Chopra P, Führing J, Ng P, Haselhorst T, Dyason JC, Rose FJ, Thomson RJ, Gerardy-Schahn R, Grice ID, Jennings MP, Münster-Kühnel AK, von Itzstein M (2025). Exploring the Scope of Functionalized N-Acylneuraminic Acid β-Methyl Glycosides as Inhibitors of Neisseria meningitidis CMP-Sialic Acid Synthetase. Molecules 2025 Nov 7;30(22):4329. doi: 10.3390/molecules30224329. PMID: 41302389

Lokau J, Garbers Y, Vicente MM, Dittrich A, Meltendorf S, Lingel H, Münster-Kühnel AK, Brunner-Weinzierl M, Garbers C (2025). Long-term increase in soluble interleukin-6 receptor levels in convalescents after mild COVID-19 infection. Front Immunol. 2025 Jan 6;15:1488745. doi: 10.3389/fimmu.2024.1488745. eCollection 2024. PMID: 39835136

Niculovic KM, Vicente MM, Wittek V, Kats E, Albers I, Flächsig-Schulz K, Peters-Bernard U, Weiss AC, Thiesler H, Dräger LS, Taft MH, Jörns A, Bakker H, Hildebrandt H, Mühlenhoff M, Weinhold B, Abeln M, Münster-Kühnel AK (2025). Polysialic acid regulates glomerular microvasculature formation by interaction with VEGF-A188 in mice. Angiogenesis 2025 May 24;28(3):31. doi: 10.1007/s10456-025-09984-6. PMID: 40411622

Schmidt M, Linder AT, Korn M, Schellenberg N, Meyer SJ, Nimmerjahn F, Werner A, Abeln M, Gerardy-Schahn R, Münster-Kühnel AK, Nitschke L (2024). Sialic acids on T cells are crucial for their maintenance and survival. Front Immunol. 2024 Jun 14;15:1359494. doi: 10.3389/fimmu.2024.1359494. eCollection 2024. PMID: 38947328

Linder AT, Schmidt M, Hitschfel J, Abeln M, Schneider P, Gerardy-Schahn R, Münster-Kühnel AK, Nitschke L (2022). Sialic acids on B cells are crucial for their survival and provide protection against apoptosis. Proc Natl Acad Sci U S A. 2022 Jun 21;119(25):e2201129119. doi: 10.1073/pnas.2201129119. Epub 2022 Jun 13. PMID: 35696562

Wedekind H, Kats E, Weiss AC, Thiesler H, Klaus C, Kispert A, Horstkorte R, Neumann H, Weinhold B, Münster-Kühnel A, Abeln M. Gne deletion in mice leads to lethal intracerebral hemorrhage during embryonic development. Glycobiology. 2021 Jul 5:cwab069. doi: 10.1093/glycob/cwab069. Online ahead of print. PMID: 34224569

Hachem NE, Humpfle L, Simon P, Kaese M, Weinhold B, Günther J, Galuska SP, Middendorff R. The Loss of Polysialic Acid Impairs the Contractile Phenotype of Peritubular Smooth Muscle Cells in the Postnatal Testis. Cells. 2021 May 29;10(6):1347. doi: 10.3390/cells10061347.PMID: 34072405

Saha S, Coady A, Sasmal A, Kawanishi K, Choudhury B, Yu H, Sorensen RU, Inostroza J, Schoenhofen IC, Chen X, Münster-Kühnel A, Sato C, Kitajima K, Ram S, Nizet V, Varki A. Exploring the Impact of Ketodeoxynonulosonic Acid in Host-Pathogen Interactions Using Uptake and Surface Display by Nontypeable Haemophilus influenzae. mBio. 2021 Jan 19;12(1):e03226-20. doi: 10.1128/mBio.03226-20. PMID: 33468699 Free PMC article.

Kawanishi K, Saha S, Diaz S, Vaill M, Sasmal A, Siddiqui SS, Choudhury B, Sharma K, Chen X, Schoenhofen IC, Sato C, Kitajima K, Freeze HH, Münster-Kühnel A, Varki A. Evolutionary conservation of human ketodeoxynonulosonic acid production is independent of sialoglycan biosynthesis. J Clin Invest. 2021 Mar 1;131(5):e137681. doi: 10.1172/JCI137681. PMID: 33373330 Free PMC article.

Niculovic KM, Blume L, Wedekind H, Kats E, Albers I, Groos S, Abeln M, Schmitz J, Beuke E, Bräsen JH, Melk A, Schiffer M, Weinhold B, Münster-Kühnel AK (2019). Podocyte-Specific Sialylation-Deficient Mice Serve as a Model for Human Focal Segmental Glomerulosclerosis. J Am Soc Nephrol. 2019 Jun;30(6):1021-1035.

