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Zugelassene Wirkstoffe

2016

Avsar, M., Jansson, K., Sommer, W., Kruse, B., Thissen S., Dreckmann, K., Knoefel, A.-K., Salman, J., Gottlieb, J., Hafer, C., Hecker, J., Buechler, G., Karstens, J.H., Jonigk, D., Länger, F., KAEVER, V., Falk, C., Hewicker-Trautwein, M., Ungefroren, H., Haverich, A., Strüber, M., Warnecke, G. (2016)
Augmentation of transient donor cell chimerism and alloantigen-specific regulation of lung transplants in miniature swine.
Am. J. Transplant. 16, 1371-82 

 

2015

Lachmann, N., Czarnecki, K., Brennig, S., Phaltane, R., Heise, M., Heinz, N., Kempf, H., Dilloo, D., KAEVER, V., Schambach, A., Heuser, M., Moritz, T.
Deoxycytidine-kinase knockdown as a novel myeloprotective strategy in the context of fludarabine, cytarabine or cladribine therapy.
Leukemia 29, 2266-2269

 

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Experimentelle Wirkstoffe

Abeln, M., Borst, K., Cajic, S., Thiesler, H., Kats, E., Albers, I., Kuhn, M., KAEVER, V., Rapp E, Münster-Kühnel A, Weinhold, B. (2017)
Sialylation is dispensable for early murine embryonic development in vitro.
Chembiochem, 18: 1305-1316 

Chaturvedi, A., Goparaju, R., Gupta, C., Weder, J., Klünemann, T., Araujo Cruz, M.M. Kloos, A., Goerlich, K., Schottmann, R., Othman, B., Struys, E.A., Bähre, H., Grote-Koska, D., Brand, K., Ganser, A., Preller, M., Heuser, M. (2019)
In vivo efficacy of mutant IDH1 inhibitor HMS-101 and structural resolution of distinct binding site.
Leukemia 2020; 34: 416-426]

Melzer, C., Rehn, V., Yang, Y., BÄHRE, H., von der Ohe, J., Hass, R. (2019)
Taxol-Loaded MSC-Derived Exosomes Provide a Therapeutic Vehicle to Target Metastatic Breast Cancer and Other Carcinoma Cells.
Cancers (Basel) 11: pii: E798.

Reichert, O., Fleming,  T., Neufang,  G., Schmelz,  M., Genth,  H., KAEVER,  V., Wenck,  H., Stäb, F., Terstegen, L., Kolbe, L., Roggenkamp, D. (2017)
Impaired glyoxalase activity is associated with reduced expression of neurotrophic factors and pro-inflammatory processes in diabetic skin cells.
Exp. Dermatol. 26, 44-50

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Targeted Metabolomics - Nukleoside

2020

Gibhardt J, Heidemann JL, Bremenkamp R, Rosenberg J, Seifert R, KAEVER V, Ficner R, Commichau FM (2020).
An extracytoplasmic protein and a moonlighting enzyme modulate synthesis of c-di-AMP in Listeria monocytogenes.
Environ Microbiol; 22: 2771-2791

 

Latoscha A, Drexler DJ, Al-Bassam MM, Bandera AM, KAEVER V, Findlay KC, Witte G, Tschowri N (2020).
c-di-AMP hydrolysis by the phosphodiesterase AtaC promotes differentiation of multicellular bacteria.
Proc Natl Acad Scie USA 2020; 117: 7392-7400

 

Schäfer H, Beckert B, Frese CK, Steinchen W, Nuss AM, Beckstette M, Hantke I, Driller K, Sudzinová P, Krásný L, KAEVER V, Dersch P, Bange G, Wilson DN, Turgay K. (2020)
The alarmones (p)ppGpp are part of the heat shock response of Bacillus subtilis.
PLoS Genet; 16: e1008275

 

Thöming JG, Tomasch J, Preusse M, Koska M, Grahl N, Pohl S, Willger SD, KAEVER V, Müsken M, Häussler S. (2020)
Parallel evolutionary paths to produce more than one Pseudomonas aeruginosa biofilm phenotype.
NPJ Biofilms Microbiomes; 6: 2

 

Wallner T, Pedroza L, Voigt K, KAEVER V, Wilde A. (2020)
The cyanobacterial phytochrome 2 regulates the expression of motility-related genes through the second messenger cyclic di-GMP.
Photochem Photobiol Sci; 19: 641-643

