Publikationen mit Unterstützung durch das Sorter-Labor

(Auswahl)

2026

B cell hyperactivation in an Ackr4-deficient mouse strain is not caused by lack of ACKR4 expression.
Eckert N, Werth K, Willenzon S, Tan L, Förster R. J Leukoc Biol. 2020 Jun;107(6):1155-1166. doi: 10.1002/JLB.2MA1119-300R. Epub 2019 Dec 16. PMID: 31841228

Ex vivo long-term expansion of human hematopoietic stem and progenitor cells as a tool for modeling vector integration sites and clonality.
Fleischauer J, John-Neek P, Ha TC, Mansel F, Kosanke M, Selich A, Hagedorn M, Bastone AL, Schinke M, Dziadek V, Dittrich-Breiholz O, von Kaisenberg C, Schambach A, Rothe M. J Transl Med. 2026 Feb 7;24(1):384. doi: 10.1186/s12967-026-07700-6. PMID: 41654907 Free PMC article.

Differentiation-induced reduction in functional diversity restricts the ability of cytomegalovirus-specific CD8 T cells to eliminate virus-infected cells.
Fritz L, Hassan A, Riemann L, Čuvalo B, Costa B, Wieland B, Eiz-Vesper B, Falk C, Roesner LM, Werfel T, Kalinke U, Georgiev H, Förster R, Bošnjak B. EBioMedicine. 2026 Jan;123:106107. doi: 10.1016/j.ebiom.2025.106107. Epub 2026 Jan 5. PMID: 41494240 Free PMC article.

Differential mitochondrial priming by BCR::ABL1 in B-cell precursor acute lymphoblastic leukemia.
Kirchhoff H, Schoenherr C, Fleischer L, Talbot SR, Heidel FH, Bergmann AK, Eder M, Scherr M. Leukemia. 2026 Mar 30. doi: 10.1038/s41375-026-02944-z. Online ahead of print. PMID: 41912910 No abstract available.

Focusing of the regulatory T-cell repertoire after allogeneic stem cell transplantation indicates protection from graft-versus-host disease.
Odak I, Raha S, Schultze-Florey C, Tavil S, Ravens S, Ganser A, Förster R, Prinz I, Koenecke C. Haematologica. 2019 Dec;104(12):e577-e580. doi: 10.3324/haematol.2019.218206. Epub 2019 Apr 24. PMID: 31018979 Free PMC article. No abstract available.

2025

Targeting BCL11B in CAR-engineered lymphoid progenitors drives NK-like cell development with prolonged anti-leukemic activity.
Baatz F, Ghosh A, Herbst J, Polten S, Meyer J, Rhiel M, Maetzig T, Geffers R, Rothe M, Bastone AL, John-Neek P, Frühauf J, Eiz-Vesper B, Bonifacius A, Falk CS, Kaisenberg CV, Cathomen T, Schambach A, van den Brink MRM, Hust M, Sauer MG. Mol Ther. 2025 Apr 2;33(4):1584-1607. doi: 10.1016/j.ymthe.2025.02.024. Epub 2025 Feb 15. PMID: 39955618 Free PMC article.

LMP2A-Targeting CAR-T Cells Equipped With Inducible IL-18 to Address EBV-Associated Malignancies.
Dragon AC, Thoelke S, Mausberg P, Zimmermann K, Blasczyk R, Hudecek M, Abken H, Schambach A, Maecker-Kolhoff B, Eiz-Vesper B. HLA. 2025 Oct;106(4):e70439. doi: 10.1111/tan.70439. PMID: 41116979 Free PMC article.

PAM-interacting domain turn-helix 51 motifs can improve Cas9-SpRY activity.
Eggenschwiler R, Hoffmann T, Dmytrenko O, Opitz M, Ackel-Zakour M, Wang P, McCallan SA, Fráguas-Eggenschwiler M, Niemann H, Patronov A, Beisel CL, Cantz T. Nucleic Acids Res. 2025 Aug 11;53(15):gkaf782. doi: 10.1093/nar/gkaf782. PMID: 40808297 Free PMC article.

Developmental features and unique characteristics of peptide-specific PLZF+ innate-like T cells in mice.
Hassan A, Heise N, Schimrock A, Willenzon S, Ravens I, Förster R, Georgiev H. Nat Commun. 2025 Jun 6;16(1):5274. doi: 10.1038/s41467-025-60617-4. PMID: 40480992 Free PMC article.

Acquisition of innate B cell properties and generation of autoreactive IgA antibodies by follicular B cells during homeostatic proliferation.
Kampe L, Melcher C, Westphal K, Brand K, Föger N, Lee KH. Front Immunol. 2025 Jan 22;16:1506628. doi: 10.3389/fimmu.2025.1506628. eCollection 2025. PMID: 39911392 Free PMC article.

Combination of targeted pharmacotherapy and immunotherapy with anti-CD19 CAR NK cells in acute lymphoblastic leukemia.
Kirchhoff H, Schoenherr C, Fleischer L, Schweighart EK, Esser R, Talbot SR, Schambach A, Koehl U, Heidenreich O, Eder M, Scherr M. Hemasphere. 2025 Oct 15;9(10):e70238. doi: 10.1002/hem3.70238. eCollection 2025 Oct. PMID: 41104377 Free PMC article.

Inflammatory modalities shape the IgA repertoire via stochastic processes.
Melcher C, Schramm CA, Kampe L, Zhang Y, Westphal K, Krautkrämer M, Shen X, Brand K, Franz P, Vital M, Douek DC, Föger N, Lee KH. Cell Rep. 2025 Oct 28;44(10):116307. doi: 10.1016/j.celrep.2025.116307. Epub 2025 Sep 16. PMID: 40966088 Free article.

Anti-FAP CAR-NK cells as a novel targeted therapy against cervical cancer and cancer-associated fibroblasts.
Polten R, Kutle I, Stalp JL, Hachenberg J, Seyda AK, Neubert L, Kamp JC, von Kaisenberg C, Schaudien D, Hillemanns P, Klapdor R, Morgan M, Schambach A. Oncoimmunology. 2025 Dec;14(1):2556714. doi: 10.1080/2162402X.2025.2556714. Epub 2025 Sep 17. PMID: 40960024 Free PMC article.

Vitamin C conditioning generates tumor-targeting CAR T cells with superior cytotoxicity and fitness in a post-transplant lymphoproliferative disorder tumor model.
Rahmati P, Bonifacius A, Dragon AC, Malinconico C, Floegel F, Halenius A, Blasczyk R, Maecker-Kolhoff B, Hudecek M, Floess S, Huehn J, Eiz-Vesper B. Mol Cancer Ther. 2025 Dec 19. doi: 10.1158/1535-7163.MCT-25-0005. Online ahead of print. PMID: 41416402

Partial Compensation of IL-17 Production by Vγ1 T Cells in the Absence of Vγ4 and Vγ6 T Cells.
Wang Z, Yang T, Lupo F, Behrens LM, Janssen A, Coffelt SB, Prinz I, Sandrock I, Ravens S. Eur J Immunol. 2025 Sep;55(9):e70061. doi: 10.1002/eji.70061. PMID: 40974348 Free PMC article.

Systematic monocyte subset analysis reveals differential contribution of Notch signaling components to monocyte heterogeneity.
Xu Y, Kapanadze T, Gaedcke S, Jirmo AC, Sablotny S, Schroth FN, Hille S, Müller OJ, Lochner M, Haller H, Schmidt-Ott K, Gamrekelashvili J, Limbourg FP. iScience. 2025 Oct 16;28(11):113795. doi: 10.1016/j.isci.2025.113795. eCollection 2025 Nov 21. PMID: 41244563 Free PMC article.

2024

Standardized generation of human iPSC-derived hematopoietic organoids and macrophages utilizing a benchtop bioreactor platform under fully defined conditions.
Ackermann M, Saleh F, Abdin SM, Rafiei Hashtchin A, Gensch I, Golgath J, Carvalho Oliveira M, Nguyen AHH, Gaedcke S, Fenske A, Jang MS, Jirmo AC, Abeln M, Hansen G, Lachmann N. Stem Cell Res Ther. 2024 Jun 18;15(1):171. doi: 10.1186/s13287-024-03785-2. PMID: 38886860 Free PMC article.

A tetravalent bispecific antibody outperforms the combination of its parental antibodies and neutralizes diverse SARS-CoV-2 variants.
Chiyyeadu A, Asgedom G, Bruhn M, Rocha C, Schlegel TU, Neumann T, Galla M, Vollmer Barbosa P, Hoffmann M, Ehrhardt K, Ha TC, Morgan M, Schoeder CT, Pöhlmann S, Kalinke U, Schambach A. Clin Immunol. 2024 Mar;260:109902. doi: 10.1016/j.clim.2024.109902. Epub 2024 Jan 11. PMID: 38218210 Free article.

Early-life thymectomy leads to an increase of granzyme-producing γδ T cells in children with congenital heart disease.
Cramer A, Yang T, Riemann L, Almeida V, Kammeyer C, Abu YE, Gluschke E, Kleiner S, León-Lara X, Janssen A, Hofmann A, Horke A, von Kaisenberg C, Förster R, Beerbaum P, Boehne M, Ravens S. Nat Commun. 2024 Nov 13;15(1):9841. doi: 10.1038/s41467-024-51673-3. PMID: 39537635 Free PMC article.

Blood-generating heart-forming organoids recapitulate co-development of the human haematopoietic system and the embryonic heart.
Dardano M, Kleemiß F, Kosanke M, Lang D, Wilson L, Franke A, Teske J, Shivaraj A, de la Roche J, Fischer M, Lange L, Schambach A, Drakhlis L, Zweigerdt R. Nat Cell Biol. 2024 Nov;26(11):1984-1996. doi: 10.1038/s41556-024-01526-4. Epub 2024 Oct 8.

Mineralocorticoid receptor promotes cardiac macrophage inflammaging.
Fraccarollo D, Geffers R, Galuppo P, Bauersachs J. Basic Res Cardiol. 2024 Apr;119(2):243-260. doi: 10.1007/s00395-024-01032-6. Epub 2024 Feb 8. PMID: 38329499 Free PMC article.

Validation of CSF-1 receptor (CD115) staining for analysis of murine monocytes by flow cytometry.
Kapanadze T, Gamrekelashvili J, Sablotny S, Schroth FN, Xu Y, Chen R, Rong S, Shushakova N, Gueler F, Haller H, Limbourg FP. J Leukoc Biol. 2024 Feb 23;115(3):573-582. doi: 10.1093/jleuko/qiad147. PMID: 38038378

Anti-Mesothelin CAR-NK cells as a novel targeted therapy against cervical cancer.
Kutle I, Polten R, Stalp JL, Hachenberg J, Todzey F, Hass R, Zimmermann K, von der Ohe J, von Kaisenberg C, Neubert L, Kamp JC, Schaudien D, Seyda AK, Hillemanns P, Klapdor R, Morgan MA, Schambach A. Front Immunol. 2024 Dec 16;15:1485461. doi: 10.3389/fimmu.2024.1485461. eCollection 2024. PMID: 39781381 Free PMC article.

