Targeted Metabolomics - Nukleoside / Nukleotide
2021
Andersen JB, Hultqvist LD, Jansen CU, Jakobsen TH, Nilsson M, Rybtke M, Uhd J, Fritz BG, Seifert R, Berthelsen J, Nielsen TE, Qvortrup K, Givskov M, Tolker-Nielsen T. Identification of small molecules that interfere with c-di-GMP signaling and induce dispersal of Pseudomonas aeruginosa biofilms. NPJ Biofilms Microbiomes 2021; 7: 59. doi: 10.1038/s41522-021-00225-4.
Bünsow D, Tantawy E, Ostermeier T, Bähre H, Garbe A, Larsen J, Winstel V. Methicillin-resistant Staphylococcus pseudintermedius synthesizes deoxyadenosine to cause persistent infection. Virulence 2021; 12: 989-1002. doi: 10.1080/21505594.2021.1903691.
Dorado-Morales P, Martínez I, Rivero-Buceta V, Díaz E, Bähre H, Lasa I, Solano C. Elevated c-di-GMP levels promote biofilm formation and biodesulfurization capacity of Rhodococcus erythropolis. Microb Biotechnol 2021; 14: 923-937. doi: 10.1111/1751-7915.13689.
Fortuna A, Bähre H, Visca P, Rampioni G, Leoni L. The two Pseudomonas aeruginosa DksA stringent response proteins are largely interchangeable at the whole transcriptome level and in the control of virulence-related traits. Environ Microbiol. 2021; 3: 5487-5504. doi: 10.1111/1462-2920.15693.
Krüger L, Herzberg C, Wicke D, Bähre H, Heidemann JL, Dickmanns J, Schmitt K, Ficner R, Stülke J. A meet-up of two second messengers: the c-di-AMP receptor DarB controls (p)ppGpp synthesis in Bacillus subtilis. Nat Commun. 2021; 12: 1210.
Oeser S, Wallner T, Nils S, Bučinská L, Sivabalasarma S, Bähre H, Albers SV, Wilde A. Minor pilins are involved in motility and natural competence of the cyanobacterium Synechocystis sp. PCC 6803. Mol Microbiol. 2021; 116: 743-765. doi: 10.1111/mmi.14768.
Rodriguez-Garcia E, Zabaleta N, Gil-Farina I, Gonzalez-Aparicio M, Echeverz M, Bähre H, Solano C, Lasa I, Gonzalez-Aseguinolaza G, Hommel M. AdrA as a Potential Immunomodulatory Candidate for STING-Mediated Antiviral Therapy That Required Both Type I IFN and TNF-α Production. J Immunol 2021; 206: 376-385
Slavik KM, Morehouse BR, Ragucci AE, Zhou W, Ai X, Chen Y, Li L, Wei Z, Bähre H, König M, Seifert R, Lee ASY, Cai H, Imler JL, Kranzusch PJ. cGAS-like receptors sense RNA and control 3'2'-cGAMP signaling in Drosophila. Nature 2021; 597: 109-113. doi: 10.1038/s41586-021-03743-5.
2020
Gibhardt J, Heidemann JL, Bremenkamp R, Rosenberg J, Seifert R, KAEVER V, Ficner R, Commichau FM (2020).
An extracytoplasmic protein and a moonlighting enzyme modulate synthesis of c-di-AMP in Listeria monocytogenes.
Environ Microbiol; 22: 2771-2791
Latoscha A, Drexler DJ, Al-Bassam MM, Bandera AM, KAEVER V, Findlay KC, Witte G, Tschowri N (2020).
c-di-AMP hydrolysis by the phosphodiesterase AtaC promotes differentiation of multicellular bacteria.
Proc Natl Acad Scie USA 2020; 117: 7392-7400
Schäfer H, Beckert B, Frese CK, Steinchen W, Nuss AM, Beckstette M, Hantke I, Driller K, Sudzinová P, Krásný L, KAEVER V, Dersch P, Bange G, Wilson DN, Turgay K. (2020)
The alarmones (p)ppGpp are part of the heat shock response of Bacillus subtilis.
PLoS Genet; 16: e1008275
Thöming JG, Tomasch J, Preusse M, Koska M, Grahl N, Pohl S, Willger SD, KAEVER V, Müsken M, Häussler S. (2020)
Parallel evolutionary paths to produce more than one Pseudomonas aeruginosa biofilm phenotype.
NPJ Biofilms Microbiomes; 6: 2
Wallner T, Pedroza L, Voigt K, KAEVER V, Wilde A. (2020)
The cyanobacterial phytochrome 2 regulates the expression of motility-related genes through the second messenger cyclic di-GMP.
Photochem Photobiol Sci; 19: 641-643
2019
Braun, F., Thomalla, L., van der Does, C., Quax, T.E.F., Allers, T., KAEVER, V., Albers, SV. (2019)
Cyclic nucleotides in archaea: Cyclic di-AMP in the archaeon Haloferax volcanii and its putative role.