 

2019

Braun, F., Thomalla, L., van der Does, C., Quax, T.E.F., Allers, T., KAEVER, V., Albers, SV. (2019)
Cyclic nucleotides in archaea: Cyclic di-AMP in the archaeon Haloferax volcanii and its putative role.
Microbiologyopen, e829 

Grobe, S, Doberenz, S., Ferreira, K., Krueger, J., Brönstrup, M., KAEVER, V., Häußler, S. (2019)
Identification and quantifi.cation of (t)RNA modifications in Pseudomonas aeruginosa by liquid chromatography-tandem mass spectrometry.
Chembiochem. 20, 1430-1437

Koppenhöfer, S., Wang, H., Scharfe, M., KAEVER, V., Wagner-Döbler, I., Tomasch, J. (2019)
Integrated Transcriptional Regulatory Network of Quorum Sensing, Replication Control, and SOS Response in Dinoroseobacter shibae.
Front. Microbiol.10, 803

Kordes, A., Grahl, N., Koska, M., Preusse, M., Arce-Rodriguez, A., Abraham, W.R., KAEVER, V., Häussler, S. (2019)
Establishment of an induced memory response in Pseudomonas aeruginosa during infection of a eukaryotic host.
ISME J. 13, 2018-2030.

Li, F, Cimdins, A., Rohde, M., Jänsch, L., KAEVER, V., Nimtz, M., Römling, U. (2019)
DncV Synthesizes Cyclic GMP-AMP and Regulates Biofilm Formation and Motility in Escherichia coli ECOR31.
MBio 10, pii: e02492-18

Nicholls T.J., Spåhr H, Jiang S., Siira S.J., Koolmeister C. Sharma S., Kauppila J.H.K., Jiang M., KAEVER V., Rackham O., Chabes A., Falkenberg M., Filipovska A., Larsson N.G., Gustafsson C.M. (2019) 
Dinucleotide Degradation by REXO2 Maintains Promoter Specificity in Mammalian Mitochondria.
Mol. Cell. 76, 784-796

Rossmann, F.M., Rick, T., Mrusek, D., Sprankel, L., Dörrich, A.K., Leonhard, T., Bubendorfer, S., KAEVER, V., Bange, G., Thormann, K.M. (2019)
The GGDEF domain of the phosphodiesterase PdeB in Shewanella putrefaciens mediates recruitment by the polar landmark protein HubP.
J. Bacteriol., pii: e00534-18

Sayner, S.L., Choi, C..S, Maulucci, M.E., Ramila, K.C., Zhou, C., Scruggs, A.K., Yarbrough, T., Blair, L.A.H., King, J.A.C., Seifert, R. KAEVER, V., Bauer N.N. (2019)
Extracellular vesicles: another compartment for the second messenger, cyclic adenosine monophosphate (cAMP).
Am. J. Physiol. Lung Cell. Mol. Physiol. 316, L691-L700

Scharrenbroich, J., KAEVER, V., Dove, S., Seifert, R. Schneider, E.H. (2019)
Hydrolysis of the non-canonical cyclic nucleotide cUMP by PDE9A: kinetics and binding mode.
Naunyn Schmiedebergs Arch. Pharmacol. 392, 199-208

Sperling L, Mulero Alegría MD, KAEVER V, Curtis PD. Analysis of Brevundimonas subvibrioides developmental signaling systems reveals inconsistencies between phenotypes and c-di-GMP levels.
J. Bacteriol., pii: JB.00447-19

Wissig, J., Grischin, J., Bassler, J., Schubert, C., Friedrich, T., BÄHRE, H., Schultz, J.E., Unden, G. (2019)
CyaC, a redox-regulated adenylate cyclase of Sinorhizobium meliloti with a quinone responsive diheme-B membrane anchor domain.
Mol. Microbiol. 112, 16-28.