Abeln M, Albers I, Peters-Bernard U, Flächsig-Schulz K, Kats E, Kispert A, Tomlinson S, Gerardy-Schahn R, Münster-Kühnel A, Weinhold B, (2018), Sialic acid is a critical fetal defense against maternal complement attack, J Clin Invest. 129(1), 422-436.

Sieve I, Münster-Kühnel AK, Hilfiker-Kleiner D (2018), Regulation and function of endothelial glycocalyx layer in vascular diseases, Vascul Pharmacol. 2018 Jan;100:26-33. doi: 10.1016/j.vph.2017.09.002. Epub 2017 Sep 12.

Abeln M, Borst KM*, Cajic S*, Thiesler H, Kats E, Albers I, Kuhn M, Kaever V, Rapp E, Münster-Kühnel A, Weinhold B (2017). Sialylation Is Dispensable for Early Murine Embryonic Development in Vitro. Chembiochem.  2017 Jul 4;18(13):1305-1316. doi: 10.1002/cbic.201700083.

Kröcher T, Malinovskaja K, Jürgenson M, Aonurm-Helm A, Zharkovskaya T, Kalda A, Röckle I, Schiff M, Weinhold B, Gerardy-Schahn R, Hildebrandt H (corresponding author), Zharkovsky A (2015) Schizophrenia-like phenotype of polysialyltransferase ST8SIA2-deficient mice. Brain Struct. Funct. 220:71-83.

Sellmeier M, Weinhold B, Münster-Kühnel A. CMP-Sialic acid Synthetase: The point of constriction in the sialylation pathway. Review. Topics in Current Chemistry 2015: 366-139, DOI: 10.1007/128_2013_477, Springer Berlin Heidelberg.

Bartel J, Feuerstacke C, Galuska C, Weinhold B, Gerardy-Schahn R, Geyer R, Münster-Kühnel A, Middendorff R, and Galuska S (2014) Laser microdissection of paraffin embedded tissue as a tool to estimate the sialylation status of selected cell populations. Analytical Chemistry

Kröcher T*, Röckle I*, Diederichs U, Weinhold B, Burkhardt H, Yanagawa Y, Gerardy-Schahn R, and Hildebrandt H. (2014) A crucial role for polysialic acid in developmental interneuron migration and the establishment of interneuron densities in the mouse prefrontal cortex. Development 141 (15): 3022-3032. doi: 10.1242/dev.111773. (* equally contributing)

Tsuchiya A, Lu WY, Weinhold B, Boulter L, Stutchfield BM, Williams MJ, Guest RV, Minnis-Lyons SE, Mackinnon AC, Schwarzer D, Ichida T, Nomoto M, Aoyagi Y, Gerardy-Schahn R, Forbes SJ. 2014. PolySia-NCAM modulates the formation of ductular reactions in liver injury. Hepatology e-pub ahead of print, doi: 10.1002/hep.27099

Weinhold B, Gerardy-Schahn R, Münster-Kühnel A. Cytidine Monophosphate N-Acetylneuraminic Acid Synthetase (CMAS). Chapter 39 in Handbook of Glycosyltransferases and Related Genes, N. Taniguchi et al. (eds.), DOI: 10.1007/978-4-431-54240-7_39, pages 1545-1557, Springer Japan 2014.

Führing J, Damerow S, Fedorov R, Schneider J, Münster-Kühnel AK, Gerardy-Schahn R., (2013) Octamerization is essential for enzymatic function of human UDP-glucose pyrophosphorylase. Glycobiology. 2013 Apr;23(4):426-37. doi: 10.1093/glycob/cws217. Epub 2012 Dec 18.

Kröcher T.*, Malinovskaja K.*, Jürgenson M., Aonurm-Helm A., Zharkovskaya T., Kalda A., Röckle I., Schiff M., Weinhold B., Gerardy-Schahn R., Hildebrandt H.* (corresponding author), Zharkovsky A.* (2013) Schizophrenia-like phenotype of polysialyltransferase ST8SIA2-deficient mice. Brain Struct. Funct. advance online publication, 22. Sept. 2013; doi:10.1007/s00429-013-0638-z

Sellmeier M, Weinhold B, and Münster-Kühnel A (2013) CMP-Sialic acid Synthetase: The point of constriction in the sialylation pathway. Top Curr Chem. 2015;366:139-67. doi: 10.1007/128_2013_477. Review.

Schaper, W., Bentrop, J., Ustinova, J., Blume, L., Kats, E., Tiralongo, J., Weinhold, B., Bastmeyer, M., and Münster-Kühnel, A. (2012) Identification and biochemical characterization of two functional CMP-sialic acid synthetases in Danio rerio. J. Biol. Chem. 287(16):13239-48.