γδ T cell profiling in a cohort of preterm infants reveals elevated frequencies of CD83+ γδ T cells in sepsis.
León-Lara X, Fichtner AS, Willers M, Yang T, Schaper K, Riemann L, Schöning J, Harms A, Almeida V, Schimrock A, Janssen A, Ospina-Quintero L, von Kaisenberg C, Förster R, Eberl M, Richter MF, Pirr S, Viemann D, Ravens S. J Exp Med. 2024 Jul 1;221(7):e20231987. doi: 10.1084/jem.20231987. Epub 2024 May 16. PMID: 38753245 Free PMC article.

Epitope-focused immunogens targeting the hepatitis C virus glycoproteins induce broadly neutralizing antibodies.
Nagarathinam K, Scheck A, Labuhn M, Ströh LJ, Herold E, Veselkova B, Tune S, Cramer JT, Rosset S, Vollers SS, Bankwitz D, Ballmaier M, Böning H, Roth E, Khera T, Ahsendorf-Abidi HP, Dittrich-Breiholz O, Obleser J, Nassal M, Jäck HM, Pietschmann T, Correia BE, Krey T. Sci Adv. 2024 Dec 6;10(49):eado2600. doi: 10.1126/sciadv.ado2600. Epub 2024 Dec 6. PMID: 39642219 Free PMC article.

Non-esterified fatty acid palmitate facilitates oxidative endoplasmic reticulum stress and apoptosis of β-cells by upregulating ERO-1α expression.
Sharifi S, Yamamoto T, Zeug A, Elsner M, Avezov E, Mehmeti I. Redox Biol. 2024 Jul;73:103170. doi: 10.1016/j.redox.2024.103170. Epub 2024 Apr 27. PMID: 38692092 Free PMC article.

Cysteine-rich with EGF-like domains 2 (CRELD2) is an endoplasmic reticulum stress-inducible angiogenic growth factor promoting ischemic heart repair.
Wu X, Zheng L, Reboll MR, Hyde LF, Mass E, Niessen HW, Kosanke M, Pich A, Giannitsis E, Tillmanns J, Bauersachs J, Heineke J, Wang Y, Korf-Klingebiel M, Polten F, Wollert KC. Nat Cardiovasc Res. 2024 Feb;3(2):186-202. doi: 10.1038/s44161-023-00411-x. Epub 2024 Jan 17. PMID: 39196188 Free PMC article.

2023

Scalable generation of functional human iPSC-derived CAR-macrophages that efficiently eradicate CD19-positive leukemia.
Abdin SM, Paasch D, Kloos A, Oliveira MC, Jang MS, Ackermann M, Stamopoulou A, Mroch PJ, Falk CS, von Kaisenberg CS, Schambach A, Heuser M, Moritz T, Hansen G, Morgan M, Lachmann N. J Immunother Cancer. 2023 Dec 22;11(12):e007705. doi: 10.1136/jitc-2023-007705. PMID: 38135346 Free PMC article.

MCK2-mediated MCMV infection of macrophages and virus dissemination to the salivary gland depends on MHC class I molecules.
Bošnjak B, Henze E, Lueder Y, Do KTH, Rezalotfi A, Čuvalo B, Ritter C, Schimrock A, Willenzon S, Georgiev H, Fritz L, Galla M, Wagner K, Messerle M, Förster R. Cell Rep. 2023 Jun 27;42(6):112597. doi: 10.1016/j.celrep.2023.112597. Epub 2023 Jun 7. PMID: 37289588 Free article.

Non-viral TRAC-knocked-in CD19KICAR-T and gp350KICAR-T cells tested against Burkitt lymphomas with type 1 or 2 EBV infection: In vivo cellular dynamics and potency.
Braun T, Pruene A, Darguzyte M, Vom Stein AF, Nguyen PH, Wagner DL, Kath J, Roig-Merino A, Heuser M, Riehm LL, Schneider A, Awerkiew S, Talbot SR, Bleich A, Figueiredo C, Bornhäuser M, Stripecke R. Front Immunol. 2023 Mar 24;14:1086433. doi: 10.3389/fimmu.2023.1086433. eCollection 2023. PMID: 37033919

Supraphysiological FOXP3 expression in human CAR-Tregs results in improved stability, efficacy, and safety of CAR-Treg products for clinical application.
Henschel P, Landwehr-Kenzel S, Engels N, Schienke A, Kremer J, Riet T, Redel N, Iordanidis K, Saetzler V, John K, Heider M, Hardtke-Wolenski M, Wedemeyer H, Jaeckel E, Noyan F. J Autoimmun. 2023 Jul;138:103057. doi: 10.1016/j.jaut.2023.103057. Epub 2023 May 23. PMID: 37224732 Free article.

Single cell RNA sequencing reveals distinct clusters of Irf8-expressing pulmonary conventional dendritic cells.
Jirmo AC, Grychtol R, Gaedcke S, Liu B, DeStefano S, Happle C, Halle O, Monteiro JT, Habener A, Breiholz OD, DeLuca D, Hansen G. Front Immunol. 2023 May 12;14:1127485. doi: 10.3389/fimmu.2023.1127485. eCollection 2023. PMID: 37251386 Free PMC article.

Individual Epitope-Specific CD8+ T Cell Immune Responses Are Shaped Differently during Chronic Viral Infection.
Klein S, Mischke J, Beruldsen F, Prinz I, Antunes DA, Cornberg M, Kraft ARM. Pathogens. 2023 May 14;12(5):716. doi: 10.3390/pathogens12050716. PMID: 37242386 Free PMC article.

A pro B cell population forms the apex of the leukemic hierarchy in Hoxa9/Meis1-dependent AML.
Lieske A, Agyeman-Duah E, Selich A, Dörpmund N, Talbot SR, Schambach A, Maetzig T. Leukemia. 2023 Jan;37(1):79-90. doi: 10.1038/s41375-022-01775-y. Epub 2022 Dec 14. PMID: 36517672 Free PMC article.

CAR-NK Cells Targeting HER1 (EGFR) Show Efficient Anti-Tumor Activity against Head and Neck Squamous Cell Carcinoma (HNSCC).
Nowak J, Bentele M, Kutle I, Zimmermann K, Lühmann JL, Steinemann D, Kloess S, Koehl U, Roßberg W, Ahmed A, Schaudien D, Neubert L, Kamp JC, Kuehnel MP, Warnecke A, Schambach A, Morgan M. Cancers (Basel). 2023 Jun 13;15(12):3169. doi: 10.3390/cancers15123169. PMID: 37370779 Free PMC article.

Expression of viral CD45 ligand E3/49K on porcine cells reduces human anti-pig immune responses.
Pokoyski C, Baars W, Windheim M, Reubold TF, Zischke J, Brinkmann A, Kay-Fedorov PC, Schwinzer R. Sci Rep. 2023 Oct 11;13(1):17218. doi: 10.1038/s41598-023-44316-y. PMID: 37821577 Free PMC article.

Downregulation of Swine Leukocyte Antigen Expression Decreases the Strength of Xenogeneic Immune Responses towards Renal Proximal Tubular Epithelial Cells.
Schmalkuche K, Schwinzer R, Wenzel N, Valdivia E, Petersen B, Blasczyk R, Figueiredo C. Int J Mol Sci. 2023 Aug 12;24(16):12711. doi: 10.3390/ijms241612711. PMID: 37628892 Free PMC article.

Pleural CD14+ monocytes/macrophages of healthy adolescents show a high expression of metallothionein family genes.
Schukfeh N, Liu B, DeLuca DS, Tumpara S, Nikolin C, Immenschuh S, Ure BM, Kuebler JF, Welte T, Viemann D, Janciauskiene SM, Vieten G. Eur J Immunol. 2023 Jan;53(1):e2250019. doi: 10.1002/eji.202250019. Epub 2022 Nov 18. PMID: 36321537 Free article.

Autolysosomal activation combined with lysosomal destabilization efficiently targets myeloid leukemia cells for cell death.
Shah H, Stankov M, Panayotova-Dimitrova D, Yazdi A, Budida R, Klusmann JH, Behrens GMN. Front Oncol. 2023 Feb 1;13:999738. doi: 10.3389/fonc.2023.999738. eCollection 2023. PMID: 36816923 Free PMC article.

Permissive ureter specification by TBX18-mediated repression of metanephric gene expression.
Weiss AC, Blank E, Bohnenpoll T, Kleppa MJ, Rivera-Reyes R, Taketo MM, Trowe MO, Kispert A. Development. 2023 Mar 15;150(6):dev201048. doi: 10.1242/dev.201048. Epub 2023 Mar 23. PMID: 36960826

RORγt+ c-Maf+ Vγ4+ γδ T cells are generated in the adult thymus but do not reach the periphery.
Yang T, Barros-Martins J, Wang Z, Wencker M, Zhang J, Smout J, Gambhir P, Janssen A, Schimrock A, Georgiev H, León-Lara X, Weiss S, Huehn J, Prinz I, Krueger A, Foerster R, Walzer T, Ravens S. Cell Rep. 2023 Oct 31;42(10):113230. doi: 10.1016/j.celrep.2023.113230. Epub 2023 Oct 9. PMID: 37815917 Free article.

2022

Improved alpharetrovirus-based Gag.MS2 particles for efficient and transient delivery of CRISPR-Cas9 into target cells.
Baron Y, Sens J, Lange L, Nassauer L, Klatt D, Hoffmann D, Kleppa MJ, Barbosa PV, Keisker M, Steinberg V, Suerth JD, Vondran FWR, Meyer J, Morgan M, Schambach A, Galla M. Mol Ther Nucleic Acids. 2022 Jan 1;27:810-823. doi: 10.1016/j.omtn.2021.12.033. eCollection 2022 Mar 8. PMID: 35141043 Free PMC article.

Profiling of epigenetic marker regions in murine ILCs under homeostatic and inflammatory conditions.
Beckstette M, Lu CW, Herppich S, Diem EC, Ntalli A, Ochel A, Kruse F, Pietzsch B, Neumann K, Huehn J, Floess S, Lochner M. J Exp Med. 2022 Oct 3;219(10):e20210663. doi: 10.1084/jem.20210663. Epub 2022 Aug 8. PMID: 35938981 Free PMC article.

PD-1/CTLA-4 Blockade Leads to Expansion of CD8+PD-1int TILs and Results in Tumor Remission in Experimental Liver Cancer.
Bufe S, Zimmermann A, Ravens S, Prinz I, Buitrago-Molina LE, Geffers R, Woller N, Kühnel F, Talbot SR, Noyan F, Manns MP, Wedemeyer H, Hardtke-Wolenski M, Jaeckel E, Davalos-Misslitz AC. Liver Cancer. 2022 Oct 7;12(2):129-144. doi: 10.1159/000526899. eCollection 2023 Jun. PMID: 37325488 Free PMC article.

Proinflammatory cytokines induce rapid, NO-independent apoptosis, expression of chemotactic mediators and interleukin-32 secretion in human pluripotent stem cell-derived beta cells.
Dettmer R, Niwolik I, Cirksena K, Yoshimoto T, Tang Y, Mehmeti I, Gurgul-Convey E, Naujok O. Diabetologia. 2022 May;65(5):829-843. doi: 10.1007/s00125-022-05654-0. Epub 2022 Feb 5. PMID: 35122482 Free PMC article.

