Publikationen
2021
- Combined high-throughput library screening and next generation RNA sequencing uncover microRNAs controlling human cardiac fibroblast biology.
Schimmel K, Stojanović SD, Huang CK, Jung M, Meyer MH, Xiao K, Grote-Levi L, Bär C, Pfanne A, Mitzka S, Just A, Geffers R, Bock K, Kenneweg F, Kleemiß F, Falk CS, Fiedler J, Thum T. J Mol Cell Cardiol. 2021 Jan;150:91-100. doi: 10.1016/j.yjmcc.2020.10.008.
- Effect of everolimus-based drug regimens on CMV-specific T-cell functionality after renal transplantation: 12-month ATHENA subcohort-study results.
Hauser IA, Marx S, Sommerer C, Suwelack B, Dragun D, Witzke O, Lehner F, Schiedel C, Porstner M, Thaiss F, Neudörfl C, Falk CS, Nashan B, Sester M. Eur J Immunol. 2021 Apr;51(4):943-955. doi: 10.1002/eji.202048855.
- Knockout-Induced Pluripotent Stem Cells for Disease and Therapy Modeling of IL-10-Associated Primary Immunodeficiencies.
Sens J, Hoffmann D, Lange L, Vollmer Barbosa P, Morgan M, Falk CS, Schambach A. Hum Gene Ther. 2021 Jan;32(1-2):77-95. doi: 10.1089/hum.2020.235.
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Growth Factors Assessed during Kasai Procedure in Liver and Serum Are Not Predictive for the Postoperative Liver Deterioration in Infants with Biliary Atresia.
Madadi-Sanjani O, Froemmel S, Falk CS, Vieten G, Petersen C, Kuebler JF, Klemann C. J Clin Med. 2021 May 5;10(9):1978. doi: 10.3390/jcm10091978.
- Genetic Correction of IL-10RB Deficiency Reconstitutes Anti-Inflammatory Regulation in iPSC-Derived Macrophages.
Hoffmann D, Sens J, Brennig S, Brand D, Philipp F, Vollmer Barbosa P, Kuehle J, Steinemann D, Lenz D, Buchegger T, Morgan M, Falk CS, Klein C, Lachmann N, Schambach A. J Pers Med. 2021 Mar 20;11(3):221. doi: 10.3390/jpm11030221.
- Influenza A virus-induced thymus atrophy differentially affects dynamics of conventional and regulatory T-cell development in mice.
Elfaki Y, Robert PA, Binz C, Falk CS, Bruder D, Prinz I, Floess S, Meyer-Hermann M, Huehn J. Eur J Immunol. 2021 Feb 26. doi: 10.1002/eji.202048981.
- Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics.
Muus C, Luecken MD, Eraslan G, Sikkema L, Waghray A, Heimberg G, Kobayashi Y, Vaishnav ED, Subramanian A, Smillie C, Jagadeesh KA, Duong ET, Fiskin E, Triglia ET, Ansari M, Cai P, Lin B, Buchanan J, Chen S, Shu J, Haber AL, Chung H, Montoro DT, Adams T, Aliee H, Allon SJ, Andrusivova Z, Angelidis I, Ashenberg O, Bassler K, Bécavin C, Benhar I, Bergenstråhle J, Bergenstråhle L, Bolt L, Braun E, Bui LT, Callori S, Chaffin M, Chichelnitskiy E, Chiou J, Conlon TM, Cuoco MS, Cuomo ASE, Deprez M, Duclos G, Fine D, Fischer DS, Ghazanfar S, Gillich A, Giotti B, Gould J, Guo M, Gutierrez AJ, Habermann AC, Harvey T, He P, Hou X, Hu L, Hu Y, Jaiswal A, Ji L, Jiang P, Kapellos TS, Kuo CS, Larsson L, Leney-Greene MA, Lim K, Litviňuková M, Ludwig LS, Lukassen S, Luo W, Maatz H, Madissoon E, Mamanova L, Manakongtreecheep K, Leroy S, Mayr CH, Mbano IM, McAdams AM, Nabhan AN, Nyquist SK, Penland L, Poirion OB, Poli S, Qi C, Queen R, Reichart D, Rosas I, Schupp JC, Shea CV, Shi X, Sinha R, Sit RV, Slowikowski K, Slyper M, Smith NP, Sountoulidis A, Strunz M, Sullivan TB, Sun D, Talavera-López C, Tan P, Tantivit J, Travaglini KJ, Tucker NR, Vernon KA, Wadsworth MH, Waldman J, Wang X, Xu K, Yan W, Zhao W, Ziegler CGK; NHLBI LungMap Consortium; Human Cell Atlas Lung Biological Network. Nat Med. 2021 Mar;27(3):546-559. doi: 10.1038/s41591-020-01227-z.
2020
- Senolytics prevent mt-DNA-induced inflammation and promote the survival of aged organs following transplantation.
Iske J, Seyda M, Heinbokel T, Maenosono R, Minami K, Nian Y, Quante M, Falk CS, Azuma H, Martin F, Passos JF, Niemann CU, Tchkonia T, Kirkland JL, Elkhal A, Tullius SG.
Nat Commun. 2020 Aug 27;11(1):4289. doi: 10.1038/s41467-020-18039-x - Staphylococcus aureus Alpha-Toxin Limits Type 1 While Fostering Type 3 Immune Responses.
Bonifacius A, Goldmann O, Floess S, Holtfreter S, Robert PA, Nordengrün M, Kruse F, Lochner M, Falk CS, Schmitz I, Bröker BM, Medina E, Huehn J.
Front Immunol. 2020 Aug 7;11:1579. doi: 10.3389/fimmu.2020.01579. eCollection 2020 - In Vitro Effects of Streptococcus oralis Biofilm on Peri-Implant Soft Tissue Cells.
