. 2020.
Publisher's page
FGF2 Inhibits Early Pancreatic Lineage Specification during Differentiation of Human Embryonic Stem Cells
Dettmer, Rabea, Cirksena, Karsten, Münchhoff, Julia, Kresse, Jasmin, Diekmann, Ulf, Niwolik, Isabell, Buettner, Falk F. R.; Naujok, Ortwin.
Cells. 2020.
Publisher's page
Altered bone development with impaired cartilage formation precedes neuromuscular symptoms in spinal muscular atrophy
Hensel, Niko, Brickwedde, Hermann, Tsaknakis, Konstantinos, Grages, Antonia, Braunschweig, Lena, Lüders, Katja A., Lorenz, Heiko M., Lippross, Sebastian, Walter, Lisa M., Tavassol, Frank, Lienenklaus, Stefan, Neunaber, Claudia, Claus, Peter; Hell, Anna K..
Human Molecular Genetics. 2020.
Publisher's page
Antagonistic Activities of Vegfr3/Flt4 and Notch1b Fine-tune Mechanosensitive Signaling during Zebrafish Cardiac Valvulogenesis
Fontana, Federica, Haack, Timm, Reichenbach, Maria, Knaus, Petra, Puceat, Michel; Abdelilah-Seyfried, Salim.
Cell Reports. 2020.
Publisher's page
Human CD16mathplus monocytes promote a pro-atherosclerotic endothelial cell phenotype via CX3CR1-CX3CL1 interaction
Roy-Chowdhury, Eva, Brauns, Nicolas, Helmke, Alexandra, Nordlohne, Johannes, Bräsen, Jan Hinrich, Schmitz, Jessica, Volkmann, Julia, Fleig, Susanne V., Kusche-Vihrog, Kristina, Haller, Hermann; von Vietinghoff, Sibylle.
Cardiovascular Research. 2020.
Publisher's page
Notch and TLR signaling coordinate monocyte cell fate and inflammation
Gamrekelashvili, Jaba, Kapanadze, Tamar, Sablotny, Stefan, Ratiu, Corina, Dastagir, Khaled, Lochner, Matthias, Karbach, Susanne, Wenzel, Philip, Sitnow, Andre, Fleig, Susanne, Sparwasser, Tim, Kalinke, Ulrich, Holzmann, Bernhard, Haller, Hermann; Limbourg, Florian P..
eLife. 2020.
Publisher's page
The Long Non-coding RNA Cyrano Is Dispensable for Pluripotency of Murine and Human Pluripotent Stem Cells
Hunkler, Hannah J., Hoepfner, Jeannine, Huang, Cheng-Kai, Chatterjee, Shambhabi, Jara-Avaca, Monica, Gruh, Ina, Bolesani, Emiliano, Zweigerdt, Robert, Thum, Thomas; Bär, Christian.
Stem Cell Reports. 2020.
Publisher's page
Early host–microbe interaction in a peri-implant oral mucosa-biofilm model
Mikolai, Carina, Kommerein, Nadine, Ingendoh-Tsakmakidis, Alexandra, Winkel, Andreas, Falk, Christine S.; Stiesch, Meike.
Cellular Microbiology. 2020.
Publisher's page
In Vitro Effects of Streptococcus oralis Biofilm on Peri-Implant Soft Tissue Cells
Ingendoh-Tsakmakidis, Alexandra, Eberhard, Jörg, Falk, Christine S., Stiesch, Meike; Winkel, Andreas.
Cells. 2020.
Publisher's page
Lagovirus europeus GI.2 (rabbit hemorrhagic disease virus 2) infection in captive mountain hares (Lepus timidus) in Germany
Buehler, Melanie, Jesse, Sonja T., Kueck, Heike, Lange, Bastian, Koenig, Patricia, Jo, Wendy K., Osterhaus, Albert; Beineke, Andreas.
BMC Veterinary Research. 2020.
Publisher's page
BET bromodomain-containing epigenetic reader proteins regulate vascular smooth muscle cell proliferation and neointima formation
Dutzmann, Jochen, Haertlé, Marco, Daniel, Jan-Marcus, Kloss, Frederik, Musmann, Robert-Jonathan, Kalies, Katrin, Knöpp, Kai, Pilowski, Claudia, Sirisko, Mirja, Sieweke, Jan-Thorben, Bauersachs, Johann, Sedding, Daniel G.; Gegel, Simona.
Cardiovascular Research. 2020.
Publisher's page
MiRNA -181a is a novel regulator of aldosterone–mineralocorticoid receptor-mediated cardiac remodelling
Garg, Ankita, Foinquinos, Ariana, Jung, Mira, Janssen-Peters, Heike, Biss, Sinje, Bauersachs, Johann, Gupta, Shashi Kumar; Thum, Thomas.
European Journal of Heart Failure. 2020.
Publisher's page
Triple ( GGTA1, CMAH, B2M ) modified pigs expressing an SLA class I low phenotype—Effects on immune status and susceptibility to human immune responses
Hein, Rabea, Sake, Hendrik J., Pokoyski, Claudia, Hundrieser, Joachim, Brinkmann, Antje, Baars, Wiebke, Nowak-Imialek, Monika, Lucas-Hahn, Andrea, Figueiredo, Constanca, Schuberth, Hans-Joachim, Niemann, Heiner, Petersen, Björn; Schwinzer, Reinhard.
American Journal of Transplantation. 2020.
Publisher's page
Inflammation-like changes in the urothelium of Lifr-deficient mice and LIFR-haploinsufficient humans with urinary tract anomalies
Christians, Anne, Weiss, Anna-Carina, Martens, Helge, Klopf, Maximilian Georg, Hennies, Imke, Haffner, Dieter, Kispert, Andreas; Weber, Ruthild G..
Human Molecular Genetics. 2020.
Publisher's page
SerpinB2 Regulates Immune Response in Kidney Injury and Aging
Sen, Payel, Helmke, Alexandra, Liao, Chieh Ming, Sörensen-Zender, Inga, Rong, Song, Bräsen, Jan-Hinrich, Melk, Anette, Haller, Hermann, von Vietinghoff, Sibylle; Schmitt, Roland.
Journal of the American Society of Nephrology. 2020.
Publisher's page
Silicon reduces the iron uptake in rice and induces iron homeostasis related genes
Becker, Martin, Ngo, Ngoc Sang; Schenk, Manfred Karl Adolf.
Scientific Reports. 2020.
Publisher's page
Patient iPSC-Derived Macrophages to Study Inborn Errors of the IFN-upgamma Responsive Pathway
Haake, Kathrin, Neehus, Anna-Lena, Buchegger, Theresa, Kühnel, Mark Philipp, Blank, Patrick, Philipp, Friederike, Oleaga-Quintas, Carmen, Schulz, Ansgar, Grimley, Michael, Goethe, Ralph, Jonigk, Danny, Kalinke, Ulrich, Boisson-Dupuis, Stéphanie, Casanova, Jean-Laurent, Bustamante, Jacinta; Lachmann, Nico.
Cells. 2020.
Publisher's page
Inducible Forward Programming of Human Pluripotent Stem Cells to Hemato-endothelial Progenitor Cells with Hematopoietic Progenitor Potential
Lange, Lucas, Hoffmann, Dirk, Schwarzer, Adrian, Ha, Teng-Cheong, Philipp, Friederike, Lenz, Daniela, Morgan, Michael; Schambach, Axel.