Vogt J., Glumm R., Schlüter L., Schmitz D., Rost B.R., Streu N., Rister B., Bharathi B.S., Gaggiannis D., Hildebrandt H., Weinhold B., Mühlenhoff M., Naumann T., Savaskan N.E., Brauer A.U., Reutter W., Heimrich B., Nitsch R, Horstkorte R. (2012) Homeostatic regulation of NCAM-polysialylation is critical for correct synaptic targeting. Cell. Mol. Life Sci. 69 (7): 1179-91.

Weinhold, B., Sellmeier, M., Schaper, W., Blume, L., Philippens, B., Kats, E., Bernard, U., Galuska, S.P., Geyer, H., Geyer, R., Worthmann, K., Schiffer, M., Groos, S., Gerardy-Schahn, R., and Münster-Kühnel A.K. (2012) Deficits in Sialylation Impair Podocyte Maturation. J Am Soc  Nephrol. 2012 Aug;23(8):1319-28. doi: 10.1681/ASN.2011090947.

Vogt J, Glumm R, Schlüter L, Schmitz D, Rost BR, Streu N, Rister B, Suman Bharathi B, Gagiannis D, Hildebrandt H,Weinhold B, Mühlenhoff M, Naumann T, Savaskan NE, Brauer AU, Reutter W, Heimrich B, Nitsch R, and Horstkorte R. (2012) Homeostatic regulation of NCAM polysialylation is critical for correct synaptic targeting. Cell Mol Life Sci. 2012 Apr;69(7):1179-91. doi: 10.1007/s00018-011-0868-2.

Schiff M., Röckle I., Burkhardt H., Weinhold B., Hildebrandt H. (2011) Thalamocortical pathfinding defects precede degeneration of the reticular thalamic nucleus in polysialic acid-deficient mice. J. Neurosci. 31 (4): 1302-1312.

Galuska, S.P., Geyer, H., Weinhold, B., Kontou, M., Rohrich, R.C., Bernard, U., Gerardy-Schahn, R. , Reutter, W., Münster-Kühnel, A., and Geyer, R. (2010) Quantification of nucleotide-activated sialic acids by a combination of reduction and fluorescent labeling. Anal. Chem. 82(11):4591–8.

Galuska, S.P.*, Rollenhagen, M.*, Kaup, M., Eggers, K., Oltmann-Norden, I., Schiff, M., Hartmann, M., Weinhold, B., Hildebrandt, H., Geyer, R., Mühlenhoff, M.*, and Geyer, H.* (2010) Synaptic cell adhesion molecule SynCAM 1 is a target for polysialylation in postnatal mouse brain. Proc. Natl. Acad. Sci. USA. 107(22):10250-5.

Pekcec, A., Weinhold, B., Gerardy-Schahn, R., and Potschka, H. (2010) Polysialic acid affects pathophysiological consequences of status epilepticus. Neuroreport. 21(8):549-53.

Drake, P. M, Stock, C. M, Nathan, J. K, Gip, P., Golden, K. P., Weinhold, B., Gerardy-Schahn, R., and Bertozzi, C.R. (2009) Polysialic acid governs T-cell development by regulating progenitor access to the thymus. Proc. Natl. Acad. Sci. U S A. 106(29):11995–2000.

Hildebrandt, H., Mühlenhoff, M., Oltmann-Norden, I., Röckle, I., Burkhardt, H., Weinhold, B., and  Gerardy-Schahn, R. (2009) Imbalance of neural cell adhesion molecule and polysialyltransferase alleles causes defective brain connectivity. Brain. 132(Pt 10):2831–8.

Jungnickel, J., Brämer, C., Bronzlik, P., Lipokatic-Takacs, E., Weinhold, B., Gerardy-Schahn, R., and Grothe, C. (2009) Level and localization of polysialic acid is critical for early peripheral nerve regeneration. Mol. Cell Neurosci. 40(3):374–81.

Mühlenhoff, M., Oltmann-Norden, I., Weinhold, B., Hildebrandt, H., and Gerardy-Schahn, R. (2009) Brain development needs sugar: the role of polysialic acid in controlling NCAM functions. Biol Chem. 2009 Jul; 390(7):567–74, Review.

Oschlies, M.; Dickmanns, A.; Haselhorst, T.; Schaper, W.; Stummeyer, K.; Tiralongo, J.; Weinhold, B.; Gerardy-Schahn, R.; von Itzstein, M.; Ficner, R. ; Münster-Kühnel, A.-K., (2009) A C-terminal phosphatase module conserved in vertebrate CMP-sialic acid synthetases  provides a tetramerization interface for the physiologically active enzyme. J. Mol. Biol. 393(1):83–97.