Microbiologyopen, e829
Grobe, S, Doberenz, S., Ferreira, K., Krueger, J., Brönstrup, M., KAEVER, V., Häußler, S. (2019)
Identification and quantifi.cation of (t)RNA modifications in Pseudomonas aeruginosa by liquid chromatography-tandem mass spectrometry.
Chembiochem. 20, 1430-1437
Koppenhöfer, S., Wang, H., Scharfe, M., KAEVER, V., Wagner-Döbler, I., Tomasch, J. (2019)
Integrated Transcriptional Regulatory Network of Quorum Sensing, Replication Control, and SOS Response in Dinoroseobacter shibae.
Front. Microbiol.10, 803
Kordes, A., Grahl, N., Koska, M., Preusse, M., Arce-Rodriguez, A., Abraham, W.R., KAEVER, V., Häussler, S. (2019)
Establishment of an induced memory response in Pseudomonas aeruginosa during infection of a eukaryotic host.
ISME J. 13, 2018-2030.
Li, F, Cimdins, A., Rohde, M., Jänsch, L., KAEVER, V., Nimtz, M., Römling, U. (2019)
DncV Synthesizes Cyclic GMP-AMP and Regulates Biofilm Formation and Motility in Escherichia coli ECOR31.
MBio 10, pii: e02492-18
Nicholls T.J., Spåhr H, Jiang S., Siira S.J., Koolmeister C. Sharma S., Kauppila J.H.K., Jiang M., KAEVER V., Rackham O., Chabes A., Falkenberg M., Filipovska A., Larsson N.G., Gustafsson C.M. (2019)
Dinucleotide Degradation by REXO2 Maintains Promoter Specificity in Mammalian Mitochondria.
Mol. Cell. 76, 784-796
Rossmann, F.M., Rick, T., Mrusek, D., Sprankel, L., Dörrich, A.K., Leonhard, T., Bubendorfer, S., KAEVER, V., Bange, G., Thormann, K.M. (2019)
The GGDEF domain of the phosphodiesterase PdeB in Shewanella putrefaciens mediates recruitment by the polar landmark protein HubP.
J. Bacteriol., pii: e00534-18
Sayner, S.L., Choi, C..S, Maulucci, M.E., Ramila, K.C., Zhou, C., Scruggs, A.K., Yarbrough, T., Blair, L.A.H., King, J.A.C., Seifert, R. KAEVER, V., Bauer N.N. (2019)
Extracellular vesicles: another compartment for the second messenger, cyclic adenosine monophosphate (cAMP).
Am. J. Physiol. Lung Cell. Mol. Physiol. 316, L691-L700
Scharrenbroich, J., KAEVER, V., Dove, S., Seifert, R. Schneider, E.H. (2019)
Hydrolysis of the non-canonical cyclic nucleotide cUMP by PDE9A: kinetics and binding mode.
Naunyn Schmiedebergs Arch. Pharmacol. 392, 199-208
Sperling L, Mulero Alegría MD, KAEVER V, Curtis PD. Analysis of Brevundimonas subvibrioides developmental signaling systems reveals inconsistencies between phenotypes and c-di-GMP levels.
J. Bacteriol., pii: JB.00447-19
Wissig, J., Grischin, J., Bassler, J., Schubert, C., Friedrich, T., BÄHRE, H., Schultz, J.E., Unden, G. (2019)
CyaC, a redox-regulated adenylate cyclase of Sinorhizobium meliloti with a quinone responsive diheme-B membrane anchor domain.
Mol. Microbiol. 112, 16-28.
2018
Munder, A., Rothschuh, J., Schirmer, B., Klockgether, J., KAEVER, V., Tümmler, B., Seifert, R., Kloth, C. (2018)
The Pseudomonas aeruginosa ExoY phenotype of high-copy-number recombinants is not detectable in natural isolates.
Open Biol 8, pii: 170250
Ostermeyer, J., Golly, F., KAEVER, V., Dove, S., Seifert, R., Schneider, E.H. (2018)
cUMP hydrolysis by PDE3B.
Naunyn Schmiedebergs Arch Pharmacol 391, 891-905
Schäper, S., Yau, H.C.L., Krol, E., Skotnicka, D., Heimerl, T., Gray, J., KAEVER, V., Søgaard-Andersen, L., Vollmer, W., Becker, A. (2018)
Seven-transmembrane receptor protein RgsP and cell wall-binding protein RgsM promote unipolar growth in Rhizobiales.
PLoS Genet. 14, e1007594
Zhang, Y., Sass, A., Van Acker, H., Wille, J., Verhasselt, B., Van Nieuwerburgh, F., KAEVER, V., Crabbé, A., Coenye, T. (2018)
Coumarin Reduces Virulence and Biofilm Formation in Pseudomonas aeruginosa by Affecting Quorum Sensing, Type III Secretion and C-di-GMP Levels.