 

2018

Munder, A., Rothschuh, J., Schirmer, B., Klockgether, J., KAEVER, V., Tümmler, B., Seifert, R., Kloth, C. (2018)
The Pseudomonas aeruginosa ExoY phenotype of high-copy-number recombinants is not detectable in natural isolates.
Open Biol 8, pii: 170250

Ostermeyer, J., Golly, F., KAEVER, V., Dove, S., Seifert, R., Schneider, E.H. (2018)
cUMP hydrolysis by PDE3B.
Naunyn Schmiedebergs Arch Pharmacol 391, 891-905

Schäper, S., Yau, H.C.L., Krol, E., Skotnicka, D., Heimerl, T., Gray, J., KAEVER, V., Søgaard-Andersen, L., Vollmer, W., Becker, A. (2018)
Seven-transmembrane receptor protein RgsP and cell wall-binding protein RgsM promote unipolar growth in Rhizobiales.
PLoS Genet. 14, e1007594

Zhang, Y., Sass, A., Van Acker, H., Wille, J., Verhasselt, B., Van Nieuwerburgh, F., KAEVER, V., Crabbé, A., Coenye, T. (2018)
Coumarin Reduces Virulence and Biofilm Formation in Pseudomonas aeruginosa by Affecting Quorum Sensing, Type III Secretion and C-di-GMP Levels.
Front Microbiol. 9, 1952

 

2017

Angerer, V., Schwenk, P., Wallner, T., KAEVER, V., Wilde A. (2017)
The protein Slr1143 is an active diguanylate cyclase in Synechocystis sp. PCC 6803 and interacts with the photoreceptor Cph2.
Microbiology 163, 920-930 

BÄHRE, H., KAEVER, V. (2017)
Mass Spectrometric Analysis of Non-canonical Cyclic Nucleotides.
Handb. Exp. Pharmacol. 238; 293-306

BÄHRE, H., KAEVER, V. (2017)
Identification and quantification of cyclic d-guanosine monophosphate and its linear metabolites by reversed-phase LC-MS/MS.
Methods Mol. Biol. 1657, 45-68

Berrisch, S., Ostermeyer, J., KAEVER, V., Kälble, S., Hilfiker-Kleiner, D., Seifert, R., Schneider, E.H. (2017)
cUMP hydrolysis by PDE3A.
Naunyn Schmiedeberg's Arch. Pharmacol. 390, 269-280

Blötz, C., Treffon, K., KAEVER, V., Schwede, F., Hammer, E., Stülke, J. (2017)
Identification of the Components Involved in Cyclic Di-AMP Signaling in Mycoplasma pneumoniae.
Front Microbiol 8, 1328

Doberenz, S., Eckweiler, D., Reichert, O., Jensen, V., Bunk, B., Spröer, C., Kordes, A., Frangipani, E., Luong, K., Korlach, J., Heeb, S., Overmann, J., KAEVER, V., Häussler, S. (2017)
Identification of a Pseudomonas aeruginosa PAO1 DNA Methyltransferase, Its Targets, and Physiological Roles.
MBio. 8, pii: e02312-16

Fazli, M., Rybtke, M., Steiner, E., Weidel ,E., Berthelsen, J., Groizeleau, J., Bin, W., Zhi, B.Z., Yaming, Z., KAEVER, V., Givskov, M., Hartmann, R.W., Eberl, L., Tolker-Nielsen, T. (2017)
Regulation of Burkholderia cenocepacia biofilm formation by RpoN and the c-di-GMP effector BerB.
Microbiologyopen 6

Gundlach, J., Herzberg, C., KAEVER, V., Gunka, K., Hoffmann, T., Weiß, M., Gibhardt, J., Thürmer, A., Hertel, D., Daniel, R., Bremer, E., Commichau, F.M., Stülke, J. (2017)
Control of potassium homeostasis is an essential function of the second messenger cyclic di-AMP in Bacillus subtilis.
Sci Signal, 10, pii: eaal3011.

Moreira, R.N., Dressaire, C., Barahona, S., Galego, L., KAEVER, V., Jenal, U., Arraiano, C.M. (2017)
BolA Is Required for the Accurate Regulation of c-di-GMP, a Central Player in Biofilm Formation.
MBio 8, e00443-17

Paijo J., KAEVER, V., Kalinke, U. (2017) 
cGAMP Quantification in Virus-Infected Human Monocyte-Derived Cells by HPLC-Coupled Tandem Mass Spectrometry.
Methods Mol. Biol. 656, 153-166 

Sarenko, O., Klauck, G., Wilke, F.M., Pfiffer, V., Richter, A.M., Herbst, S., KAEVER, V., Hengge R. (2017) 
More than Enzymes That Make or Break Cyclic Di-GMP-Local Signaling in the Interactome of GGDEF/EAL Domain Proteins of Escherichia coli.
MBio. 8, e01639-17.