Ingendoh-Tsakmakidis A, Eberhard J, Falk CS, Stiesch M, Winkel A.
Cells. 2020 May 15;9(5):1226. doi: 10.3390/cells9051226. - Early host-microbe interaction in a peri-implant oral mucosa-biofilm model.
Mikolai C, Kommerein N, Ingendoh-Tsakmakidis A, Winkel A, Falk CS, Stiesch M.
Cell Microbiol. 2020 Aug;22(8):e13209. doi: 10.1111/cmi.13209. Epub 2020 May 14. - Differential effects of Belatacept on virus-specific memory versus de novo allo-specific T cell responses of kidney transplant recipients and healthy donors.
Kühne JF, Neudörfl C, Beushausen K, Keil J, Malysheva S, Wandrer F, Haller H, Messerle M, Blume C, Neuenhahn M, Schlott F, Hammerschmidt W, Zeidler R, Falk CS.
Transpl Immunol. 2020Aug;61:101291. doi: 10.1016/j.trim.2020.101291. Epub 2020 Apr 21. - Extracorporeal cytokine removal in severe CAR-T cell associated cytokine release syndrome.
Stahl K, Schmidt BMW, Hoeper MM, Skripuletz T, Möhn N, Beutel G, Eder M, Welte T, Ganser A, Falk CS, Koenecke C, David S.
J Crit Care. 2020 Feb 19;57:124-129. doi: 10.1016/j.jcrc.2020.02.010.
- MAIT cells are enriched and highly functional in ascites of patients with decompensated liver cirrhosis.
Niehaus CE, Strunz B, Cornillet M, Falk CS, Schnieders A, Maasoumy B, Hardtke S, Manns MP, Rm Kraft A, Björkström NK, Cornberg M.
Hepatology. 2020 Feb 3. doi: 10.1002/hep.31153
2019
- Long-term follow-up in peripartum cardiomyopathy patients with contemporary treatment: low mortality, high cardiac recovery, but significant cardiovascular co-morbidities.
Moulig V, Pfeffer TJ, Ricke-Hoch M, Schlothauer S, Koenig T, Schwab J, Berliner D, Pfister R, Michels G, Haghikia A, Falk CS, Duncker D, Veltmann C, Hilfiker-Kleiner D, Bauersachs J.
Eur J Heart Fail. 2019 Dec;21(12):1534-1542. doi: 10.1002/ejhf.1624. Epub 2019 Nov 13. PubMed PMID: 31724271.
- Impact of immunosuppressive therapy on brain derived cytokines after liver transplantation.
Dirks M, Pflugrad H, Tryc AB, Schrader AK, Ding X, Lanfermann H, Jäckel E, Schrem H, Beneke J, Barg-Hock H, Klempnauer J, Falk CS, Weissenborn K.
Transpl Immunol. 2019 Oct 24:101248. doi: 10.1016/j.trim.2019.101248. [Epub ahead of print] PubMed PMID: 31669260.
- Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition).
Cossarizza A, Chang HD, Radbruch A, Acs A, Adam D, Adam-Klages S, Agace WW, Aghaeepour N, Akdis M, Allez M, Almeida LN, Alvisi G, Anderson G, Andrä I, Annunziato F, Anselmo A, Bacher P, Baldari CT, Bari S, Barnaba V, Barros-Martins J, Battistini L, Bauer W, Baumgart S, Baumgarth N, Baumjohann D, Baying B, Bebawy M, Becher B, Beisker W, Benes V, Beyaert R, Blanco A, Boardman DA, Bogdan C, Borger JG, Borsellino G, Boulais PE, Bradford JA, Brenner D, Brinkman RR, Brooks AES, Busch DH, Büscher M, Bushnell TP, Calzetti F, Cameron G, Cammarata I, Cao X, Cardell SL, Casola S, Cassatella MA, Cavani A, Celada A, Chatenoud L, Chattopadhyay PK, Chow S, Christakou E, Čičin-Šain L, Clerici M, Colombo FS, Cook L, Cooke A, Cooper AM, Corbett AJ, Cosma A, Cosmi L, Coulie PG, Cumano A, Cvetkovic L, Dang VD, Dang-Heine C, Davey MS, Davies D, De Biasi S, Del Zotto G, Dela Cruz GV, Delacher M, Della Bella S, Dellabona P, Deniz G, Dessing M, Di Santo JP, Diefenbach A, Dieli F, Dolf A, Dörner T, Dress RJ, Dudziak D, Dustin M, Dutertre CA, Ebner F, Eckle SBG, Edinger M, Eede P, Ehrhardt GRA, Eich M, Engel P, Engelhardt B, Erdei A, Esser C, Everts B, Evrard M, Falk CS, Fehniger TA, Felipo-Benavent M, Ferry H, Feuerer M, Filby A, Filkor K, Fillatreau S, Follo M, Förster I, Foster J, Foulds GA, Frehse B, Frenette PS, Frischbutter S, Fritzsche W, Galbraith DW, Gangaev A, Garbi N, Gaudilliere B, Gazzinelli RT, Geginat J, Gerner W, Gherardin NA, Ghoreschi K, Gibellini L, Ginhoux F, Goda K, Godfrey DI, Goettlinger C, González-Navajas JM, Goodyear CS, Gori A, Grogan JL, Grummitt D, Grützkau A, Haftmann C, Hahn J, Hammad H, Hämmerling G, Hansmann L, Hansson G, Harpur CM, Hartmann