Stem Cell Reports. 2020.
Publisher's page
B cell hyperactivation in an Ackr4 -deficient mouse strain is not caused by lack of ACKR4 expression
Eckert, Nadine, Werth, Kathrin, Willenzon, Stefanie, Tan, Likai; Förster, Reinhold.
Journal of Leukocyte Biology. 2019.
Publisher's page
Long Noncoding RNA-Enriched Vesicles Secreted by Hypoxic Cardiomyocytes Drive Cardiac Fibrosis
Kenneweg, Franziska, Bang, Claudia, Xiao, Ke, Boulanger, Chantal M., Loyer, Xavier, Mazlan, Stephane, Schroen, Blanche, Hermans-Beijnsberger, Steffie, Foinquinos, Ariana, Hirt, Marc N., Eschenhagen, Thomas, Funcke, Sandra, Stojanovic, Stevan, Genschel, Celina, Schimmel, Katharina, Just, Annette, Pfanne, Angelika, Scherf, Kristian, Dehmel, Susann, Raemon-Buettner, Stella M., Fiedler, Jan; Thum, Thomas.
Molecular Therapy - Nucleic Acids. 2019.
Publisher's page
Potent Antitumor Activity of Liposomal Irinotecan in an Organoid- and CRISPR-Cas9-Based Murine Model of Gallbladder Cancer
Erlangga, Zulrahman, Wolff, Katharina, Poth, Tanja, Peltzer, Alexander, Nahnsen, Sven, Spielberg, Steffi, Timrott, Kai, Woller, Norman, Kühnel, Florian, Manns, Michael P., Saborowski, Anna, Vogel, Arndt; Saborowski, Michael.
Cancers. 2019.
Publisher's page
Continuous WNT Control Enables Advanced hPSC Cardiac Processing and Prognostic Surface Marker Identification in Chemically Defined Suspension Culture
Halloin, Caroline, Schwanke, Kristin, Löbel, Wiebke, Franke, Annika, Szepes, Monika, Biswanath, Santoshi, Wunderlich, Stephanie, Merkert, Sylvia, Weber, Natalie, Osten, Felix, de la Roche, Jeanne, Polten, Felix, Wollert, Kai Christoph, Kraft, Theresia, Fischer, Martin, Martin, Ulrich, Gruh, Ina, Kempf, Henning; Zweigerdt, Robert.
Stem Cell Reports. 2019.
Publisher's page
Cytokine Selection of MSC Clones with Different Functionality
Selich, Anton, Ha, Teng-Cheong, Morgan, Michael, Falk, Christine S., von Kaisenberg, Constantin, Schambach, Axel; Rothe, Michael.
Stem Cell Reports. 2019.
Publisher's page
Commensal and pathogenic biofilms differently modulate peri-implant oral mucosa in an organotypic model
Ingendoh-Tsakmakidis, Alexandra, Mikolai, Carina, Winkel, Andreas, Szafraʼnski, Szymon P., Falk, Christine S., Rossi, Angela, Walles, Heike; Stiesch, Meike.
Cellular Microbiology. 2019.
Publisher's page
High-Throughput Screening for Modulators of CFTR Activity Based on Genetically Engineered Cystic Fibrosis Disease-Specific iPSCs
Merkert, Sylvia, Schubert, Madline, Olmer, Ruth, Engels, Lena, Radetzki, Silke, Veltman, Mieke, Scholte, Bob J., Zöllner, Janina, Pedemonte, Nicoletta, Galietta, Luis J. V., von Kries, Jens P.; Martin, Ulrich.
Stem Cell Reports. 2019.
Publisher's page
Kaposi's sarcoma-associated herpesvirus vIRF2 protein utilizes an IFN-dependent pathway to regulate viral early gene expression
Koch, Sandra, Damas, Modester, Freise, Anika, Hage, Elias, Dhingra, Akshay, Rückert, Jessica, Gallo, Antonio, Kremmer, Elisabeth, Tegge, Werner, Brönstrup, Mark, Brune, Wolfram; Schulz, Thomas F..
PLOS Pathogens. 2019.
Publisher's page
The FMS-like tyrosine kinase-3 ligand/lung dendritic cell axis contributes to regulation of pulmonary fibrosis
Tarrés, Meritxell Tort, Aschenbrenner, Franziska, Maus, Regina, Stolper, Jennifer, Schuette, Lisanne, Knudsen, Lars, Rodriguez, Elena Lopez, Jonigk, Danny, Kühnel, Mark Philipp, DeLuca, David, Prasse, Antje, Welte, Tobias, Gauldie, Jack, Kolb, Martin R. J.; Maus, Ulrich A..
Thorax. 2019.
Publisher's page
Delayed onset of smooth muscle cell differentiation leads to hydroureter formation in mice with conditional loss of the zinc finger transcription factor gene Gata2 in the ureteric mesenchyme
Weiss, Anna-Carina, Bohnenpoll, Tobias, Kurz, Jennifer, Blank, Patrick, Airik, Rannar, Lüdtke, Timo H., Kleppa, Marc-Jens, Deuper, Lena, Kaiser, Marina, Mamo, Tamrat M., Costa, Rui, Hahn, Thomas, Trowe, Mark-Oliver; Kispert, Andreas.
The Journal of Pathology. 2019.
Publisher's page
Polarized microglia do not influence oligodendrocyte lineage cells via astrocytes
Gingele, Stefan, Merkel, Lukas, Prajeeth, Chittappen K., Kronenberg, Jessica, Hoevel, Friederike Freiin, Skripuletz, Thomas, Gudi, Viktoria; Stangel, Martin.
International Journal of Developmental Neuroscience. 2019.
Publisher's page
An evolutionary divergent pestivirus lacking the Npro gene systemically infects a whale species
Jo, Wendy K., van Elk, Cornelis, van de Bildt, Marco, van Run, Peter, Petry, Monique, Jesse, Sonja T., Jung, Klaus, Ludlow, Martin, Kuiken, Thijs; Osterhaus, Albert.
Emerging Microbes & Infections. 2019.
Publisher's page
Analysis of Cdcs1 colitogenic effects in the hematopoietic compartment reveals distinct microbiome interaction and a new subcongenic interval active in T cells
Bruesch, Inga, Meier, Pascal, Vital, Marius, Pieper, Dietmar H., Selke, Kristin, Böhlen, Sebastian, Basic, Marijana, Meier, Martin, Glage, Silke, Hundrieser, Joachim, Wedekind, Dirk, Buettner, Manuela; Bleich, André.
Mucosal Immunology. 2019.
Publisher's page
Selective Effects of mTOR Inhibitor Sirolimus on Naïve and CMV-Specific T Cells Extending Its Applicable Range Beyond Immunosuppression
Bak, Szilvia, Tischer, Sabine, Dragon, Anna, Ravens, Sarina, Pape, Lars, Koenecke, Christian, Oelke, Mathias, Blasczyk, Rainer, Maecker-Kolhoff, Britta; Eiz-Vesper, Britta.
Frontiers in Immunology. 2018.