Front Microbiol. 9, 1952
2017
Angerer, V., Schwenk, P., Wallner, T., KAEVER, V., Wilde A. (2017)
The protein Slr1143 is an active diguanylate cyclase in Synechocystis sp. PCC 6803 and interacts with the photoreceptor Cph2.
Microbiology 163, 920-930
BÄHRE, H., KAEVER, V. (2017)
Mass Spectrometric Analysis of Non-canonical Cyclic Nucleotides.
Handb. Exp. Pharmacol. 238; 293-306
BÄHRE, H., KAEVER, V. (2017)
Identification and quantification of cyclic d-guanosine monophosphate and its linear metabolites by reversed-phase LC-MS/MS.
Methods Mol. Biol. 1657, 45-68
Berrisch, S., Ostermeyer, J., KAEVER, V., Kälble, S., Hilfiker-Kleiner, D., Seifert, R., Schneider, E.H. (2017)
cUMP hydrolysis by PDE3A.
Naunyn Schmiedeberg's Arch. Pharmacol. 390, 269-280
Blötz, C., Treffon, K., KAEVER, V., Schwede, F., Hammer, E., Stülke, J. (2017)
Identification of the Components Involved in Cyclic Di-AMP Signaling in Mycoplasma pneumoniae.
Front Microbiol 8, 1328
Doberenz, S., Eckweiler, D., Reichert, O., Jensen, V., Bunk, B., Spröer, C., Kordes, A., Frangipani, E., Luong, K., Korlach, J., Heeb, S., Overmann, J., KAEVER, V., Häussler, S. (2017)
Identification of a Pseudomonas aeruginosa PAO1 DNA Methyltransferase, Its Targets, and Physiological Roles.
MBio. 8, pii: e02312-16
Fazli, M., Rybtke, M., Steiner, E., Weidel ,E., Berthelsen, J., Groizeleau, J., Bin, W., Zhi, B.Z., Yaming, Z., KAEVER, V., Givskov, M., Hartmann, R.W., Eberl, L., Tolker-Nielsen, T. (2017)
Regulation of Burkholderia cenocepacia biofilm formation by RpoN and the c-di-GMP effector BerB.
Microbiologyopen 6
Gundlach, J., Herzberg, C., KAEVER, V., Gunka, K., Hoffmann, T., Weiß, M., Gibhardt, J., Thürmer, A., Hertel, D., Daniel, R., Bremer, E., Commichau, F.M., Stülke, J. (2017)
Control of potassium homeostasis is an essential function of the second messenger cyclic di-AMP in Bacillus subtilis.
Sci Signal, 10, pii: eaal3011.
Moreira, R.N., Dressaire, C., Barahona, S., Galego, L., KAEVER, V., Jenal, U., Arraiano, C.M. (2017)
BolA Is Required for the Accurate Regulation of c-di-GMP, a Central Player in Biofilm Formation.
MBio 8, e00443-17
Paijo J., KAEVER, V., Kalinke, U. (2017)
cGAMP Quantification in Virus-Infected Human Monocyte-Derived Cells by HPLC-Coupled Tandem Mass Spectrometry.
Methods Mol. Biol. 656, 153-166
Sarenko, O., Klauck, G., Wilke, F.M., Pfiffer, V., Richter, A.M., Herbst, S., KAEVER, V., Hengge R. (2017)
More than Enzymes That Make or Break Cyclic Di-GMP-Local Signaling in the Interactome of GGDEF/EAL Domain Proteins of Escherichia coli.
MBio. 8, e01639-17.
Schmid, N., Suppiger, A., Steiner, E., Pessi, G., KAEVER, V., Fazli M., Tolker-Nielsen, T., Jenal, U., Eberl, L. (2017)
High intracellular c-di-GMP levels antagonize quorum sensing and virulence gene expression in Burkholderia cenocepacia H111.
Microbiology 163: 754-764
Sprecher, K.S., Hug, I., Nesper, J., Potthoff, E., Mahi, M.A., Sangermani, M., KAEVER, V., Schwede, T., Vorholt, J., Jenal, U. (2017)
Cohesive Properties of the Caulobacter crescentus Holdfast Adhesin Are Regulated by a Novel c-di-GMP Effector Protein.
MBio. 8, pii: e00294-17
Zhang, Y. Agrebi, R., Bellows, L.E., Collet, J.F., KAEVER, V., Gründling, A. (2017)
Evolutionary Adaptation of the Essential tRNA Methyltransferase TrmD to the Signaling Molecule 3',5'-cAMP in Bacteria.
J. Biol. Chem. 292, 313-327
2016
Abbey, M., Hakim, C., Anand, R., Lafera, J., Schambach, A., Kispert, A., Taft, M.H., KAEVER, V., Kotlyarov, A., Gaestel, M., Menon, M.B. (2016)
GTPase domain driven dimerization of SEPT7 is dispensable for the critical role of septins in fibroblast cytokinesis.