S, Hauser A, Hauser AE, Haviland DL, Hedley D, Hernández DC, Herrera G, Herrmann M, Hess C, Höfer T, Hoffmann P, Hogquist K, Holland T, Höllt T, Holmdahl R, Hombrink P, Houston JP, Hoyer BF, Huang B, Huang FP, Huber JE, Huehn J, Hundemer M, Hunter CA, Hwang WYK, Iannone A, Ingelfinger F, Ivison SM, Jäck HM, Jani PK, Jávega B, Jonjic S, Kaiser T, Kalina T, Kamradt T, Kaufmann SHE, Keller B, Ketelaars SLC, Khalilnezhad A, Khan S, Kisielow J, Klenerman P, Knopf J, Koay HF, Kobow K, Kolls JK, Kong WT, Kopf M, Korn T, Kriegsmann K, Kristyanto H, Kroneis T, Krueger A, Kühne J, Kukat C, Kunkel D, Kunze-Schumacher H, Kurosaki T, Kurts C, Kvistborg P, Kwok I, Landry J, Lantz O, Lanuti P, LaRosa F, Lehuen A, LeibundGut-Landmann S, Leipold MD, Leung LYT, Levings MK, Lino AC, Liotta F, Litwin V, Liu Y, Ljunggren HG, Lohoff M, Lombardi G, Lopez L, López-Botet M, Lovett-Racke AE, Lubberts E, Luche H, Ludewig B, Lugli E, Lunemann S, Maecker HT, Maggi L, Maguire O, Mair F, Mair KH, Mantovani A, Manz RA, Marshall AJ, Martínez-Romero A, Martrus G, Marventano I, Maslinski W, Matarese G, Mattioli AV, Maueröder C, Mazzoni A, McCluskey J, McGrath M, McGuire HM, McInnes IB, Mei HE, Melchers F, Melzer S, Mielenz D, Miller SD, Mills KHG, Minderman H, Mjösberg J, Moore J, Moran B, Moretta L, Mosmann TR, Müller S, Multhoff G, Muñoz LE, Münz C, Nakayama T, Nasi M, Neumann K, Ng LG, Niedobitek A, Nourshargh S, Núñez G, O'Connor JE, Ochel A, Oja A, Ordonez D, Orfao A, Orlowski-Oliver E, Ouyang W, Oxenius A, Palankar R, Panse I, Pattanapanyasat K, Paulsen M, Pavlinic D, Penter L, Peterson P, Peth C, Petriz J, Piancone F, Pickl WF, Piconese S, Pinti M, Pockley AG, Podolska MJ, Poon Z, Pracht K, Prinz I, Pucillo CEM, Quataert SA, Quatrini L, Quinn KM, Radbruch H, Radstake TRDJ, Rahmig S, Rahn HP, Rajwa B, Ravichandran G, Raz Y, Rebhahn JA, Recktenwald D, Reimer D, Reis E Sousa C, Remmerswaal EBM, Richter L, Rico LG, Riddell A, Rieger AM, Robinson JP, Romagnani C, Rubartelli A, Ruland J, Saalmüller A, Saeys Y, Saito T, Sakaguchi S, Sala-de-Oyanguren F, Samstag Y, Sanderson S, Sandrock I, Santoni A, Sanz RB, Saresella M, Sautes-Fridman C, Sawitzki B, Schadt L, Scheffold A, Scherer HU, Schiemann M, Schildberg FA, Schimisky E, Schlitzer A, Schlosser J, Schmid S, Schmitt S, Schober K, Schraivogel D, Schuh W, Schüler T, Schulte R, Schulz AR, Schulz SR, Scottá C, Scott-Algara D, Sester DP, Shankey TV, Silva-Santos B, Simon AK, Sitnik KM, Sozzani S, Speiser DE, Spidlen J, Stahlberg A, Stall AM, Stanley N, Stark R, Stehle C, Steinmetz T, Stockinger H, Takahama Y, Takeda K, Tan L, Tárnok A, Tiegs G, Toldi G, Tornack J, Traggiai E, Trebak M, Tree TIM, Trotter J, Trowsdale J, Tsoumakidou M, Ulrich H, Urbanczyk S, van de Veen W, van den Broek M, van der Pol E, Van Gassen S, Van Isterdael G, van Lier RAW, Veldhoen M, Vento-Asturias S, Vieira P, Voehringer D, Volk HD, von Borstel A, von Volkmann K, Waisman A, Walker RV, Wallace PK, Wang SA, Wang XM, Ward MD, Ward-Hartstonge KA, Warnatz K, Warnes G, Warth S, Waskow C, Watson JV, Watzl C, Wegener L, Weisenburger T, Wiedemann A, Wienands J, Wilharm A, Wilkinson RJ, Willimsky G, Wing JB, Winkelmann R, Winkler TH, Wirz OF, Wong A, Wurst P, Yang JHM, Yang J, Yazdanbakhsh M, Yu L, Yue A, Zhang H, Zhao Y, Ziegler SM, Zielinski C, Zimmermann J, Zychlinsky A.
Eur J Immunol. 2019 Oct;49(10):1457-1973. doi: 10.1002/eji.201970107. PubMed PMID: 31633216.
- Soluble immune markers in the different phases of chronic hepatitis B virus infection.
Wiegand SB, Beggel B, Wranke A, Aliabadi E, Jaroszewicz J, Xu CJ, Li Y, Manns MP, Lengauer T, Wedemeyer H, Kraft ARM, Falk CS, Cornberg M.
Sci Rep. 2019 Oct 1;9(1):14118. doi: 10.1038/s41598-019-50729-5. PubMed PMID: 31575964; PubMed Central PMCID: PMC6773856.
- Alloresponses of Mixed Lymphocyte Hepatocyte Culture to Immunosuppressive Drugs as an In-Vitro Model of Hepatocyte Transplantation.