Specific T cells targeting Staphylococcus aureus fibronectin-binding protein 1 induce a type 2/type 1 inflammatory response in sensitized atopic dermatitis patients.
Farag AK, Roesner LM, Wieschowski S, Heratizadeh A, Eiz-Vesper B, Kwok WW, Valenta R, Werfel T. Allergy. 2022 Apr;77(4):1245-1253. doi: 10.1111/all.15120. Epub 2021 Oct 22. PMID: 34601735 Free PMC article.

Loss of vascular endothelial notch signaling promotes spontaneous formation of tertiary lymphoid structures.
Fleig S, Kapanadze T, Bernier-Latmani J, Lill JK, Wyss T, Gamrekelashvili J, Kijas D, Liu B, Hüsing AM, Bovay E, Jirmo AC, Halle S, Ricke-Hoch M, Adams RH, Engel DR, von Vietinghoff S, Förster R, Hilfiker-Kleiner D, Haller H, Petrova TV, Limbourg FP. Nat Commun. 2022 Apr 19;13(1):2022. doi: 10.1038/s41467-022-29701-x. PMID: 35440634 Free PMC article.

Airway basal cells show a dedifferentiated KRT17highPhenotype and promote fibrosis in idiopathic pulmonary fibrosis.
Jaeger B, Schupp JC, Plappert L, Terwolbeck O, Artysh N, Kayser G, Engelhard P, Adams TS, Zweigerdt R, Kempf H, Lienenklaus S, Garrels W, Nazarenko I, Jonigk D, Wygrecka M, Klatt D, Schambach A, Kaminski N, Prasse A. Nat Commun. 2022 Sep 26;13(1):5637. doi: 10.1038/s41467-022-33193-0. PMID: 36163190 Free PMC article.

Membrane-bound IL-2 improves the expansion, survival, and phenotype of CAR Tregs and confers resistance to calcineurin inhibitors.
Kremer J, Henschel P, Simon D, Riet T, Falk C, Hardtke-Wolenski M, Wedemeyer H, Noyan F, Jaeckel E. Front Immunol. 2022 Dec 23;13:1005582. doi: 10.3389/fimmu.2022.1005582. eCollection 2022. PMID: 36618378 Free PMC article.

Acetyl-CoA-Carboxylase 1-mediated de novo fatty acid synthesis sustains Lgr5+ intestinal stem cell function.
Li S, Lu CW, Diem EC, Li W, Guderian M, Lindenberg M, Kruse F, Buettner M, Floess S, Winny MR, Geffers R, Richnow HH, Abraham WR, Grassl GA, Lochner M. Nat Commun. 2022 Jul 9;13(1):3998. doi: 10.1038/s41467-022-31725-2. PMID: 35810180 Free PMC article.

Real-Time Characterization of Clonal Fate Decisions in Complex Leukemia Samples by Fluorescent Genetic Barcoding.
Maetzig T, Lieske A, Dörpmund N, Rothe M, Kleppa MJ, Dziadek V, Hassan JJ, Dahlke J, Borchert D, Schambach A. Cells. 2022 Dec 14;11(24):4045. doi: 10.3390/cells11244045. PMID: 36552809 Free PMC article.

B cell-mediated regulatory mechanisms control tumor-promoting intestinal inflammation.
Melcher C, Yu J, Duong VHH, Westphal K, Helmi Siasi Farimany N, Shaverskyi A, Zhao B, Strowig T, Glage S, Brand K, Chan AC, Föger N, Lee KH. Cell Rep. 2022 Jul 12;40(2):111051. doi: 10.1016/j.celrep.2022.111051. PMID: 35830810 Free article.

Cross-Reactive T Cell Response Exists in Chronic Lymphocytic Choriomeningitis Virus Infection upon Pichinde Virus Challenge.
Mischke J, Klein S, Seamann A, Prinz I, Selin L, Ghersi D, Cornberg M, Kraft ARM. Viruses. 2022 Oct 18;14(10):2293. doi: 10.3390/v14102293. PMID: 36298848 Free PMC article.

Ex Vivo Generation of CAR Macrophages from Hematopoietic Stem and Progenitor Cells for Use in Cancer Therapy.
Paasch D, Meyer J, Stamopoulou A, Lenz D, Kuehle J, Kloos D, Buchegger T, Holzinger A, Falk CS, Kloth C, von Kaisenberg CS, Abken H, Schambach A, Lachmann N, Morgan M, Moritz T. Cells. 2022 Mar 15;11(6):994. doi: 10.3390/cells11060994. PMID: 35326445 Free PMC article.

T-cell receptor sequencing specifies psoriasis as a systemic and atopic dermatitis as a skin-focused, allergen-driven disease.
Roesner LM, Farag AK, Pospich R, Traidl S, Werfel T. Allergy. 2022 Sep;77(9):2737-2747. doi: 10.1111/all.15272. Epub 2022 Mar 14. PMID: 35255168

Healthy-like CD4+ Regulatory and CD4+ Conventional T-Cell Receptor Repertoires Predict Protection from GVHD Following Donor Lymphocyte Infusion.
Schneider J, Kuhlmann L, Xiao Y, Raha S, Bernhardt G, Stadler M, Thol F, Heuser M, Eder M, Ganser A, Ravens S, Förster R, Prinz I, Koenecke C, Schultze-Florey CR. Int J Mol Sci. 2022 Sep 18;23(18):10914. doi: 10.3390/ijms231810914. PMID: 36142824 Free PMC article.

Targeted biallelic integration of an inducible Caspase 9 suicide gene in iPSCs for safer therapies.
Wunderlich S, Haase A, Merkert S, Jahn K, Deest M, Frieling H, Glage S, Korte W, Martens A, Kirschning A, Zeug A, Ponimaskin E, Göhring G, Ackermann M, Lachmann N, Moritz T, Zweigerdt R, Martin U. Mol Ther Methods Clin Dev. 2022 May 31;26:84-94. doi: 10.1016/j.omtm.2022.05.011. eCollection 2022 Sep 8. PMID: 35795779 Free PMC article.

2021

A 3D iPSC-differentiation model identifies interleukin-3 as a regulator of early human hematopoietic specification.
Ackermann M, Haake K, Kempf H, Kaschutnig P, Weiss AC, Nguyen AHH, Abeln M, Merkert S, Kühnel MP, Hartmann D, Jonigk D, Thum T, Kispert A, Milsom MD, Lachmann N. Haematologica. 2021 May 1;106(5):1354-1367. doi: 10.3324/haematol.2019.228064. PMID: 32327499 Free PMC article.

Efficient Genetic Safety Switches for Future Application of iPSC-Derived Cell Transplants.
Dahlke J, Schott JW, Vollmer Barbosa P, Klatt D, Selich A, Lachmann N, Morgan M, Moritz T, Schambach A. J Pers Med. 2021 Jun 17;11(6):565. doi: 10.3390/jpm11060565. PMID: 34204193 Free PMC article.

Lymph-Derived Neutrophils Primarily Locate to the Subcapsular and Medullary Sinuses in Resting and Inflamed Lymph Nodes.
de Castro Pinho J, Förster R. Cells. 2021 Jun 12;10(6):1486. doi: 10.3390/cells10061486. PMID: 34204825 Free PMC article.

New hPSC SOX9 and INS Reporter Cell Lines Facilitate the Observation and Optimization of Differentiation into Insulin-Producing Cells.
Dettmer R, Niwolik I, Mehmeti I, Jörns A, Naujok O. Stem Cell Rev Rep. 2021 Dec;17(6):2193-2209. doi: 10.1007/s12015-021-10232-9. Epub 2021 Aug 19. PMID: 34415483 Free PMC article.

A selectable all-in-one CRISPR prime editing piggyBac transposon allows for highly efficient gene editing in human cell lines.
Eggenschwiler R, Gschwendtberger T, Felski C, Jahn C, Langer F, Sterneckert J, Hermann A, Lühmann J, Steinemann D, Haase A, Martin U, Petri S, Cantz T. Sci Rep. 2021 Nov 12;11(1):22154. doi: 10.1038/s41598-021-01689-2. PMID: 34773059 Free PMC article.

Expansion of CD10neg neutrophils and CD14+HLA-DRneg/low monocytes driving proinflammatory responses in patients with acute myocardial infarction.
Fraccarollo D, Neuser J, Möller J, Riehle C, Galuppo P, Bauersachs J. Elife. 2021 Jul 22;10:e66808. doi: 10.7554/eLife.66808. PMID: 34289931 Free PMC article.

Multiple Genes Surrounding Bcl-xL, a Common Retroviral Insertion Site, Can Influence Hematopoiesis Individually or in Concert.
Ha TC, Stahlhut M, Rothe M, Paul G, Dziadek V, Morgan M, Brugman M, Fehse B, Kustikova O, Schambach A, Baum C. Hum Gene Ther. 2021 May;32(9-10):458-472. doi: 10.1089/hum.2019.344. Epub 2020 Dec 7. PMID: 33012194

Regulatory B cells control airway hyperreactivity and lung remodeling in a murine asthma model.
Habener A, Happle C, Grychtol R, Skuljec J, Busse M, Dalüge K, Obernolte H, Sewald K, Braun A, Meyer-Bahlburg A, Hansen G. J Allergy Clin Immunol. 2021 Jun;147(6):2281-2294.e7. doi: 10.1016/j.jaci.2020.09.041. Epub 2020 Nov 27. PMID: 33249168

A Multiplex CRISPR-Screen Identifies PLA2G4A as Prognostic Marker and Druggable Target for HOXA9 and MEIS1 Dependent AML.
Hassan JJ, Lieske A, Dörpmund N, Klatt D, Hoffmann D, Kleppa MJ, Kustikova OS, Stahlhut M, Schwarzer A, Schambach A, Maetzig T. Int J Mol Sci. 2021 Aug 30;22(17):9411. doi: 10.3390/ijms22179411. PMID: 34502319 Free PMC article.

Peritoneal dialysate-range hypertonic glucose promotes T-cell IL-17 production that induces mesothelial inflammation.
Helmke A, Hüsing AM, Gaedcke S, Brauns N, Balzer MS, Reinhardt M, Hiss M, Shushakova N, de Luca D, Prinz I, Haller H, von Vietinghoff S. Eur J Immunol. 2021 Feb;51(2):354-367. doi: 10.1002/eji.202048733. Epub 2020 Sep 30. PMID: 32926407 Free article.

Genetic Correction of IL-10RB Deficiency Reconstitutes Anti-Inflammatory Regulation in iPSC-Derived Macrophages.
Hoffmann D, Sens J, Brennig S, Brand D, Philipp F, Vollmer Barbosa P, Kuehle J, Steinemann D, Lenz D, Buchegger T, Morgan M, Falk CS, Klein C, Lachmann N, Schambach A. J Pers Med. 2021 Mar 20;11(3):221. doi: 10.3390/jpm11030221. PMID: 33804706 Free PMC article.

Pulmonary transplantation of alpha-1 antitrypsin (AAT)-transgenic macrophages provides a source of functional human AAT in vivo.
Janosz E, Hetzel M, Spielmann H, Tumpara S, Rossdam C, Schwabbauer M, Kloos D, von Kaisenberg C, Schambach A, Buettner FFR, Janciauskiene S, Lachmann N, Moritz T. Gene Ther. 2021 Sep;28(9):477-493. doi: 10.1038/s41434-021-00269-3. Epub 2021 Jul 19. PMID: 34276045 Free PMC article. Review.