Schmid, N., Suppiger, A., Steiner, E., Pessi, G., KAEVER, V., Fazli M., Tolker-Nielsen, T., Jenal, U., Eberl, L. (2017)
High intracellular c-di-GMP levels antagonize quorum sensing and virulence gene expression in Burkholderia cenocepacia H111.
Microbiology 163: 754-764

Sprecher, K.S., Hug, I., Nesper, J., Potthoff, E., Mahi, M.A., Sangermani, M., KAEVER, V., Schwede, T., Vorholt, J., Jenal, U. (2017)
Cohesive Properties of the Caulobacter crescentus Holdfast Adhesin Are Regulated by a Novel c-di-GMP Effector Protein.
MBio. 8, pii: e00294-17

Zhang, Y. Agrebi, R., Bellows, L.E., Collet, J.F., KAEVER, V., Gründling, A. (2017)
Evolutionary Adaptation of the Essential tRNA Methyltransferase TrmD to the Signaling Molecule 3',5'-cAMP in Bacteria.
J. Biol. Chem. 292, 313-327

 

2016

Abbey, M., Hakim, C., Anand, R., Lafera, J., Schambach, A., Kispert, A., Taft, M.H., KAEVER, V., Kotlyarov, A., Gaestel, M., Menon, M.B. (2016)
GTPase domain driven dimerization of SEPT7 is dispensable for the critical role of septins in fibroblast cytokinesis.
Sci. Rep. 28, 20007

Bæk, K.T., Bowman, L., Millership, C., Dupont Søgaard, M., KAEVER, V., Siljamäki,  P., Savijoki, K., Varmanen, P., Nyman, T.A., Gründling, A., Frees, D. (2016)
The Cell Wall Polymer Lipoteichoic Acid Becomes Nonessential in Staphylococcus aureus Cells Lacking the ClpX Chaperone.
MBio 7, e01228-16

Bowman, L., Zeden, M.S., Schuster, C.F., KAEVER, V., Grundling, A. (2016)
New Insights into the Cyclic di-Adenosine Monophosphate (c-di-AMP) Degradation Pathway and the Requirement of the Cyclic-Dinucleotide for Acid Stress Resistance in Staphylococcus aureus.
J Biol Chem. 291: 26970-26986

Gaupels, F., Furch, A.C., Zimmermann, M.R., Chen, F., KAEVER, V., Buhtz, A., Kehr, J., Sarioglu, H., Kogel, K.H., Durner, J. (2016)
Systemic Induction of NO-, Redox-, and cGMP Signaling in the Pumpkin Extrafascicular Phloem upon Local Leaf Wounding.
Front. Plant. Sci. 7, 154.

Corrigendum: Front. Plant. Sci. 7, 281

Groizeleau, J., Rybtke, M., Andersen, J.B., Berthelsen, J., Liu, Y., Yang, L., Nielsen, T.E., KAEVER, V., Givskov, M., Tolker-Nielsen, T. (2016)
The anti-cancerous drug doxorubicin decreases the c-di-GMP content in Pseudomonas aeruginosa but promotes biofilm formation.
Microbiology 162, 1797-1807

Krol, E., Klaner, C., Gnau, P., KAEVER, V., Essen, L.O., Becker, A. (2016)
Cyclic mononucleotide- and Clr-dependent gene regulation in Sinorhizobium meliloti.
Microbiology 162, 1840-1856 

Lacanna, E., Bigosch, C., KAEVER, V., Boehm, A., Becker, A. (2016)
Evidence for Escherichia coli diguanylate cyclase DgcZ interlinking surface sensing and adhesion via multiple regulatory routes.
J. Bacteriol. 198: 2524-2535 

Paijo, J., Döring, M., Spanier, J., Grabski, E., Nooruzzaman, M., Schmidt, T., Witte, G., Messerle, M., Hornung, V., KAEVER, V., Kalinke, U. (2016) 
cGAS Senses Human Cytomegalovirus and Induces Type I Interferon Responses in Human Monocyte-Derived Cells.
PLoS Pathog. 12, e1005546.