Publisher's page
Bioreactor-based mass production of human iPSC-derived macrophages enables immunotherapies against bacterial airway infections
Ackermann, Mania, Kempf, Henning, Hetzel, Miriam, Hesse, Christina, Hashtchin, Anna Rafiei, Brinkert, Kerstin, Schott, Juliane Wilhelmine, Haake, Kathrin, Kühnel, Mark Philipp, Glage, Silke, Figueiredo, Constanca, Jonigk, Danny, Sewald, Katherina, Schambach, Axel, Wronski, Sabine, Moritz, Thomas, Martin, Ulrich, Zweigerdt, Robert, Munder, Antje; Lachmann, Nico.
Nature Communications. 2018.
Publisher's page
Colony-stimulating factor-1 receptor provides a growth advantage in epithelial cancer cell line A431 in the presence of epidermal growth factor receptor inhibitor gefitinib
Niehus, Svenja Ellen, Tran, Doan Duy Hai, Mischak, Michaela; Koch, Alexandra.
Cellular Signalling. 2018.
Publisher's page
Human Teratoma-Derived Hematopoiesis Is a Highly Polyclonal Process Supported by Human Umbilical Vein Endothelial Cells
Philipp, Friederike, Selich, Anton, Rothe, Michael, Hoffmann, Dirk, Rittinghausen, Susanne, Morgan, Michael A., Klatt, Denise, Glage, Silke, Lienenklaus, Stefan, Neuhaus, Vanessa, Sewald, Katherina, Braun, Armin; Schambach, Axel.
Stem Cell Reports. 2018.
Publisher's page
TBX2 and TBX3 act downstream of canonical WNT signaling in patterning and differentiation of the mouse ureteric mesenchyme
Aydoğdu, Nurullah, Rudat, Carsten, Trowe, Mark-Oliver, Kaiser, Marina, Lüdtke, Timo H., Taketo, Makoto Mark, Christoffels, Vincent M., Moon, Anne; Kispert, Andreas.
Development. 2018.
Publisher's page
Absence of Regulatory T Cells Causes Phenotypic and Functional Switch in Murine Peritoneal Macrophages
Skuljec, Jelena, Jirmo, Adan Chari, Habener, Anika, Talbot, Steven R., Pul, Refik, Grychtol, Ruth, Aydin, Malik, Kleinschnitz, Christoph, Happle, Christine; Hansen, Gesine.
Frontiers in Immunology. 2018.
Publisher's page
MSC stimulate ovarian tumor growth during intercellular communication but reduce tumorigenicity after fusion with ovarian cancer cells
Melzer, Catharina, von der Ohe, Juliane; Hass, Ralf.
Cell Communication and Signaling. 2018.
Publisher's page
Neonatal selection by Toll-like receptor 5 influences long-term gut microbiota composition
Fulde, Marcus, Sommer, Felix, Chassaing, Benoit, van Vorst, Kira, Dupont, Aline, Hensel, Michael, Basic, Marijana, Klopfleisch, Robert, Rosenstiel, Philip, Bleich, André, Bäckhed, Fredrik, Gewirtz, Andrew T.; Hornef, Mathias W..
Nature. 2018.
Publisher's page
Early cell death induced by Clostridium difficile TcdB: Uptake and Rac1-glucosylation kinetics are decisive for cell fate
Beer, Lara-Antonia, Tatge, Helma, Reich, Nicole, Tenspolde, Michel, Olling, Alexandra, Goy, Sebastian, Rottner, Klemens, Alekov, Alexi Kirilov; Gerhard, Ralf.
Cellular Microbiology. 2018.
Publisher's page
Kaposi's Sarcoma-Associated Herpesvirus Nonstructural Membrane Protein pK15 Recruits the Class II Phosphatidylinositol 3-Kinase PI3K-C2upalpha To Activate Productive Viral Replication
Abere, Bizunesh, Samarina, Naira, Gramolelli, Silvia, Rückert, Jessica, Gerold, Gisa, Pich, Andreas; Schulz, Thomas F..
Journal of Virology. 2018.
Publisher's page
Shared and Unique Features Distinguishing Follicular T Helper and Regulatory Cells of Peripheral Lymph Node and Peyer's Patches
Georgiev, Hristo, Ravens, Inga, Papadogianni, Georgia, Halle, Stephan, Malissen, Bernard, Loots, Gabriela G., Förster, Reinhold; Bernhardt, Günter.
Frontiers in Immunology. 2018.
Publisher's page
Blocking the ART2.2/P2X7-system is essential to avoid a detrimental bias in functional CD4 T cell studies
Georgiev, Hristo, Ravens, Inga, Papadogianni, Georgia, Malissen, Bernard, Förster, Reinhold; Bernhardt, Günter.
European Journal of Immunology. 2018.
Publisher's page
In Vitro Fusion of Normal and Neoplastic Breast Epithelial Cells with Human Mesenchymal Stroma/Stem Cells Partially Involves Tumor Necrosis Factor Receptor Signaling
Melzer, Catharina, von der Ohe, Juliane; Hass, Ralf.
STEM CELLS. 2018.
Publisher's page
Enhanced metastatic capacity of breast cancer cells after interaction and hybrid formation with mesenchymal stroma/stem cells (MSC)
Melzer, Catharina, von der Ohe, Juliane; Hass, Ralf.
Cell Communication and Signaling. 2018.
Publisher's page
Loss of CD14 leads to disturbed epithelial-B cell crosstalk and impairment of the intestinal barrier after E. coli Nissle monoassociation
Basic, Marijana, Buettner, Manuela, Keubler, Lydia M., Smoczek, Anna, Bruesch, Inga, Buchheister, Stephanie; Bleich, André.
Scientific Reports. 2018.
Publisher's page
Retinoic acid signaling maintains epithelial and mesenchymal progenitors in the developing mouse ureter
Bohnenpoll, Tobias, Weiss, Anna-Carina, Labuhn, Maurice, Lüdtke, Timo H., Trowe, M.-O.; Kispert, Andreas.
Scientific Reports. 2017.
Publisher's page
Identification of a Predominantly Interferon-uplambda-Induced Transcriptional Profile in Murine Intestinal Epithelial Cells
Selvakumar, Tharini A., Bhushal, Sudeep, Kalinke, Ulrich, Wirth, Dagmar, Hauser, Hansjörg, Köster, Mario; Hornef, Mathias W..
Frontiers in Immunology. 2017.
Publisher's page
GATA3 regulates FLG and FLG2 expression in human primary keratinocytes
Zeitvogel, Jana, Jokmin, Neele, Rieker, Samira, Klug, Ilona, Brandenberger, Christina; Werfel, Thomas.
Scientific Reports. 2017.
Publisher's page
Myc target gene, long intergenic noncoding RNA, Linc00176 in hepatocellular carcinoma regulates cell cycle and cell survival by titrating tumor suppressor microRNAs
Tran, D. D. H., Kessler, C., Niehus, S. E., Mahnkopf, M., Koch, A.; Tamura, T..
Oncogene. 2017.
Publisher's page
The Kaposi's sarcoma-associated herpesvirus (KSHV) non-structural membrane protein K15 is required for viral lytic replication and may represent a therapeutic target
Abere, Bizunesh, Mamo, Tamrat M., Hartmann, Silke, Samarina, Naira, Hage, Elias, Rückert, Jessica, Hotop, Sven-Kevin, Büsche, Guntram; Schulz, Thomas F..
PLOS Pathogens. 2017.