Venetoclax and dexamethasone synergize with inotuzumab ozogamicin-induced DNA damage signaling in B-lineage ALL.
Kirchhoff H, Karsli U, Schoenherr C, Battmer K, Erschow S, Talbot SR, Steinemann D, Heuser M, Heidenreich O, Hilfiker-Kleiner D, Ganser A, Eder M, Scherr M. Blood. 2021 May 13;137(19):2657-2661. doi: 10.1182/blood.2020008544. PMID: 33512436 Free PMC article.

Myeloid-Derived Growth Factor Protects Against Pressure Overload-Induced Heart Failure by Preserving Sarco/Endoplasmic Reticulum Ca2+-ATPase Expression in Cardiomyocytes.
Korf-Klingebiel M, Reboll MR, Polten F, Weber N, Jäckle F, Wu X, Kallikourdis M, Kunderfranco P, Condorelli G, Giannitsis E, Kustikova OS, Schambach A, Pich A, Widder JD, Bauersachs J, van den Heuvel J, Kraft T, Wang Y, Wollert KC. Circulation. 2021 Oct 12;144(15):1227-1240. doi: 10.1161/CIRCULATIONAHA.120.053365. Epub 2021 Aug 10. PMID: 34372689

An Improved Lentiviral Fluorescent Genetic Barcoding Approach Distinguishes Hematopoietic Stem Cell Properties in Multiplexed In Vivo Experiments.
Lieske A, Ha TC, Schambach A, Maetzig T. Hum Gene Ther. 2021 Oct;32(19-20):1280-1294. doi: 10.1089/hum.2021.042. PMID: 34139894

Improved Activity against Acute Myeloid Leukemia with Chimeric Antigen Receptor (CAR)-NK-92 Cells Designed to Target CD123.
Morgan MA, Kloos A, Lenz D, Kattre N, Nowak J, Bentele M, Keisker M, Dahlke J, Zimmermann K, Sauer M, Heuser M, Schambach A. Viruses. 2021 Jul 14;13(7):1365. doi: 10.3390/v13071365. PMID: 34372571 Free PMC article.

Differential retention of lymph-borne CD8 memory T cell subsets in the subcapsular sinus of resting and inflamed lymph nodes.
Nikolova G, Weiss S, Bosnjak B, Förster R. Cell Mol Immunol. 2021 May;18(5):1317-1319. doi: 10.1038/s41423-020-0451-6. Epub 2020 May 12. PMID: 32398805 Free PMC article. No abstract available.

Efficient IL-2R signaling differentially affects the stability, function, and composition of the regulatory T-cell pool.
Permanyer M, Bošnjak B, Glage S, Friedrichsen M, Floess S, Huehn J, Patzer GE, Odak I, Eckert N, Zargari R, Ospina-Quintero L, Georgiev H, Förster R. Cell Mol Immunol. 2021 Feb;18(2):398-414. doi: 10.1038/s41423-020-00599-z. Epub 2021 Jan 6. PMID: 33408345 Free PMC article.

Human CD16+ monocytes promote a pro-atherosclerotic endothelial cell phenotype via CX3CR1-CX3CL1 interaction.
Roy-Chowdhury E, Brauns N, Helmke A, Nordlohne J, Bräsen JH, Schmitz J, Volkmann J, Fleig SV, Kusche-Vihrog K, Haller H, von Vietinghoff S. Cardiovasc Res. 2021 May 25;117(6):1510-1522. doi: 10.1093/cvr/cvaa234. PMID: 32717023

Generation of an NFκB-Driven Alpharetroviral "All-in-One" Vector Construct as a Potent Tool for CAR NK Cell Therapy.
Rudek LS, Zimmermann K, Galla M, Meyer J, Kuehle J, Stamopoulou A, Brand D, Sandalcioglu IE, Neyazi B, Moritz T, Rossig C, Altvater B, Falk CS, Abken H, Morgan MA, Schambach A. Front Immunol. 2021 Nov 3;12:751138. doi: 10.3389/fimmu.2021.751138. eCollection 2021. PMID: 34804035 Free PMC article.

Clonal expansion of CD8+ T cells reflects graft-versus-leukemia activity and precedes durable remission following DLI.
Schultze-Florey CR, Kuhlmann L, Raha S, Barros-Martins J, Odak I, Tan L, Xiao Y, Ravens S, Hambach L, Venturini L, Stadler M, Eder M, Thol F, Heuser M, Förster R, Ganser A, Prinz I, Koenecke C. Blood Adv. 2021 Nov 9;5(21):4485-4499. doi: 10.1182/bloodadvances.2020004073. PMID: 34535011 Free PMC article.

Knockout-Induced Pluripotent Stem Cells for Disease and Therapy Modeling of IL-10-Associated Primary Immunodeficiencies.
Sens J, Hoffmann D, Lange L, Vollmer Barbosa P, Morgan M, Falk CS, Schambach A. Hum Gene Ther. 2021 Jan;32(1-2):77-95. doi: 10.1089/hum.2020.235. Epub 2021 Jan 11. PMID: 33023317

Conditionally immortalised leukaemia initiating cells co-expressing Hoxa9/Meis1 demonstrate microenvironmental adaptation properties ex vivo while maintaining myelomonocytic memory.
Stahlhut M, Ha TC, Takmakova E, Morgan MA, Schwarzer A, Schaudien D, Eder M, Schambach A, Kustikova OS. Sci Rep. 2021 Mar 5;11(1):5294. doi: 10.1038/s41598-021-84468-3. PMID: 33674652 Free PMC article.

Expression of ACKR4 demarcates the "peri-marginal sinus," a specialized vascular compartment of the splenic red pulp.
Werth K, Hub E, Gutjahr JC, Bosjnak B, Zheng X, Bubke A, Russo S, Rot A, Förster R. Cell Rep. 2021 Jul 13;36(2):109346. doi: 10.1016/j.celrep.2021.109346. PMID: 34260918 Free article.

Targeted delivery of regulatory macrophages to lymph nodes interferes with T cell priming by preventing the formation of stable immune synapses.
Yu K, Hammerschmidt SI, Permanyer M, Galla M, Rothe M, Zheng X, Werth K, Martens R, Lueder Y, Janssen A, Friedrichsen M, Bernhardt G, Förster R. Cell Rep. 2021 Jun 22;35(12):109273. doi: 10.1016/j.celrep.2021.109273. PMID: 34161766 Free article.

2020

TCR repertoire analysis reveals phosphoantigen-induced polyclonal proliferation of Vγ9Vδ2 T cells in neonates and adults.#
Fichtner AS, Bubke A, Rampoldi F, Wilharm A, Tan L, Steinbrück L, Schultze-Florey C, von Kaisenberg C, Prinz I, Herrmann T, Ravens S. J Leukoc Biol. 2020 Jun;107(6):1023-1032. doi: 10.1002/JLB.1MA0120-427RR. Epub 2020 Feb 17. PMID: 32064671

Human Lentiviral Gene Therapy Restores the Cellular Phenotype of Autosomal Recessive Complete IFN-γR1 Deficiency.
Hahn K, Pollmann L, Nowak J, Nguyen AHH, Haake K, Neehus AL, Waqas SFH, Pessler F, Baumann U, Hetzel M, Casanova JL, Schulz A, Bustamante J, Ackermann M, Lachmann N. Mol Ther Methods Clin Dev. 2020 Apr 11;17:785-795. doi: 10.1016/j.omtm.2020.04.002. eCollection 2020 Jun 12. PMID: 32355867 Free PMC article.

Effective hematopoietic stem cell-based gene therapy in a murine model of hereditary pulmonary alveolar proteinosis.
Hetzel M, Lopez-Rodriguez E, Mucci A, Nguyen AHH, Suzuki T, Shima K, Buchegger T, Dettmer S, Rodt T, Bankstahl JP, Malik P, Knudsen L, Schambach A, Hansen G, Trapnell BC, Lachmann N, Moritz T. Haematologica. 2020 Apr;105(4):1147-1157. doi: 10.3324/haematol.2018.214866. Epub 2019 Jul 9. PMID: 31289207 Free PMC article.

IL-17 regulates DC migration to the peribronchial LNs and allergen presentation in experimental allergic asthma.
Jirmo AC, Busse M, Happle C, Skuljec J, Dalüge K, Habener A, Grychtol R, DeLuca DS, Breiholz OD, Prinz I, Hansen G. Eur J Immunol. 2020 Jul;50(7):1019-1033. doi: 10.1002/eji.201948409. Epub 2020 Mar 29. PMID: 32142593 Free article.

Effective drug treatment identified by in vivo screening in a transplantable patient-derived xenograft model of chronic myelomonocytic leukemia.
Kloos A, Mintzas K, Winckler L, Gabdoulline R, Alwie Y, Jyotsana N, Kattre N, Schottmann R, Scherr M, Gupta C, Adams FF, Schwarzer A, Heckl D, Schambach A, Imren S, Humphries RK, Ganser A, Thol F, Heuser M. Leukemia. 2020 Nov;34(11):2951-2963. doi: 10.1038/s41375-020-0929-3. Epub 2020 Jun 24. PMID: 32576961 Free PMC article.

Targeted Integration of Inducible Caspase-9 in Human iPSCs Allows Efficient in vitro Clearance of iPSCs and iPSC-Macrophages.
Lipus A, Janosz E, Ackermann M, Hetzel M, Dahlke J, Buchegger T, Wunderlich S, Martin U, Cathomen T, Schambach A, Moritz T, Lachmann N. Int J Mol Sci. 2020 Apr 3;21(7):2481. doi: 10.3390/ijms21072481. PMID: 32260086 Free PMC article.

Efficient homing of T cells via afferent lymphatics requires mechanical arrest and integrin-supported chemokine guidance.
Martens R, Permanyer M, Werth K, Yu K, Braun A, Halle O, Halle S, Patzer GE, Bošnjak B, Kiefer F, Janssen A, Friedrichsen M, Poetzsch J, Kohli K, Lueder Y, Gutierrez Jauregui R, Eckert N, Worbs T, Galla M, Förster R. Nat Commun. 2020 Feb 28;11(1):1114. doi: 10.1038/s41467-020-14921-w. PMID: 32111837 Free PMC article.

Electroconvulsive therapy, changes in immune cell ratios, and their association with seizure quality and clinical outcome in depressed patients.
Moschny N, Jahn K, Maier HB, Khan AQ, Ballmaier M, Liepach K, Sack M, Skripuletz T, Bleich S, Frieling H, Neyazi A. Eur Neuropsychopharmacol. 2020 Jul;36:18-28. doi: 10.1016/j.euroneuro.2020.03.019. Epub 2020 May 21. PMID: 32446707

DNA Methylation of the t-PA Gene Differs Between Various Immune Cell Subtypes Isolated From Depressed Patients Receiving Electroconvulsive Therapy.
Moschny N, Jahn K, Bajbouj M, Maier HB, Ballmaier M, Khan AQ, Pollak C, Bleich S, Frieling H, Neyazi A. Front Psychiatry. 2020 Jun 19;11:571. doi: 10.3389/fpsyt.2020.00571. eCollection 2020. PMID: 32636772 Free PMC article.

