Signalübertragung und Genregulation

Signaltransduktionspfade
Huber, René/Klinische Chemie/MHH

 

Forschungskonzept: Unsere Arbeitsgruppe beschäftigt sich mit Mechanismen, die an der Terminierung TNF-induzierter Signalübertragung während der TNF-Langzeitinkubation beteiligt sind bzw. die Ausprägung der TNF-Toleranz vermitteln.

 

Laufende Forschungsprojekte:

  • Regulation des nicht-kanonischen NF-κB-Signalwegs durch GSK3 unter TNF-Langzeitinkubation
    (Dr. R. Huber, Dr. R. Bikker, Prof. Dr. K. Brand)
  • Ubiquitin als Regulator der Signalterminierung bei TNF-Langzeitinkubation
    (Dr. M. Christmann)
  • Funktion von MARCKS bei TNF-Toleranz
    (Dr. B. Welz)

 

 

 

 

 

Projektleitung: Dr. R. Huber, Prof. Dr. K. Brand
huber.rene@mh-hannover.de, brand.korbinian@mh-hannover.de

 

Doktoranden:

Leonie Hoffmeister (M.Sc. Biochemie, Doktorandin)
Telefon: 0511 532 5388
email: hoffmeister.leonie@mh-hannover.de

Mareike Weber (M.Sc. Biochemie, Doktorandin)
Telefon: 0511 532 5887
email: weber.mareike@mh-hannover.de

 

Förderung: DFG, DGKL

 

Ausgewählte Publikationen:

  • Huber R, Kirsten H, Näkki A, Pohlers D, Thude H, Eidner T, Heinig M, Brand K, Ahnert P, Kinne RW. (2019). Association of human FOS promoter variants with the occurrence of knee-osteoarthritis in a case control association study. Int J Mol Sci. 20: 1382.
  • Welz B, Bikker R, Junemann J, Christmann M, Neumann K, Weber M, Hoffmeister L, Preuß K, Pich A, Huber R, Brand K. (2019). Proteome and phospho-proteome analysis in TNF long term-exposed primary human monocytes. Int J Mol Sci. 20: 1241.
  • Yu J, Duong VHH, Westphal K, Westphal A, Suwandi A, Grassl GA, Brand K, Chan AC, Föger N, Lee KH. (2018). Surface receptor Toso controls B cell-mediated regulation of T cell immunity. J Clin Invest. 128: 1820-1836.
  • Jyotsana N, Sharma A, Chaturvedi A, Scherr M, Kuchenbauer F, Sajti L, Barchanski A, Lindner R, Noyan F, Sühs KW, Grote-Koska D, Brand K, Vornlocher HP, Stanulla M, Bornhauser B, Bourquin JP, Eder M, Thol F, Ganser A, Humphries RK, Ramsay E, Cullis P, Heuser M. (2018). RNA interference efficiently targets human leukemia driven by a fusion oncogene in vivo. Leukemia. 32: 224-226.
  • Huber R, Bikker R, Welz B, Christmann M, Brand K. (2017). TNF tolerance in monocytes and macrophages: characteristics and molecular mechanisms. J Immunol Res. 2017: 9570129.
  • Bikker R, Christmann M, Preuß K, Welz B, Friesenhagen J, Dittrich-Breiholz O, Huber R, Brand K. (2017). TNF phase III signalling in tolerant cells is tightly controlled by A20 and CYLD. Cell Signal. 37: 123-135.
  • Schinke J, Kolog Gulko M, Christmann M, Valerius O, Stumpf SK, Stirz M, Braus GH. (2016). The DenA/DEN1 Interacting Phosphatase DipA Controls Septa Positioning and Phosphorylation-Dependent Stability of Cytoplasmatic DenA/DEN1 during Fungal Development. PLoS Genet. 12: e1005949.
  • Frantzi M, Van Kessel KE, Zwarthoff EC, Marquez M, Rava M, Malats N, Merseburger AS, Katafigiotis I, Stravodimos K, Mullen W, Zoidakis J, Makridakis M, Pejchinovski M, Critselis E, Lichtinghagen R, Brand K, Dakna M, Roubelakis MG, Theodorescu D, Vlahou A, Mischak H, Anagnou NP. (2016). Development and validation of urine-based peptide biomarker panels for detecting bladder cancer in a multi-center study. Clin Cancer Res. 22: 4077-4086.
  • Huber R, Pietsch D, Günther J, Welz B, Vogt N, Brand K. (2014). Regulation of monocyte differentiation by specific signaling modules and associated transcription factor networks. Cell Mol Life Sci. 71: 63-92.
  • Gunther J, Vogt N, Hampel K, Bikker R, Page S, Müller B, Kandemir J, Kracht M, Dittrich-Breiholz O, Huber R, Brand K. (2014). Identification of two forms of TNF tolerance in human monocytes: differential inhibition of NF-κB/AP-1- and PP1-associated signalling. J Immunol. 192: 3143-3155.
  • Lichtinghagen R, Pietsch D, Bantel H, Manns MP, Brand K, Bahr MJ. (2013). The enhanced liver fibrosis (ELF) score: normal values, influence factors, and proposed cut-off values. J Hepatol. 59: 236-242.
  • Christmann M, Schmaler T, Gordon C, Huang X, Bayram O, Schinke J, Stumpf S, Dubiel W, Braus GH. (2013). Control of multicellular development by the physically interacting deneddylases DEN1/DenA and COP9 signalosome. PLoS Genet. 9: e1003275.
  • Gutsch R, Kandemir JD, Pietsch D, Cappello C, Meyer J, Simanowski K, Huber R, Brand K. (2011). CCAAT/enhancer-binding protein beta inhibits proliferation in monocytic cells by affecting the retinoblastoma protein/E2F/cyclin E pathway but is not directly required for macrophage morphology. J Biol Chem. 286: 22716-22729.