Pawar, V.S., Messina, M., Rinaldo, S., Cutruzzola, F., KAEVER, V., Rampioni, G., Leonie, L. (2016)
Novel genetic tools to tackle c-di-GMP-dependent signaling in Pseudomonas aeruginosa.
J. Appl. Microbiol. 120, 205-217

Rismondo, J., Gibhardt, J., Rosenberg, J., KAEVER, V., Halbedel, S., Commichau, F.M. (2016)
Phenotypes associated with the essential diadenylate cyclase CdaA and its potential regulator CdaR in the human pathogen Listeria monocytogenes.
J. Microbiol. 198, 416-426

Schäper, S., Krol, E., Skotnicka, D., KAEVER, V., Hilker, R., Sogaard-Andersen, L., Becker, A. (2016)
Cyclic di-GMP regulates multiple cellular functions in the symbiotic α-proteobacterium Sinorhizobium meliloti
J. Bacteriol. 198, 521-535

Schmidt, A., Hammerbacher, A.S., Bastian, M., Nieken, K.J., Klockgether, J., Merighi, M., Lapouge, K., Poschgan, C., Kölle, J., Acharya, K.R., Ulrich, M., Tümmler, B., Unden, G., KAEVER, V., Lory S., Haas D., Schwarz S., Döring G. (2016)
Oxygen-dependent regulation of c-di-GMP synthesis by SadC controls alginate production in Pseudomonas aeruginosa.
Environ. Microbiol. 18, 3390-3402

Skotnicka, D., Smaldone, G.T., Petters, T., Trampari, E., Liang, J., KAEVER, V., Malone, J.G., Singer, M., Søgaard-Andersen, L. (2016)
A minimal threshold of c-di-GMP is essential for fruiting body formation and sporulation in Myxococcus xanthus.
PLoS Genet. 12, e1006080.

Suppiger, A., Eshwar, A.K., Stephan, R., KAEVER, V., Eberl, L., Lehner, A. (2016)
The DSF type quorum sensing signalling system RpfF/R regulates diverse phenotypes in the opportunistic pathogen Cronobacter
Sci. Rep. 6, 18753

Zhang,  Y., Agrebi, R., Bellows, L.E., Collet, J.F., KAEVER, V., Gründling, A. (2016)
Evolutionary Adaptation of the Essential tRNA Methyltransferase TrmD to the Signaling Molecule 3,5-cAMP in Bacteria.
J Biol Chem 2016 292, 313-327

 

2015

BÄHRE, H., Hartwig, C., Munder, A., Wolter, S., Stelzer, T., Schirmer, B., Beckert, U., Frank, D.W., Tümmler, B., KAEVER, V., Seifert, R. (2015)
cCMP and cUMP occur in vivo.
Biochim. Biophys. Res. Commun. 460, 909 - 914

Blanka, A., Düvel, J., Dötsch, A., Klinkert, B., Abraham, W.-R., KAEVER, V., Ritter, C., Narberhaus, F., Häussler, S. (2015)
Constitutive production of c-di-GMP is associated with mutations in a variant of Pseudomonas aeruginosa with altered membrane composition.
Sci. Signal. 8, ra36

Bridgeman, A., Maelfait, J., Davenne, T., Partridge, T., Peng, Y., Mayer, A., Dong, T., KAEVER, V., Borrow, P., Rehwinkel, J. (2015)
Viruses transfer the antiviral second messenger cGAMP between cells.
Science 349, 1228 - 1232

Cohen, D., Mechold, U., Nevenzal, H., Yarmiyhu, Y., Randall, T.E., Bay, D.C., Rich, J.D., Parsek, M.R., KAEVER, V., Harrison, J.J., Banin, E. (2015)
Oligoribonuclease is a central feature of cyclic  diguanylate signaling in Pseudomonas aeruginosa.
P. Natl. Acad. Sci. USA 112, 11359 - 11364

Corrigan, R.M., Bowman, L., Willis, A.R., KAEVER, V., Gründling, A. (2015)
Crosstalk between two nucleotide-signaling pathways in Staphylococcus aureus.
J. Biol. Chem. 290, 5826 - 5839

Dittmar, F., Abdelilah-Seyfried, S., Tschirner, S.K., KAEVER, V., Seifert, R. (2015)
Temporal and organ-specific detection of cNMPs including cUMP in the zebrafish.
Biochem. Biophys. Res. Commun. 468, 708 - 712

Gundlach, J., Dickmanns, A., Schröder-Tittmann, K., Neumann, Piotr, Kampf, J., Herzberg, C., Hammer, E., Schwede, F., KAEVER, V., Tittmann, K., Stülke, J., Ficner, R. (2015)
Identification, characterization and structure analysis of the c-di-AMP binding PII-like protein DarA
J. Biol. Chem. 290, 3069 - 3080