Publisher's page
A SHH-FOXF1-BMP4 signaling axis regulating growth and differentiation of epithelial and mesenchymal tissues in ureter development
Bohnenpoll, Tobias, Wittern, Anna B., Mamo, Tamrat M., Weiss, Anna-Carina, Rudat, Carsten, Kleppa, Marc-Jens, Schuster-Gossler, Karin, Wojahn, Irina, Lüdtke, Timo H.-W., Trowe, Mark-Oliver; Kispert, Andreas.
PLOS Genetics. 2017.
Publisher's page
Sialylation Is Dispensable for Early Murine Embryonic Development in Vitro
Abeln, Markus, Borst, Kristina M., Cajic, Samanta, Thiesler, Hauke, Kats, Elina, Albers, Iris, Kuhn, Maike, Kaever, Volkhard, Rapp, Erdmann, Münster-Kühnel, Anja; Weinhold, Birgit.
ChemBioChem. 2017.
Publisher's page
Filtration and Normalization of Sequencing Read Data in Whole-Metagenome Shotgun Samples.
Chouvarine P, Wiehlmann L, Moran Losada P, DeLuca DS, Tümmler B.
PLoS One. 2016 Oct 19;11(10):e0165015.
Publisher's page
The cystic fibrosis lower airways microbial metagenome.
Moran Losada P, Chouvarine P, Dorda M, Hedtfeld S, Mielke S, Schulz A, Wiehlmann L, Tümmler B.
ERJ Open Res. 2016 May 9;2(2). pii: 00096-2015.
Publisher's page
Molecular Epidemiology of Mutations in Antimicrobial Resistance Loci of Pseudomonas aeruginosa Isolates from Airways of Cystic Fibrosis Patients.
Greipel L, Fischer S, Klockgether J, Dorda M, Mielke S, Wiehlmann L, Cramer N, Tümmler B.
Antimicrob Agents Chemother. 2016 Oct 21;60(11):6726-6734.
Publisher's page
Intraclonal genome diversity of the major Pseudomonas aeruginosa clones C and PA14.
Fischer S, Klockgether J, Morán Losada P, Chouvarine P, Cramer N, Davenport CF, Dethlefsen S, Dorda M, Goesmann A, Hilker R, Mielke S, Schönfelder T, Suerbaum S, Türk O, Woltemate S, Wiehlmann L, Tümmler B.
Environ Microbiol Rep. 2016 Apr;8(2):227-34.
Publisher's page
C/EBPβ is a transcriptional key regulator of IL-36α in murine macrophages.
Nerlich A, Ruangkiattikul N, Laarmann K, Janze N, Dittrich-Breiholz O, Kracht M, Goethe R.
Biochimica et Biophysica Acta. 2015; 1849(8):966-78.
Publisher's page
Transcriptional profiling of intestinal CD4+ T cells in the neonatal and adult mice.
Torow N, Dittrich-Breiholz O, Hornef MW.
Genomics Data. 2015; 5: 371–374.
Publisher's page
The Histamine H4 Receptor Regulates Chemokine Production in Human Natural Killer Cells.
Mommert S, Dittrich-Breiholz O, Stark H, Gutzmer R, Werfel T.
International Archives of Allergy and Immunology. 2015; 166:225-230.
Publisher's page
The Activation of IL-1-Induced Enhancers Depends on TAK1 Kinase Activity and NF-κB p65.
Jurida L, Soelch J, Bartkuhn M, Handschick K, Müller H, Newel D, Weber A, Dittrich-Breiholz O, Schneider H, Bhuju S, Saul VV, Schmitz ML, Kracht M.
Cell Reports. 2015; pii: S2211-1247(15)00002-9.
Publisher's page
Habitat-associated skew of clone abundance in the Pseudomonas aeruginosa population.
Wiehlmann L, Cramer N, Tümmler B.
Environ Microbiol Rep. 2015 Dec;7(6):955-60.
Publisher's page
Interclonal gradient of virulence in the Pseudomonas aeruginosa pangenome from disease and environment.
Hilker R, Munder A, Klockgether J, Losada PM, Chouvarine P, Cramer N, Davenport CF, Dethlefsen S, Fischer S, Peng H, Schönfelder T, Türk O, Wiehlmann L, Wölbeling F, Gulbins E, Goesmann A, Tümmler B.
Environ Microbiol. 2015 Jan;17(1):29-46.
Publisher's page
Stromal cells as trend-setters for cells migrating into the lymph node.
Buettner M, Dittrich-Breiholz O, Falk CS, Lochner M, Smoczek A, Menzel F, Bornemann M, Bode U.
Mucosal Immunology. 2014; 10.1038/mi.2014.97.
Publisher's page
THOC5 controls 3'end-processing of immediate early genes via interaction with polyadenylation specific factor 100 (CPSF100).
Tran DD, Saran S, Williamson AJ, Pierce A, Dittrich-Breiholz O, Wiehlmann L, Koch A, Whetton AD, Tamura T.
Nucleic Acids Research. 2014; 42(19):12249-60.
Publisher's page
DESC1 and MSPL activate influenza A viruses and emerging coronaviruses for host cell entry.
Zmora P, Blazejewska P, Moldenhauer AS, Welsch K, Nehlmeier I, Wu Q, Schneider H, Pöhlmann S, Bertram S.
Journal of Virology. 2014; 88(20):12087-97.
Publisher's page
Thrombin selectively induces transcription of genes in human monocytes involved in inflammation and wound healing.
López ML, Bruges G, Crespo G, Salazar V, Deglesne PA, Schneider H, Cabrera-Fuentes H, Schmitz ML, Preissner KT.
Thrombosis and Haemostasis. 2014; 112(5):992-1001.
Publisher's page
Copper Metabolism Domain-containing 1 Represses Genes that Promote Inflammation and Protects Mice From Colitis and Colitis-associated Cancer.
Li H, Chan L, Bartuzi P, Melton SD, Weber A, Ben-Shlomo S, Varol C, Raetz M, Mao X, Starokadomskyy P, van Sommeren S, Mokadem M, Schneider H, Weisberg R, Westra HJ, Esko T, Metspalu A, Kumar V, Faubion WA, Yarovinsky F, Hofker M, Wijmenga C, Kracht M, Franke L, Aguirre V, Weersma RK, Gluck N, van de Sluis B, Burstein E.
Gastroenterology. 2014; S0016-5085(14)00461-2.
Publisher's page
Identification of Two Forms of TNF Tolerance in Human Monocytes: Differential Inhibition of NF-κB/AP-1- and PP1-Associated Signaling.
Günther J, Vogt N, Hampel K, Bikker R, Page S, Müller B, Kandemir J, Kracht M, Dittrich-Breiholz O, Huber R, Brand K.
The Journal of Immunology. 2014; 192(7):3143-55.
Publisher's page
THOC5 controls 3'end-processing of immediate early genes via interaction with polyadenylation specific factor 100 (CPSF100).
Tran DD, Saran S, Williamson AJ, Pierce A, Dittrich-Breiholz O, Wiehlmann L, Koch A, Whetton AD, Tamura T.
Nucleic Acids Res. 2014 Oct 29;42(19):12249-60.
Publisher's page
Genetic characterization of acquired aplastic anemia by targeted sequencing.