Sci. Rep. 28, 20007
Bæk, K.T., Bowman, L., Millership, C., Dupont Søgaard, M., KAEVER, V., Siljamäki, P., Savijoki, K., Varmanen, P., Nyman, T.A., Gründling, A., Frees, D. (2016)
The Cell Wall Polymer Lipoteichoic Acid Becomes Nonessential in Staphylococcus aureus Cells Lacking the ClpX Chaperone.
MBio 7, e01228-16
Bowman, L., Zeden, M.S., Schuster, C.F., KAEVER, V., Grundling, A. (2016)
New Insights into the Cyclic di-Adenosine Monophosphate (c-di-AMP) Degradation Pathway and the Requirement of the Cyclic-Dinucleotide for Acid Stress Resistance in Staphylococcus aureus.
J Biol Chem. 291: 26970-26986
Gaupels, F., Furch, A.C., Zimmermann, M.R., Chen, F., KAEVER, V., Buhtz, A., Kehr, J., Sarioglu, H., Kogel, K.H., Durner, J. (2016)
Systemic Induction of NO-, Redox-, and cGMP Signaling in the Pumpkin Extrafascicular Phloem upon Local Leaf Wounding.
Front. Plant. Sci. 7, 154.
Corrigendum: Front. Plant. Sci. 7, 281
Groizeleau, J., Rybtke, M., Andersen, J.B., Berthelsen, J., Liu, Y., Yang, L., Nielsen, T.E., KAEVER, V., Givskov, M., Tolker-Nielsen, T. (2016)
The anti-cancerous drug doxorubicin decreases the c-di-GMP content in Pseudomonas aeruginosa but promotes biofilm formation.
Microbiology 162, 1797-1807
Krol, E., Klaner, C., Gnau, P., KAEVER, V., Essen, L.O., Becker, A. (2016)
Cyclic mononucleotide- and Clr-dependent gene regulation in Sinorhizobium meliloti.
Microbiology 162, 1840-1856
Lacanna, E., Bigosch, C., KAEVER, V., Boehm, A., Becker, A. (2016)
Evidence for Escherichia coli diguanylate cyclase DgcZ interlinking surface sensing and adhesion via multiple regulatory routes.
J. Bacteriol. 198: 2524-2535
Paijo, J., Döring, M., Spanier, J., Grabski, E., Nooruzzaman, M., Schmidt, T., Witte, G., Messerle, M., Hornung, V., KAEVER, V., Kalinke, U. (2016)
cGAS Senses Human Cytomegalovirus and Induces Type I Interferon Responses in Human Monocyte-Derived Cells.
PLoS Pathog. 12, e1005546.
Pawar, V.S., Messina, M., Rinaldo, S., Cutruzzola, F., KAEVER, V., Rampioni, G., Leonie, L. (2016)
Novel genetic tools to tackle c-di-GMP-dependent signaling in Pseudomonas aeruginosa.
J. Appl. Microbiol. 120, 205-217
Rismondo, J., Gibhardt, J., Rosenberg, J., KAEVER, V., Halbedel, S., Commichau, F.M. (2016)
Phenotypes associated with the essential diadenylate cyclase CdaA and its potential regulator CdaR in the human pathogen Listeria monocytogenes.
J. Microbiol. 198, 416-426
Schäper, S., Krol, E., Skotnicka, D., KAEVER, V., Hilker, R., Sogaard-Andersen, L., Becker, A. (2016)
Cyclic di-GMP regulates multiple cellular functions in the symbiotic α-proteobacterium Sinorhizobium meliloti
J. Bacteriol. 198, 521-535
Schmidt, A., Hammerbacher, A.S., Bastian, M., Nieken, K.J., Klockgether, J., Merighi, M., Lapouge, K., Poschgan, C., Kölle, J., Acharya, K.R., Ulrich, M., Tümmler, B., Unden, G., KAEVER, V., Lory S., Haas D., Schwarz S., Döring G. (2016)
Oxygen-dependent regulation of c-di-GMP synthesis by SadC controls alginate production in Pseudomonas aeruginosa.
Environ. Microbiol. 18, 3390-3402
Skotnicka, D., Smaldone, G.T., Petters, T., Trampari, E., Liang, J., KAEVER, V., Malone, J.G., Singer, M., Søgaard-Andersen, L. (2016)
A minimal threshold of c-di-GMP is essential for fruiting body formation and sporulation in Myxococcus xanthus.
PLoS Genet. 12, e1006080.