Oldhafer F, Wittauer EM, Falk CS, DeTemple DE, Beetz O, Timrott K, Kleine M, Vondran FWR.
Ann Transplant. 2019 Aug 13;24:472-480. doi: 10.12659/AOT.915982. PubMed PMID: 31406101; PubMed Central PMCID: PMC6705178.
- Cytokine Selection of MSC Clones with Different Functionality.
Selich A, Ha TC, Morgan M, Falk CS, von Kaisenberg C, Schambach A, Rothe M.
Stem Cell Reports. 2019 Aug 13;13(2):262-273. doi: 10.1016/j.stemcr.2019.06.001. Epub 2019 Jul 11. PubMed PMID: 31303506; PubMed Central PMCID: PMC6700478.
- Defining the Inflammatory Microenvironment in the Human Cochlea by Perilymph Analysis: Toward Liquid Biopsy of the Cochlea.
Warnecke A, Prenzler NK, Schmitt H, Daemen K, Keil J, Dursin M, Lenarz T, Falk CS.
Front Neurol. 2019 Jun 25;10:665. doi: 10.3389/fneur.2019.00665. eCollection 2019. PubMed PMID: 31293504; PubMed Central PMCID: PMC6603180.
- Commensal and pathogenic biofilms differently modulate peri-implant oral mucosa in an organotypic model.
Ingendoh-Tsakmakidis A, Mikolai C, Winkel A, Szafrański SP, Falk CS, Rossi A, Walles H, Stiesch M.
Cell Microbiol. 2019 Oct;21(10):e13078. doi: 10.1111/cmi.13078. Epub 2019 Jul 17. PubMed PMID: 31270923; PubMed Central PMCID: PMC6771885.
- Hepatocyte growth factor levels in livers and serum at Kasai-portoenterostomy are not predictive of clinical outcome in infants with biliary atresia.
Madadi-Sanjani O, Kuebler JF, Dippel S, Gigina A, Falk CS, Vieten G, Petersen C, Klemann C.
Growth Factors. 2019 Apr;37(1-2):68-75. doi: 10.1080/08977194.2019.1626379. Epub 2019 Jun 11. PubMed PMID: 31185750.
- Silencing of HLA class I on primary human hepatocytes as a novel strategy for reduction in alloreactivity.
Figueiredo C, Oldhafer F, Wittauer EM, Carvalho-Oliveira M, Akhdar A, Beetz O, Chen-Wacker C, Yuzefovych Y, Falk CS, Blasczyk R, Vondran FWR.
J Cell Mol Med. 2019 Aug;23(8):5705-5714. doi: 10.1111/jcmm.14484. Epub 2019 Jun 10. PubMed PMID: 31180181; PubMed Central PMCID: PMC6653539.
- Back signaling of HLA class I molecules and T/NK cell receptor ligands in epithelial cells reflects the rejection-specific microenvironment in renal allograft biopsies.
Egelkamp J, Chichelnitskiy E, Kühne JF, Wandrer F, Daemen K, Keil J, Bräsen JH, Schmitz J, Bellmàs-Sanz R, Iordanidis S, Katsirntaki K, Hake K, Akhdar A, Neudörfl C, Haller H, Blume C, Falk CS.
Am J Transplant. 2019 Oct;19(10):2692-2704. doi: 10.1111/ajt.15417. Epub 2019 May 28. PubMed PMID: 31062482.
- Transplant arteriosclerosis in humanized mice reflects chronic lung allograft dysfunction and is controlled by regulatory T cells.
Siemeni T, Knöfel AK, Ius F, Sommer W, Salman J, Böthig D, Falk CS, Tudorache I, Haverich A, Warnecke G.
J Thorac Cardiovasc Surg. 2019 Jun;157(6):2528-2537. doi: 10.1016/j.jtcvs.2019.01.134. Epub 2019 Feb 28. PubMed PMID: 30955963.
- HCC Immune Surveillance and Antiviral Therapy of Hepatitis C Virus Infection.
Owusu Sekyere S, Schlevogt B, Mettke F, Kabbani M, Deterding K, Wirth TC, Vogel A, Manns MP, Falk CS, Cornberg M, Wedemeyer H.
Liver Cancer. 2019 Feb;8(1):41-65. doi: 10.1159/000490360. Epub 2018 Jul 18. PubMed PMID: 30815394; PubMed Central PMCID: PMC6388568.
- Session 10: Biofilms Implant related infections.
Mikolai C, Ingendoh-Tsakmakidis A, Winkel A, Kommerein N, Falk CS, Rossi A, Walles H, Stiesch M.
Biomed Tech (Berl). 2019 Feb 1;64(s1):63-65. doi: 10.1515/bmt-2019-7010. PubMed PMID: 30753148.
- Equally Interchangeable? How Sex and Gender Affect Transplantation.
Melk A, Babitsch B, Borchert-Mörlins B, Claas F, Dipchand AI, Eifert S, Eiz-Vesper B, Epping J, Falk CS, Foster B, Geyer S, Gjertson D, Greer M, Haubitz M, Lau A, Maecker-Kolhoff B, Memaran N, Messner HA, Ostendorf K, Samuel U, Schmidt BMW, Tullius SG, West L, Wong G, Zimmermann T, Berenguer M.
Transplantation. 2019 Jun;103(6):1094-1110. doi: 10.1097/TP.0000000000002655. PubMed PMID: 30747857.
- Immune Status in Children Before Liver Transplantation-A Cross-Sectional Analysis Within the ChilsSFree Multicentre Cohort Study.