Mutations of the gene FNIP1 associated with a syndromic autosomal recessive immunodeficiency with cardiomyopathy and pre-excitation syndrome.
Niehues T, Özgür TT, Bickes M, Waldmann R, Schöning J, Bräsen J, Hagel C, Ballmaier M, Klusmann JH, Niedermayer A, Pannicke U, Enders A, Dückers G, Siepermann K, Hempel J, Schwarz K, Viemann D. Eur J Immunol. 2020 Jul;50(7):1078-1080. doi: 10.1002/eji.201948504. Epub 2020 Apr 20. PMID: 32181500 Free article.

Microbial exposure drives polyclonal expansion of innate γδ T cells immediately after birth.
Ravens S, Fichtner AS, Willers M, Torkornoo D, Pirr S, Schöning J, Deseke M, Sandrock I, Bubke A, Wilharm A, Dodoo D, Egyir B, Flanagan KL, Steinbrück L, Dickinson P, Ghazal P, Adu B, Viemann D, Prinz I. Proc Natl Acad Sci U S A. 2020 Aug 4;117(31):18649-18660. doi: 10.1073/pnas.1922588117. Epub 2020 Jul 20. PMID: 32690687 Free PMC article.

Meningioma 1 is indispensable for mixed lineage leukemia-rearranged acute myeloid leukemia.
Sharma A, Jyotsana N, Gabdoulline R, Heckl D, Kuchenbauer F, Slany RK, Ganser A, Heuser M. Haematologica. 2020 May;105(5):1294-1305. doi: 10.3324/haematol.2018.211201. Epub 2019 Aug 14. PMID: 31413090 Free PMC article.

Dual Function of iPSC-Derived Pericyte-Like Cells in Vascularization and Fibrosis-Related Cardiac Tissue Remodeling In Vitro.
Szepes M, Melchert A, Dahlmann J, Hegermann J, Werlein C, Jonigk D, Haverich A, Martin U, Olmer R, Gruh I. Int J Mol Sci. 2020 Nov 25;21(23):8947. doi: 10.3390/ijms21238947. PMID: 33255686 Free PMC article.

S100A8 and S100A9 Are Important for Postnatal Development of Gut Microbiota and Immune System in Mice and Infants.
Willers M, Ulas T, Völlger L, Vogl T, Heinemann AS, Pirr S, Pagel J, Fehlhaber B, Halle O, Schöning J, Schreek S, Löber U, Essex M, Hombach P, Graspeuntner S, Basic M, Bleich A, Cloppenborg-Schmidt K, Künzel S, Jonigk D, Rupp J, Hansen G, Förster R, Baines JF, Härtel C, Schultze JL, Forslund SK, Roth J, Viemann D. Gastroenterology. 2020 Dec;159(6):2130-2145.e5. doi: 10.1053/j.gastro.2020.08.019. Epub 2020 Aug 15. PMID: 32805279 Free article.

2019

The stem cell-specific long noncoding RNA HOXA10-AS in the pathogenesis of KMT2A-rearranged leukemia.
Al-Kershi S, Bhayadia R, Ng M, Verboon L, Emmrich S, Gack L, Schwarzer A, Strowig T, Heckl D, Klusmann JH. Blood Adv. 2019 Dec 23;3(24):4252-4263. doi: 10.1182/bloodadvances.2019032029. PMID: 31867596 Free PMC article.

Chemically defined and xenogeneic-free differentiation of human pluripotent stem cells into definitive endoderm in 3D culture.
Diekmann U, Wolling H, Dettmer R, Niwolik I, Naujok O, Buettner FFR. Sci Rep. 2019 Jan 30;9(1):996. doi: 10.1038/s41598-018-37650-z. PMID: 30700818 Free PMC article.

Macrophage Mineralocorticoid Receptor Is a Pleiotropic Modulator of Myocardial Infarct Healing.
Fraccarollo D, Thomas S, Scholz CJ, Hilfiker-Kleiner D, Galuppo P, Bauersachs J. Hypertension. 2019 Jan;73(1):102-111. doi: 10.1161/HYPERTENSIONAHA.118.12162. PMID: 30543467 Free PMC article.

Heparan Sulfate-Editing Extracellular Sulfatases Enhance VEGF Bioavailability for Ischemic Heart Repair.
Korf-Klingebiel M, Reboll MR, Grote K, Schleiner H, Wang Y, Wu X, Klede S, Mikhed Y, Bauersachs J, Klintschar M, Rudat C, Kispert A, Niessen HW, Lübke T, Dierks T, Wollert KC. Circ Res. 2019 Oct 11;125(9):787-801. doi: 10.1161/CIRCRESAHA.119.315023. Epub 2019 Aug 22. PMID: 31434553 Free article.

CX3CL1-CX3CR1 interaction mediates macrophage-mesothelial cross talk and promotes peritoneal fibrosis.
Helmke A, Nordlohne J, Balzer MS, Dong L, Rong S, Hiss M, Shushakova N, Haller H, von Vietinghoff S. Kidney Int. 2019 Jun;95(6):1405-1417. doi: 10.1016/j.kint.2018.12.030. Epub 2019 Mar 5. PMID: 30948201 Free article.

Lipid nanoparticle-mediated siRNA delivery for safe targeting of human CML in vivo.
Jyotsana N, Sharma A, Chaturvedi A, Budida R, Scherr M, Kuchenbauer F, Lindner R, Noyan F, Sühs KW, Stangel M, Grote-Koska D, Brand K, Vornlocher HP, Eder M, Thol F, Ganser A, Humphries RK, Ramsay E, Cullis P, Heuser M. Ann Hematol. 2019 Aug;98(8):1905-1918. doi: 10.1007/s00277-019-03713-y. Epub 2019 May 18. PMID: 31104089 Free PMC article.

Mechanisms of Progression of Myeloid Preleukemia to Transformed Myeloid Leukemia in Children with Down Syndrome.
Labuhn M, Perkins K, Matzk S, Varghese L, Garnett C, Papaemmanuil E, Metzner M, Kennedy A, Amstislavskiy V, Risch T, Bhayadia R, Samulowski D, Hernandez DC, Stoilova B, Iotchkova V, Oppermann U, Scheer C, Yoshida K, Schwarzer A, Taub JW, Crispino JD, Weiss MJ, Hayashi Y, Taga T, Ito E, Ogawa S, Reinhardt D, Yaspo ML, Campbell PJ, Roberts I, Constantinescu SN, Vyas P, Heckl D, Klusmann JH. Cancer Cell. 2019 Aug 12;36(2):123-138.e10. doi: 10.1016/j.ccell.2019.06.007. Epub 2019 Jul 11. PMID: 31303423 Free PMC article.

Single-Cell Transcriptomics Identifies the Adaptation of Scart1+ Vγ6+ T Cells to Skin Residency as Activated Effector Cells.
Tan L, Sandrock I, Odak I, Aizenbud Y, Wilharm A, Barros-Martins J, Tabib Y, Borchers A, Amado T, Gangoda L, Herold MJ, Schmidt-Supprian M, Kisielow J, Silva-Santos B, Koenecke C, Hovav AH, Krebs C, Prinz I, Ravens S. Cell Rep. 2019 Jun 18;27(12):3657-3671.e4. doi: 10.1016/j.celrep.2019.05.064. PMID: 31216482 Free article.

2018

Bhayadia R, Krowiorz K, Haetscher N, Jammal R, Emmrich S, Obulkasim A, Fiedler J, Schwarzer A, Rouhi A, Heuser M, Wingert S, Bothur S, Döhner K, Mätzig T, Ng M, Reinhardt D, Döhner H, Zwaan CM, van den Heuvel Eibrink M, Heckl D, Fornerod M, Thum T, Humphries RK, Rieger MA, Kuchenbauer F, Klusmann JH. Endogenous Tumor Suppressor microRNA-193b: Therapeutic and Prognostic Value in Acute Myeloid Leukemia. J Clin Oncol. 2018 Apr 1;36(10):1007-1016.

Blume, J., Zietara, N., Witzlau, K., Liu, Y., Sanchez, O. O., Puchalka, J., Winter, S. J., Kunze-Schumacher, H., Saran, N., Duber, S., Roy, B., Weiss, S., Klein, C., Wurst, W., Lyszkiewicz, M., and Krueger, A. miR-191 modulates B-cell development and targets transcription factors E2A, Foxp1, and Egr1. Eur J Immunol 49, 121-132.

Georgiev H, Ravens I, Papadogianni G, Halle S, Malissen B, Loots GG, Förster R, Bernhardt G. Shared and Unique Features Distinguishing Follicular T Helper and Regulatory Cells of Peripheral Lymph Node and Peyer's Patches. Front Immunol. 2018 Apr 9;9:714. doi: 10.3389/fimmu.2018.00714. eCollection 2018. PubMed PMID: 29686684; PubMed Central PMCID: PMC5900012.

Georgiev H, Ravens I, Papadogianni G, Malissen B, Förster R, Bernhardt G. Blocking the ART2.2/P2X7-system is essential to avoid a detrimental bias in functional CD4 T cell studies. Eur J Immunol. 2018 Jun;48(6):1078-1081. doi: 10.1002/eji.201747420. Epub 2018 Mar 23. PubMed PMID: 29508376.

Germeshausen M, Ancliff P, Estrada J, Metzler M, Ponstingl E, Rütschle H, Schwabe D, Scott RH, Unal S, Wawer A, Zeller B, Ballmaier M. MECOM-associated syndrome: a heterogeneous inherited bone marrow failure syndrome with amegakaryocytic thrombocytopenia. Blood Adv. 2018 Mar 27;2(6):586-596. doi: 10.1182/bloodadvances.2018016501. PubMed PMID: 29540340; PubMed Central PMCID: PMC5873238.

Getzin T, Krishnasamy K, Gamrekelashvili J, Kapanadze T, Limbourg A, Häger C, Napp LC, Bauersachs J, Haller H, Limbourg FP. The chemokine receptor CX(3)CR1 coordinates monocyte recruitment and endothelial regeneration after arterial injury. EMBO Mol Med. 2018 Feb;10(2):151-159.

Gialesaki S, Mahnken AK, Schmid L, Labuhn M, Bhayadia R, Heckl D, Klusmann JH. GATA1s exerts developmental stage-specific effects in human hematopoiesis. Haematologica. 2018 Aug;103(8):e336-e340.

Glaesener S, Jaenke C, Habener A, Geffers R, Hagendorff P, Witzlau K, Imelmann E, Krueger A, Meyer-Bahlburg A. Decreased production of class-switched antibodies in neonatal B cells is associated with increased expression of miR-181b. PLoS One. 2018 Feb 1;13(2):e0192230. doi: 10.1371/journal.pone.0192230. eCollection 2018. PubMed PMID: 29389970; PubMed Central PMCID: PMC5794184.