Heuser M, Schlarmann C, Dobbernack V, Panagiota V, Wiehlmann L, Walter C, Beier F, Ziegler P, Yun H, Kade S, Kirchner A, Huang L, Koenecke C, Eder M, Brümmendorf TH, Dugas M, Ganser A, Thol F.
Haematologica. 2014 Sep;99(9):e165-7.
Publisher's page
In vivo imaging of bioluminescent Pseudomonas aeruginosa in an acute murine airway infection model.
Munder A, Wölbeling F, Klockgether J, Wiehlmann L, Tümmler B.
Pathog Dis. 2014 Oct;72(1):74-7.
Publisher's page
Advances in understanding Pseudomonas.
Tümmler B, Wiehlmann L, Klockgether J, Cramer N.
F1000Prime Rep. 2014 Feb 3;6:9.
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Mutations in the cohesin complex in acute myeloid leukemia: clinical and prognostic implications.
Thol F, Bollin R, Gehlhaar M, Walter C, Dugas M, Suchanek KJ, Kirchner A, Huang L, Chaturvedi A, Wichmann M, Wiehlmann L, Shahswar R, Damm F, Göhring G, Schlegelberger B, Schlenk R, Döhner K, Döhner H, Krauter J, Ganser A, Heuser M.
Blood. 2014 Feb 6;123(6):914-20.
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Cyclin-Dependent Kinase 6 Is a Chromatin-Bound Cofactor for NF-κB-Dependent Gene Expression.
Handschick K, Beuerlein K, Jurida L, Bartkuhn M, Müller H, Soelch J, Weber A, Dittrich-Breiholz O, Schneider H, Scharfe M, Jarek M, Stellzig J, Schmitz ML, Kracht M.
Molecular Cell. 2013; 10.1016/j.molcel.2013.12.002.
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The Inflammatory Kinase MAP4K4 Promotes Reactivation of Kaposi's Sarcoma Herpesvirus and Enhances the Invasiveness of Infected Endothelial Cells.
Haas DA, Bala K, Büsche G, Weidner-Glunde M, Santag S, Kati S, Gramolelli S, Damas M, Dittrich-Breiholz O, Kracht M, Rückert J, Varga Z, Keri G, Schulz TF.
PLOS Pathogens. 2013; 10.1371/journal.ppat.1003737.
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Transcriptional regulation of immediate-early gene response by THOC5, a member of mRNA export complex, contributes to the M-CSF-induced macrophage differentiation.
Tran DD, Saran S, Dittrich-Breiholz O, Williamson AJ, Klebba-Färber S, Koch A, Kracht M, Whetton AD, Tamura T.
Cell Death & Disease. 2013; 4:e879.
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Mitogen-activated protein kinase-activated protein kinases 2 and 3 regulate SERCA2a expression and fiber type composition to modulate skeletal muscle and cardiomyocyte function.
Scharf M, Neef S, Freund R, Geers-Knörr C, Franz-Wachtel M, Brandis A, Krone D, Schneider H, Groos S, Menon MB, Chang KC, Kraft T, Meissner JD, Boheler KR, Maier LS, Gaestel M, Scheibe RJ.
Molecular and Cellular Biology. 2013; 33(13):2586-602.
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Interleukin-17 (IL-17) and IL-1 activate translation of overlapping sets of mRNAs, including that of the negative regulator of inflammation, MCPIP1.
Dhamija S, Winzen R, Doerrie A, Behrens G, Kuehne N, Schauerte C, Neumann E, Dittrich-Breiholz O, Kracht M, Holtmann H.
The Journal of Biological Chemistry. 2013; 288(26):19250-9.
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THOC5, a member of the mRNA export complex, contributes to processing of a subset of wingless/integrated (Wnt) target mRNAs and integrity of the gut epithelial barrier.
Saran S, Tran DD, Klebba-Färber S, Moran-Losada P, Wiehlmann L, Koch A, Chopra H, Pabst O, Hoffmann A, Klopfleisch R, Tamura T.
BMC Cell Biol. 2013 Nov 22;14:51. doi: 10.1186/1471-2121-14-51.
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EU FP7 funded COST Action BM1003 "Cell surface virulence determinants of cystic fibrosis pathogens". Developing an international Pseudomonas aeruginosa reference panel.
De Soyza A, Hall AJ, Mahenthiralingam E, Drevinek P, Kaca W, Drulis-Kawa Z, Stoitsova SR, Toth V, Coenye T, Zlosnik JE, Burns JL, Sá-Correia I, De Vos D, Pirnay JP, Kidd TJ, Reid D, Manos J, Klockgether J, Wiehlmann L, Tümmler B, McClean S, Winstanley C.
Microbiology open. 2013 Dec;2(6):1010-23.
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Intraclonal diversity of the Pseudomonas aeruginosa cystic fibrosis airway isolates TBCF10839 and TBCF121838: distinct signatures of transcriptome, proteome, metabolome, adherence and pathogenicity despite an almost identical genome sequence.
Klockgether J, Miethke N, Kubesch P, Bohn YS, Brockhausen I, Cramer N, Eberl L, Greipel J, Herrmann C, Herrmann S, Horatzek S, Lingner M, Luciano L, Salunkhe P, Schomburg D, Wehsling M, Wiehlmann L, Davenport CF, Tümmler B.
Environ Microbiol. 2013 Jan;15(1):191-210.
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The coactivator role of histone deacetylase 3 in IL-1-signaling involves deacetylation of p65 NF-κB.
Ziesché E, Kettner-Buhrow D, Weber A, Wittwer T, Jurida L, Soelch J, Müller H, Newel D, Kronich P, Schneider H, Dittrich-Breiholz O, Bhaskara S, Hiebert SW, Hottiger MO, Li H, Burstein E, Schmitz ML, Kracht M.
Nucleic Acids Research. 2012; 1–20.
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Regulation of NF-κB-dependent gene expression by ligand-induced endocytosis of the interleukin-1 receptor.
Hansen B, Dittrich-Breiholz O, Kracht M, Windheim M.
Cellular Signalling. 2012; 25(1):214-228.
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Kaposi's Sarcoma Herpesvirus K15 Protein Contributes to Virus-Induced Angiogenesis by Recruiting PLCγ1 and Activating NFAT1-dependent RCAN1 Expression.
Bala K, Bosco R, Gramolelli S, Haas DA, Kati S, Pietrek M, Hävemeier A, Yakushko Y, Singh VV, Dittrich-Breiholz O, Kracht M, Schulz TF.
PLoS Pathogens. 2012; 8(9):e1002927.
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Induction of a broad spectrum of inflammation-related genes by Coxsackievirus B3 requires Interleukin-1 signaling.
Rehren F, Ritter B, Dittrich-Breiholz O, Henke A, Lam E, Kati S, Kracht M, Heim A.
Medical Microbiology and Immunology. 2012;
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Human primary keratinocytes show a restricted ability to up-regulate suppressor of cytokine signaling (SOCS)3 compared to autologous macrophages.
Zeitvogel J, Dalpke A, Eiz-Vesper B, Kracht M, Dittrich-Breiholz O, Werfel T, Wittmann M.
The Journal of Biological Chemistry. 2012;
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Deficient CCR7 signaling promotes TH2 polarization and B-cell activation in vivo.
Moschovakis GL, Bubke A, Dittrich-Breiholz O, Braun A, Prinz I, Kremmer E, Förster R.