Suppiger, A., Eshwar, A.K., Stephan, R., KAEVER, V., Eberl, L., Lehner, A. (2016)
The DSF type quorum sensing signalling system RpfF/R regulates diverse phenotypes in the opportunistic pathogen Cronobacter
Sci. Rep. 6, 18753
Zhang, Y., Agrebi, R., Bellows, L.E., Collet, J.F., KAEVER, V., Gründling, A. (2016)
Evolutionary Adaptation of the Essential tRNA Methyltransferase TrmD to the Signaling Molecule 3,5-cAMP in Bacteria.
J Biol Chem 2016 292, 313-327
2015
BÄHRE, H., Hartwig, C., Munder, A., Wolter, S., Stelzer, T., Schirmer, B., Beckert, U., Frank, D.W., Tümmler, B., KAEVER, V., Seifert, R. (2015)
cCMP and cUMP occur in vivo.
Biochim. Biophys. Res. Commun. 460, 909 - 914
Blanka, A., Düvel, J., Dötsch, A., Klinkert, B., Abraham, W.-R., KAEVER, V., Ritter, C., Narberhaus, F., Häussler, S. (2015)
Constitutive production of c-di-GMP is associated with mutations in a variant of Pseudomonas aeruginosa with altered membrane composition.
Sci. Signal. 8, ra36
Bridgeman, A., Maelfait, J., Davenne, T., Partridge, T., Peng, Y., Mayer, A., Dong, T., KAEVER, V., Borrow, P., Rehwinkel, J. (2015)
Viruses transfer the antiviral second messenger cGAMP between cells.
Science 349, 1228 - 1232
Cohen, D., Mechold, U., Nevenzal, H., Yarmiyhu, Y., Randall, T.E., Bay, D.C., Rich, J.D., Parsek, M.R., KAEVER, V., Harrison, J.J., Banin, E. (2015)
Oligoribonuclease is a central feature of cyclic diguanylate signaling in Pseudomonas aeruginosa.
P. Natl. Acad. Sci. USA 112, 11359 - 11364
Corrigan, R.M., Bowman, L., Willis, A.R., KAEVER, V., Gründling, A. (2015)
Crosstalk between two nucleotide-signaling pathways in Staphylococcus aureus.
J. Biol. Chem. 290, 5826 - 5839
Dittmar, F., Abdelilah-Seyfried, S., Tschirner, S.K., KAEVER, V., Seifert, R. (2015)
Temporal and organ-specific detection of cNMPs including cUMP in the zebrafish.
Biochem. Biophys. Res. Commun. 468, 708 - 712
Gundlach, J., Dickmanns, A., Schröder-Tittmann, K., Neumann, Piotr, Kampf, J., Herzberg, C., Hammer, E., Schwede, F., KAEVER, V., Tittmann, K., Stülke, J., Ficner, R. (2015)
Identification, characterization and structure analysis of the c-di-AMP binding PII-like protein DarA
J. Biol. Chem. 290, 3069 - 3080
Gundlach, J., Mehne, F.M., Herzberg, C., Kampf, J., Valerius, O., KAEVER, V., Stülke, J. (2015)
An essential poison: Synthesis and degradation of cyclic di-AMP in Bacillus subtilis.
J. Microbiol 197, 3265 - 3274
Morrow, K.A., Seifert, R., KAEVER, V., Britain, A.L., Sayner, S.L., Ochoa, C.D., Cioffi, E.A., Frank, D.W., Rich, T.C., Stevens, T. (2015)
Heterogeneity of pulmonary endothelial cyclic nucleotide response to Pseudomonas aeruginosa ExoY infection.
Am. J. Physiol. Lung Cell Mol. Physiol. 309, L1199 – L1207
Peltier, J., Shaw, H.A., Couchman, E.C., Dawson, L.F., Yu, L., Choudhary, J.S., KAEVER, V., Brendan, W.W., Fairweather, N.F. (2015)
Cyclic-di-GMP regulates production of sortase substrates of Clostridium difficile and their surface exposure through ZmpI protease-mediated cleavage.
J. Biol. Chem. 290, 24453 - 24469
Reinartz, M.T., Kälble, S., Littmann, T., Ozawa, T., Dove, S., KAEVER, V., Wainer, I.W., Seifert, R. (2015)
Structure-bias relationships for fenoterol stereoisomers in six molecular and cellular assays at the ß2-adrenoceptor
Naunyn-Schmiedeberg's Arch. Pharmacol. 388, 51 - 65
Rosenberg, J., Dickmanns, A., Neumann, P., Gunka, K., Arens, J., KAEVER, V., Stülke, J., Ficner, R., Commichau, F.M. (2015)
Structural and biochemical analysis of the essential diadenylate cyclase CdaA from Listeria monocytogenes.