Möhring T, Karch A, Falk CS, Laue T, D'Antiga L, Debray D, Hierro L, Kelly D, McLin V, McKiernan P, Pawlowska J, Czubkowski P, Mikolajczyk RT, Baumann U, Goldschmidt I.
Front Immunol. 2019 Jan 25;10:52. doi: 10.3389/fimmu.2019.00052. eCollection 2019. PubMed PMID: 30740106; PubMed Central PMCID: PMC6357985.
- Role of soluble inflammatory mediators and different immune cell populations in early control of symptomatic acute hepatitis C virus infection.
Hengst J, Klein AL, Lunemann S, Deterding K, Hardtke S, Falk CS, Manns MP, Cornberg M, Schlaphoff V, Wedemeyer H.
J Viral Hepat. 2019 Apr;26(4):466-475. doi: 10.1111/jvh.13050. Epub 2019 Feb 1. PubMed PMID: 30548086
2018
- Blood cytokine expression correlates with early multi-organ damage in a mouse model of moderate hypothermia with circulatory arrest using cardiopulmonary bypass.
Natanov R, Gueler F, Falk CS, Kühn C, Maus U, Boyle EC, Siemeni T, Knoefel AK, Cebotari S, Haverich A, Madrahimov N. PLoS One. 2018 Oct 11;13(10):e0205437. doi: 10.1371/journal.pone.0205437. eCollection 2018. PMID: 30308065
- Long-term outcome and necessity of liver transplantation in infants with biliary atresia are independent of cytokine milieu in native liver and serum.
Madadi-Sanjani O, Kuebler JF, Dippel S, Gigina A, Falk CS, Vieten G, Petersen C, Klemann C. Cytokine. 2018 Nov;111:382-388. doi: 10.1016/j.cyto.2018.09.010. Epub 2018 Oct 6. PMID: 30300856
- Second generation atypical antipsychotics olanzapine and aripiprazole reduce expression and secretion of inflammatory cytokines in human immune cells.
Stapel B, Sieve I, Falk CS, Bleich S, Hilfiker-Kleiner D, Kahl KG. J Psychiatr Res. 2018 Oct;105:95-102. doi: 10.1016/j.jpsychires.2018.08.017. Epub 2018 Sep 4. PMID:30216787
- The chemokine receptor CCR7 is a promising target for rheumatoid arthritis therapy.
Moschovakis GL, Bubke A, Friedrichsen M, Ristenpart J, Back JW, Falk CS, Kremmer E, Förster R. Cell Mol Immunol. 2019 Oct;16(10):791-799. doi: 10.1038/s41423-018-0056-5. Epub 2018 Jul 4. PMID: 29973648
- Functional Pulmonary Magnetic Resonance Imaging for Detection of Ischemic Injury in a Porcine Ex-Vivo Lung Perfusion System Prior to Transplantation.
Renne J, Gutberlet M, Voskrebenzev A, Kern A, Kaireit T, Hinrichs JB, Braubach P, Falk CS, Höffler K, Warnecke G, Zardo P, Haverich A, Wacker F, Vogel-Claussen J, Zinne N. Acad Radiol. 2019 Feb;26(2):170-178. doi: 10.1016/j.acra.2018.05.006. Epub 2018 Jun 19. PMID: 29929935
- The Antiviral Activity of the Cellular Glycoprotein LGALS3BP/90K Is Species Specific.
Lodermeyer V, Ssebyatika G, Passos V, Ponnurangam A, Malassa A, Ewald E, Stürzel CM, Kirchhoff F, Rotger M, Falk CS, Telenti A, Krey T, Goffinet C. J Virol. 2018 Jun 29;92(14). pii: e00226-18. doi: 10.1128/JVI.00226-18. Print 2018 Jul 15. PMID: 29743357
- Systemic inflammation and immune cell phenotypes are associated with neuro-psychiatric symptoms in patients with chronic inflammatory liver diseases.
Aregay A, Dirks M, Schlaphoff V, Owusu Sekyere S, Haag K, Falk CS, Hengst J, Bremer B, Schuppner R, Manns MP, Pflugrad H, Cornberg M, Wedemeyer H, Weissenborn K. Liver Int. 2018 Dec;38(12):2317-2328. doi: 10.1111/liv.13869. Epub 2018 Jun 12.PMID:29710425
- A positive feedback loop between IL-1β, LPS and NEU1 may promote atherosclerosis by enhancing a pro-inflammatory state in monocytes and macrophages.
Sieve I, Ricke-Hoch M, Kasten M, Battmer K, Stapel B, Falk CS, Leisegang MS, Haverich A, Scherr M, Hilfiker-Kleiner D. Vascul Pharmacol. 2018 Apr;103-105:16-28. doi: 10.1016/j.vph.2018.01.005. Epub 2018 Jan 31. PMID: 29371126
- Hepatocyte-induced CD4+ T cell alloresponse is associated with major histocompatibility complex class II up-regulation on hepatocytes and suppressible by regulatory T cells.
DeTemple DE, Oldhafer F, Falk CS, Chen-Wacker C, Figueiredo C, Kleine M, Ramackers W, Timrott K, Lehner F, Klempnauer J, Bock M, Vondran FWR. Liver Transpl. 2018 Mar;24(3):407-419. doi: 10.1002/lt.25019. PMID: 29365365
- Baseline IL-2 and the AIH score can predict the response to standard therapy in paediatric autoimmune hepatitis.
Diestelhorst J, Junge N, Jonigk D, Schlue J, Falk CS, Manns MP, Baumann U, Jaeckel E, Taubert R. Sci Rep. 2018 Jan 11;8(1):419. doi: 10.1038/s41598-017-18818-5. PMID: 29323192
- Phase II trial of ipilimumab in melanoma patients with preexisting humoural immune response to NY-ESO-1.
