Szenker-Ravi, E., Ott, T., Khatoo, M., Moreau de Bellaing A., Goh W. X., Beckers A. et al. Discovery of a genetic module essential for assigning left–right asymmetry in humans and ancestral vertebrates. Nat Genet 54, 62–72 (2022)




Beckers A., Fuhl F., Ott T., Boldt K., Brislinger M., Walentek P., Schuster-Gossler K., Hegermann J., Alten L., Kremmer E., Przykopanski A., Serth K, Ueffing M., Blum M., Gossler A. The highly conserved FOXJ1 target CFAP161 is dispensable for motile ciliary function in mouse and Xenopus. Sci Rep. 2021; 11: 13333. Published online 2021 Jun 25. doi: 10.1038/s41598-021-92495-3




Beckers A, Adis C, Schuster-Gossler K, Tveriakhina L, Ott T, Fuhl F, Hegermann J, Boldt K, Serth K, Rachev E, Alten L, Kremmer E, Ueffing M, Blum M, Gossler A. Development. 2020 Jun 15;147(21):dev188052. doi: 10.1242/dev.188052.




Rachev, Ev.; Schuster-Gossler, K.; Fuhl, F.; Ott, T.; Tveriakhina, L.; Beckers, A.; Hegermann, J.; Boldt, K.; Mai, M.; Kremmer, E.; Ueffing, M.; Blum ,M.; Gossler,A..CFAP43 modulates ciliary beating in mouse and Xenopus. Dev. Biol., 2019, Elsevier Inc.


Ronkina, N.; Schuster-Gossler, K.; Hansmann, F.; Kunze-Schumacher, H.; Sandrock, I.; Yakovleva, T.; Lafera, J.; Baumgartner, W.; Krueger, A.; Prinz, I.; Gossler, A.; Kotlyarov, A.; Gaestel,M.,Germ Line Deletion Reveals a Nonessential Role of Atypical Mitogen-Activated Protein Kinase 6/Extracellular Signal-Regulated Kinase 3.Mol.Cell.Biol., 2019, 39, 6, e00516-18 [pii]




Tveriakhina, L., Schuster-Gossler, K., Jarrett, S.M., Andrawes, M.B., Rohrbach, M., Blacklow, S.C., Gossler, A., 2018. The ectodomains determine ligand function in vivo and selectivity of DLL1 and DLL4 toward NOTCH1 and NOTCH2 in vitro. Elife 7, 25477. doi:10.7554/eLife.40045


Beckers, A., Ott, T., Schuster-Gossler, K., Boldt, K., Alten, L., Ueffing, M., Blum, M., Gossler, A., 2018. The evolutionary conserved FOXJ1 target gene Fam183b is essential for motile cilia in Xenopus but dispensable for ciliary function in mice. Sci Rep 8, 14678. doi:10.1038/s41598-018-33045-2



Stauber, M., Boldt, K., Wrede, C., Weidemann, M., Kellner, M., Schuster-Gossler, K., Kühnel, M.P., Hegermann, J., Ueffing, M., Gossler, A., 2017. 1700012B09Rik, a FOXJ1 effector gene active in ciliated tissues of the mouse but not essential for motile ciliogenesis. Dev Biol. doi:10.1016/j.ydbio.2017.06.027


Stauber, M., Weidemann, M., Dittrich Breiholz, O., Lobschat, K., Alten, L., Mai, M., Beckers, A., Kracht, M., Gossler, A., 2017. Identification of FOXJ1 effectors during ciliogenesis in the foetal respiratory epithelium and embryonic left-right organiser of the mouse. Dev Biol 423, 170–188. doi:10.1016/j.ydbio.2016.11.019



Schuster-Gossler, K., Cordes, R., Müller, J., Geffers, I., Delany-Heiken, P., Taft, M., Preller, M., Gossler, A., 2016. Context-Dependent Sensitivity to Mutations Disrupting the Structural Integrity of Individual EGF Repeats in the Mouse Notch Ligand DLL1. Genetics 202, 1119–1133. doi:10.1534/genetics.115.184515