European Journal of Immunology. 2012; 42(1):48-57.
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Macrophages from patients with atopic dermatitis show a reduced CXCL10 expression in response to staphylococcal a-toxin.
Kasraie S, Niebuhr M, Kopfnagel V, Dittrich-Breiholz O, Kracht M, Werfel T.
Allergy. 2012; 67(1):41-49.
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Molecular epidemiology of chronic Pseudomonas aeruginosa airway infections in cystic fibrosis.
Cramer N, Wiehlmann L, Ciofu O, Tamm S, Høiby N, Tümmler B.
PLoS One. 2012;7(11):e50731.
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Molecular typing and epidemiological investigation of clinical populations of Pseudomonas aeruginosa using an oligonucleotide-microarray.
Ballarini A, Scalet G, Kos M, Cramer N, Wiehlmann L, Jousson O.
BMC Microbiol. 2012 Jul 27;12:152.
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Genotypic analysis of UK keratitis-associated Pseudomonas aeruginosa suggests adaptation to environmental water as a key component in the development of eye infections.
Shankar J, Sueke H, Wiehlmann L, Horsburgh MJ, Tuft S, Neal TJ, Kaye SB, Winstanley C.
FEMS Microbiol Lett. 2012 Sep;334(2):79-86.
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Pseudomonas aeruginosa population structure revisited under environmental focus: impact of water quality and phage pressure.
Selezska K, Kazmierczak M, Müsken M, Garbe J, Schobert M, Häussler S, Wiehlmann L, Rohde C, Sikorski J.
Environ Microbiol. 2012 Aug;14(8):1952-67.
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Effective prevention of Pseudomonas aeruginosa cross-infection at a cystic fibrosis centre - results of a 10-year prospective study.
Wiehlmann L, Cramer N, Ulrich J, Hedtfeld S, Weissbrodt H, Tümmler B.
Int J Med Microbiol. 2012 Mar;302(2):69-77.
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Intranodal Interaction with Dendritic Cells Dynamically Regulates Surface Expression of the Co-stimulatory Receptor CD226 Protein on Murine T Cells.
Seth S, Qiu Q, Danisch S, Maier MK, Braun A, Ravens I, Czeloth N, Hyde R, Dittrich-Breiholz O, Förster R, Bernhardt G.
The Journal of Biological Chemistry. 2011; 286(45):39153-63.
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Deletion of Kaposi's Sarcoma-Associated Herpesvirus FLICE Inhibitory Protein, vFLIP, from the Viral Genome Compromises the Activation of STAT1-Responsive Cellular Genes and Spindle Cell Formation in Endothelial Cells.
Alkharsah KR, Singh VV, Bosco R, Santag S, Grundhoff A, Konrad A, Stürzl M, Wirth D, Dittrich-Breiholz O, Kracht M, Schulz TF.
Journal of Virology. 2011; 85(19):10375-10388.
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Interleukin-1 Activates Synthesis of Interleukin-6 by Interfering with a KH-type Splicing Regulatory Protein (KSRP)-dependent Translational Silencing Mechanism.
Dhamija S, Kuehne N, Winzen R, Doerrie A, Dittrich-Breiholz O, Thakur BK, Kracht M, Holtmann H.
The Journal of Biological Chemistry. 2011; 286(38):33279-33288.
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Identification of novel target genes of nerve growth factor (NGF) in human mastocytoma cell line (HMC-1 (V560G c-Kit)) by transcriptome analysis.
Dutta P, Koch A, Breyer B, Schneider H, Dittrich-Breiholz O, Kracht M, Tamura T.
BMC Genomics. 2011; 12196.
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Down-regulation of interleukin-16 in human mast cells HMC-1 by Clostridium difficile toxins A and B.
Gerhard R, Queisser S, Tatge H, Meyer G, Dittrich-Breiholz O, Kracht M, Feng H, Just I.
Naunyn Schmiedeberg's Archives of Pharmacology. 2011; 383(3):285-295.
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Cellular Gene Expression That Correlates with EBER Expression in Epstein-Barr Virus-Infected Lymphoblastoid Cell Lines.
Gregorovic G, Bosshard R, Karstegl CE, White RE, Pattle S, Chiang AK, Dittrich-Breiholz O, Kracht M, Russ R, Farrell PJ.
Journal of Virology. 2011; 85(7):3535-45.
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Regulation of NF-κB activity by competition between RelA acetylation and ubiquitination.
Li H, Wittwer T, Weber A, Schneider H, Moreno R, Maine GN, Kracht M, Schmitz ML, Burstein E.
Oncogene. 2011;
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c-Jun N-terminal kinase phosphorylates DCP1a to control formation of P bodies.
Rzeczkowski K, Beuerlein K, Müller H, Dittrich-Breiholz O, Schneider H, Kettner-Buhrow D, Holtmann H, Kracht M.
The Journal of Cell Biology. 2011; 194(4):581-596.
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Pseudomonas aeruginosa Genomic Structure and Diversity.
Klockgether J, Cramer N, Wiehlmann L, Davenport CF, Tümmler B.
Front Microbiol. 2011 Jul 13;2:150.
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Genetic characterization indicates that a specific subpopulation of Pseudomonas aeruginosa is associated with keratitis infections.
Stewart RM, Wiehlmann L, Ashelford KE, Preston SJ, Frimmersdorf E, Campbell BJ, Neal TJ, Hall N, Tuft S, Kaye SB, Winstanley C.
J Clin Microbiol. 2011 Mar;49(3):993-1003.
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Genotypic and phenotypic characterization of Pseudomonas aeruginosa isolates from urinary tract infections.
Tielen P, Narten M, Rosin N, Biegler I, Haddad I, Hogardt M, Neubauer R, Schobert M, Wiehlmann L, Jahn D.
Int J Med Microbiol. 2011 Apr;301(4):282-92.
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IL-1-induced Post-transcriptional Mechanisms Target Overlapping Translational Silencing and Destabilizing Elements in IκBζ mRNA.
Dhamija S, Doerrie A, Winzen R, Dittrich-Breiholz O, Taghipour A, Kuehne N, Kracht M, Holtmann H.
The Journal of Biological Chemistry. 2010; 285(38):29165-78.
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Mutant PIK3CA licenses TRAIL and CD95L to induce non-apoptotic caspase-8-mediated ROCK activation.
Ehrenschwender M, Siegmund D, Wicovsky A, Kracht M, Dittrich-Breiholz O, Spindler V, Waschke J, Kalthoff H, Trauzold A, Wajant H.
Cell Death and Differentiation. 2010; 17(9):1435-47.
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Role of the Kaposi's Sarcoma-Associated Herpesvirus K15 SH3 Binding Site in Inflammatory Signaling and B-Cell Activation.
Pietrek M, Brinkmann MM, Glowacka I, Enlund A, Havemeier A, Dittrich-Breiholz O, Kracht M, Lewitzky M, Saksela K, Feller SM, Schulz TF.
Journal of Virology. 2010; 84(16):8231-40.
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Clonal epidemiology of Pseudomonas aeruginosa in cystic fibrosis.
Cramer N, Wiehlmann L, Tümmler B.
Int J Med Microbiol. 2010 Dec;300(8):526-33.
