nih.gov/pubmed/30785826 (Apr 2019) Unsere Arbeit zu HER2 Mutationen im lobulären Karzinom ist in Genes Chromosomes and Cancer erschienen: www.ncbi.nlm.nih.gov/pubmed/30520184 (Jan 2019) Die AG klinische [...] nih.gov/36347887/ ( Nov. 2022) Together with the West German Study Group (WSG) we have characterized gene expression pattern in breast cancers under anti-HER2 therapy with trastuzumab/pertuzumab. The results [...] German Study Group (WSG) we have conducted the first clinical trial worldwide, that has combined a gene expression-based assay (Oncotype DX Recurrence Score) with Ki67-response evaluation after pre-operative
Farris AB, Geldenhuys L, Loupy A, Nickeleit V, Rabant M, Randhawa P, Regele H, Mengel M. Intragraft Gene Expression in Native Kidney BK Virus Nephropathy versus T‐Cell Mediated Rejection: Prospects for Molecular [...] Vogtmann J, Schipper E, Büsche G, Schlue J, Kreipe H, Lehmann U. Feasibility of Combined Detection of Gene Mutations and Fusion Transcripts in Bone Marrow Trephines from Leukemic Neoplasms . J Mol Diagn. 2020 [...] Harbeck N. Efficacy of deescalated chemotherapy according to PAM50 subtypes, immune and proliferation genes in triple-negative early breast cancer: Primary translational analysis of the WSG-ADAPT-TN trial.
Gentner B, Casanova JL, Bustamante J, Schambach A, Kalinke U, Lachmann N. Hematopoietic stem cell gene therapy for IFNgammaR1 deficiency protects mice from mycobacterial infections. Blood 2017; 131(5):533-545 [...] Künzel S, Suwandi A, Grassl GA, Rosenstiel P, Baines JF. Multigenerational Influences of the Fut2 gene on the dynamics of the gut microbiota in mice. Front Microbiol 2017; 8:991. Rosner BM, Schielke A
Hasemeier B, Länger F, Kreipe H: Promoter hypermethylation of the death-associated protein kinase gene in breast cancer is associated with the invasive lobular subtype. Cancer Res 2002; 62(22): 6634-8 [...] 118: 675-82 Warmann S, Hunger M, Teichmann B, Flemming P, Gratz KF, Fuchs J: The role of the MDR1 gene in the development of multidrug resistance in human hepatoblastoma: clinical course and in vivo model
others. Until today, however, no specific genes (=hereditary disposition) could be identified that actually causes tics. The aim of this study is to discover the genes responsible for the inheritance of tics [...] to answer whether early traumatic childhood experiences and the methylation of exon IV of the BDNF gene have an influence on the differential effectiveness of the two treatments. Mediator analyzes are used
auftreten. Bis heute konnte aber kein spezielles Gen (=Erbanlage) identifiziert werden, das tatsächlich Tics verursacht. Ziel dieser Studie ist es, die Gene zu entdecken, die für die Vererbung von Tics v [...] untersucht, ob frühe traumatisierende Kindheitserfahrungen sowie die Methylierung von Exon IV des BDNF-Gens einen Einfluss auf die differentielle Wirksamkeit der beiden Behandlungen haben. Durch Mediatorenanalysen
Bereich umfassen elektrophysiologische Störungen (z. B. Brugada-Syndrom aufgrund von Mutationen im SCN5A-Gen), die Störung kardialer Transkriptionsfaktoren (z. B. NKX2.5 Knock Out in HFOs) und die Untersuchung [...] Ansatz gehören elektrophysiologische Störungen (z. B. Brugada-Syndrom aufgrund von Mutationen im SCN5A-Gen), die Inaktivierung kardialer Transkriptionsfaktoren (z. B. NKX2.5-Knock-out in HFOs) und jüngste [...] and MHHi021-B) from a patient with hypertrophic cardiomyopathy with p.Arg723Gly mutation in the MYH7 gene. Stem Cell Res. 2021 Apr;52:102208. doi: 10.1016/j.scr.2021.102208. Epub 2021 Feb 3. PMID: 33578365
chronic lung disease initiation. By using patient-derived iPS cells, we also study the effect of gene deficiencies on alveolar cell functionality. Single-cell transcriptomics, data integration approaches
Viable pigs after simultaneous inactivation of porcine MHC class I and three xenoreactive antigen genes GGTA1, CMAH and B4GALNT2. Fischer K, Rieblinger B, Hein R, Sfriso R, Zuber J, Fischer A, Klinger B
Hämatologie Molekularbiologie der Zelle Alberts Alternativ: Molecular Biology of the cell Alberts Gene therapy immunology Herzog Textbook of Hematology / McKenzie Principles of regenerative medicine Atala