Gundlach, J., Mehne, F.M., Herzberg, C., Kampf, J., Valerius, O., KAEVER, V., Stülke, J. (2015)
An essential poison: Synthesis and degradation of cyclic di-AMP in Bacillus subtilis.
J. Microbiol 197, 3265 - 3274

Morrow, K.A., Seifert, R., KAEVER, V., Britain, A.L., Sayner, S.L., Ochoa, C.D., Cioffi, E.A., Frank,  D.W., Rich, T.C., Stevens, T. (2015)
Heterogeneity of pulmonary endothelial cyclic nucleotide response to Pseudomonas aeruginosa ExoY infection.
Am. J. Physiol. Lung Cell Mol. Physiol. 309, L1199 – L1207

Peltier, J., Shaw, H.A., Couchman, E.C., Dawson, L.F., Yu, L., Choudhary, J.S., KAEVER, V., Brendan, W.W., Fairweather, N.F. (2015)
Cyclic-di-GMP regulates production of sortase substrates of Clostridium difficile and their surface exposure through ZmpI protease-mediated cleavage.
J. Biol. Chem. 290, 24453 - 24469

Reinartz, M.T., Kälble, S., Littmann, T., Ozawa, T., Dove, S., KAEVER, V., Wainer, I.W., Seifert, R. (2015)
Structure-bias relationships for fenoterol stereoisomers in six molecular and cellular assays at the ß2-adrenoceptor
Naunyn-Schmiedeberg's Arch. Pharmacol. 388, 51 - 65

Rosenberg, J., Dickmanns, A., Neumann, P., Gunka, K., Arens, J., KAEVER, V., Stülke, J., Ficner, R., Commichau, F.M. (2015)
Structural and biochemical analysis of the essential diadenylate cyclase CdaA from Listeria monocytogenes.
Biol. Chem. 290, 6596 - 6606

Skotnicka, D., Petters, T., Heering, J., Hoppert, MK., KAEVER, V., Sogaard-Andersen, L. (2015)
c-di-GMP regulates type IV pili-dependent mobility in Myxococcus xanthus
J. Bacteriol. 198, 77 - 90

Visaggio, D., Pasqua, M., Bonchi, C., KAEVER, V., Visca, P., Imperi, F. (2015)
Cell aggregation promotes pyoverdine-dependent iron uptake and virulence in Pseudomonas aeruginosa
Frontiers Microbiol. 6, 902

 

2014

BÄHRE, H., Danker, K.Y., Stasch, J.-P., KAEVER, V., Seifert, R. (2014)
Nucleotidyl cyclase activity of soluble guanylyl cyclase in intact cells.
Biochim. Biophys. Res. Commun. 443, 1195 - 1199

BÄHRE, H., KAEVER, V. (2014)
Measurement of 2´, 3´-cyclic nucleotides by liquid chromatography-tandem mass spectrometry in cells.
J. Chromatogr. B 964, 208 - 211

Beckert, U., Grundmann, M., Wolter, S., Schwede, F., Rehmann, H., KAEVER, V., Kostenis, E., Seifert, R. (2014)
cNMP-AMs mimic and dissect bacterial nucleotidyl cyclase toxin effects.
Biochim. Biophys. Res. Commun. 451, 497 – 502

Beckert, U., Wolter S., Hartwig, C., Bähre H., KAEVER, V., Ladant, D., Frank, D.W., Seifert, R. (2014)
ExoY from Pseudomonas aeruginosa is a nucletotidyl cyclase with preference for cGMP and cUMP formation.
Biochim. Biophys. Res. Commun. 450, 870 - 874

Blanka, A., Schulz, S., Eckweiler, D., Franke, R., Bielecka, A., Nicolai, T., Casilag, F., Düvel, J., Abraham, W.-R., KAEVER, V., Häussler, S. (2014)
Identification of the alternative sigma factor SigX regulon and its implication for Pseudomonas aeruginosa pathogenicity.
J. Microbiol. 196, 345 - 356

Diethmaier, C., Newman, J.A., Kovacs, A.T., KAEVER, V., Herzberg, C., Rodrigues, C., Boonstra, M., Kuipers, O.P., Lewis, R.J, Stülke, J. (2014)
The YmdB phosphodiesterase is a global regulator of late adaptive responses in Bacillus subtilis.
J. Bacteriol. 196, 265 - 275