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Genome diversity of Pseudomonas aeruginosa PAO1 laboratory strains.
Klockgether J, Munder A, Neugebauer J, Davenport CF, Stanke F, Larbig KD, Heeb S, Schöck U, Pohl TM, Wiehlmann L, Tümmler B.
J Bacteriol. 2010 Feb;192(4):1113-21.
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Oligomerized tumor necrosis factor-related apoptosis inducing ligand strongly induces cell death in myeloma cells, but also activates proinflammatory signaling pathways.
Berg D, Stühmer T, Siegmund D, Müller N, Giner T, Dittrich-Breiholz O, Kracht M, Bargou R, Wajant H.
FEBS Journal. 2009; 276(23):6912-27.
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Phosphorylation of NF-κB p65 at Ser468 controls its COMMD1-dependent ubiquitination and target gene-specific proteasomal elimination.
Geng H, Wittwer T, Dittrich-Breiholz O, Kracht M, Schmitz ML.
EMBO reports. 2009; 10(4):381-86.
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Role of the C5a receptor (C5aR) in acute and chronic dextran sulfate-induced models of inflammatory bowel disease.
Johswich K, Martin M, Bleich A, Kracht M, Dittrich-Breiholz O, Gessner JE, Suerbaum S, Wende E, Rheinheimer C, Klos A.
Inflammatory Bowel Diseases. 2009; 15(12):1812-23.
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Caspase-8 deficiency in epidermal keratinocytes triggers an inflammatory skin disease.
Kovalenko A, Kim JC, Kang TB, Rajput A, Bogdanov K, Dittrich-Breiholz O, Kracht M, Brenner O, Wallach D.
The Journal of Experimental Medicine. 2009; 206(10):2161-77.
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Nonhematopoietic Cells Control the Outcome of Infection with Listeria monocytogenes in a Nucleotide Oligomerization Domain 1-Dependent Manner.
Mosa A, Trumstedt C, Eriksson E, Soehnlein O, Heuts F, Janik K, Klos A, Dittrich-Breiholz O, Kracht M, Hidmark Å, Wigzell H, Rottenberg ME.
Infection and Immunity. 2009; 77(7):2908-2918.
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Identification and functional characterization of a spliced rhesus rhadinovirus gene with homology to the K15 gene of Kaposi's sarcoma-associated herpesvirus.
Wang L, Pietrek M, Brinkmann MM, Havemeier A, Fischer I, Hillenbrand B, Dittrich-Breiholz O, Kracht M, Chanas S, Blackbourn DJ, Schulz TF.
Journal of General Virology. 2009; 90(Pt 5):1190-1201.
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Pseudomonas aeruginosa population biology in chronic obstructive pulmonary disease.
Rakhimova E, Wiehlmann L, Brauer AL, Sethi S, Murphy TF, Tümmler B.
J Infect Dis. 2009 Dec 15;200(12):1928-35.
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Concordant genotype of upper and lower airways P aeruginosa and S aureus isolates in cystic fibrosis.
Mainz JG, Naehrlich L, Schien M, Käding M, Schiller I, Mayr S, Schneider G, Wiedemann B, Wiehlmann L, Cramer N, Pfister W, Kahl BC, Beck JF, Tümmler B.
Thorax. 2009 Jun;64(6):535-40.
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Visualization of Pseudomonas genomic structure by abundant 8-14mer oligonucleotides.
Davenport CF, Wiehlmann L, Reva ON, Tümmler B.
Environ Microbiol. 2009 May;11(5):1092-104. doi: 10.1111/j.1462-2920.2008.01839.x. Epub 2009 Jan 21.
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CX3CR1+ c-kit+ bone marrow cells give rise to CD103+ and CD103- dendritic cells with distinct functional properties.
del Rio ML, Rodriguez-Barbosa JI, Bölter J, Ballmaier M, Dittrich-Breiholz O, Kracht M, Jung S, Förster R.
The Journal of Immunology. 2008; 181(9):6178-88.
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Transcriptional Regulation of EGR-1 by the Interleukin-1-JNK-MKK7-c-Jun Pathway.
Hoffmann E, Ashouri J, Wolter S, Doerrie A, Dittrich-Breiholz O, Schneider H, Wagner EF, Troppmair J, Mackman N, Kracht M.
The Journal of Biological Chemistry. 2008; 283(18):12120-28.
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Differential Gene Regulation by Epstein-Barr Virus Type 1 and Type 2 EBNA2.
Lucchesi W, Brady G, Dittrich-Breiholz O, Kracht M, Russ R, Farrell PJ.
Journal of Virology. 2008; 82(15):7456-66.
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c-Jun Controls Histone Modifications, NF-κB Recruitment, and RNA Polymerase II Function To Activate the ccl2 Gene.
Wolter S, Doerrie A, Weber A, Schneider H, Hoffmann E, von der Ohe J, Bakiri L, Wagner EF, Resch K, Kracht M.
Molecular and Cellular Biology. 2008; 28(13):4407-4423.
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Transcript profiling of the Pseudomonas aeruginosa genomic islands PAGI-2 and pKLC102.
Klockgether J, Würdemann D, Wiehlmann L, Tümmler B.
Microbiology. 2008 Jun;154(Pt 6):1599-604.
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The neglected intrinsic resistome of bacterial pathogens.
Fajardo A, Martínez-Martín N, Mercadillo M, Galán JC, Ghysels B, Matthijs S, Cornelis P, Wiehlmann L, Tümmler B, Baquero F, Martínez JL.
PLoS One. 2008 Feb 20;3(2):e1619.
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The Mitogen-Activated Protein Kinase (MAPK)-Activated Protein Kinases MK2 and MK3 Cooperate in Stimulation of Tumor Necrosis Factor Biosynthesis and Stabilization of p38 MAPK.
Ronkina N, Kotlyarov A, Dittrich-Breiholz O, Kracht M, Hitti E, Milarski K, Askew R, Marusic S, Lin LL, Gaestel M, Telliez JB.
Molecular and Cellular Biology. 2007; 27(1):170-81.
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Modulation of Host Gene Expression by the K15 Protein of Kaposi's Sarcoma-Associated Herpesvirus.
Brinkmann MM, Pietrek M, Dittrich-Breiholz O, Kracht M, Schulz TF.
Journal of Virology. 2007; 81(1):42-58.
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Functional characterization of the M-type K15-encoded membrane protein of Kaposi's sarcoma-associated herpesvirus.
Wang L, Brinkmann MM, Pietrek M, Ottinger M, Dittrich-Breiholz O, Kracht M, Schulz TF.
Journal of General Virology. 2007; 88(Pt 6):1698-707.
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Functional Analysis of KSRP Interaction with the AU-Rich Element of Interleukin-8 and Identification of Inflammatory mRNA Targets.
Winzen R, Thakur BK, Dittrich-Breiholz O, Shah M, Redich N, Dhamija S, Kracht M, Holtmann H.
Molecular and Cellular Biology. 2007; 27(23):8388-8400.
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Functional genomics of Pseudomonas aeruginosa to identify habitat-specific determinants of pathogenicity.
Wiehlmann L, Munder A, Adams T, Juhas M, Kolmar H, Salunkhe P, Tümmler B.
Int J Med Microbiol. 2007 Nov;297(7-8):615-23.
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Population structure of Pseudomonas aeruginosa.