Weidemann, M., Schuster-Gossler, K., Stauber, M., Wrede, C., Hegermann, J., Ott, T., Boldt, K., Beyer, T., Serth, K., Kremmer, E., Blum, M., Ueffing, M., Gossler, A., 2016. CFAP157 is a murine downstream effector of FOXJ1 that is specifically required for flagellum morphogenesis and sperm motility. Development 143, 4736–4748. doi:10.1242/dev.139626



Kristina Preuße, Lena Tveriakhina, Karin Schuster-Gossler, Cláudia Gaspar, Alexandra Isabel Rosa2, Domingos Henrique, Achim Gossler, Michael Stauber. (2015). Context-Dependent Functional Divergence of the Notch Ligands DLL1 and DLL4 In Vivo. PLoS Genet 11(6):e1005328.


Katrin Serth, Karin Schuster-Gossler, Elisabeth Kremmer, Birte Hansen, Britta Marohn-Köhn, Achim Gossler. (2015). O-fucosylation of DLL3 is required for its function during somitogenesis. PLoS ONE 10(4):e0123776.



Müller, J., Rana, N. A., Serth, K., Kakuda, S., Haltiwanger, R. S. and Gossler, A. (2014). O-fucosylation of the Notch Ligand mDLL1 by POFUT1 Is Dispensable for Ligand Function. PLoS ONE 9, e88571.


Braune, E.-B., Schuster-Gossler, K., Lyszkiewicz, M., Serth, K., Preusse, K., Madlung, J., Macek, B., Krueger, A. and Gossler, A. (2014). S/T Phosphorylation of DLL1 Is Required for Full Ligand Activity In Vitro but Dispensable for DLL1 Function In Vivo during Embryonic Patterning and Marginal Zone B Cell Development. Molecular and Cellular Biology 34, 1221–1233.


Manoj B. Menon, Akihiro Sawada, Anuhar Chaturvedi, Pooja Mishra, Karin Schuster-Gossler, Melanie Galla, Axel Schambach, Achim Gossler, Reinhold Förster, Michael Heuser, Alexey Kotlyarov, Makoto Kinoshita, Matthias Gaestel (2014) Genetic deletion of SEPT7 reveals a cell type-specific role of septins in microtubule destabilization for the completion of cytokinesis. PLoS Genet 10(8):e1004558.



Redeker, C., Schuster-Gossler, K., Kremmer, E. and Gossler, A. (2013). Normal development in mice over-expressing the intracellular domain of DLL1 argues against reverse signaling by DLL1 in vivo. PLoS ONE 8, e79050.


Zender, S., Nickeleit, I., Wuestefeld, T., Sörensen, I., Dauch, D., Bozko, P., El-Khatib, M., Geffers, R., Bektas, H., Manns, M. P., et al. (2013). A Critical Role for Notch Signaling in the Formation of Cholangiocellular Carcinomas. Cancer Cell 23, 784–795.



Alten, L., Schuster-Gossler, K., Eichenlaub, M. P., Wittbrodt, B., Wittbrodt, J. and Gossler, A. A novel mammal-specific three partite enhancer element regulates node and notochord-specific Noto expression. PLoS ONE 7, e47785.


Alten, L., Schuster-Gossler, K., Beckers, A., Groos, S., Ulmer, B., Hegermann, J., Ochs, M. and Gossler, A. Differential regulation of node formation, nodal ciliogenesis and cilia positioning by Noto and Foxj1. Development 139, 1276–1284.



Girós A, Grgur K, Gossler A, Costell M. Α5β1 integrin-mediated adhesion to fibronectin is required for axis elongation and somitogenesis in mice. PLoS ONE. 6(7):e22002. 


Hoch M, Fischer P, Stapel B, et al. Erythropoietin preserves the endothelial differentiation capacity of cardiac progenitor cells and reduces heart failure during anticancer therapies. Cell Stem Cell. 2011;9(2):131–143. 