Hammerschmidt SI, Werth K, Rothe M, Galla M, Permanyer M, Patzer GE, Bubke A, Frenk DN, Selich A, Lange L, Schambach A, Bošnjak B, Förster R. CRISPR/Cas9 Immunoengineering of Hoxb8-Immortalized Progenitor Cells for Revealing CCR7-Mediated Dendritic Cell Signaling and Migration Mechanisms in vivo. Front Immunol. 2018 Aug 28;9:1949. doi: 10.3389/fimmu.2018.01949. eCollection 2018. PubMed PMID: 30210501; PubMed Central PMCID: PMC6120996.

Happle C, Meyer-Decking L, Dreier A, Wetzke M, Gläsener S, Grychtol R, Braubach P, Jablonka A, Haid S, Jirmo AC, Habener A, Skuljec J, Hansen G. Improved protocol for simultaneous analysis of leukocyte subsets and epithelial cells from murine and human lung. Exp Lung Res. 2018 Apr;44(3):127-136. doi: 10.1080/01902148.2018.1432721. Epub 2018 Apr 20. PMID: 29677457 Free article.

Hetzel M, Mucci A, Blank P, Nguyen AHH, Schiller J, Halle O, Kühnel MP, Billig S, Meineke R, Brand D, Herder V, Baumgärtner W, Bange FC, Goethe R, Jonigk D, Förster R, Gentner B, Casanova JL, Bustamante J, Schambach A, Kalinke U, Lachmann N. Hematopoietic stem cell gene therapy for IFNγR1 deficiency protects mice from mycobacterial infections. Blood. 2018 Feb 1;131(5):533-545. doi: 10.1182/blood-2017-10-812859. Epub 2017 Dec 12. PubMed PMID: 29233822.

Jyotsana N, Sharma A, Chaturvedi A, Scherr M, Kuchenbauer F, Sajti L, Barchanski A, Lindner R, Noyan F, Sühs KW, Grote-Koska D, Brand K, Vornlocher HP, Stanulla M, Bornhauser B, Bourquin JP, Eder M, Thol F, Ganser A, Humphries RK, Ramsay E, Cullis P, Heuser M. RNA interference efficiently targets human leukemia driven by a fusion oncogene in vivo. Leukemia. 2018 Jan;32(1):224-226. doi: 10.1038/leu.2017.269. Epub 2017 Aug 22. PMID: 28827563 Free PMC article. No abstract available.

Melzer C, von der Ohe J, Hass R. Enhanced metastatic capacity of breast cancer cells after interaction and hybrid formation with mesenchymal stroma/stem cells (MSC). Cell Commun Signal. 2018 Jan 5;16(1)

Melzer C, von der Ohe J, Hass R. In Vitro Fusion of Normal and Neoplastic Breast Epithelial Cells with Human Mesenchymal Stroma/Stem Cells Partially Involves Tumor Necrosis Factor Receptor Signaling. Stem Cells. 2018 Jul;36(7):977-989.

Melzer C, von der Ohe J, Hass R. MSC stimulate ovarian tumor growth during intercellular communication but reduce tumorigenicity after fusion with ovarian cancer cells. Cell Commun Signal. 2018 Oct 13;16(1):67.

Raud B, Roy DG, Divakaruni AS, Tarasenko TN, Franke R, Ma EH, Samborska B, Hsieh WY, Wong AH, Stüve P, Arnold-Schrauf C, Guderian M, Lochner M, Rampertaap S, Romito K, Monsale J, Brönstrup M, Bensinger SJ, Murphy AN, McGuire PJ, Jones RG, Sparwasser T, Berod L. Etomoxir Actions on Regulatory and Memory T Cells Are Independent of Cpt1a-Mediated Fatty Acid Oxidation. Cell Metab. 2018 Sep 4;28(3):504-515.e7. doi: 10.1016/j.cmet.2018.06.002. Epub 2018 Jun 28. PubMed PMID: 30043753.

Ravens S, Hengst J, Schlapphoff V, Deterding K, Dhingra A, Schultze-Florey C, Koenecke C, Cornberg M, Wedemeyer H, Prinz I. Human γδ T Cell Receptor Repertoires in Peripheral Blood Remain Stable Despite Clearance of Persistent Hepatitis C Virus Infection by Direct-Acting Antiviral Drug Therapy. Front Immunol. 2018 Mar 16;9:510. doi: 10.3389/fimmu.2018.00510. eCollection 2018. PubMed PMID: 29616028; PubMed Central PMCID: PMC5864898.

Sandrock I, Reinhardt A, Ravens S, Binz C, Wilharm A, Martins J, Oberdörfer L, Tan L, Lienenklaus S, Zhang B, Naumann R, Zhuang Y, Krueger A, Förster R, Prinz I. Genetic models reveal origin, persistence and non-redundant functions of IL-17-producing γδ T cells. J Exp Med. 2018 Dec 3;215(12):3006-3018.

Schultze-Florey RE, Tischer S, Kuhlmann L, Hundsdoerfer P, Koch A,Anagnostopoulos I, Ravens S, Goudeva L, Schultze-Florey C, Koenecke C, Blasczyk R, Koehl U, Heuft HG, Prinz I, Eiz-Vesper B, Maecker-Kolhoff B. Dissecting Epstein-Barr Virus-Specific T-Cell Responses After Allogeneic EBV-Specific T-Cell Transfer for Central Nervous System Posttransplant Lymphoproliferative Disease. Front Immunol. 2018 Jun 27;9:1475.

Skuljec J, Jirmo AC, Habener A, Talbot SR, Pul R, Grychtol R, Aydin M, Kleinschnitz C, Happle C, Hansen G. Absence of Regulatory T Cells Causes Phenotypic and Functional Switch in Murine Peritoneal Macrophages. Front. Immunol., 31 October 2018, doi.org/10.3389/fimmu.2018.02458

Stüve P, Minarrieta L, Erdmann H, Arnold-Schrauf C, Swallow M, Guderian M, Krull F, Hölscher A, Ghorbani P, Behrends J, Abraham WR, Hölscher C, Sparwasser TD, Berod L. De Novo Fatty Acid Synthesis During Mycobacterial Infection Is a Prerequisite for the Function of Highly Proliferative T Cells, But Not for Dendritic Cells or Macrophages. Front Immunol. 2018 Apr 5;9:495. doi: 10.3389/fimmu.2018.00495. eCollection 2018. PubMed PMID: 29675017; PubMed Central PMCID: PMC5895737.

Theobald SJ, Khailaie S, Meyer-Hermann M, Volk V, Olbrich H, Danisch S, Gerasch L, Schneider A, Sinzger C, Schaudien D, Lienenklaus S, Riese P, Guzman CA, Figueiredo C, von Kaisenberg C, Spineli LM, Glaesener S, Meyer-Bahlburg A, Ganser A, Schmitt M, Mach M, Messerle M, Stripecke R. Signatures of T and B Cell Development, Functional Responses and PD-1 Upregulation After HCMV Latent Infections and Reactivations in Nod.Rag.Gamma Mice Humanized With Cord Blood CD34(+) Cells. Front Immunol. 2018 Nov 22;9:2734.

Yu J, Duong VHH, Westphal K, Westphal A, Suwandi A, Grassl GA, Brand K, Chan AC, Föger N, Lee KH. Surface receptor Toso controls B cell-mediated regulation of T cell immunity. J Clin Invest. 2018 May 1;128(5):1820-1836. doi: 10.1172/JCI97280. Epub 2018 Apr 3. PMID: 29461978 Free PMC article.

2017

Ackermann M, Kuhn A, Kunkiel J, Merkert S, Martin U, Moritz T, Lachmann N. Ex vivo Generation of Genetically Modified Macrophages from Human Induced Pluripotent Stem Cells. Transfus Med Hemother. 2017 Jun;44(3):135-142.

Adams FF, Heckl D, Hoffmann T, Talbot SR, Kloos A, Thol F, Heuser M, Zuber J, Schambach A, Schwarzer A. An optimized lentiviral vector system for conditional RNAi and efficient cloning of microRNA embedded short hairpin RNA libraries. Biomaterials. 2017 Sep;139:102-115. doi: 10.1016/j.biomaterials.2017.05.032.

Budida R, Stankov MV, Döhner K, Buch A, Panayotova-Dimitrova D, Tappe KA, Pohlmann A, Sodeik B, Behrens GMN. Herpes simplex virus 1 interferes with autophagy of murine dendritic cells and impairs their ability to stimulate CD8(+) T lymphocytes. Eur J Immunol. 2017 Oct;47(10):1819-1834.

Diekmann U, Davenport C, Kresse J, Naujok O. Purification of Definitive Endoderm Generated from Pluripotent Stem Cells by Magnetic Cell Sorting. Curr Protoc Stem Cell Biol. 2017 Feb 2;40:1D.9.1-1D.9.17.

Fraccarollo D, Galuppo P, Bauersachs J. Modeling Cardiac Fibrosis in Mice: (Myo)Fibroblast Phenotype After Ischemia. Methods Mol Biol. 2017;1627:123-137. doi: 10.1007/978-1-4939-7113-8_9. PubMed PMID: 28836199.

Galuppo P, Vettorazzi S, Hövelmann J, Scholz CJ, Tuckermann JP, Bauersachs J, Fraccarollo D. The glucocorticoid receptor in monocyte-derived macrophages is critical for cardiac infarct repair and remodeling. FASEB J. 2017 Nov;31(11):5122-5132. doi: 10.1096/fj.201700317R. Epub 2017 Aug 2.

Geis FK, Galla M, Hoffmann D, Kuehle J, Zychlinski D, Maetzig T, Schott JW, Schwarzer A, Goffinet C, Goff SP, Schambach A. Potent and reversible lentiviral vector restriction in murine induced pluripotent stem cells. Retrovirology. 2017 May 31;14(1):34.

Habener A, Behrendt AK, Skuljec J, Jirmo AC, Meyer-Bahlburg A, Hansen G. B cell subsets are modulated during allergic airway inflammation but are not required for the development of respiratory tolerance in a murine model. Eur J Immunol. 2017 Mar;47(3):552-562. doi: 10.1002/eji.201646518. Epub 2017 Jan 17. PMID: 27995616 Free article.

Hetzel M, Mucci A, Blank P, Nguyen AHH, Schiller J, Halle O, Kühnel MP, Billig S, Meineke R, Brand D, Herder V, Baumgärtner W, Bange FC, Goethe R, Jonigk D, Förster R, Gentner B, Casanova JL, Bustamante J, Schambach A, Kalinke U, Lachmann N. Hematopoietic stem cell gene therapy for IFNγR1 deficiency protects mice from mycobacterial infections. Blood. 2017 Dec 12. pii: blood-2017-10-812859. doi: 10.1182/blood-2017-10-812859. [Epub ahead of print]

Hetzel M, Suzuki T, Hashtchin AR, Arumugam P, Carey B, Schwabbauer M, Kuhn A, Meyer J, Schambach A, Van Der Loo J, Moritz T, Trapnell BC, Lachmann N. Function and Safety of Lentivirus-Mediated Gene Transfer for CSF2RA-Deficiency. Hum Gene Ther Methods. 2017 Dec;28(6):318-329.

Lino CNR, Barros-Martins J, Oberdörfer L, Walzer T, Prinz I. Eomes expression reports the progressive differentiation of IFN-γ-producing Th1-like γδ T cells. Eur J Immunol. 2017 Jun;47(6):970-981.