Haag GM, Zoernig I, Hassel JC, Halama N, Dick J, Lang N, Podola L, Funk J, Ziegelmeier C, Juenger S, Bucur M, Umansky L, Falk CS, Freitag A, Karapanagiotou-Schenkel I, Beckhove P, Enk A, Jaeger D. Eur J Cancer. 2018 Feb;90:122-129. doi: 10.1016/j.ejca.2017.12.001. Epub 2018 Jan 5. PMID:29306769
2017
- Cellular Differentiation of Human Monocytes Is Regulated by Time-Dependent Interleukin-4 Signaling and the Transcriptional Regulator NCOR2.
Sander J, Schmidt SV, Cirovic B, McGovern N, Papantonopoulou O, Hardt AL, Aschenbrenner AC, Kreer C, Quast T, Xu AM, Schmidleithner LM, Theis H, Thi Huong LD, Sumatoh HRB, Lauterbach MAR, Schulte-Schrepping J, Günther P, Xue J, Baßler K, Ulas T, Klee K, Katzmarski N, Herresthal S, Krebs W, Martin B, Latz E, Händler K, Kraut M, Kolanus W, Beyer M, Falk CS, Wiegmann B, Burgdorf S, Melosh NA, Newell EW, Ginhoux F, Schlitzer A, Schultze JL. Immunity. 2017 Dec 19;47(6):1051-1066.e12. doi: 10.1016/j.immuni.2017.11.024. PMID: 29262348
- Blood vessel control of macrophage maturation promotes arteriogenesis in ischemia.
Krishnasamy K, Limbourg A, Kapanadze T, Gamrekelashvili J, Beger C, Häger C, Lozanovski VJ, Falk CS, Napp LC, Bauersachs J, Mack M, Haller H, Weber C, Adams RH, Limbourg FP. Nat Commun. 2017 Oct 16;8(1):952. doi: 10.1038/s41467-017-00953-2. PMID: 29038527
- Guidelines for the use of flow cytometry and cell sorting in immunological studies.
Cossarizza A, Chang HD, Radbruch A, Akdis M, Andrä I, Annunziato F, Bacher P, Barnaba V, Battistini L, Bauer WM, Baumgart S, Becher B, Beisker W, Berek C, Blanco A, Borsellino G, Boulais PE, Brinkman RR, Büscher M, Busch DH, Bushnell TP, Cao X, Cavani A, Chattopadhyay PK, Cheng Q, Chow S, Clerici M, Cooke A, Cosma A, Cosmi L, Cumano A, Dang VD, Davies D, De Biasi S, Del Zotto G, Della Bella S, Dellabona P, Deniz G, Dessing M, Diefenbach A, Di Santo J, Dieli F, Dolf A, Donnenberg VS, Dörner T, Ehrhardt GRA, Endl E, Engel P, Engelhardt B, Esser C, Everts B, Dreher A, Falk CS, Fehniger TA, Filby A, Fillatreau S, Follo M, Förster I, Foster J, Foulds GA, Frenette PS, Galbraith D, Garbi N, García-Godoy MD, Geginat J, Ghoreschi K, Gibellini L, Goettlinger C, Goodyear CS, Gori A, Grogan J, Gross M, Grützkau A, Grummitt D, Hahn J, Hammer Q, Hauser AE, Haviland DL, Hedley D, Herrera G, Herrmann M, Hiepe F, Holland T, Hombrink P, Houston JP, Hoyer BF, Huang B, Hunter CA, Iannone A, Jäck HM, Jávega B, Jonjic S, Juelke K, Jung S, Kaiser T, Kalina T, Keller B, Khan S, Kienhöfer D, Kroneis T, Kunkel D, Kurts C, Kvistborg P, Lannigan J, Lantz O, Larbi A, LeibundGut-Landmann S, Leipold MD, Levings MK, Litwin V, Liu Y, Lohoff M, Lombardi G, Lopez L, Lovett-Racke A, Lubberts E, Ludewig B, Lugli E, Maecker HT, Martrus G, Matarese G, Maueröder C, McGrath M, McInnes I, Mei HE, Melchers F, Melzer S, Mielenz D, Mills K, Mirrer D, Mjösberg J, Moore J, Moran B, Moretta A, Moretta L, Mosmann TR, Müller S, Müller W, Münz C, Multhoff G, Munoz LE, Murphy KM, Nakayama T, Nasi M, Neudörfl C, Nolan J, Nourshargh S, O'Connor JE, Ouyang W, Oxenius A, Palankar R, Panse I, Peterson P, Peth C, Petriz J, Philips D, Pickl W, Piconese S, Pinti M, Pockley AG, Podolska MJ, Pucillo C, Quataert SA, Radstake TRDJ, Rajwa B, Rebhahn JA, Recktenwald D, Remmerswaal EBM, Rezvani K, Rico LG, Robinson JP, Romagnani C, Rubartelli A, Ruckert B, Ruland J, Sakaguchi S, Sala-de-Oyanguren F, Samstag Y, Sanderson S, Sawitzki B, Scheffold A, Schiemann M, Schildberg F, Schimisky E, Schmid SA, Schmitt S, Schober K, Schüler T, Schulz AR, Schumacher T, Scotta C, Shankey TV, Shemer A, Simon AK, Spidlen J, Stall AM, Stark R, Stehle C, Stein M, Steinmetz T, Stockinger H, Takahama Y, Tarnok A, Tian Z, Toldi G, Tornack J, Traggiai E, Trotter J, Ulrich H, van der Braber M, van Lier RAW, Veldhoen M, Vento-Asturias S, Vieira P, Voehringer D, Volk HD, von Volkmann K, Waisman A, Walker R, Ward MD, Warnatz K, Warth S, Watson JV, Watzl C, Wegener L, Wiedemann A, Wienands J, Willimsky G, Wing J, Wurst P, Yu L, Yue A, Zhang Q, Zhao Y, Ziegler S, Zimmermann J. Eur J Immunol. 2017 Oct;47(10):1584-1797. doi: 10.1002/eji.201646632. No abstract available. PMID: 29023707
- T cell specific Cxcr5 deficiency prevents rheumatoid arthritis.