Biol. Chem. 290, 6596 - 6606
Skotnicka, D., Petters, T., Heering, J., Hoppert, MK., KAEVER, V., Sogaard-Andersen, L. (2015)
c-di-GMP regulates type IV pili-dependent mobility in Myxococcus xanthus
J. Bacteriol. 198, 77 - 90
Visaggio, D., Pasqua, M., Bonchi, C., KAEVER, V., Visca, P., Imperi, F. (2015)
Cell aggregation promotes pyoverdine-dependent iron uptake and virulence in Pseudomonas aeruginosa
Frontiers Microbiol. 6, 902
2014
BÄHRE, H., Danker, K.Y., Stasch, J.-P., KAEVER, V., Seifert, R. (2014)
Nucleotidyl cyclase activity of soluble guanylyl cyclase in intact cells.
Biochim. Biophys. Res. Commun. 443, 1195 - 1199
BÄHRE, H., KAEVER, V. (2014)
Measurement of 2´, 3´-cyclic nucleotides by liquid chromatography-tandem mass spectrometry in cells.
J. Chromatogr. B 964, 208 - 211
Beckert, U., Grundmann, M., Wolter, S., Schwede, F., Rehmann, H., KAEVER, V., Kostenis, E., Seifert, R. (2014)
cNMP-AMs mimic and dissect bacterial nucleotidyl cyclase toxin effects.
Biochim. Biophys. Res. Commun. 451, 497 – 502
Beckert, U., Wolter S., Hartwig, C., Bähre H., KAEVER, V., Ladant, D., Frank, D.W., Seifert, R. (2014)
ExoY from Pseudomonas aeruginosa is a nucletotidyl cyclase with preference for cGMP and cUMP formation.
Biochim. Biophys. Res. Commun. 450, 870 - 874
Blanka, A., Schulz, S., Eckweiler, D., Franke, R., Bielecka, A., Nicolai, T., Casilag, F., Düvel, J., Abraham, W.-R., KAEVER, V., Häussler, S. (2014)
Identification of the alternative sigma factor SigX regulon and its implication for Pseudomonas aeruginosa pathogenicity.
J. Microbiol. 196, 345 - 356
Diethmaier, C., Newman, J.A., Kovacs, A.T., KAEVER, V., Herzberg, C., Rodrigues, C., Boonstra, M., Kuipers, O.P., Lewis, R.J, Stülke, J. (2014)
The YmdB phosphodiesterase is a global regulator of late adaptive responses in Bacillus subtilis.
J. Bacteriol. 196, 265 - 275
Dove S., Danker, K.Y., Stasch, J.-P., KAEVER, V., Seifert, R. (2014)
Structure/activity relationships of (M)ANT- and TNP-nucleotides for inhibition of rat soluble guanylyl cyclase α1ß1.
Mol. Pharmacol. 85, 598 - 607
Frangipani, E., Visaggio, D., Heeb, S., KAEVER, V., Camara, M., Visca, P., Imperi, F. (2014)
The Gac/Rsm and cyclic-di-GMP signalling networks coordinately regulate iron uptake in Pseudomonas aeruginosa.
Environ. Microbiol. 16, 676 - 688
Gao, S., Romdhane, S.B., Beullens, S., KAEVER, V., Lambrichts, I., Fauvart, M., Michiels, J. (2014)
Genomic analysis of cyclic-di-GMP-related genes in rhizobial type strains and functional analysis in Rhizobium etli.
Appl. Microbiol. Biotechnol. 98, 4589 - 4602
Hasan, A., Danker, K.Y., Wolter, S., BÄHRE, H., KAEVER, V., Seifert, R. (2014)
Soluble adenylyl cyclase accounts for high basal cCMP and cUMP concentrations in HEK293 and B103 cells.
Biochim. Biophys. Res. Commun. 448, 236 - 240
Hartwig, C., BÄHRE, H., Wolter, S., Beckert, U., KAEVER, V., Seifert, R. (2014)
cAMP, cGMP, cCMP and cUMP concentrations across the tree of life: High cCMP and cUMP levels in astrocytes.
Neurosci. Lett. 579, 183 - 187
Laue, S., Winterhoff, M., KAEVER, V., van den Heuvel, J.J., Russel, F.G., Seifert, R. (2014)
cCMP is a substrate for MRP5.
Naunyn-Schmiedeberg's Arch. Pharmacol. 387, 893 - 895
Mehne, F.M.P., Schröder-Tittmann, K., Eijlander, R.T., Herzberg C., Hewitt, L., KAEVER, V., Lewis, R.J., Kuipers, O.P., Tittmann, K., Stülke, J. (2014)
Control of diadenylate cyclase CdaS in Bacillus subtilis: an autoinhibitory domain limits c-di-AMP production.
J. Biol. Chem. 289, 21098 - 21107
Targeted metabolomics - Oncometaboliten
Berod L, Friedrich C, Nandan A, Freitag J, Hagemann S, Harmrolfs K, Sandouk A, Hesse C, Castro CN, BÄHRE H, Tschirner SK, Gorinski N, Gohmert M, Mayer CT, Huehn J, Ponimaskin E, Abraham WR, Müller R, Lochner M, Sparwasser T.De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells.
