y, OE 6810, project: Genetics and metabolism: characterization of individual genetic variation of UDP-glucuronosyltransferase regulation in a mouse model Final exam November 2009 Luis Guachalla Gutierrez

of diseases, including cancer, heart failure, and malaria. Catalysis and allosteric regulation of UDP-glucose pyrophosphorylase (UGP) Cramer et al. (2018) ACS Catalysis. 8:2683-2692. Allosteric mechanisms

Journal , (1999) 338: 561-568 J.D. Meissner, A. Naumann, W.H. Mueller & R.J. Scheibe. Regulation of UDP- N -acetylglucosamine: dolichyl-phosphate N -acetylglucosamine-1-phosphate transferase by retinoic

J, Shepherd SM, Eadsforth TC, Gray D, Fedorov R and Routier FH. Identification of Leishmania major UDP-Sugar Pyrophosphorylase Inhibitors Using Biosensor-Based Small Molecule Fragment Library Screening [...] Fedorov R. (2015) A Quaternary Mechanism Enables the Complex Biological Functions of Octameric Human UDP-glucose Pyrophosphorylase, a Key Enzyme in Cell Metabolism. Sci. Rep. 5, 9618; DOI:10.1038/srep09618 [...] Lamerz A-C, Baruch P, Gerardy-Schahn R and Fedorov R. Catalytic mechanism and allosteric regulation of UDP-glucose pyrophosphorylase from Leishmania major. (2013) ACS Catalysis. 3:2976-2985. Führing J, Damerow

Hepatocarcinogenesis" 19. November 2005, San Fransisco, AASLD. Poster award "Polymorphisms of the UDP-Glucuronosyl-transferase UGT1A7 Gene as a Risk Factor in Chronic Pancreatitis and Pancreatitic Cancer"

Tetramerization is essential for the enzymatic function of the Pseudomonas aeruginosa virulence factor UDP-glucose pyrophosphorylase. mBio. 2024 Mar 12:e0211423. doi: 10.1128/mbio.02114-23. Online ahead of

E., Deng, B., Hunt, A., Sigel, E. A., Troast, D. M. & Dejonge, B. L. ( 2021 ). Discovery of novel UDP-N-Acetylglucosamine Acyltransferase (LpxA) inhibitors with activity against Pseudomonas aeruginosa

15, 3067-3082. Meissner, J.D. , Naumann, A., Müller, W.H., and Scheibe, R.J., 1999. Regulation of UDP-N-acetylglucosamine:dolichyl-phosphate N-acetylglucosamine-1-phosphate transferase by retinoic acid

Münster-Kühnel AK, Gerardy-Schahn R. , (2013) Octamerization is essential for enzymatic function of human UDP-glucose pyrophosphorylase. Glycobiology . 2013 Apr;23(4):426-37. doi: 10.1093/ glycob /cws217. Epub

Birkhäuser Verlag, 2000, p.375-399. Meissner, J.D., A. Naumann, W.H. Müller and R.J. Scheibe Regulation of UDP-N-acetylglucosamine:dolichyl-phosphate N-acetylglucosamine-1-phosphate transferase by retinoic acid