Moschovakis GL, Bubke A, Friedrichsen M, Falk CS, Feederle R, Förster R. Sci Rep. 2017 Aug 21;7(1):8933. doi: 10.1038/s41598-017-08935-6. PMID: 28827539
- Pediatric autoimmune hepatitis shows a disproportionate decline of regulatory T cells in the liver and of IL-2 in the blood of patients undergoing therapy.
Diestelhorst J, Junge N, Schlue J, Falk CS, Manns MP, Baumann U, Jaeckel E, Taubert R. PLoS One. 2017 Jul 11;12(7):e0181107. doi: 10.1371/journal.pone.0181107. eCollection 2017. PMID: 28700730
- The human cytomegalovirus glycoprotein pUL11 acts via CD45 to induce T cell IL-10 secretion.
Zischke J, Mamareli P, Pokoyski C, Gabaev I, Buyny S, Jacobs R, Falk CS, Lochner M, Sparwasser T, Schulz TF, Kay-Fedorov PC. PLoS Pathog. 2017 Jun 19;13(6):e1006454. doi: 10.1371/journal.ppat.1006454. eCollection 2017 Jun. PMID: 28628650
- Systemic Virus Infections Differentially Modulate Cell Cycle State and Functionality of Long-Term Hematopoietic Stem Cells In Vivo.
Hirche C, Frenz T, Haas SF, Döring M, Borst K, Tegtmeyer PK, Brizic I, Jordan S, Keyser K, Chhatbar C, Pronk E, Lin S, Messerle M, Jonjic S, Falk CS, Trumpp A, Essers MAG, Kalinke U. Cell Rep. 2017 Jun 13;19(11):2345-2356. doi: 10.1016/j.celrep.2017.05.063. PMID: 28614719
- Hyperferritinemia and hypergammaglobulinemia predict the treatment response to standard therapy in autoimmune hepatitis.
Taubert R, Hardtke-Wolenski M, Noyan F, Lalanne C, Jonigk D, Schlue J, Krech T, Lichtinghagen R, Falk CS, Schlaphoff V, Bantel H, Muratori L, Manns MP, Jaeckel E. PLoS One. 2017 Jun 8;12(6):e0179074. doi: 10.1371/journal.pone.0179074. eCollection 2017. PMID: 28594937
- CD4 T Cell Dependent Colitis Exacerbation Following Re-Exposure of Mycobacterium avium ssp. paratuberculosis.
Suwandi A, Bargen I, Pils MC, Krey M, Zur Lage S, Singh AK, Basler T, Falk CS, Seidler U, Hornef MW, Goethe R, Weiss S. Front Cell Infect Microbiol. 2017 Mar 16;7:75. doi: 10.3389/fcimb.2017.00075. eCollection 2017. PMID: 28361039
- CD40 Signaling Drives Potent Cellular Immune Responses in Heterologous Cancer Vaccinations.
Nimanong S, Ostroumov D, Wingerath J, Knocke S, Woller N, Gürlevik E, Falk CS, Manns MP, Kühnel F, Wirth TC. Cancer Res. 2017 Apr 15;77(8):1918-1926. doi: 10.1158/0008-5472.CAN-16-2089. Epub 2017 Feb 15. PMID: 28202532
- Effect of extracorporeal cytokine removal on vascular barrier function in a septic shock patient.
David S, Thamm K, Schmidt BMW, Falk CS, Kielstein JT. J Intensive Care. 2017 Jan 21;5:12. doi: 10.1186/s40560-017-0208-1. eCollection 2017. PMID: 28127437
2016
- Viral and Host Responses After Stopping Long-term Nucleos(t)ide Analogue Therapy in HBeAg-Negative Chronic Hepatitis B.
Höner Zu Siederdissen C, Rinker F, Maasoumy B, Wiegand SB, Filmann N, Falk CS, Deterding K, Port K, Mix C, Manns MP, Herrmann E, Wedemeyer H, Kraft AR, Cornberg M. J Infect Dis. 2016 Nov 15;214(10):1492-1497. Epub 2016 Sep 7. PMID: 27609808
- In Vivo Development of Transplant Arteriosclerosis in Humanized Mice Reflects Alloantigen Recognition and Peripheral Treg Phenotype of Lung Transplant Recipients.
Siemeni T, Knöfel AK, Madrahimov N, Sommer W, Avsar M, Salman J, Ius F, Frank N, Büchler G, Jonigk D, Jansson K, Maus U, Tudorache I, Falk CS, Haverich A, Warnecke G. Am J Transplant. 2016 Nov;16(11):3150-3162. doi: 10.1111/ajt.13905. Epub 2016 Jul 29. PMID: 27273729
- Direct-Acting Antiviral-Induced Hepatitis C Virus Clearance Does Not Completely Restore the Altered Cytokine and Chemokine Milieu in Patients With Chronic Hepatitis C.
Hengst J, Falk CS, Schlaphoff V, Deterding K, Manns MP, Cornberg M, Wedemeyer H. J Infect Dis. 2016 Dec 15;214(12):1965-1974. Epub 2016 Sep 28. PMID: 27683821
- Identification of miR-126 as a new regulator of skin ageing.
