References

Research publications:

Schimmel K, Jung M, Foinquinos A, et al. and Thum T. Natural Compound Library Screening Identifies New Molecules for the Treatment of Cardiac Fibrosis and Diastolic Dysfunction. Circulation. 2020 Mar 3;141(9):751-767. https://doi.org/10.1161/CIRCULATIONAHA.119.042559

Kreutzer FP, Meinecke A, Mitzka S, et al. and Thum T. Development and characterization of anti-fibrotic natural compound similars with improved effectivity. Basic Res Cardiol. 2022 Mar 2;117(1):9. https://doi.org/10.1007/s00395-022-00919-6 

Mester-Tonczar J, Winkler J, Einzinger P, et al. and Thum T, Gyöngyösi M. Association between Circular RNA CDR1as and Post-Infarction Cardiac Function in Pig Ischemic Heart Failure: Influence of the Anti-Fibrotic Natural Compounds Bufalin and Lycorine. Biomolecules. 2020 Aug 14;10(8):1180. https://doi.org/10.3390/biom10081180

Kreutzer FP, Meinecke A, Schmidt K, Fiedler J, Thum T. Alternative strategies in cardiac preclinical research and new clinical trial formats. Cardiovasc Res. 2022 Feb 21;118(3):746-762. https://doi.org/10.1093/cvr/cvab075

Communication materials:

IBT Lower Saxony: 2,1 Mio. Euro für innovative Behandlungen der Lunge - zukunft.niedersachsen

Medizinische Hochschule Hannover : Naturstoff-Spray gegen Lungenfibrose