Nikolovska K, Spillmann D, Haier J, Ladányi A, Stock C, Seidler DG. Melanoma Cell Adhesion and Migration Is Modulated by the Uronyl 2-O Sulfotransferase. PLoS One. 2017 Jan 20;12(1):e0170054. doi: 10.1371/journal.pone.0170054. PubMed PMID: 28107390; PubMed Central PMCID: PMC5249195.

Pittermann E, Lachmann N, MacLean G, Emmrich S, Ackermann M, Göhring G, Schlegelberger B, Welte K, Schambach A, Heckl D, Orkin SH, Cantz T, Klusmann JH. Gene correction of HAX1 reversed Kostmann disease phenotype in patient-specific induced pluripotent stem cells. Blood Adv. 2017 Jun 2;1(14):903-914. doi: 10.1182/bloodadvances.2016003798.

Ravens S, Schultze-Florey C, Raha S, Sandrock I, Drenker M, Oberdörfer L, Reinhardt A, Ravens I, Beck M, Geffers R, von Kaisenberg C, Heuser M, Thol F, Ganser A, Förster R, Koenecke C, Prinz I. Human γδ T cells are quickly reconstituted after stem-cell transplantation and show adaptive clonal expansion in response to viral infection. Nat Immunol. 2017 Apr;18(4):393-401

Reboll MR, Korf-Klingebiel M, Klede S, Polten F, Brinkmann E, Reimann I, Schönfeld HJ, Bobadilla M, Faix J, Kensah G, Gruh I, Klintschar M, Gaestel M, Niessen HW, Pich A, Bauersachs J, Gogos JA, Wang Y, Wollert KC. EMC10 (Endoplasmic Reticulum Membrane Protein Complex Subunit 10) Is a Bone Marrow-Derived Angiogenic Growth Factor Promoting Tissue Repair After Myocardial Infarction. Circulation. 2017 Nov 7;136(19):1809-1823.

Reimer J, Knöß S, Labuhn M, Charpentier EM, Göhring G, Schlegelberger B, Klusmann JH, Heckl D. CRISPR-Cas9-induced t(11;19)/MLL-ENL translocations initiate leukemia in human hematopoietic progenitor cells in vivo. Haematologica. 2017 Sep;102(9):1558-1566.

Schrimpf C, Wrede C, Glage S, Hegermann J, Backhaus S, Blasczyk R, Heuft HG, Müller T. Differentiation of induced pluripotent stem cell-derived neutrophil granulocytes from common marmoset monkey (Callithrix jacchus). Transfusion. 2017 Jan;57(1):60-69.

Schwarzer A, Emmrich S, Schmidt F, Beck D, Ng M, Reimer C, Adams FF, Grasedieck S, Witte D, Käbler S, Wong JWH, Shah A, Huang Y, Jammal R, Maroz A, Jongen-Lavrencic M, Schambach A, Kuchenbauer F, Pimanda JE, Reinhardt D, Heckl D, Klusmann JH. The non-coding RNA landscape of human hematopoiesis and leukemia. Nat Commun. 2017 Aug 9;8(1):218.

Sgodda M, Dai Z, Zweigerdt R, Sharma AD, Ott M, Cantz T. A Scalable Approach for the Generation of Human Pluripotent Stem Cell-Derived Hepatic Organoids with Sensitive Hepatotoxicity Features. Stem Cells Dev. 2017 Oct 15;26(20):1490-1504.

Thol F, Klesse S, Köhler L, Gabdoulline R, Kloos A, Liebich A, Wichmann M, Chaturvedi A, Fabisch J, Gaidzik VI, Paschka P, Bullinger L, Bug G, Serve H, Göhring G, Schlegelberger B, Lübbert M, Kirchner H, Wattad M, Kraemer D, Hertenstein B, Heil G, Fiedler W, Krauter J, Schlenk RF, Döhner K, Döhner H, Ganser A, Heuser M. Acute myeloid leukemia derived from lympho-myeloid clonal hematopoiesis. Leukemia. 2017, 31(6):1286-1295

Westphal A, Cheng W, Yu J, Grassl G, Krautkrämer M, Holst O, Föger N, Lee KH. Lysosomal trafficking regulator Lyst links membrane trafficking to toll-like receptor-mediated inflammatory responses. J Exp Med. 2017 Jan;214(1):227-244. doi: 10.1084/jem.20141461.

2016

Abbey M, Hakim C, Anand R, Lafera J, Schambach A, Kispert A, Taft MH, Kaever V, Kotlyarov A, Gaestel M, Menon MB. GTPase domain driven dimerization of SEPT7 is dispensable for the critical role of septins in fibroblast cytokinesis. Sci Rep. 2016 Jan 28;6:20007.

Chaturvedi A, Araujo Cruz MM, Jyotsana N, Sharma A, Goparaju R, Schwarzer A, Görlich K, Schottmann R, Struys EA, Jansen EE, Rohde C, Müller-Tidow C, Geffers R, Göhring G, Ganser A, Thol F, Heuser M. Enantiomer-specific and paracrine leukemogenicity of mutant IDH metabolite 2-hydroxyglutarate. Leukemia. 2016 Aug;30(8):1708-15.

Davenport C, Diekmann U, Budde I, Detering N, Naujok O. Anterior-Posterior Patterning of Definitive Endoderm Generated from Human Embryonic Stem Cells Depends on the Differential Signaling of Retinoic Acid, Wnt-, and BMP-Signaling. Stem Cells. 2016 Jun 14. doi: 10.1002/stem.2428. [Epub ahead of print] PubMed PMID: 27299363.

Dudek M, Puttur F, Arnold-Schrauf C, Kühl AA, Holzmann B, Henriques-Normark B, Berod L, Sparwasser T. Lung epithelium and myeloid cells cooperate to clear acute pneumococcal infection. Mucosal Immunol. 2016 Sep;9(5):1288-302.

Eggenschwiler R, Moslem M, Fráguas MS, Galla M, Papp O, Naujock M, Fonfara I, Gensch I, Wähner A, Beh-Pajooh A, Mussolino C, Tauscher M, Steinemann D, Wegner F, Petri S, Schambach A, Charpentier E, Cathomen T, Cantz T. Improved bi-allelic modification of a transcriptionally silent locus in patient-derived iPSC by Cas9 nickase. Sci Rep. 2016 Dec 2;6:38198.

Gamrekelashvili J, Giagnorio R, Jussofie J, Soehnlein O, Duchene J, Briseño CG, Ramasamy SK, Krishnasamy K, Limbourg A, Kapanadze T, Ishifune C, Hinkel R, Radtke F, Strobl LJ, Zimber-Strobl U, Napp LC, Bauersachs J, Haller H, Yasutomo K, Kupatt C, Murphy KM, Adams RH, Weber C, Limbourg FP. Regulation of monocyte cell fate by blood vessels mediated by Notch signalling. Nat Commun. 2016 Aug 31;7:12597.

Georgiev H, Ravens I, Benarafa C, Förster R, Bernhardt G. Distinct gene expression patterns correlate with developmental and functional traits of iNKT subsets. Nat Commun. 2016 Oct 10;7:13116.

Georgiev H, Ravens I, Shibuya A, Förster R, Bernhardt G. CD155/CD226-interaction impacts on the generation of innate CD8(+) thymocytes by regulating iNKT-cell differentiation. Eur J Immunol. 2016 Apr;46(4):993-1003.

Gupta SK, Itagaki R, Zheng X, Batkai S, Thum S, Ahmad F, Van Aelst LN, Sharma A, Piccoli MT, Weinberger F, Fiedler J, Heuser M, Heymans S, Falk CS, Förster R, Schrepfer S, Thum T. miR-21 promotes fibrosis in an acute cardiac allograft transplantation model. Cardiovasc Res. 2016 May 15;110(2):215-26.

Halle S, Keyser KA, Stahl FR, Busche A, Marquardt A, Zheng X, Galla M, Heissmeyer V, Heller K, Boelter J, Wagner K, Bischoff Y, Martens R, Braun A, Werth K, Uvarovskii A, Kempf H, Meyer-Hermann M, Arens R, Kremer M, Sutter G, Messerle M, Förster R. In Vivo Killing Capacity of Cytotoxic T Cells Is Limited and Involves Dynamic Interactions and T Cell Cooperativity. Immunity. 2016 Feb 16;44(2):233-45.

Hübner J, Hoseini SS, Suerth JD, Hoffmann D, Maluski M, Herbst J, Maul H, Ghosh A, Eiz-Vesper B, Yuan Q, Ott M, Heuser M, Schambach A, Sauer MG. Generation of Genetically Engineered Precursor T-Cells From Human Umbilical Cord Blood Using an Optimized Alpharetroviral Vector Platform. Mol Ther. 2016 Aug;24(7):1216-26.

Jirmo AC, Daluege K, Happle C, Albrecht M, Dittrich AM, Busse M, Habener A, Skuljec J, Hansen G. IL-27 Is Essential for Suppression of Experimental Allergic Asthma by the TLR7/8 Agonist R848 (Resiquimod). J Immunol. 2016 Dec 1;197(11):4219-4227.

Klemann C, Schröder A, Dreier A, Möhn N, Dippel S, Winterberg T, Wilde A, Yu Y, Thorenz A, Gueler F, Jörns A, Tolosa E, Leonhardt J, Haas JD, Prinz I, Vieten G, Petersen C, Kuebler JF. Interleukin 17, Produced by γδ T Cells, Contributes to Hepatic Inflammation in a Mouse Model of Biliary Atresia and Is Increased in Livers of Patients. Gastroenterology. 2016 Jan;150(1):229-241.e5.

Kohli K, Janssen A, Förster R. Plasmacytoid dendritic cells induce tolerance predominantly by cargoing antigen to lymph nodes. Eur J Immunol. 2016 Nov;46(11):2659-2668

Labenski V, Suerth JD, Barczak E, Heckl D, Levy C, Bernadin O, Charpentier E, Williams DA, Fehse B, Verhoeyen E, Schambach A. Alpharetroviral self-inactivating vectors produced by a superinfection-resistant stable packaging cell line allow genetic modification of primary human T lymphocytes. Biomaterials. 2016 Aug;97:97-109.

Lee CW, Wohlan K, Dallmann I, Förster R, Ganser A, Krueger A, Scherr M, Eder M, Koenecke C. miR-181a Expression in Donor T Cells Modulates Graft-versus-Host Disease after Allogeneic Bone Marrow Transplantation. J Immunol. 2016 May 1;196(9):3927-34.

Mahapatra S, Albrecht M, Baru AM, Sparwasser T, Herrick C, Dittrich AM. Superior Suppressive Capacity of Skin Tregs Compared with Lung Tregs in a Model of Epicutaneous Priming. J Invest Dermatol. 2015 Oct;135(10):2418-26.

Manukjan G, Ripperger T, Venturini L, Stadler M, Göhring G, Schambach A, Schlegelberger B, Steinemann D. GABP is necessary for stem/progenitor cell maintenance and myeloid differentiation in human hematopoiesis and chronic myeloid leukemia. Stem Cell Res. 2016 May;16(3):677-81.