Xu k, Nieuwenhuis E, Cohen BL, Wang W, Canty AJ, Danska JS, Coultas L, Rossant J, Wu MYJ, Piscione TD, Nagy A, Gossler A, Hicks GG, Hui C, Henkelman RM, Yu LX, Sled JG, Gridley T and Egan SE. Lunatic Fringe-mediated Notch signaling is required for lung alveogenesis. Am J Physiol Lung Cell Mol Physiol vol. 298 (1) pp. L45-56



Benedito R., Roca C., Sörensen I., Adams S., Gossler A., Fruttiger M. and Adams R.H. (2009). The Notch ligands Dll4 and Jagged1 have opposing effects on angiogenesis. Cell 137, 1124-1135


Sörensen, I., Adam, R., and Gossler, A. (2009). DLL1 mediated Notch activation regulates endothelial identity in mouse fetal arteries. Blood, 113, 5680-5688

Notch signalling in the paraxial mesoderm is most sensitive to reduced Pofut1 levels during early mouse development. (2009). Schuster-Gossler K., Harris B., Johnson KR., Serth J. and Gossler A. BMC Dev Biol. 2009 Jan 22;9:6


Feyerabend TB, Terszowski G, Tietz A, Blum C, Luche H, Gossler A, Gale NW, Radtke F, Fehling HJ, and Rodewald HR. (2009). Deletion of Notch1 Converts Pro-T Cells to Dendritic Cells and Promotes Thymic B Cells by Cell-Extrinsic and Cell-Intrinsic Mechanisms. Immunity, 30, 67-79.


Rocha SF., Lopes SS., Gossler A., Henrique D. (2009). Dll1 and Dll4 function sequentially in the retina and pV2 domain of the spinal cord to regulate neurogenesis and create cell diversity. Developmental Biology, 328, 54-65



Feller J., Schneider A., Schuster-Gossler K., and Gossler A. (2008). Non-cyclic Notch activity in the presomitic mesoderm demonstrates uncoupling of somite compartmentalization and boundary formation. Genes and Development, 22, 2166-2171.


Estrach S., Cordes R., Hozumi K., Gossler A., and Watt FM. (2008). Role of the Notch ligand Delta1 in embryonic and adult mouse epidermis. The Journal of Investigative Dermatology, 128, 825-832.



Schuster-Gossler K., Cordes R. and Gossler A. (2007). Premature myogenic differentiation and depletion of progenitor cells cause severe muscle hypotrophy in Delta1 mutants. PNAS, 104, 537-542.


Limbourg A., Ploom M., Elligsen D., Sörensen I., Ziegelhoeffer T., Gossler A., Drexler H. and Limbourg F. P. (2007) The Notch Ligand Delta-like 1 (Dll1) is Essential for Postnatal Arteriogenesis. Circ. Res., 100, 363-371.


Cheng H-T., Kim M., Valerius M.T., Surendran K., Schuster-Gossler K., Gossler A., McMahon A.P.and Kopan R. (2007) Notch2, but not Notch1, is required for proximal fate acquisition in the mammalian nephron. Development, 134, 801-811.


Geffers I., Serth K., Chapman G., Jaekel R., Schuster-Gossler K., Cordes R., Sparrow D.B., Kremmer E., Dunwoodie S.L., Klein T., and Gossler A. (2007). Divergent functions and distinct localization of the Notch ligands DLL1 and DLL3 in vivo. The Journal of Cell Biology, 178, 465-476.


Wittler L., Shin E., GroteP., Kispert A., Beckers A., Gossler A., Werber M, and Herrmann B. G. (2007). Expression of Msgn1 in the presomitic mesoderm is controlled by synergism of WNT signaling and Tbx6. EMBO Reports, 8, 784-789.


Teppner I., Becker S., Hrabe de Angelis, M. Gossler A., and Beckers J. (2007). Compartmentalised expression of Delta-like 1 in epithelial somites is required for the formation of intervertebral joints. BMC Developmental Biology 7:68 (17 June 2007)


Beckers A., Alten L., Viebahn C., Andre P. and Gossler A. (2007). The mouse homeobox gene Noto regulates node morphogenesis, notochordal ciliogenesis, and left-right patterning. PNAS, 104, 15765–15770.