Dove S., Danker, K.Y., Stasch, J.-P., KAEVER, V., Seifert, R. (2014)
Structure/activity relationships of (M)ANT- and TNP-nucleotides for inhibition of rat soluble guanylyl cyclase α1ß1.
Mol. Pharmacol. 85, 598 - 607

Frangipani, E., Visaggio, D., Heeb, S., KAEVER, V., Camara, M., Visca, P., Imperi, F. (2014)
The Gac/Rsm and cyclic-di-GMP signalling networks coordinately regulate iron uptake in Pseudomonas aeruginosa.
Environ. Microbiol. 16, 676 - 688

Gao, S., Romdhane, S.B., Beullens, S., KAEVER, V., Lambrichts, I., Fauvart, M., Michiels, J. (2014)
Genomic analysis of cyclic-di-GMP-related genes in rhizobial type strains and functional analysis in Rhizobium etli.
Appl. Microbiol. Biotechnol. 98, 4589 - 4602

Hasan, A., Danker, K.Y., Wolter, S., BÄHRE, H., KAEVER, V., Seifert, R. (2014)
Soluble adenylyl cyclase accounts for high basal cCMP and cUMP concentrations in HEK293 and B103 cells.
Biochim. Biophys. Res. Commun. 448, 236 - 240

Hartwig, C., BÄHRE, H., Wolter, S., Beckert, U., KAEVER, V., Seifert, R. (2014)
cAMP, cGMP, cCMP and cUMP concentrations across the tree of life: High cCMP and cUMP levels in astrocytes.
Neurosci. Lett. 579, 183 - 187

Laue, S., Winterhoff, M., KAEVER, V., van den Heuvel, J.J., Russel, F.G., Seifert, R. (2014)
cCMP is a substrate for MRP5.
Naunyn-Schmiedeberg's Arch. Pharmacol. 387, 893 - 895

Mehne, F.M.P., Schröder-Tittmann, K., Eijlander, R.T., Herzberg C., Hewitt, L.,  KAEVER, V., Lewis, R.J., Kuipers, O.P., Tittmann, K., Stülke, J. (2014)
Control of diadenylate cyclase CdaS in Bacillus subtilis: an autoinhibitory domain limits c-di-AMP production.
J. Biol. Chem. 289, 21098 - 21107

nach oben

Targeted metabolomics - Neurotransmitter

2017

BÄHRE, H., KAEVER, V. (2017)
Analytical Methods for the Quantification of Histamine and Histamine Metabolites.
Handb. Exp. Pharmacol. 241, 3-19

 

2016

Tschirner, S.K., Gutzki, F., Schneider, E.H., Seifert, R., KAEVER, V. (2016)
Neurotransmitter and their metabolite concentrations in different areas of the HPRT knockout mouse brain.
J. Neurol. Sci. 365, 169-174

Tschirner, S.K., BÄHRE, H., Kaever, A., Schneider, E.H., Seifert, R., KAEVER, V. (2016)
Non-targeted metabolomics by high resolution mass spectrometry in HPRT knockout mice.
Life Sci. 156, 68-73

 

2015

Tschirner, S.K., Gutzki, F., KAEVER, V., Seifert, R., Schneider, E.H. (2015)
Altered histamine neurotransmission in HPRT-deficient mice.
Neurosci. Lett.  609, 74 - 80

 

2014

Mahapatra, S., Albrecht, M., Behrens, B., Jirmo, A., Behrens, G., Hartwig, C., Neumann, D., Raap, U., Bähre, H., Herrick, C., Dittrich, A.M. (2014)
Delineating the role of histamine-1- and -4-receptors in a mouse model of Th2-dependent antigen-specific skin inflammation.
PLoS One 9, e87296

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Targeted metabolomics - Oncometaboliten

Berod L, Friedrich C, Nandan A, Freitag J, Hagemann S, Harmrolfs K, Sandouk A, Hesse C, Castro CN, BÄHRE H, Tschirner SK, Gorinski N, Gohmert M, Mayer CT, Huehn J, Ponimaskin E, Abraham WR, Müller R, Lochner M, Sparwasser T.De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells.
Nat. Med. 2014; 20: 1327 -1333