Nat. Med. 2014; 20: 1327 -1333
Erratum in: Nat. Med. 2015; 21: 414
Targeted Metabolomics - Andere Metaboliten
2021
Neumann J, Grobe JM, Weisgut J, Schwelberger HG, Fogel WA, Marušáková M, Wache H, Bähre H, Buchwalow IB, Dhein S, Hofmann B, Kirchhefer U, Gergs U. Histamine can be Formed and Degraded in the Human and Mouse Heart. Front Pharmacol 2021; 12: 582916. doi: 10.3389/fphar.2021.582916.
Perduns R, Volk J, Plum M, Jochums A, Gutzki F, Kaever V, Geurtsen W. Camphorquinone alters the expression of extracellular proteases in a 3D co-culture model of the oral mucosa. Dent Mater 2021; 37: 236-248. doi: 10.1016/j.dental.2020.11.005.
Winterhoff M, Chen F, Sahini N, Ebensen T, Kuhn M, Kaever V, Bähre H, Pessler F. Establishment, Validation, and Initial Application of a Sensitive LC-MS/MS Assay for Quantification of the Naturally Occurring Isomers Itaconate, Mesaconate, and Citraconate. Metabolites 2021; 11: 270. doi: 10.3390/metabo11050270.
2015-2020
de Araujo L.S., Pessler K., Sühs K.W., Novoselova N., Klawonn F., Kuhn M., KAEVER V., Müller-Vahl K., Trebst C., Skripuletz T., Stangel M., Pessler F. (2020) Phosphatidylcholine PC ae C44:6 in cerebrospinal fluid is a sensitive biomarker for bacterial meningitis.
J Transl Med 18:9
Chen, F., Lukat, P., Iqbal, A.A., Saile, K., KAEVER, V., van den Heuvel, J., Blankenfeldt, W., Büssow, K., Pessler, F. (2019)
Crystal structure of cis-aconitate decarboxylase reveals the impact of naturally occurring human mutations on itaconate synthesis.
Proc. Natl. Acad.Sci. U.S.A. 116, 20644-20654
Kuhla, B., KAEVER, V., Tuchscherer, A., Kuhla, A. (2020)
Involvement of plasma endocannabinoids and the hypothalamic endocannabinoid system in increasing feed intake after parturition of dairy cows.
Neuroendocrinology 110, 246-257
Kuhn, M., Sühs, K.W., Akmatov, M.K., Klawonn, F., Wang, J., Skripuletz, T., KAEVER, V., Stangel, M., Pessler, F. (2018)
Mass-spectrometric profiling of cerebrospinal fluid reveals metabolite biomarkers for CNS involvement in varicella zoster virus reactivation.
J. Neuroinflammation 15, 20
Perduns R, Volk J, Plum M, GUTZKI, F., KAEVER, V., Geurtsen W. (2019)
Effects of HEMA on Nrf2-related gene expression using a newly developed 3D co-culture model of the oral mucosa.
Dent. Mater. pii: S0109-5641.
Ratuszny, D., Sühs, K.W., Novoselova, N., Kuhn, M., KAEVER, V., Skripuletz, T., Pessler, F., Stangel, M. (2019)
Identification of Cerebrospinal Fluid Metabolites as Biomarkers for Enterovirus Meningitis.
Int. J. Mol. Sci. 20, pii: E337
Schimmel K,. Jung M., Foinquinos A., San José G., Beaumont J., Bock K., Grote-Levi L., Xiao K., Bär C., Pfanne A., Just A., Zimmer K., Ngoy S., López B., Ravassa S., Samolovac S., Janssen-Peters H., Remke J., Scherf K., Dangwal S., Piccoli M.T., Kleemiss F., Kreutzer F.P., Kenneweg F., Leonardy J., Hobuß L., Santer L., Do Q.T., Geffers R., Braesen J.H., Schmitz J., Brandenberger C., Müller D.N., Wilck N., Kaever V., Bähre H., Batkai S., Fiedler J., Alexander K.M., Wertheim B.M., Fisch S., Liao R., Diez J., González A., Thum T. (2020)
Natural Compound Library Screening Identifies New Molecules for the Treatment of Cardiac Fibrosis and Diastolic Dysfunction.
Circulation; 141: 751-767
Sühs, K.W., Novoselova, N., Kuhn, M., Seegers, L., KAEVER, V., Müller-Vahl, K., Trebst, C., Skripuletz, T., Stangel, M., Pessler, F. (2019)
Kynurenine is a cerebrospinal fluid biomarker for bacterial and viral CNS infections.
J. Infect. Dis. 220, 127-138
Zwadlo, C., Schmidtmann, E., Szaroszyk, M., Badder, K., Froese, N., Hinz, H., Schmitto, J.D., Widder, J., Batkai, S., BÄHRE, H., KAEVER, V., Thum, T., Bauersachs, J., Heinecke, J. (2015)
Anti-androgenic therapy with finasteride attenuates cardiac hypertrophy and left ventricular dysfunction.