Schiff, M., Weinhold, B., Grothe, C., and Hildebrandt, H. (2009) NCAM and polysialyltransferase profiles match dopaminergic marker gene expression but polysialic acid is dispensable for development of the midbrain dopamine system.  J. Neurochem. 110: 1661–1673.

Drake, P.M., Nathan. J.K., Stock, C.M., Chang, P.V., Muench, M.O., Nakata, D., Reader, J.R., Gip, P., Golden, K.P., Weinhold, B., Gerardy-Schahn, R., Troy, F.A. 2nd, and Bertozzi, C.R. (2008) Polysialic acid, a glycan with highly restricted expression, is found on human and murine leukocytes and modulates immune responses. J Immunol. 181(10):6850-8.

Hartlieb, S., Günzel, A., Gerardy-Schahn, R., Münster-Kühnel, A.K., Kirschning, A., and Dräger, G. (2008) Chemoenzymatic synthesis of CMP-N-acetyl-7-fluoro-7-deoxy-neuraminic acid. Carbohydr Res. 343(12):2075-82.

Potschka, H., Pekcec, A., Weinhold, B., and Gerardy-Schahn, R. (2008) Deficiency of neural cell adhesion molecule or its polysialylation modulates pharmacological effects of the AMPA receptor antagonist NBQX. Neuroscience 152(4):1093-8.

Röckle, I., Seidenfaden, R., Weinhold, B., Mühlenhoff, M., Gerardy-Schahn, R., and Hildebrandt, H. (2008) Polysialic acid controls NCAM-induced differentiation of neuronal precursors into calretinin-positive olfactory bulb interneurons. Dev Neurobiol. 68(9):1170-1184.

Haselhorst, T., Münster-Kühnel, A.K., Oschlies, M., Tiralongo, J., Gerardy-Schahn, R., and Itzstein, M.V. (2007) Direct detection of ligand binding to Sepharose-immobilised protein using saturation transfer double difference (STDD) NMR spectroscopy. Biochem. Biophys. Res. Commun. 359(4):866-70.

Hildebrandt, H.,  Mühlenhoff, M., Weinhold, B., Gerardy-Schahn, R., (2007),  Dissecting polysialic acid and NCAM functions in brain development. J. Neurochem 103(Suppl.1): 56-64, Review

Tiralongo, J., Fujita, A., Sato, C., Kitajima, K., Lehmann, F., Oschlies, M., Gerardy-Schahn, R., and Münster-Kühnel, A.K. (2007) The rainbow trout CMP-sialic acid synthetase utilises a nuclear localization signal different from that identified in the mouse enzyme. Glycobiology 17(9):945-54.

Galuska, S.P., Oltmann-Norden, I., Geyer, H., Weinhold, B., Kuchelmeister, K., Hildebrandt, H., Gerardy-Schahn, R., Geyer, R., and Mühlenhoff, M. (2006) Polysialic acid profiles of mice expressing variant allelic combinations of the polysialyltransferases ST8SiaII and ST8SiaIV. J. Biol. Chem. 281(42):31605-15.

Senkov, O., Sun, M., Weinhold, B., Gerardy-Schahn, R., Schachner, M., and Dityatev, A. (2006) Polysialylated neural cell adhesion molecule is involved in induction of long-term potentiation and memory acquisition and consolidation in a fear-conditioning paradigm. J. Neurosci. 26(42): 10888-109898.

Stoenica, L., Senkov, O., Gerardy-Schahn, R., Weinhold, B., Schachner, M., Dityatev, A. (2006) In vivo synaptic plasticity in the dentate gyrus of mice deficient in the neural cell adhesion molecule NCAM or its polysialic acid. Eur. J. Neurosci. 23(9):2255-64.

Fujita, A., Sato, C., Münster-Kühnel, A.K., Gerardy-Schahn, R., and Kitajima, K. (2005) Development of a simple and efficient method for assaying cytidine monophosphate sialic acid synthetase activity using an enzymatic reduced nicotinamide adenine dinucleotide/oxidized nicotinamide adenine dinucleotide converting system. Anal. Biochem. 337: 12-21.

Haselhorst, T., Münster-Kühnel, A.K., Stolz, A., Oschlies, M., Tiralongo, J., Kitajima, K., Gerardy-Schahn, R., and von Itzstein, M. (2005) Probing a CMP-Kdn synthetase by 1H, 31P, and STD NMR spectroscopy. Biochem. Biophys. Res. Commun. 327: 565-570.

Weinhold, B., Seidenfaden, R., Röckle, I., Mühlenhoff, M., Schertzinger, F., Conzelmann, S., Marth, J.D., Gerardy-Schahn, R., and Hildebrandt, H. (2005) Genetic ablation of polysialic acid causes severe neurodevelopmental defects rescued by deletion of the neural cell adhesion molecule. J. Biol. Chem. 280: 42971-42977.