Erratum in: Nat. Med. 2015; 21: 414

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Targeted Metabolomics - Andere Metaboliten

de Araujo L.S., Pessler K., Sühs K.W., Novoselova N., Klawonn F., Kuhn M., KAEVER V., Müller-Vahl K., Trebst C., Skripuletz T., Stangel M., Pessler F. (2020)
Phosphatidylcholine PC ae C44:6 in cerebrospinal fluid is a sensitive biomarker for bacterial meningitis.
J Transl Med 18:9

Chen, F., Lukat, P., Iqbal, A.A., Saile, K., KAEVER, V., van den Heuvel, J., Blankenfeldt, W., Büssow, K., Pessler, F. (2019)
Crystal structure of cis-aconitate decarboxylase reveals the impact of naturally occurring human mutations on itaconate synthesis. 
Proc. Natl. Acad.Sci. U.S.A. 116, 20644-20654

Kuhla, B., KAEVER, V., Tuchscherer, A., Kuhla, A. (2020)
Involvement of plasma endocannabinoids and the hypothalamic endocannabinoid system in increasing feed intake after parturition of dairy cows.
Neuroendocrinology 110, 246-257

Kuhn, M., Sühs, K.W., Akmatov, M.K., Klawonn, F., Wang, J., Skripuletz, T., KAEVER, V., Stangel, M., Pessler, F. (2018)
Mass-spectrometric profiling of cerebrospinal fluid reveals metabolite biomarkers for CNS involvement in varicella zoster virus reactivation.
J. Neuroinflammation 15, 20  

Perduns R, Volk J, Plum M, GUTZKI, F., KAEVER, V., Geurtsen W. (2019)
Effects of HEMA on Nrf2-related gene expression using a newly developed 3D co-culture model of the oral mucosa.
Dent. Mater. pii: S0109-5641.

Ratuszny, D., Sühs, K.W., Novoselova, N., Kuhn, M., KAEVER, V., Skripuletz, T., Pessler, F., Stangel, M. (2019)
Identification of Cerebrospinal Fluid Metabolites as Biomarkers for Enterovirus Meningitis.
Int. J. Mol. Sci. 20, pii: E337

Schimmel K,. Jung M., Foinquinos A., San José G., Beaumont J., Bock K., Grote-Levi L., Xiao K., Bär C., Pfanne A., Just A., Zimmer K., Ngoy S., López B., Ravassa S., Samolovac S., Janssen-Peters H., Remke J., Scherf K., Dangwal S., Piccoli M.T., Kleemiss F., Kreutzer F.P., Kenneweg F., Leonardy J., Hobuß L., Santer L., Do Q.T., Geffers R., Braesen J.H., Schmitz J., Brandenberger C., Müller D.N., Wilck N., Kaever V., Bähre H., Batkai S., Fiedler J., Alexander K.M., Wertheim B.M., Fisch S., Liao R., Diez J., González A., Thum T. (2020) 
Natural Compound Library Screening Identifies New Molecules for the Treatment of Cardiac Fibrosis and Diastolic Dysfunction.
Circulation; 141: 751-767

Sühs, K.W., Novoselova, N., Kuhn, M., Seegers, L., KAEVER, V., Müller-Vahl, K., Trebst, C., Skripuletz, T., Stangel, M., Pessler, F. (2019)
Kynurenine is a cerebrospinal fluid biomarker for bacterial and viral CNS infections.
J. Infect. Dis. 220, 127-138

Zwadlo, C., Schmidtmann, E., Szaroszyk, M., Badder, K., Froese, N., Hinz, H., Schmitto, J.D., Widder, J., Batkai, S., BÄHRE, H., KAEVER, V., Thum, T., Bauersachs, J., Heinecke, J. (2015)
Anti-androgenic therapy with finasteride attenuates cardiac hypertrophy and left ventricular dysfunction.
Circulation 131, 1071 - 108

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Non-targeted metabolomics

Tschirner, S.K., BÄHRE, H., Kaever, A., Schneider, E.H., Seifert, R., KAEVER, V. (2016)
Non-targeted metabolomics by high resolution mass spectrometry in HPRT knockout mice.
Life Sci. 156, 68-73

Tschirner, S.K., BÄHRE, H., Seifert R., KAEVER, V. (2014)
Non-targeted Metabolomics in a cell model for Lesch-Nyhan Syndrome.
Naunyn-Schmiedeberg´s Arch Pharmacol 387 (Suppl 1) S97 (Abstract)

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