Yojiro Yamanaka Y., Tamplin O.J., Beckers A., Gossler A., and Rossant J. (2007). A changing genetic hierarchy regulates morphogenesis in three regions of the mouse notochord. Dev. Cell, 13, 884-896.



Sekita Y., Wagatsuma H., Irie M., Kobayashi S., Kohda T., Matsuda J., Yokoyama M., Ogura A., Schuster-Gossler K., Gossler A., Ishino F. and Kaneko-Ishino T. (2006) Aberrant regulation of imprinted gene expression in Gtl2lacZ mice. Cytogenetic and Genome Research, 113, 223-229.


Schröder N., Sekhar A., Geffers I., Müller J., Dittrich-Breiholz O., Kracht M., Wedemeyer J. and Gossler A. (2006). Identification of mouse genes with highly specific expression patterns in differentiated intestinal epithelium. Gastroenterology, 130, 902-907.


Mizuguchi R., Kriks S., Cordes R., Gossler A., Ma Q., and Goulding M. (2006). Ascl1 and Gsh1/2 control inhibitory and excitatory cell fate in spinal sensory interneurons. Nat Neurosci., 9, 770-778.


Ji SJ, Zhuang B., Falco C., Schneider A., Schuster-Gossler K., Gossler A., and Sockanathan S. (2006) Mesodermal and neuronal retinoids regulate the induction and maintenance of limb innervating spinal motor neurons. Dev Biol, 297, 249-61.


Castro D.S., Skowronska-Krawczyk D., Armant O., Donaldson I.J., Parras C., Hunt C., Critchley J., Nguyen L., Gossler A., Göttgens B., Matter J.-M., and Guillemot F. (2006). Proneural bHLH and Brn proteins co-regulate a neurogenic programme through cooperative binding to a conserved DNA motif. Dev. Cell 11, 831-44.



Kiernan, A. E., Cordes R., Kopan R., Gossler A. and Gridley T. (2005). The Notch ligands DLL1 and JAG2 act synergistically to regulate hair cell development in the mammalian inner ear. Development, 132, 4353-4362.



Cordes, R., Schuster-Gossler, K., Serth, K. and Gossler, A. (2004). Specification of vertebral identity is coupled to Notch signalling and the segmentation clock. Development, 131, 1221-1233.


Bussen, M., Petry, M., Schuster-Gossler, K., Leitges, M. Gossler, A. and Kispert, A. (2004). The T-box transcription factor Tbx18 maintains the separation of anterior and posterior somite compartments. Genes & Development, 18, 1209-1221


Ben Abdelkhalek H., Beckers A., Schuster-Gossler K., Pavlova M.N., Burkhardt H., Lickert H., Rossant J., Reinhardt R., Schalkwyk L.C., Müller I., Herrmann B.G., Ceolin M., Rivera-Pomar R., and Gossler A. (2004). The mouse homeobox gene Not is required for caudal notochord development and affected by the truncate mutation. Genes & Development, 18, 1725-36.


Hofmann M., Schuster-Gossler K., Watabe-Rudolph M., Auhlela A., Herrman B.G. and Gossler A. (2004). WNT signaling, in synergy with T/TBX6 controls Notch signaling by regulating Dll1 expression in the presomitic mesoderm of mouse embryos. Genes & Development, 18, 2712-2717.



Aulehla A., Wehrle C., Brand-Saberi B., Kemler R., Gossler A., Kanzler B., Herrmann B. G. (2003). Wnt3a plays a major role in the segmentation clock controlling somitogenesis. Dev. Cell 4(3), 395-406.


Serth, K., Schuster-Gossler, K., Cordes, R. and Gossler, A. (2003). Transcriptional oscillation of Lunatic fringe is essential for somitogenesis. Genes & Development 17, 912-925


Kispert, A. and Gossler, A. (2004). Introduction into early mouse development. In Handbook of Experimental Animals: The Laboratory Mouse (H.J. Hedrich, ed.). Academic press


Takahashi, Y., Inoue, T., Gossler, A. and Saga, Y. (2003). Feedback loops comprising Dll1, Dll3 and Mesp2, and differential involvement of Psen1 are essential for rostro-caudal patterning of somites. Development, 130, 4259-4268