Wiehlmann L, Wagner G, Cramer N, Siebert B, Gudowius P, Morales G, Köhler T, van Delden C, Weinel C, Slickers P, Tümmler B.
Proc Natl Acad Sci U S A. 2007 May 8;104(19):8101-6.
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Diversity of the abundant pKLC102/PAGI-2 family of genomic islands in Pseudomonas aeruginosa.
Klockgether J, Würdemann D, Reva O, Wiehlmann L, Tümmler B.
J Bacteriol. 2007 Mar;189(6):2443-59.
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Identification of Mouse Genes With Highly Specific Expression Patterns in Differentiated Intestinal Epithelium.
Schröder N, Sekhar A, Geffers I, Müller J, Dittrich-Breiholz O, Kracht M, Wedemeyer J, Gossler A.
Gastroenterology. 2006; 130(3):902-7.
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Inhibition of mRNA deadenylation and degradation by different types of cell stress.
Gowrishankar G, Winzen R, Dittrich-Breiholz O, Redich N, Kracht M, Holtmann H.
Biological Chemistry. 2006; 387(3):323-7.
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Small interfering RNAs generated by recombinant dicer induce inflammatory gene expression independent from the TAK1-NF?B-MAPK signaling pathways.
Kettner-Buhrow D, Dittrich-Breiholz O, Schneider H, Wolter S, Resch K, Kracht M.
Biochemical and Biophysical Research Communications. 2006; 347(3):566-73.
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Induction of C3 and CCL2 by C3a in Keratinocytes: A Novel Autocrine Amplification Loop of Inflammatory Skin Reactions.
Purwar R, Wittmann M, Zwirner J, Oppermann M, Kracht M, Dittrich-Breiholz O, Gutzmer R, Werfel T.
The Journal of Immunology. 2006; 177(7):4444-50.
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Cell target genes of Epstein–Barr virus transcription factor EBNA-2: induction of the p55a regulatory subunit of PI3-kinase and its role in survival of EREB2.5 cells.
Spender LC, Lucchesi W, Bodelon G, Bilancio A, Karstegl CE, Asano T, Dittrich-Breiholz O, Kracht M, Vanhaesebroeck B, Farrell PJ.
Journal of General Virology. 2006; 87(Pt 10):2859-67.
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Host chemokine (C-C motif) ligand-2 (CCL2) is differentially regulated in HIV type 1 (HIV-1)-infected individuals.
Ansari AW, Bhatnagar N, Dittrich-Breiholz O, Kracht M, Schmidt RE, Heiken H.
International Immunology. 2006; 18(10):1443-51.
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Sequence diversity of the mucABD locus in Pseudomonas aeruginosa isolates from patients with cystic fibrosis.
Bragonzi A, Wiehlmann L, Klockgether J, Cramer N, Worlitzsch D, Döring G, Tümmler B.
Microbiology. 2006 Nov;152(Pt11):3261-9.
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GeneChip expression analysis of the VqsR regulon of Pseudomonas aeruginosa TB.
Juhas M, Wiehlmann L, Salunkhe P, Lauber J, Buer J, Tümmler B.
FEMS Microbiol Lett. 2005 Jan 15;242(2):287-95.
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Alpha-toxin is produced by skin colonizing Staphylococcus aureus and induces a T helper type 1 response in atopic dermatitis.
Breuer K, Wittmann M, Kempe K, Kapp A, Mai U, Dittrich-Breiholz O, Kracht M, Mrabet-Dahbi S, Werfel T.
Clinical & Experimental Allergy. 2005; 35(8):1088-95.
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MEK1-dependent Delayed Expression of Fos-related Antigen-1 Counteracts c-Fos and p65 NF-?B-mediated Interleukin-8 Transcription in Response to Cytokines or Growth Factors.
Hoffmann E, Thiefes A, Buhrow D, Dittrich-Breiholz O, Schneider H, Resch K, Kracht M.
The Journal of Biological Chemistry. 2005; 280(10):9706-18.
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Simultaneous Blockade of NF?B, JNK, and p38 MAPK by a Kinase-inactive Mutant of the Protein Kinase TAK1 Sensitizes Cells to Apoptosis and Affects a Distinct Spectrum of Tumor Necrosis Target Genes.
Thiefes A, Wolter S, Mushinski JF. Hoffmann E, Dittrich-Breiholz O, Graue N, Dörrie A, Schneider H, Wirth D, Luckow B, Resch K, Kracht M.
The Journal of Biological Chemistry. 2005; 280(30):27728-41.
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Death Receptor-Induced Signaling Pathways Are Differentially Regulated by Gamma Interferon Upstream of Caspase 8 Processing.
Siegmund D, Wicovsky A, Schmitz I, Schulze-Osthoff K, Kreuz S, Leverkus M, Dittrich-Breiholz O, Kracht M, Wajant H.
Molecular and Cellular Biology. 2005; 25(15):6363-79.
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Alpha-toxin is produced by skin colonizing Staphylococcus aureus and induces a T helper type 1 response in atopic dermatitis.
Breuer K, Wittmann M, Kempe K, Kapp A, Mai U, Dittrich-Breiholz O, Kracht M, Mrabet-Dahbi S, Werfel T.
Clinical & Experimental Allergy. 2005; 35(8):1088-95.
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Structure of Pseudomonas aeruginosa populations analyzed by single nucleotide polymorphism and pulsed-field gel electrophoresis genotyping.
Morales G, Wiehlmann L, Gudowius P, van Delden C, Tümmler B, Martínez JL, Rojo F.
J Bacteriol. 2004 Jul;186(13):4228-37.
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Comparative analysis of T-cell costimulation and CD43 activation reveals novel signaling pathways and target genes.
Mattioli I, Dittrich-Breiholz O, Livingstone M, Kracht M, Schmitz ML.
Blood. 2004; 104(10):3302-4.
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NFκB activation by Fas is mediated through FADD, caspase-8, and RIP and is inhibited by FLIP.
Kreuz S, Siegmund D, Rumpf J, Samel D, Leverkus M, Janssen O, Häcker G, Dittrich-Breiholz O, Kracht M, Scheurich P, Wajant H.
The Journal of Cell Biology. 2004; 166(3):369-80.
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Entwicklung und Evaluierung eines DNA Mikroarrays für entzündungsrelevante Gene.
Dittrich-Breiholz O, Schneider H, Wehmeier L, Resch K, Kracht M.
Biospektrum. 2003; 1/03:88-92.
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Biochips in klinischen Applikationen: Ermittlung von Genexpressionsprofilen im Entzündungsprozess.
Wehmeier L, Dittrich-Breiholz O, Kracht M.
Managment und Krankenhaus. 2003;
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Disruption of the c-JUN-JNK Complex by a Cell-permeable Peptide Containing the c-JUN δ Domain Induces Apoptosis and Affects a Distinct Set of Interleukin-1-induced Inflammatory Genes.
Holzberg D, Knight CG, Dittrich-Breiholz O, Schneider H, Dörrie A, Hoffmann E, Resch K, Kracht M.
The Journal of Biological Chemistry. 2003; 278(41):40213-23.
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Multiple control of interleukin-8 gene expression.
Hoffmann E, Dittrich-Breiholz O, Holtmann H, Kracht M.
Journal of Leukocyte Biology. 2002; 72(5):847-855.
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