Mucci A, Kunkiel J, Suzuki T, Brennig S, Glage S, Kühnel MP, Ackermann M, Happle C, Kuhn A, Schambach A, Trapnell BC, Hansen G, Moritz T, Lachmann N. Murine iPSC-Derived Macrophages as a Tool for Disease Modeling of Hereditary Pulmonary Alveolar Proteinosis due to Csf2rb Deficiency. Stem Cell Reports. 2016 Aug 9;7(2):292-305.

Noyan F, Zimmermann K, Hardtke-Wolenski M, Knoefel A, Schulde E, Geffers R, Hust M, Huehn J, Galla M, Morgan M, Jokuszies A, Manns MP, Jaeckel E. Prevention of allograft rejection by use of regulatory T cells with a MHC-specific chimeric antigen receptor. Am J Transplant. 2016 Dec 20. doi: 10.1111/ajt.14175. [Epub ahead of print]

Pfaender S, Grabski E, Detje CN, Riebesehl N, Lienenklaus S, Steinmann E, Kalinke U, Pietschmann T. Hepatitis C Virus Stimulates Murine CD8α-Like Dendritic Cells to Produce Type I Interferon in a TRIF-Dependent Manner. PLoS Pathog. 2016 Jul;12(7):e1005736.

Puttur F, Francozo M, Solmaz G, Bueno C, Lindenberg M, Gohmert M, Swallow M, Tufa D, Jacobs R, Lienenklaus S, Kühl AA, Borkner L, Cicin-Sain L, Holzmann B, Wagner H, Berod L, Sparwasser T. Conventional Dendritic Cells Confer Protection against Mouse Cytomegalovirus Infection via TLR9 and MyD88 Signaling. Cell Rep. 2016 Oct 18;17(4):1113-1127.

Roesner LM, Heratizadeh A, Wieschowski S, Mittermann I, Valenta R, Eiz-Vesper B, Hennig C, Hansen G, Falk CS, Werfel T. α-NAC-Specific Autoreactive CD8+ T Cells in Atopic Dermatitis Are of an Effector Memory Type and Secrete IL-4 and IFN-γ. J Immunol. 2016 Apr 15;196(8):3245-52.

Ronkina N, Lafera J, Kotlyarov A, Gaestel M. Stress-dependent phosphorylation of myocardin-related transcription factor A (MRTF-A) by the p38(MAPK)/MK2 axis. Sci Rep. 2016 Aug 5;6:31219.

Roth A, Glaesener S, Schütz K, Meyer-Bahlburg A. Reduced Number of Transitional and Naive B Cells in Addition to Decreased BAFF Levels in Response to the T Cell Independent Immunogen Pneumovax®23. PLoS One. 2016 Mar 31;11(3):e0152215.

Selich A, Daudert J, Hass R, Philipp F, von Kaisenberg C, Paul G, Cornils K, Fehse B, Rittinghausen S, Schambach A, Rothe M. Massive Clonal Selection and Transiently Contributing Clones During Expansion of Mesenchymal Stem Cell Cultures Revealed by Lentiviral RGB-Barcode Technology. Stem Cells Transl Med. 2016 May;5(5):591-601.

Siemeni T, Knöfel AK, Madrahimov N, Sommer W, Avsar M, Salman J, Ius F, Frank N, Büchler G, Jonigk D, Jansson K, Maus U, Tudorache I, Falk CS, Haverich A, Warnecke G. In Vivo Development of Transplant Arteriosclerosis in Humanized Mice Reflects Alloantigen Recognition and Peripheral Treg Phenotype of Lung Transplant Recipients. Am J Transplant. 2016 Nov;16(11):3150-3162.

Song G, Pacher M, Balakrishnan A, Yuan Q, Tsay HC, Yang D, Reetz J, Brandes S, Dai Z, Pützer BM, Araúzo-Bravo MJ, Steinemann D, Luedde T, Schwabe RF, Manns MP, Schöler HR, Schambach A, Cantz T, Ott M, Sharma AD. Direct Reprogramming of Hepatic Myofibroblasts into Hepatocytes In Vivo Attenuates Liver Fibrosis. Cell Stem Cell. 2016 Jun 2;18(6):797-808.

Stahlhut M, Ha TC, Morgan M, Schambach A, Kustikova OS. Comparison of tetracycline-regulated promoters in lentiviral-based vectors in murine transplantation studies. Curr Gene Ther. 2016 Oct 13. [Epub ahead of print]

Thiesler CT, Cajic S, Hoffmann D, Thiel C, van Diepen L, Hennig R, Sgodda M, Weiβmann R, Reichl U, Steinemann D, Diekmann U, Huber NM, Oberbeck A, Cantz T, Kuss AW, Körner C, Schambach A, Rapp E, Buettner FF. Glycomic Characterization of Induced Pluripotent Stem Cells Derived from a Patient Suffering from Phosphomannomutase 2 Congenital Disorder of Glycosylation (PMM2-CDG). Mol Cell Proteomics. 2016 Apr;15(4):1435-52.

Tiedje C, Diaz-Muñoz MD, Trulley P, Ahlfors H, Laaß K, Blackshear PJ, Turner M, Gaestel M. The RNA-binding protein TTP is a global post-transcriptional regulator of feedback control in inflammation. Nucleic Acids Res. 2016 Sep 6;44(15):7418-40.

Tufa DM, Ahmad F, Chatterjee D, Ahrenstorf G, Schmidt RE, Jacobs R. IL-1β limits the extent of human 6-sulfo LacNAc dendritic cell (slanDC)-mediated NK cell activation and regulates CD95-induced apoptosis. Cell Mol Immunol. 2016 Apr 18. doi: 10.1038/cmi.2016.17. [Epub ahead of print]

Tufa DM, Ahmad F, Chatterjee D, Ahrenstorf G, Schmidt RE, Jacobs R. Brief Report: HIV-1 Infection Results in Increased Frequency of Active and Inflammatory SlanDCs that Produce High Level of IL-1β. J Acquir Immune Defic Syndr. 2016 Sep 1;73(1):34-8.

Zheng X, Halle S, Yu K, Mishra P, Scherr M, Pietzsch S, Willenzon S, Janssen A, Boelter J, Hilfiker-Kleiner D, Eder M, Förster R. Cardiomyocytes display low mitochondrial priming and are highly resistant toward cytotoxic T-cell killing. Eur J Immunol. 2016 Jun;46(6):1415-26.

2015

Ballmaier M, Holter W, Germeshausen M. Flow cytometric detection of MPL (CD110) as a diagnostic tool for differentiation of congenital thrombocytopenias. Haematologica. 100:e341-4.

Brennig S, Lachmann N, Buchegger T, Hetzel M, Schambach A, Moritz T (2015) Chemoprotection of murine hematopoietic cells by combined gene transfer of cytidine deaminase (CDD) and multidrug resistance 1 gene (MDR1). J Exp Clin Cancer Res. 34:148

Buettner M, Dittrich-Breiholz O, Falk CS, Lochner M, Smoczek A, Menzel F, Bornemann M, Bode U. (2015) Stromal cells as trend-setters for cells migrating into the lymph node. Mucosal Immunol. 8:640-9

Daenthanasanmak A, Salguero G, Sundarasetty BS, Waskow C, Cosgun KN, Guzman CA, Riese P, Gerasch L, Schneider A, Ingendoh A, Messerle M, Gabaev I, Woelk B, Ruggiero E, Schmidt M, von Kalle C, Figueiredo C, Eiz-Vesper B, von Kaisenberg C, Ganser A, Stripecke R (2015) Engineered dendritic cells from cord blood and adult blood accelerate effector T cell immune reconstitution against HCMV. Mol Ther Methods Clin Dev. 1:14060.

Dudek M, Puttur F, Arnold-Schrauf C, Kühl AA, Holzmann B, Henriques-Normark B, Berod L, Sparwasser T. (2015) Lung epithelium and myeloid cells cooperate to clear acute pneumococcal infection. Mucosal Immunol. 2015 Dec 2. [Epub ahead of print]

Dong L, Nordlohne J, Ge S, Hertel B, Melk A, Rong S, Haller H, von Vietinghoff S. (2015) T Cell CX3CR1 Mediates Excess Atherosclerotic Inflammation in Renal Impairment. J Am Soc Nephrol. 2015 Oct 8. [Epub ahead of print]

Emmrich S, Engeland F, El-Khatib M, Henke K, Obulkasim A, Schöning J, Katsman-Kuipers JE, Michel Zwaan C, Pich A, Stary J, Baruchel A, de Haas V, Reinhardt D, Fornerod M, van den Heuvel-Eibrink MM, Klusmann JH. (2015) miR-139-5p controls translation in myeloid leukemia through EIF4G2. Oncogene. 2015 Jul 13. [Epub ahead of print]

Garrels W, Mukherjee A, Holler S, Cleve N, Talluri TR, Barg-Kues B, Diederich M, Köhler P, Petersen B, Lucas-Hahn A, Niemann H, Izsvák Z, Ivics Z, Kues WA. (2015) Identification and re-addressing of a transcriptionally permissive locus in the porcine genome. Transgenic Res. 2015 Oct 29. [Epub ahead of print]

Georgiev H, Ravens I, Shibuya A, Förster R, Bernhardt G. (2015) CD155/CD226-interaction impacts on the generation of innate CD8(+) thymocytes by regulating iNKT-cell differentiation. Eur J Immunol. 2015 Dec 22. [Epub ahead of print]

Hardtke-Wolenski M, Taubert R, Noyan F, Sievers M, Dywicki J, Schlue J, Falk CS, Ardesjö Lundgren B, Scott HS, Pich A, Anderson MS, Manns MP, Jaeckel E. (2015) Autoimmune hepatitis in a murine autoimmune polyendocrine syndrome type 1 model is directed against multiple autoantigens. Hepatology. 2015 Apr;61(4):1295-305.

Hoseini SS, Hapke M, Herbst J, Wedekind D, Baumann R, Heinz N, Schiedlmeier B, Vignali DA, van den Brink MR, Schambach A, Blazar BR, Sauer MG (2015) Inducible T-cell receptor expression in precursor T cells for leukemia control. Leukemia. 29:1530-42.

Kashani E, Föhse L, Raha S, Sandrock I, Oberdörfer L, Koenecke C, Suerbaum S, Weiss S, Prinz I (2015) A clonotypic Vγ4Jγ1/Vδ5Dδ2Jδ1 innate γδ T-cell populationrestricted to the CCR6(+)CD27(-) subset. Nat Commun. 6:6477.

Korf-Klingebiel M, Reboll MR, Klede S, Brod T, Pich A, Polten F, Napp LC, Bauersachs J, Ganser A, Brinkmann E, Reimann I, Kempf T, Niessen HW, Mizrahi J, Schönfeld HJ, Iglesias A, Bobadilla M, Wang Y, Wollert KC (2015) Myeloid-derived growth factor (C19orf10) mediates cardiac repair following myocardial infarction. Nat Med. 21:140-9

Lachmann N, Ackermann M, Frenzel E, Liebhaber S, Brennig S, Happle C, Hoffmann D, Klimenkova O, Lüttge D, Buchegger T, Kühnel MP, Schambach A, Janciauskiene S, Figueiredo C, Hansen G, Skokowa J, Moritz T (2015) Large-scale hematopoietic differentiation of human induced pluripotent stem cells provides granulocytes or macrophages for cell replacement therapies. Stem Cell Reports. 4:282-96.

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