Circulation 131, 1071 - 108
Targeted metabolomics - Neurotransmitter
2017
BÄHRE, H., KAEVER, V. (2017)
Analytical Methods for the Quantification of Histamine and Histamine Metabolites.
Handb. Exp. Pharmacol. 241, 3-19
2016
Tschirner, S.K., Gutzki, F., Schneider, E.H., Seifert, R., KAEVER, V. (2016)
Neurotransmitter and their metabolite concentrations in different areas of the HPRT knockout mouse brain.
J. Neurol. Sci. 365, 169-174
Tschirner, S.K., BÄHRE, H., Kaever, A., Schneider, E.H., Seifert, R., KAEVER, V. (2016)
Non-targeted metabolomics by high resolution mass spectrometry in HPRT knockout mice.
Life Sci. 156, 68-73
2015
Tschirner, S.K., Gutzki, F., KAEVER, V., Seifert, R., Schneider, E.H. (2015)
Altered histamine neurotransmission in HPRT-deficient mice.
Neurosci. Lett. 609, 74 - 80
2014
Mahapatra, S., Albrecht, M., Behrens, B., Jirmo, A., Behrens, G., Hartwig, C., Neumann, D., Raap, U., Bähre, H., Herrick, C., Dittrich, A.M. (2014)
Delineating the role of histamine-1- and -4-receptors in a mouse model of Th2-dependent antigen-specific skin inflammation.
PLoS One 9, e87296
Zugelassene Wirkstoffe
2016
Avsar, M., Jansson, K., Sommer, W., Kruse, B., Thissen S., Dreckmann, K., Knoefel, A.-K., Salman, J., Gottlieb, J., Hafer, C., Hecker, J., Buechler, G., Karstens, J.H., Jonigk, D., Länger, F., KAEVER, V., Falk, C., Hewicker-Trautwein, M., Ungefroren, H., Haverich, A., Strüber, M., Warnecke, G. (2016)
Augmentation of transient donor cell chimerism and alloantigen-specific regulation of lung transplants in miniature swine.
Am. J. Transplant. 16, 1371-82
2015
Lachmann, N., Czarnecki, K., Brennig, S., Phaltane, R., Heise, M., Heinz, N., Kempf, H., Dilloo, D., KAEVER, V., Schambach, A., Heuser, M., Moritz, T.
Deoxycytidine-kinase knockdown as a novel myeloprotective strategy in the context of fludarabine, cytarabine or cladribine therapy.
Leukemia 29, 2266-2269
Experimentelle Wirkstoffe
Abeln, M., Borst, K., Cajic, S., Thiesler, H., Kats, E., Albers, I., Kuhn, M., KAEVER, V., Rapp E, Münster-Kühnel A, Weinhold, B. (2017)
Sialylation is dispensable for early murine embryonic development in vitro.
Chembiochem, 18: 1305-1316
Chaturvedi, A., Goparaju, R., Gupta, C., Weder, J., Klünemann, T., Araujo Cruz, M.M. Kloos, A., Goerlich, K., Schottmann, R., Othman, B., Struys, E.A., Bähre, H., Grote-Koska, D., Brand, K., Ganser, A., Preller, M., Heuser, M. (2019)
In vivo efficacy of mutant IDH1 inhibitor HMS-101 and structural resolution of distinct binding site.
Leukemia 2020; 34: 416-426]
Melzer, C., Rehn, V., Yang, Y., BÄHRE, H., von der Ohe, J., Hass, R. (2019)
Taxol-Loaded MSC-Derived Exosomes Provide a Therapeutic Vehicle to Target Metastatic Breast Cancer and Other Carcinoma Cells.
Cancers (Basel) 11: pii: E798.
Reichert, O., Fleming, T., Neufang, G., Schmelz, M., Genth, H., KAEVER, V., Wenck, H., Stäb, F., Terstegen, L., Kolbe, L., Roggenkamp, D. (2017)
Impaired glyoxalase activity is associated with reduced expression of neurotrophic factors and pro-inflammatory processes in diabetic skin cells.
Exp. Dermatol. 26, 44-50
Non-targeted metabolomics
Tschirner, S.K., BÄHRE, H., Kaever, A., Schneider, E.H., Seifert, R., KAEVER, V. (2016)
Non-targeted metabolomics by high resolution mass spectrometry in HPRT knockout mice.
Life Sci. 156, 68-73
Tschirner, S.K., BÄHRE, H., Seifert R., KAEVER, V. (2014)
Non-targeted Metabolomics in a cell model for Lesch-Nyhan Syndrome.
Naunyn-Schmiedeberg´s Arch Pharmacol 387 (Suppl 1) S97 (Abstract)