Fiedler J, Grönniger E, Pfanne A, Brönneke S, Schmidt K, Falk CS, Wenck H, Terstegen L, Thum T, Winnefeld M. Exp Dermatol. 2017 Mar;26(3):284-286. doi: 10.1111/exd.13173. No abstract available. PMID: 27574096
- T Cells Going Innate.
Seyda M, Elkhal A, Quante M, Falk CS, Tullius SG. Trends Immunol. 2016 Aug;37(8):546-556. doi: 10.1016/j.it.2016.06.004. Epub 2016 Jul 8. Review. PMID: 27402226
- Tumoral Immune Cell Exploitation in Colorectal Cancer Metastases Can Be Targeted Effectively by Anti-CCR5 Therapy in Cancer Patients.
Halama N, Zoernig I, Berthel A, Kahlert C, Klupp F, Suarez-Carmona M, Suetterlin T, Brand K, Krauss J, Lasitschka F, Lerchl T, Luckner-Minden C, Ulrich A, Koch M, Weitz J, Schneider M, Buechler MW, Zitvogel L, Herrmann T, Benner A, Kunz C, Luecke S, Springfeld C, Grabe N, Falk CS, Jaeger D. Cancer Cell. 2016 Apr 11;29(4):587-601. doi: 10.1016/j.ccell.2016.03.005. PMID: 27070705
- Immunological aspects of liver cell transplantation.
Oldhafer F, Bock M, Falk CS, Vondran FW. World J Transplant. 2016 Mar 24;6(1):42-53. doi: 10.5500/wjt.v6.i1.42. Review. PMID: 27011904
- α-NAC-Specific Autoreactive CD8+ T Cells in Atopic Dermatitis Are of an Effector Memory Type and Secrete IL-4 and IFN-γ.
Roesner LM, Heratizadeh A, Wieschowski S, Mittermann I, Valenta R, Eiz-Vesper B, Hennig C, Hansen G, Falk CS, Werfel T. J Immunol. 2016 Apr 15;196(8):3245-52. doi: 10.4049/jimmunol.1500351. Epub 2016 Mar 9. PMID: 26962231
- PI3K/AKT/mTOR-dependent stabilization of oncogenic far-upstream element binding proteins in hepatocellular carcinoma cells.
Samarin J, Laketa V, Malz M, Roessler S, Stein I, Horwitz E, Singer S, Dimou E, Cigliano A, Bissinger M, Falk CS, Chen X, Dooley S, Pikarsky E, Calvisi DF, Schultz C, Schirmacher P, Breuhahn K. Hepatology. 2016 Mar;63(3):813-26. doi: 10.1002/hep.28357. Epub 2016 Jan 14. PMID: 26901106
- miR-21 promotes fibrosis in an acute cardiac allograft transplantation model.
Gupta SK, Itagaki R, Zheng X, Batkai S, Thum S, Ahmad F, Van Aelst LN, Sharma A, Piccoli MT, Weinberger F, Fiedler J, Heuser M, Heymans S, Falk CS, Förster R, Schrepfer S, Thum T. Cardiovasc Res. 2016 May 15;110(2):215-26. doi: 10.1093/cvr/cvw030. Epub 2016 Feb 9. PMID: 26865549
- Cross-genotype-specific T-cell responses in acute hepatitis E virus (HEV) infection.
Gisa A, Suneetha PV, Behrendt P, Pischke S, Bremer B, Falk CS, Manns MP, Cornberg M, Wedemeyer H, Kraft AR. J Viral Hepat. 2016 Apr;23(4):305-15. doi: 10.1111/jvh.12495. Epub 2016 Feb 8. PMID: 26852892
- Augmentation of Transient Donor Cell Chimerism and Alloantigen-Specific Regulation of Lung Transplants in Miniature Swine.
Avsar M, Jansson K, Sommer W, Kruse B, Thissen S, Dreckmann K, Knoefel AK, Salman J, Hafer C, Hecker J, Buechler G, Karstens JH, Jonigk D, Länger F, Kaever V, Falk CS, Hewicker-Trautwein M, Ungefroren H, Haverich A, Strüber M, Warnecke G. Am J Transplant. 2016 May;16(5):1371-82. doi: 10.1111/ajt.13629. Epub 2016 Feb 22. PMID: 26602894
- Interferon-Mediated Cytokine Induction Determines Sustained Virus Control in Chronic Hepatitis C Virus Infection.
Wandrer F, Falk CS, John K, Skawran B, Manns MP, Schulze-Osthoff K, Bantel H. J Infect Dis. 2016 Mar 1;213(5):746-54. doi: 10.1093/infdis/jiv505. Epub 2015 Oct 26. PMID: 26503984
- Interferon-γ and Tumor Necrosis Factor-α Produced by T Cells Reduce the HBV Persistence Form, cccDNA, Without Cytolysis.
Xia Y, Stadler D, Lucifora J, Reisinger F, Webb D, Hösel M, Michler T, Wisskirchen K, Cheng X, Zhang K, Chou WM, Wettengel JM, Malo A, Bohne F, Hoffmann D, Eyer F, Thimme R, Falk CS, Thasler WE, Heikenwalder M, Protzer U. Gastroenterology. 2016 Jan;150(1):194-205. doi: 10.1053/j.gastro.2015.09.026. Epub 2015 Sep 28. PMID: 26416327
- Efficient generation of gene-modified human natural killer cells via alpharetroviral vectors.
Suerth JD, Morgan MA, Kloess S, Heckl D, Neudörfl C, Falk CS, Koehl U, Schambach A. J Mol Med (Berl). 2016 Jan;94(1):83-93. doi: 10.1007/s00109-015-1327-6. Epub 2015 Aug 25. PMID: 26300042